Family Search for PF11935 (SYMPK_PTA1_N)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

Running HMMer for PF11935

PF11935 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

PTA1_YEAST / Q01329 Pre-tRNA-processing protein PTA1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
Aligns to 91:333 / 785 (31.0%), covers 100.0% of PF11935, 216.5 bits

• function: Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation
  subunit: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.

SYMPK_HUMAN / Q92797 Symplekin from Homo sapiens (Human) (see 7 papers)
Aligns to 122:348 / 1274 (17.8%), covers 98.7% of PF11935, 196.8 bits

• function: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
  subunit: Found in a heat-sensitive complex at least composed of several cleavage and polyadenylation specific and cleavage stimulation factors (PubMed:16230528). Interacts with CPSF2, CPSF3 and CSTF2 (PubMed:10669729, PubMed:18688255). Interacts (via N-terminus) with HSF1; this interaction is direct and occurs upon heat shock (PubMed:14707147). Interacts with SSU72 (PubMed:20861839, PubMed:23070812).

SYMPK_DROME / Q8MSU4 Symplekin from Drosophila melanogaster (Fruit fly) (see 4 papers)
Aligns to 116:343 / 1165 (19.6%), covers 96.9% of PF11935, 193.7 bits

• function: Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.
  subunit: Interacts with Cpsf73 and Cpsf100 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.

SYMPK_XENLA / Q7ZYV9 Symplekin from Xenopus laevis (African clawed frog) (see 2 papers)
Aligns to 112:340 / 1202 (19.1%), covers 99.1% of PF11935, 191.8 bits

• function: Involved in histone mRNA 3'-end processing (By similarity). Involved in the cytoplasmic polyadenylation element (CPE)-mediated polyadenylation of maternal mRNAs in maturing oocytes. Serves as a scaffold upon which cytoplasmic polyadenylation regulatory factors are assembled.
  subunit: Identification in a complex with cpsf2, cpsf73, cpsf160 and sympk. Interacts with cpeb1, cpsf2 and papd4.

PTA1_SCHPO / Q10222 mRNA cleavage and polyadenylation specificity factor complex subunit pta1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Aligns to 86:309 / 670 (33.4%), covers 91.3% of PF11935, 160.2 bits

• function: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB
  subunit: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of cft1, cft2, ysh1, pta1, swd2, pfs2, dis2, yth1, ssu72, and fip1.

Or search for genetic data about PF11935 in the Fitness Browser