Family Search for PF11738 (DUF3298)
Running HMMer for PF11738
PF11738 hits 59 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
CD630_15590, CDIF630erm_01728 anti-sigma-V factor rsiV from Clostridioides difficile 630
CD1559 hypothetical protein from Clostridium difficile 630
Aligns to 199:284 / 289 (29.8%), covers 97.6% of PF11738, 85.8 bits
- Activation of the extracytoplasmic function σ factor σV by lysozyme
Ho, Molecular microbiology 2019 - “...CD630_15560 N-acetylglucosamine deacetylase* pdaVprsA2sigVrsiV15601562 prsA2 CD630_15570 Peptidyl isomerase pdaVprsA2sigVrsiV15601562 sigV (csfV) CD630_15580 factor* pdaVprsA2sigVrsiV15601562 rsiV CD630_15590 Anti- factor* pdaVprsA2sigVrsiV15601562 cd1560 CD630_15600 Lysozyme binding protein pdaVprsA2sigVrsiV15601562 cd1561 CD630_15561 XdhC-like Xanthine dehydrogenase maturation factor pdaVprsA2sigVrsiV15601562 cd1562 CD630_15562 cytoplasmic zinc metalloprotease pdaVprsA2sigVrsiV15601562 dltD CD630_28540 D-alanine transfer from undecaprenol-phosphate to...”
- Iron Regulation in Clostridioides difficile
Berges, Frontiers in microbiology 2018 - “...-0.58 3.69 0.16 + CD630_15580 CDIF630erm_01727 csfV ECF RNA polymerase sigma factor CsfV 2.29 3.42 CD630_15590 CDIF630erm_01728 rsiV Anti ECF RNA polymerase sigma factor RsiV 1.55 2.73 CD630_26510 CDIF630erm_02905 murG UDP- N -acetylglucosamine- N -acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N - acetylglucosamine transferase 1.30 0.63 1.54 1.34 CD630_26520 CDIF630erm_02906...”
- “...3.69 0.16 + CD630_15580 CDIF630erm_01727 csfV ECF RNA polymerase sigma factor CsfV 2.29 3.42 CD630_15590 CDIF630erm_01728 rsiV Anti ECF RNA polymerase sigma factor RsiV 1.55 2.73 CD630_26510 CDIF630erm_02905 murG UDP- N -acetylglucosamine- N -acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N - acetylglucosamine transferase 1.30 0.63 1.54 1.34 CD630_26520 CDIF630erm_02906 spoVE...”
- Clostridium difficile extracytoplasmic function σ factor σV regulates lysozyme resistance and is necessary for pathogenesis in the hamster model of infection
Ho, Infection and immunity 2014 - “...cd1117 cd1555 cd1556 (pdaV) cd1557 (prsA2) cd1558 (csfV) cd1559 (rsiV) cd1560 cd1561 cd1562 cd1565 cd1605 cd1606 cd1607 cd1608 cd1609 cd1610 cd1611 cd3329...”
- PrsW is required for colonization, resistance to antimicrobial peptides, and expression of extracytoplasmic function σ factors in Clostridium difficile
Ho, Infection and immunity 2011 - “...domains in the predicted protein sequence. Both CsfV and CD1559 (RsiV) have strong homology to B. subtilis V and anti-V (RsiV) (Fig. 1). For both csfT and...”
- “...csfU and cd1888 (rsiU) as well as csfV and cd1559 (rsiV) coexpressions (Fig. 3). This finding suggests that these genes encode negative regulators of the ECF...”
RSIV_BACSU / O05403 Anti-sigma-V factor RsiV from Bacillus subtilis (strain 168) (see 2 papers)
BSU27130 anti-sigma(V) factor from Bacillus subtilis subsp. subtilis str. 168
NP_390591 anti-sigma(V) factor from Bacillus subtilis subsp. subtilis str. 168
Aligns to 189:272 / 285 (29.5%), covers 98.8% of PF11738, 84.4 bits
- function: Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction.
subunit: Interacts (via N-terminal region) with SigV. - Activation of the extracytoplasmic function σ factor σV by lysozyme
Ho, Molecular microbiology 2019 - “...Operon 4 B. subtilis sigV BSU27120 RNA polymerase ECF-type sigma factor V * sigVrsiVoatAyrhK rsiV BSU27130 Anti- factor for V * sigVrsiVoatAyrhK oatA BSU27140 O-acetyl transferase* sigVrsiVoatAyrhK yrhK BSU27150 Hypothetical protein sigVrsiVoatAyrhK dltA BSU27150 D-alanyl-D-alanine carrier protein ligase dltABCDE dltB BSU38510 D-alanine transfer from DltC to...”
- Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme.
Lewerke, PLoS genetics 2018 - GeneRIF: In Bacillus subtilis upon lysozyme binding to RsiV, the hydrophobic face of the amphipathic helix becomes accessible to a membrane-impermeable reagent. Thus, study proposes that amphipathic helices protect RsiV from cleavage in the absence of lysozyme.
- Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.
Hastie, PLoS genetics 2014 - GeneRIF: RsiV directly binds to lysozyme.RsiV controls activation of the factor sigma V.
- The activity of σV, an extracytoplasmic function σ factor of Bacillus subtilis, is controlled by regulated proteolysis of the anti-σ factor RsiV.
Hastie, Journal of bacteriology 2013 - GeneRIF: Authors demonstrate that the activation of a member of the ECF30 subfamily of ECF sigma factors, sigma(V) in Bacillus subtilis, is controlled by the proteolytic destruction of the anti-sigma factor RsiV.
Cthe_1437 hypothetical protein from Clostridium thermocellum ATCC 27405
Aligns to 200:287 / 300 (29.3%), covers 96.4% of PF11738, 82.0 bits
- Global transcriptome analysis of Clostridium thermocellum ATCC 27405 during growth on dilute acid pretreated Populus and switchgrass
Wilson, Biotechnology for biofuels 2013 - “...0.09 -2.28 -1.36 Cthe_1404 GTP-binding protein HSR1-related -1.26 -1.33 0.02 -0.02 -2.55 -1.46 -3.82 -2.78 Cthe_1437 Hypothetical protein -2.50 -1.23 -0.16 -0.04 -0.16 -0.07 -2.50 -1.26 Cthe_1438 RNA polymerase sigma factor, sigma-70 family -1.90 -1.40 -0.10 -0.09 -1.03 -0.16 -2.83 -1.46 Cthe_1480 Hypothetical protein -0.38 -0.32...”
- “...(Table 4 ). Other genes affected in the growth stage comparison include an anti-sigma factor (Cthe_1437) and a putative ABC transporter subunit (Cthe_2573). These genes are potentially contributing to the transition of the cells from log to stationary phase. Substrate-specific gene expression Comparison of differentially expressed...”
CD630_15600 DUF3298 and DUF4163 domain-containing protein from Clostridioides difficile 630
CD1560 hypothetical protein from Clostridium difficile 630
Aligns to 160:245 / 251 (34.3%), covers 96.4% of PF11738, 78.8 bits
CD0543 hypothetical protein from Clostridium difficile 630
Aligns to 193:270 / 287 (27.2%), covers 97.6% of PF11738, 75.0 bits
CDR20291_1409 hypothetical protein from Clostridium difficile R20291
Aligns to 160:245 / 251 (34.3%), covers 96.4% of PF11738, 73.5 bits
OG1RF_12447 RsiV family protein from Enterococcus faecalis OG1RF
Aligns to 196:281 / 294 (29.3%), covers 96.4% of PF11738, 71.4 bits
EF3179 conserved hypothetical protein from Enterococcus faecalis V583
EF_3179 RsiV family protein from Enterococcus faecalis V583
Aligns to 196:281 / 294 (29.3%), covers 95.2% of PF11738, 70.5 bits
PGN_1502 hypothetical protein from Porphyromonas gingivalis ATCC 33277
Aligns to 187:266 / 290 (27.6%), covers 100.0% of PF11738, 70.1 bits
- The Porphyromonas gingivalis ferric uptake regulator orthologue binds hemin and regulates hemin-responsive biofilm development
Butler, PloS one 2014 - “...for EMSA PGN_0001_240bp_For GGTGTTGATAACTCGGTCGCGCCTT PGN_0001Rev CTAAAAAAATATCGTTTTGAGAGCAGT Construction of har mutant PGN_1502-Fwd ATGTCGCCTTCCGAGGCTAT ErmF-PGN_1502-Rev GCAATAGCGGAAGCTATCGG TTATCTTTTCGATCCATTCTTGC PGN_1502- ErmF -Fwd AGAATGGATCGAAAAGATAA CCGATAGCTTCCGCTATTGC Term- ErmF -Rev GTCTTTCGACTGAGCCTTTCGTT TTAGCATCTAATTTAACTTCAATTCC Term- Prom-region -Fwd GCTCAGTCGAAAGACTGGGCCTTTCGTTTTA CGGAGTGAAAAAGGAGCCG PGN_1504- Prom-region -Rev CAATGTTATATGTCTGTGTTA TCTCTCTTTTACATCATATTTTCC Prom-region- PGN_1504 -Fwd AATATGATGTAAAAGAGAGA TAACACAGACATATAACATTGATCC PGN_1504-Rev GCAGATATTTTGTAGCCTCCATC Construction of har complement...”
- “...cassette for deletion of the har gene consisted of the final 600 bp of the PGN_1502 gene, the ermF gene encoding erythromycin resistance in P. gingivalis , followed by a transcriptional terminator then a copy of the promoter region that drives the operon containing PGN_1503, followed...”
CPR_2297 hypothetical protein from Clostridium perfringens SM101
Aligns to 149:224 / 236 (32.2%), covers 98.8% of PF11738, 67.9 bits
lpl0749 hypothetical protein from Legionella pneumophila str. Lens
Aligns to 137:214 / 231 (33.8%), covers 100.0% of PF11738, 64.5 bits
LPC_2581 endo-1,4-beta-xylanase-like protein from Legionella pneumophila str. Corby
Aligns to 137:214 / 231 (33.8%), covers 100.0% of PF11738, 64.5 bits
lpp0767 hypothetical protein from Legionella pneumophila str. Paris
Aligns to 137:214 / 231 (33.8%), covers 100.0% of PF11738, 64.4 bits
lpg0712 endo-1,4-beta-xylanase-like from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Aligns to 137:214 / 231 (33.8%), covers 100.0% of PF11738, 64.4 bits
BTHUR0008_RS23575 DUF3298 and DUF4163 domain-containing protein from Bacillus thuringiensis serovar berliner ATCC 10792
Aligns to 154:229 / 247 (30.8%), covers 98.8% of PF11738, 61.4 bits
Cthe_0057 hypothetical protein from Clostridium thermocellum ATCC 27405
Aligns to 122:194 / 210 (34.8%), covers 96.4% of PF11738, 60.0 bits
CD3580 hypothetical protein from Clostridium difficile 630
Aligns to 144:217 / 247 (30.0%), covers 100.0% of PF11738, 59.5 bits
- Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically-relevant faecal environment, with implications for pathogenicity
Ternan, Scientific reports 2018 - “...of genes reported to be regulated by sporulationspecific sigma factors 41 43 , including K (CD3580 & CD1065), G (CD2808 & CD2375) and E (CD1063A-C, CD2150A & CD3522) were also DE in FW. Dembek 83 reported that a large proportion of C. difficile spore transcripts encoded...”
- A Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile
Serrano, PLoS genetics 2016 - “...+/- 8 6 +/-0.2 CD1133 31 +/- 2 2.7 +/- 0.8 30 +/-1 2.2 +/-0.8 CD3580 70 +/-15 2.9 +/- 0.9 50 +/-5 3 +/- 0.5 Total RNAs were extracted from C . difficile 630 erm strain, the CD1231 and CD1234 mutants, and the complementation strains...”
- SpoIIID-mediated regulation of σK function during Clostridium difficile sporulation
Pishdadian, Molecular microbiology 2015 - “...gene expression between the spoIIID train and swild type for K regulon genes, sleC, cotE, CD3580 and cdeC ( Fig. 4 ; 100-fold, 55-fold, 224-fold and 27-fold respectively; p < 0.001), consistent with results of the RNA-Seq analyses ( Tables S4 and S5 ). While no...”
- “...both the spoIIID and sigK mutants fail to produce K -regulated gene products (SleC, CotE, CD3580 and CotE) even though they produce wild-type levels of the E -regulated gene products SpoIVA and CotB ( Fig. S5 ; Fimlaid et al ., 2013 ). As the spoIIID...”
- Genome-Wide Transcriptional Profiling of Clostridium perfringens SM101 during Sporulation Extends the Core of Putative Sporulation Genes and Genes Determining Spore Properties and Germination Characteristics
Xiao, PloS one 2015 - “...( yyaC ), CPR2565 ( yyaD/ykvI ), CPR_0309 (CD0546), CPR_1322 (CD1594), CPR_2328 (CD2809), CPR_2525(CD3522), CPR_2297 (CD3580) * Homologs of the known sporulation genes summarized in reference [ 8 ] but that do not have specific sporulation-associated increased expression (grouped in Clusters 36) can be retrieved from...”
- Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile
Saujet, PLoS genetics 2013 - “...protein 0.01 0.01 + CD2055 Conserved hypothetical protein 0.33 CD2409 Conserved hypothetical protein 0.11 K CD3580 Conserved hypothetical protein 0.11 0.12 K + CD3613 Conserved hypothetical protein 0.04 K + CD3620 Conserved hypothetical protein, similar to YmaF 0.34 0.04 + a A gene is considered differentially...”
- “...-dependent promoter upstream five of their encoding genes ( CD1063.1 , CD1067 , CD1133 , CD3580 and CD3613 ). These proteins are most likely spore coat proteins but further work would be necessary to characterize their localization and their function in C. difficile . In conclusion,...”
CDR20291_3418 DUF3298 and DUF4163 domain-containing protein from Clostridioides difficile R20291
Aligns to 144:217 / 247 (30.0%), covers 100.0% of PF11738, 59.4 bits
HMPREF1322_RS07770 RsiV family protein from Porphyromonas gingivalis W50
Aligns to 175:254 / 271 (29.5%), covers 98.8% of PF11738, 59.1 bits
- Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis
Costeira, mSystems 2023 - “...32.73% 1.48E-05 HMPREF1322_RS00725 Lactate utilization protein Yes HMPREF1322_RS00720,HMPREF1322_RS00725, HMPREF1322_RS00730 NZ_AJZS01000079.1 3864 76.11% 60.84% 15.27% 1.52E-05 HMPREF1322_RS07770 DUF3298 domain-containing protein No HMPREF1322_RS07770,HMPREF1322_RS07775, HMPREF1322_RS07780 NZ_AJZS01000011.1 14512 + 5.03% 41.65% 36.62% 1.56E-05 HMPREF1322_RS00730 Hypothetical protein Yes HMPREF1322_RS00725,HMPREF1322_RS00730, HMPREF1322_RS00735 NZ_AJZS01000007.1 2872 16.32% 6.02% 10.30% 1.62E-05 HMPREF1322_RS00445,HMPREF1322_RS00450 NZ_AJZS01000011.1 14323 + 2.43%...”
- “...Table S5 ). We observed, however, that the 4-alpha-glucanotransferase HMPREF1322_RS03650 and the DUF3298 domain-containing protein HMPREF1322_RS07770 contained respectively two and one DMAs within 500 bp of a GATC-DMM. Overall, DMAs and GATC-DMMs shared 13 genes annotated within 1 kb of their location (out of 75 and...”
- Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis
Costeira, 2022
PG1308 hypothetical protein from Porphyromonas gingivalis W83
Aligns to 185:264 / 281 (28.5%), covers 98.8% of PF11738, 59.0 bits
- Role of vimA in cell surface biogenesis in Porphyromonas gingivalis
Osbourne, Microbiology (Reading, England) 2010 - “...55 7 Probable outer membrane lipoprotein PG1177 Cell wall biogenesis 21 18 Conserved hypothetical protein PG1308 Unknown 100 24 Conserved hypothetical protein PG1496 Transport 99 19 Conserved hypothetical protein PG1772 Proteolysis 98 4 Hypothetical protein PG1790 Unknown 10 1 Outer-membrane protein (immunogenic 23kDa lipoprotein) PG1793 Cell...”
A1S_0556 hypothetical protein from Acinetobacter baumannii ATCC 17978
Aligns to 169:247 / 275 (28.7%), covers 100.0% of PF11738, 58.6 bits
ABBFA_003004 hypothetical protein from Acinetobacter baumannii AB307-0294
Aligns to 189:267 / 295 (26.8%), covers 100.0% of PF11738, 58.4 bits
HMPREF0010_01698 RsiV family protein from Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
Aligns to 207:285 / 313 (25.2%), covers 98.8% of PF11738, 57.0 bits
P9WIN9 Immunogenic protein MPT64 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
NP_216496 immunogenic protein Mpt64 from Mycobacterium tuberculosis H37Rv
NP_216496, Rv1980c IMMUNOGENIC PROTEIN MPT64 (ANTIGEN MPT64/MPB64) from Mycobacterium tuberculosis H37Rv
Mb2002c IMMUNOGENIC PROTEIN MPT64 (ANTIGEN MPT64/MPB64) from Mycobacterium bovis AF2122/97
Aligns to 145:221 / 228 (33.8%), covers 97.6% of PF11738, 55.2 bits
- A standardized production pipeline for high profile targets from Mycobacterium tuberculosis
Milewski, Proteomics. Clinical applications 2016 - “...32.7 4.93 Rv1886c Ag85b (FbpB) P9WQP1 Diacylglycerol acyltransferase/mycolyltransferase 1 S 18 34.6 5.62 Rv1980c Mpt64 P9WIN9 Immunogenic protein 2 S 18 24.9 4.84 Rv2031c Acr (HspX) P9WMK1 Alphacrystallin 0 C; M 16.2 5.00 Rv2654c Antitoxin Rv2654 P9WJ11 Antitoxin component of a toxinantitoxin module (Rv2654cRv2653c) 0 g...”
- Electrochemical aptasensor using optimized surface chemistry for the detection of Mycobacterium tuberculosis secreted protein MPT64 in human serum.
Sypabekova, Biosensors & bioelectronics 2019 (PubMed)- GeneRIF: The study investigates combinatorial effects of an aptamer linker and a co-adsorbent onto a gold electrode for optimal binding efficiency and reduced non-specific interactions for label-free detection of MPT64 using electrochemical impedance spectroscopy.
- Association of Mycobacterium tuberculosis L-formmpb64 gene and lung cancer.
Abudureheman, European review for medical and pharmacological sciences 2019 (PubMed)- GeneRIF: The Mpb64 gene fragment is highly expressed in the nucleus of pulmonary tuberculosis tissues. Its expression in the nucleus of pulmonary tuberculosis plus lung cancer tissue is significant and the expression in the nucleus of lung cancer tissue is also high. The expression of Mpb64 is independent from the various pathological features of the cancerous tissues.
- Immunochromatographic detection of MPB64 secreted from active BCG by heating: toward same-day diagnosis of tuberculosis.
Nakaishi, BioTechniques 2019 (PubMed)- GeneRIF: When BCG was included in solution at a concentration >2.75 x 10(4) CFU/ml, our method for collecting MPB64 through heating active BCG combined with an immunochromatographic assay detected active bacilli within 2.5 h.
- Selection, characterization, and application of DNA aptamers for detection of Mycobacterium tuberculosis secreted protein MPT64.
Sypabekova, Tuberculosis (Edinburgh, Scotland) 2017 (PubMed)- GeneRIF: Aptamers against Mtb secreted protein MPT64 were successfully selected and could be used as an alternative for detection and diagnosis of tuberculosis.
- Polymorphism of antigen MPT64 in Mycobacterium tuberculosis strains.
Jiang, Journal of clinical microbiology 2013 - GeneRIF: we found that polymorphisms of the mpt64 gene in the MTBC may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions, thereby allowing immune evasion.
- A DNA vaccine expressing CFP21 and MPT64 fusion protein enhances BCG-induced protective immunity against Mycobacterium tuberculosis infection in mice.
Wang, Medical microbiology and immunology 2011 (PubMed)- GeneRIF: CFP21 (cutinase precursor) and MPT64 fusion protein stimulate higher level of interferon (IFN)-gamma in tuberculin skin test (TST)-positive healthy population than in TST-negative healthy population.
- [Immunoprophylaxis of recombinant Mycobacterium vaccae secreted MPT64 of Mycobacterium tuberculosis].
Bai, Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2009 (PubMed)- GeneRIF: Data show that Recombinant Mycobacterium vaccae secreted MPT64 could induce high level humoral and cell mediated immune responses in mice and could be used as a candidate of new vaccine against TB.
- Design and optimization of a recombinant system for large-scale production of the MPT64 antigen from Mycobacterium tuberculosis.
Geisbrecht, Protein expression and purification 2006 (PubMed)- GeneRIF: Recombinant rMPT64 elicits a specific immune response indistinguishable from that of MPB64 purified from BCG Tokyo culture filtrates.
- Unveiling the Significance of LysE in Survival and Virulence of Mycobacterium tuberculosis: A Review Reveals It as a Potential Drug Target, Diagnostic Marker, and a Vaccine Candidate
Upadhyay, Vaccines 2024 - “...region, which encompasses both T and B cell epitopic regions. The results indicate that proteins Rv1980c, Rv1985, and Rv1986 in the RD2 region undergo antigenic variation in response to host immune pressure, suggesting their potential role in ongoing immune evasion. The data confirmed that RD2 regions,...”
- Sustained transmission over two decades of a previously unrecognised MPT64 negative Mycobacterium tuberculosis strain in Queensland, Australia: a whole genome sequencing study
Bainomugisa, The Lancet regional health. Western Pacific 2024 - “...assays are unable to interrogate drug resistance to many new and repurposed treatment agents. MPT64 (Rv1980c) is a 24-kDa secreted protein found in all MTBC species except some strains of M.bovis and M.bovis BCG, 6 that is hypothesised to be one of the first proteins to...”
- “...8 Mustafa A.S. Shaban F. Mapping of Th1-cell epitope regions of mycobacterium tuberculosis protein MPT64 (Rv1980c) using synthetic peptides and t-cell lines from M. tuberculosis-infected healthy humans Med Princ Pract 2010 10.1159/000273073 9 Li Q. Yu H. Zhang Y. Immunogenicity and protective efficacy of a fusion...”
- Construction of novel multi-epitope-based diagnostic biomarker HP16118P and its application in the differential diagnosis of Mycobacterium tuberculosis latent infection
Wang, Molecular biomedicine 2024 - “...to both the RD-related antigens and latent infection stage antigens, including Rv1511, Rv1736c, Rv1737c, Rv1978, Rv1980c, Rv1981c, Rv2031c, Rv2626c, Rv2653c, Rv2654c, Rv2656c, Rv2657c, Rv2658c, Rv2659c, Rv2660c, Rv3425, Rv3429, Rv3872, Rv3873, Rv3878, and Rv3879c [ 13 31 ]. We further studied the Th1-type helper T lymphocyte (HTL)...”
- “...], Rv1736c [ 13 ], Rv1737c [ 14 , 15 ], Rv1978 [ 28 ], Rv1980c [ 21 ], Rv1981c [ 22 ], Rv2031c [ 29 31 ], Rv2626c [ 16 19 ], Rv2656c [ 40 ], Rv2659c [ 20 ], Rv3425 [ 25 27 ],...”
- Exploring the Potential of Exosomes as Biomarkers in Tuberculosis and Other Diseases
Arya, International journal of molecular sciences 2024 - “...is possible to identify mycobacterial-specific protein biomarkers for TB diagnosis. The Mtb protein biomarkers MPT64 (Rv1980c, 24 kDa) serve as a pivotal component in immuno-chromatographic assays for the rapid identification of the MTBC [ 61 ] and alanine and proline-rich secreted protein (Apa, Rv1860, 45/47 kDa)...”
- Evaluation of serological assays for the diagnosis of childhood tuberculosis disease: a study protocol
Neudecker, BMC infectious diseases 2024 - “...PstS1 Rv0934 PapA4 Rv1528 GarA Rv1827 Apa (Mpt32) Rv1860 FbpB (Ag85B) Rv1886c Mpt63 Rv1926c Mpt64 Rv1980c HspX (Acr) Rv2031c Acg Rv2032 Rv2034 Rv2034 Hrp1 Rv2626c EsxO-EsxP Rv2346-Rv2347 EspA Rv3616c FbpD (Mpt51) Rv3803c FbpA (Ag85A) Rv3804c EsxB (CFP-10) Rv3874 EsxA (ESAT-6) Rv3875 EsxA-EsxB (ESAT6-CFP10) Rv3875-Rv3874 EspD-EspC Rv3614-Rv3615...”
- Overexpression of LAG-3: a potential indicator of low immune function in tuberculosis
Pan, Frontiers in cellular and infection microbiology 2024 - “...(DCs) are one of the most important innate immune cells. Upon exposure to the MPT64 (Rv1980c) protein released by MTB, the differentiation of bone marrow-derived dendritic cells (BMDCs) into myeloid-derived suppressor cells (MDSCs), rather than dendritic cells (DCs), under a milieu conducive to DC differentiation (consisting...”
- From pathogenesis to antigens: the key to shaping the future of TB vaccines
Yang, Frontiers in immunology 2024 - “...DCs are less effective in stimulating T cells than uninfected DCs ( 134 ) MPT64 (Rv1980c) DCs exposed to MPT64 develop into myeloid-derived suppressor cells (MDSCs) ( 135 ) PDIM PDIM lowers the expression of CD86 and IL-12, suppresses the activation of DCs and macrophages, and...”
- Discovering peptides and computational investigations of a multiepitope vaccine target Mycobacterium tuberculosis
Nguyen, Synthetic and systems biotechnology 2024 - “...al. selected 17 latent tuberculosis infection and regions of difference (LTBI-RD) antigens (Rv1511, Rv1736c, Rv1737c, Rv1980c, Rv1981c, Rv2031c, Rv2626c, Rv2653c, Rv2656c, Rv2659c, Rv2660c, Rv3425, Rv3429, Rv3872, Rv3873, Rv3878, and Rv3879) to identify immunodominant epitopes [ 12 ]. Similarly, Bellini et al. designed and characterized a multistage...”
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- Towards Reverse Vaccinology for Bovine TB: High Throughput Expression of Full Length Recombinant Mycobacterium bovis Proteins
Paliwal, Frontiers in molecular biosciences 2022 - “...& Insect +++ +++ Mb3644c ESX-1 secretion-associated protein espd E. coli & Insect - - Mb2002c Immunogenic protein mpt64 (antigen mpt64/mpb64) E. coli & Insect +++ +++ Mb1762 Probable conserved transmembrane protein E. coli & Insect 0 ++ Information pathway related proteins Mb0055 Single-strand binding protein...”
- Proteome characterization of the culture supernatant of Mycobacterium bovis in different growth stages
Assal, Biochemistry and biophysics reports 2021 - “...complex B (Ag85B) Mb2397c + + + S Y 16.6 Low molecular weight antigen MTB12 Mb2002c + + S Y 24.8 Antigen MPB64 Mb0192A + + + U N 5.7 Metallothionein OS Mb1858 + + + CW/EC N 17.3 Uncharacterized protein Mb1858 Mb1891 + + +...”
- “...a role in the development of immune responses to mycobacterial infection, MTB12 (Mb2397c) and MPB64 (Mb2002c), were also identified [ 31 ]. MPB64 is a possible plasminogen-binding protein that may have a role in the bacterial virulence [ 32 ]. Mb1858 is another possible extracellular protein...”
- Proteomic analysis of protein purified derivative of Mycobacterium bovis
Roperto, Journal of translational medicine 2017 - “...H37Rv, and M. bovis, strain AN5, are highly related. Accordingly, some proteins including Mb0448, Mb1918c, Mb2002c, Mb3789, Mb3834c, Mb3904, Mb3905, just like their orthologs from M. tuberculosis H37RV, could have more than 20 different T cell epitopes since they are known to be evolutionarily hyperconserved [...”
- Understanding HIV-Mycobacteria synergism through comparative proteomics of intra-phagosomal mycobacteria during mono- and HIV co-infection
Ganji, Scientific reports 2016 - “...Rv2100 13 BCG0079c 7.5 30.8 cell wall and cell processes Possible membrane protein/Unknown Rv0048c 14 Mb2002c 4.5 24.8 cell wall and cell processes Immunogenic protein Mpt64/Unknown. Rv1980c 15 BCG3662c 10.69 12 information pathways Iron-regulated H-NS-like protein Lsr2/Has DNA-bridging activity. Rv3597c 16 BCG3174 5.2 85.3 intermediary metabolism...”
- Single-antigen serological testing for bovine tuberculosis
Green, Clinical and vaccine immunology : CVI 2009 - “...MPB83 (Mb2898) ESAT6 (Mb3905) CFP10 (Mb3904) Acr1 (Mb3423) MPB64 (Mb2002c) PPE68 (Mb3903) 100 (4e121) 76 (2e83) ND 40 (1e22) 100 (2e46) 97 (2e45) ND 71 (7e30)...”
APJL_1469 hypothetical protein from Actinobacillus pleuropneumoniae serovar 3 str. JL03
Aligns to 228:305 / 335 (23.3%), covers 98.8% of PF11738, 54.9 bits
- Genome-wide screening of lipoproteins in Actinobacillus pleuropneumoniae identifies three antigens that confer protection against virulent challenge
Cao, Scientific reports 2020 - “...APP7_1356 APJL_1380 YP_001652380.1 hypothetical protein 87.4 APL_1362 APP7_1413 APJL_1467 YP_001652463.1 hypothetical protein 42.0 APL_1435 APP7_1497 APJL_1469 YP_001652465.1 hypothetical protein 62.6 APL_1437 APP7_1495 APJL_1726 YP_001652722.1 putative ABC transporter periplasmic binding protein 53.9 APL_1694 APP7_1755 APJL_1919 YP_001652913.1 hypothetical protein 50.9 APL_1875 APP7_1963 APJL_1942 YP_001652936.1 Zn-dependent protease with chaperone...”
- “...as hypothetical. It is worth noting that a number of hypothetical proteins (APJL_0221, APJL_1318, APJL_1380, APJL_1469, APJL_1726 and APJL_1976) yielded clearly positive reactions with rabbit anti- A. pleuropneumoniae serum in western blotting. Two hypothetical lipoproteins, APJL_1380 and APJL_1976, were selected for further investigation. On the basis...”
APP7_1495 hypothetical protein from Actinobacillus pleuropneumoniae serovar 7 str. AP76
Aligns to 251:328 / 358 (21.8%), covers 98.8% of PF11738, 54.8 bits
MUL_5032 immunogenic protein Mpt64 from Mycobacterium ulcerans Agy99
Aligns to 147:223 / 230 (33.5%), covers 96.4% of PF11738, 54.3 bits
- Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia
O'Brien, Emerging infectious diseases 2017 - “...MUL_4830 Putative GTPase T/C Synonymous mu248 T: 0, A: 0, G: 0, C: 20 5577431 MUL_5032 Immunogenic protein mbt64 A/G Synonymous mu394 T: 0, A: 0, G: 28, C: 0 *A total of 4,918 core single-nucleotide polymorphisms were identified for all 6 isolates compared with the...”
- Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing
Qi, PLoS pathogens 2009 - “...protein COG2185I 77 MUL_3194 - hypothetical protein COG2261S 77 MUL_0424 - hypothetical protein - 77 MUL_5032 mpt64 immunogenic protein Mpt64 COG0425O 77 MUL_4365 - hypothetical protein COG0393S 77 MUL_4394 - hypothetical protein COG0526OC 78 MUL_3305 ribD hypothetical protein COG1985H 78 MUL_3524 - diphosphomevalonate decarboxylase COG3407I 78...”
BP1296 RsiV family protein from Bordetella pertussis Tohama I
NP_880063 putative lipoprotein from Bordetella pertussis Tohama I
Aligns to 182:261 / 275 (29.1%), covers 83.1% of PF11738, 53.8 bits
- Genomic epidemiology of Iranian Bordetella pertussis: 50 years after the implementation of whole cell vaccine
Safarchi, Emerging microbes & infections 2019 - “...isolates P8 (1), P9 (1) Genic (18) 10 nsSNPs: BP0082 ( bplL ), BP0724, BP1142, BP1296, BP1324 ( malA ), BP1881 ( fhaD ), BP2117, BP2467, BP3271, BP3385 Insertion: BP0192 (1), cusC (1), copA (5) 8 sSNPs: BP0222 ( catJ ), BP0454, BP1037 ( cutE ),...”
- A gel-free proteomic-based method for the characterization of Bordetella pertussis clinical isolates
Williamson, Journal of microbiological methods 2012 - “...29 OM 13 (2) 25 (4) 16 (4) 11 (3) Putative transport Putative lipoprotein NP_880063 BP1296 Pu 30 U 16 (3) 12 (2) 12 (2) 12 (2) U Putative lipoprotein NP_880303 BP1296 Pu 41 U 26 (5) 30 (6) 22 (5) 30 (7) Putative membrane Putative...”
- Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains
Bottero, Clinical and vaccine immunology : CVI 2007 - “...III secretion protein Hypothetical protein BP1146 BP3441 BP2667 BP1296 BP2360 29.8 19.8 263.6 30.6 27.2 5.0 5.1 9.7 7.4 6.2 Unknown Cytoplasmic/membranec Outer...”
- A gel-free proteomic-based method for the characterization of Bordetella pertussis clinical isolates
Williamson, Journal of microbiological methods 2012 - “...Pu 29 OM 13 (2) 25 (4) 16 (4) 11 (3) Putative transport Putative lipoprotein NP_880063 BP1296 Pu 30 U 16 (3) 12 (2) 12 (2) 12 (2) U Putative lipoprotein NP_880303 BP1296 Pu 41 U 26 (5) 30 (6) 22 (5) 30 (7) Putative membrane...”
TDE0098 conserved domain protein from Treponema denticola ATCC 35405
Aligns to 153:236 / 239 (35.1%), covers 98.8% of PF11738, 53.0 bits
MAP3084c hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
Aligns to 144:220 / 227 (33.9%), covers 98.8% of PF11738, 52.6 bits
Mjls_1842 immunogenic protein MPB64/MPT64 precursor from Mycobacterium sp. JLS
Aligns to 148:224 / 232 (33.2%), covers 97.6% of PF11738, 52.0 bits
ESTR2_MYCTU / I6YF08 Esterase Rv3036c; EC 3.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
Rv3036c PROBABLE CONSERVED SECRETED PROTEIN TB22.2 from Mycobacterium tuberculosis H37Rv
Aligns to 144:220 / 227 (33.9%), covers 98.8% of PF11738, 51.8 bits
- function: Hydrolyzes ester substrates carbon chain lengths ranging from C2 to C14 (PubMed:25224799). In vitro, acetate (C2), butyrate (C4) and caprylate (C6) are hydrolyzed with high efficiency. Has lower activity against laurate (C12), myristate (C14) and caproate (C8), and weak activity against palmitate (C16) (PubMed:25224799).
catalytic activity: a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+) (RHEA:59388)
catalytic activity: an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+) (RHEA:12957)
catalytic activity: a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+) (RHEA:47348)
catalytic activity: a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate (RHEA:47352)
catalytic activity: a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+) (RHEA:47364)
catalytic activity: a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate (RHEA:47388)
catalytic activity: an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate (RHEA:47356) - Roles of Lipolytic enzymes in Mycobacterium tuberculosis pathogenesis
Lin, Frontiers in microbiology 2024 - “...enzymes containing Rv3091, Rv0183, Rv1592c, Rv2037c, and Rv1683 are functionally characterized as lipases. Rv0774c, Rv1075c, Rv3036c, Rv0045c, Rv1430, and Rv3539 are functionally characterized as esterases. Rv2224c and Rv0519c, with the catalytic triad that is found in esterases, lipases, and proteases, are identified as lipases/esterases by experiments...”
- “...J. Yu S. Wu D. . ( 2014 ). Characterization of a novel exported esterase Rv3036c from Mycobacterium tuberculosis . Prot. Expr. Purif. 104 , 50 56 . doi: 10.1016/j.pep.2014.09.003 , PMID: 25224799 Chownk M. Kaur J. Singh K. Kaur J. ( 2018 ). mbtJ: an...”
- Target Identification in Anti-Tuberculosis Drug Discovery
Capela, International journal of molecular sciences 2023 - “...it was possible to identify esterases present in dormant conditions (Culp1, LipH, LipM, LipN, and Rv3036c) or in both states (CaeA, Rv0183, and Rv1683) ( Figure 18 ) [ 108 , 109 , 110 ]. 4.1.3. Other Membrane Targets Acyltrehaloses biosynthesis. Acyltrehaloses are components of the...”
- Chemical approaches to unraveling the biology of mycobacteria
Finin, Cell chemical biology 2023 - “...and to detect esterases that were missed by FP-based ABPs, such as Culp1 (Rv1984c) and Rv3036c. 16 , 17 DCF-AME and DDAO-OME ( Figure 1 ) are ester-masked fluorogenic probes that produce fluorescence upon serine-mediated hydrolysis. Therefore, these turn-on substrates and FP-based ABPs can be used...”
- Comparative Analysis on Proteomics Profiles of Intracellular and Extracellular M.tb and BCG From Infected Human Macrophages
Liu, Frontiers in genetics 2022 - “...TB22.2, among them, TB22.2 was mostly down-regulated (five folds down) ( Table 3 ). TB22.2 (Rv3036c), as a surface-anchored esterase, may play a role in structurally modifying the cell wall composition when M.tb infection ( Trivedi et al., 2005 ). In addition, of the top 10...”
- “...et al., 2012 ). Other interested proteins with the expression difference above fourfold contained TB22.2 (Rv3036c) and gnd1. TB22.2 was characterized as a novel cell wallanchored esterase from M.tb that can efficiently hydrolyze soluble p -nitrophenyl esters ( Chen et al., 2014 ). Gnd1 encoding 6-phosphogluconate...”
- Identification of Mycobacterium tuberculosis Antigens with Vaccine Potential Using a Machine Learning-Based Reverse Vaccinology Approach
Teahan, Vaccines 2021 - “...Rv0755c PPE30 Rv1802 peptidase S1C HtrA Rv1223 PepD Rv0983 PstS PstS2 Rv0932c RsiV Hypothetical protein Rv3036c Rv3036c WXG100 EsxI Rv1037c vaccines-09-01098-t002_Table 2 Table 2 Novel Vaxign-ML-predicted PAgs having biological processes related to MTB virulence or latency. More than 72 proteins are listed here due to redundancy...”
- Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes
Modlin, mSystems 2021 - “...Conserved hypothetical alanine-rich protein Rv2991 Probable flavin/deazaflavin oxidoreductase 26434506 Conserved protein Conserved protein (F420-dependent protein) Rv3036c Esterase 25224799 Probable conserved secreted protein TB22.2 Probable conserved secreted protein TB22.2 Possible membrane protein Rv3354 Protein kinase 25139900 Conserved hypothetical protein Lipoprotein Possible lipoprotein LprJ Orthogonal annotation Rv0256c* B...”
- “...Probable membrane oxidoreductase component (MRC) DoxX RIF 26067605 Rv1184c Exported protein Mycoacyltransferase RIF 25331437, 25124040 Rv3036c Secreted protein Secreted esterase RIF, INH 25224799 Rv2190c Hypothetical protein Peptidoglycan peptidase RipC/antigen RIF 24843173, 22952680, 28241799 Rv0079 Hypothetical protein Putative dormancy-associated translation inhibitor (DATIN) RIF (+) 22719925, 23819907, 28261197...”
- Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
Carette, mBio 2018 - “...in expression of the corresponding genes. The 5 proteins with the greatest decrease in expression (Rv3036c [antigen TB22.2], Rv3668c [a predicted protease], Rv1815 [a protein of unknown function], Rv3572 [a protein of unknown function], and Rv1887 [a possible protease]) were all experimentally verified to be secreted...”
- Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis
Tallman, ACS infectious diseases 2016 - “...active in all three culture conditions. Fluorogenic probes additionally revealed LipH (Rv1399c), Culp1 (Rv1984c), and Rv3036c esterase activity in dormant and active cultures. Esterases with persistent activity are potential diagnostic biomarkers or therapeutic targets for Mtb -infected individuals with latent or active tuberculosis. Graphical Abstract Mycobacterium...”
- “...probes to confirm esterase functionality and to detect esterases that were missed by ABPs (e.g., Rv3036c). We propose that esterases with persistent activity in dormancy and reactivation are valuable targets for new diagnostic assays or therapeutics. RESULTS AND DISCUSSION TAMRA-FP Reveals Serine Hydrolase Activity Is Down-regulated...”
- More
MMAR_1665 hypothetical protein from Mycobacterium marinum M
Aligns to 141:217 / 224 (34.4%), covers 97.6% of PF11738, 49.6 bits
BLi04185 hypothetical protein from Bacillus licheniformis DSM 13
Aligns to 139:224 / 227 (37.9%), covers 97.6% of PF11738, 49.3 bits
PDAC_BACSU / O34798 Peptidoglycan-N-acetylmuramic acid deacetylase PdaC; Peptidoglycan MurNAc deacetylase; Polysaccharide deacetylase PdaC; EC 3.5.1.- from Bacillus subtilis (strain 168) (see 2 papers)
BSU12100 secreted deoxyriboendonuclease from Bacillus subtilis subsp. subtilis str. 168
Aligns to 156:235 / 467 (17.1%), covers 98.8% of PF11738, 48.5 bits
BJAB0868_02946 RsiV family protein from Acinetobacter baumannii BJAB0868
Aligns to 163:242 / 262 (30.5%), covers 86.7% of PF11738, 47.2 bits
MSMEG_1051 immunogenic protein MPB64/MPT64 from Mycobacterium smegmatis str. MC2 155
Aligns to 150:225 / 233 (32.6%), covers 97.6% of PF11738, 46.8 bits
APL_1437 hypothetical protein from Actinobacillus pleuropneumoniae L20
Aligns to 228:305 / 335 (23.3%), covers 98.8% of PF11738, 46.4 bits
A1S_1734 hypothetical protein from Acinetobacter baumannii ATCC 17978
Aligns to 130:203 / 224 (33.0%), covers 95.2% of PF11738, 46.3 bits
MAV_4130 immunogenic protein MPT64 from Mycobacterium avium 104
Aligns to 155:251 / 258 (37.6%), covers 90.4% of PF11738, 46.1 bits
S5ZKA9 Endo-1,4-beta-xylanase from Treponema pedis str. T A4
Aligns to 146:228 / 231 (35.9%), covers 94.0% of PF11738, 45.9 bits
HD0195 hypothetical protein from Haemophilus ducreyi 35000HP
Aligns to 227:304 / 332 (23.5%), covers 97.6% of PF11738, 44.7 bits
PP_4920 lipoprotein, putative from Pseudomonas putida KT2440
Aligns to 156:233 / 248 (31.5%), covers 97.6% of PF11738, 43.4 bits
ACIAD1781 conserved hypothetical protein from Acinetobacter sp. ADP1
Aligns to 178:252 / 271 (27.7%), covers 95.2% of PF11738, 42.8 bits
- Pangenome of Acinetobacter baumannii uncovers two groups of genomes, one of them with genes involved in CRISPR/Cas defence systems associated with the absence of plasmids and exclusive genes for biofilm formation
Mangas, Microbial genomics 2019 - “..., pepO , moeA_2 , kstR and five unknown genes (annotated as BIT33_04875, NT90_15810, BAV2244, ACIAD1781 and unknown126). Some of these genes are hypothetical proteins, but others, such as hdsS , are involved in a type I restriction-modification system, and together with the peptidase pepO ,...”
B1MNL7 Immunogenic protein MPT64 from Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948)
MAB_1835c Immunogenic protein MPT64 precursor from Mycobacterium abscessus ATCC 19977
Aligns to 161:268 / 275 (39.3%), covers 90.4% of PF11738, 42.2 bits
- Predominantly Orphan Secretome in the Lung Pathogen Mycobacterium abscessus Revealed by a Multipronged Growth-Phase-Driven Strategy.
Chandra, Microorganisms 2024 - “...* Antigen 85-A//B/C MAB_0177 34.9/6.13 2, 3, 3, 3, 3 5 ML, LL ML15, LL21 B1MNL7 * Immunogenic protein MPT64 MAB_1835c 29.4/6.19 4, 6 2 ML, LL ML17, LL22 B1MDW2 * Putative secreted hydrolase MAB_3355 28.9/6.3 2, 4 2 ML,LL ML18, ML19, LL23, LL24 B1MMY7 *...”
- Predominantly Orphan Secretome in the Lung Pathogen Mycobacterium abscessus Revealed by a Multipronged Growth-Phase-Driven Strategy
Chandra, Microorganisms 2024 - “...2, 3, 3, 3, 3 5 ML, LL ML15, LL21 B1MNL7 * Immunogenic protein MPT64 MAB_1835c 29.4/6.19 4, 6 2 ML, LL ML17, LL22 B1MDW2 * Putative secreted hydrolase MAB_3355 28.9/6.3 2, 4 2 ML,LL ML18, ML19, LL23, LL24 B1MMY7 * Uncharacterized protein MAB_1614 22.3/4.88 4,...”
MSMEG_1150 hypothetical protein from Mycobacterium smegmatis str. MC2 155
Aligns to 158:260 / 273 (37.7%), covers 97.6% of PF11738, 40.0 bits
PA4972 hypothetical protein from Pseudomonas aeruginosa PAO1
Aligns to 156:233 / 248 (31.5%), covers 97.6% of PF11738, 37.6 bits
PFLU0494 putative lipoprotein from Pseudomonas fluorescens SBW25
Aligns to 156:233 / 248 (31.5%), covers 98.8% of PF11738, 37.3 bits
MAB_1003c hypothetical protein from Mycobacterium abscessus ATCC 19977
Aligns to 159:260 / 272 (37.5%), covers 97.6% of PF11738, 36.9 bits
- A Simplified and Efficient Method for Himar-1 Transposon Sequencing in Bacteria, Demonstrated by Creation and Analysis of a Saturated Transposon-Mutant Library in Mycobacterium abscessus
Foreman, mSystems 2020 - “...CGCGCCAAGCAG MAB_0962 2,403 259 + ACCCGGGATCAA TA CTGCCCTCGGGC MAB_0978 2,235 967 + CTGGCCGAGCCT TA CCTCCTGGAGGG MAB_1003c 819 531 ATCCAGTGCTAC TA CGGCTTCTACGC MAB_1011c 858 708 ACCGCATCAACT TA TGTACCCCCGAT MAB_1011c 858 15 CGAATCGTGGCC TA CGGTCGTGTCCG MAB_1019c 1,071 608 GGAAAAGATACC TA TAGCCGAGCAGA MAB_1103 729 369 + CCCGCTGCCCTT TA CTTATCCGCCTT...”
- Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses
Checkley, PloS one 2011 - “...protein MMAR_0160 [Mycobacterium marinum M], YP_908294.1: hypothetical protein MUL_4936 [Mycobacterium ulcerans Agy99], YP_001701747.1: hypothetical protein MAB_1003c [Mycobacterium abscessus ATCC 19977], NP_959049.1: hypothetical protein MAP0115 [Mycobacterium avium subsp. paratuberculosis K-10], YP_879405.1: hypothetical protein MAV_0109 [Mycobacterium avium 104], NZ_ABIN01000160_P_8921: predicted protein sequence from M. intracellulare genome, NOTNCBI_FOR324_P_3844: predicted...”
PSPTO_4974 lipoprotein, putative from Pseudomonas syringae pv. tomato str. DC3000
Aligns to 156:233 / 248 (31.5%), covers 97.6% of PF11738, 35.2 bits
MAP0087 hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
Aligns to 152:224 / 238 (30.7%), covers 83.1% of PF11738, 32.9 bits
- Selection of vaccine-candidate peptides from Mycobacterium avium subsp. paratuberculosis by in silico prediction, in vitro T-cell line proliferation, and in vivo immunogenicity
Lybeck, Frontiers in immunology 2024 - “...VYLVVVSSTPIALVA 15 1,530.88 MAP0147c 112 (12) RIRRALTTLARRVVI 15 1,794.24 MAP2192-b 83 (9) VENILHAAPTAFSNG 15 1,540.71 MAP0087 113 (12) ATRVSVLRSAIAPLISP 17 1,751.12 MAP2184c 84 (9) KGGVIQLTRAVAIEA 15 1,525.83 MAP0014 114 (12) QLQRVHWRLSAHALI 15 1,828.17 MAP3750 85 (9) TLSVITTLPSMSVNV 15 1,561.87 MAP1723-a 115 (12) PGARVIKAFNTLHARYII 18 2,040.46 MAP3749...”
- Early antibody response against Mycobacterium avium subspecies paratuberculosis antigens in subclinical cattle
Bannantine, Proteome science 2008 - “...on the upper right corner of the array (in column 12) are polyhistidine tagged proteins (MAP0087, MAP2121c and MAP3084c). The remaining 89 spots contain MBP fusion proteins of M. paratuberculosis coding sequences. Note that the MAP2121c coding sequence is represented twice on the array; once as...”
- Profiling bovine antibody responses to Mycobacterium avium subsp. paratuberculosis infection by using protein arrays
Bannantine, Infection and immunity 2008 - “...are shown in Fig. 2A. The three polyhistidine-tagged proteins (MAP0087, MAP2121c, and MAP3084c) are present on the upper right corner of the array (Fig. 2A,...”
MAP1858 hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
Aligns to 147:247 / 255 (39.6%), covers 97.6% of PF11738, 31.9 bits
MAV_2381 hypothetical protein from Mycobacterium avium 104
Aligns to 147:247 / 255 (39.6%), covers 97.6% of PF11738, 31.9 bits
MUL_3803 conserved hypothetical secreted protein from Mycobacterium ulcerans Agy99
MMAR_3871 hypothetical protein from Mycobacterium marinum M
Aligns to 151:251 / 259 (39.0%), covers 98.8% of PF11738, 31.2 bits
- Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses
Checkley, PloS one 2011 - “...sequences making up cluster B: YP_001852137.1: hypothetical protein MMAR_3871 [Mycobacterium marinum M], YP_907374.1: hypothetical protein MUL_3803 [Mycobacterium ulcerans Agy99], NP_960792.1: hypothetical protein MAP1858 [Mycobacterium avium subsp. paratuberculosis K-10], YP_881582.1: hypothetical protein MAV_2381 [Mycobacterium avium 104], NZ_ABIN01000058_P_11097: predicted protein sequence from M. intracellulare genome, YP_001848485.1: hypothetical protein...”
- Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses
Checkley, PloS one 2011 - “...protein [Mycobacterium abscessus ATCC 19977]. B. Protein sequences making up cluster B: YP_001852137.1: hypothetical protein MMAR_3871 [Mycobacterium marinum M], YP_907374.1: hypothetical protein MUL_3803 [Mycobacterium ulcerans Agy99], NP_960792.1: hypothetical protein MAP1858 [Mycobacterium avium subsp. paratuberculosis K-10], YP_881582.1: hypothetical protein MAV_2381 [Mycobacterium avium 104], NZ_ABIN01000058_P_11097: predicted protein sequence...”
MAV_0109 hypothetical protein from Mycobacterium avium 104
Aligns to 147:247 / 261 (38.7%), covers 81.9% of PF11738, 30.5 bits
MAP0115 hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
Aligns to 147:247 / 261 (38.7%), covers 81.9% of PF11738, 30.5 bits
MUL_4936 conserved secreted protein from Mycobacterium ulcerans Agy99
Aligns to 138:240 / 252 (40.9%), covers 97.6% of PF11738, 30.0 bits
MMAR_0160 hypothetical protein from Mycobacterium marinum M
Aligns to 149:251 / 263 (39.2%), covers 97.6% of PF11738, 29.3 bits
XC_2828 hypothetical protein from Xanthomonas campestris pv. campestris str. 8004
Aligns to 173:264 / 280 (32.9%), covers 45.8% of PF11738, 26.6 bits
Or search for genetic data about PF11738 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory