Family Search for PF12012 (DUF3504)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

PF12012 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

ZMYM3_MOUSE / Q9JLM4 Zinc finger MYM-type protein 3; DXHXS6673E protein; Zinc finger protein 261 from Mus musculus (Mouse) (see paper)
Aligns to 1186:1353 / 1370 (12.3%), covers 99.4% of PF12012, 221.2 bits

• function: Plays a role in the regulation of cell morphology and cytoskeletal organization.
  subunit: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

ZMYM3_HUMAN / Q14202 Zinc finger MYM-type protein 3; Zinc finger protein 261 from Homo sapiens (Human) (see 3 papers)
Aligns to 1185:1353 / 1370 (12.3%), covers 99.4% of PF12012, 221.0 bits

• function: Plays a role in the regulation of cell morphology and cytoskeletal organization.
  subunit: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

ZMYM4_HUMAN / Q5VZL5 Zinc finger MYM-type protein 4; Zinc finger protein 262 from Homo sapiens (Human) (see 2 papers)
Aligns to 1356:1526 / 1548 (11.0%), covers 100.0% of PF12012, 221.0 bits

• function: Plays a role in the regulation of cell morphology and cytoskeletal organization.

QRIC1_HUMAN / Q2TAL8 Transcriptional regulator QRICH1; Glutamine-rich protein 1 from Homo sapiens (Human) (see 4 papers)
Aligns to 599:759 / 776 (20.7%), covers 98.8% of PF12012, 213.1 bits

• function: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).

QRIC1_MOUSE / Q3UA37 Transcriptional regulator QRICH1; Glutamine-rich protein 1 from Mus musculus (Mouse) (see 2 papers)
Aligns to 600:760 / 777 (20.7%), covers 98.8% of PF12012, 211.8 bits

• function: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR), an ER- stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (By similarity). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (By similarity). Up- regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).

ZMYM2_MOUSE / Q9CU65 Zinc finger MYM-type protein 2; Zinc finger protein 198 from Mus musculus (Mouse) (see paper)
Aligns to 1191:1359 / 1376 (12.3%), covers 99.4% of PF12012, 204.4 bits

• function: Involved in the negative regulation of transcription.
  subunit: Can form homodimers (By similarity). May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with FOXP1 and FOXP2 (By similarity).

ZMYM2_HUMAN / Q9UBW7 Zinc finger MYM-type protein 2; Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198 from Homo sapiens (Human) (see 3 papers)
Aligns to 1192:1360 / 1377 (12.3%), covers 99.4% of PF12012, 204.2 bits

• function: Involved in the negative regulation of transcription.
  subunit: Can form homodimers (PubMed:32891193). May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with FOXP1 and FOXP2 (PubMed:32891193).

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