Family Search for PF12018 (FAP206)

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PF12018 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CF206_MOUSE / Q6PE87 Cilia- and flagella-associated protein 206 from Mus musculus (Mouse) (see paper)
XP_006538296 cilia- and flagella-associated protein 206 isoform X1 from Mus musculus
Aligns to 214:491 / 622 (44.7%), covers 100.0% of PF12018, 377.3 bits

• function: [Isoform 1]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681).
  function: [Isoform 2]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681).
  disruption phenotype: Mice postnatally develop hydrocephalus, show impaired mucociliary clearance of the airways and are characterized by male infertility.
• Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.
  Shen, Human genetics 2021 (PubMed)
  • GeneRIF: Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.
• The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development.
  Beckers, Development (Cambridge, England) 2020 (PubMed)
  • GeneRIF: The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development.
• Tissue expression patterns identify mouse cilia genes.
  McClintock, Physiological genomics 2008 (PubMed)
  • GeneRIF: 1700003M02Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons and testis, and is predicted to be important to cilia.

Q8IYR0 Cilia- and flagella-associated protein 206 from Homo sapiens
NP_001026913 cilia- and flagella-associated protein 206 from Homo sapiens
Aligns to 214:491 / 622 (44.7%), covers 99.6% of PF12018, 372.6 bits

• Serum proteome changes in dengue virus-infected patients from a dengue-endemic area of India: towards new molecular targets?
  Ray, Omics : a journal of integrative biology 2012
• Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.
  Shen, Human genetics 2021 (PubMed)
  • GeneRIF: Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.
• The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly
  Gupta, The Journal of cell biology 2012
  • “...showed that FAP206 shares extensive sequence homology with human C6ORF165 (NCBI Protein database accession no. NP_001026913 ) and other orthologs only expressed by organisms with motile cilia and flagella. Consistent with its presence in flagella, the expressed sequence tags of C6ORF165 are particularly enriched in testis...”

CF206_TETTS / Q23H79 Cilia- and flagella-associated protein 206; Flagella-associated protein 206 from Tetrahymena thermophila (strain SB210) (see paper)
TTHERM_00820660 Hypothetical protein from Tetrahymena thermophila SB210
Aligns to 226:497 / 635 (42.8%), covers 99.6% of PF12018, 269.5 bits

• function: May regulate cilium motility through its role in the assembly of the axonemal RS2 radial spoke.
  disruption phenotype: The mobility of cells lacking CFAP206 is decreased. If their number is normal, cilia are slightly longer and display uncoordinated motility with abnormal waveform characterized by decreased bend amplitude and decreased metachronal coordination. Cilia axonemes display a classical 9+2 organization of microtubules but their shape is abnormal.
• Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia
  Bicka, Cells 2022
  • “...3 Cfap91 RS base TTHERM_00578560 76 0/0 0/0 0/0 11/10 7/6 11/10 Cfap206 RS2 base TTHERM_00820660 74 0/0 0/0 0/0 9/9 5/5 12/12 Cfap61 RS3 stalk TTHERM_00641200 199 0/0 0/0 0/0 26/24 13/13 22/22 Cfap251 RS3 base TTHERM_01262850 115 0/0 0/0 0/0 22/22 12/12 12/11 Rsp3B...”
• The CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia
  Urbanska, Molecular biology of the cell 2015
  • “...42 Casein kinase TTHERM_00938880 19 ATU1 (-tubulin) TTHERM_00558620 24 BTU1 (-tubulin) TTHERM_00348510 52 FAP206 (DUF3508) TTHERM_00820660 25 FAP50 = CCDC135 (DRC7 of the N-DRC) TTHERM_00760390 15 Table contains proteins that were identified by 10 peptides. In Chlamydomonas , the stems and bases of RS1 and RS2...”
• FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c
  Vasudevan, Molecular biology of the cell 2015
  • “...NY) was used as a wild type. A knockout strain lacking the FAP206 homologue gene (TTHERM_00820660) was produced by targeting the micronuclear (germline) genomes of mating B2086 and CU428 strains using homologous DNA recombination ( Cassidy-Hanley etal. , 1997 ), as described in detail in Dave...”

CG13436 uncharacterized protein from Drosophila melanogaster
Aligns to 216:492 / 576 (48.1%), covers 99.6% of PF12018, 223.9 bits

• Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila
  Borg, PloS one 2015
  • “...instar larvae prior to developing moulting defects. However, the presence of a nested gene ( CG13436 ) within intron 4 ( Fig 1A ), which might also be disrupted, raises questions about the specificity of the Gemin5 mutants. Attempting at clarifying this issue as well as...”
  • “...allelic combinations. ( A ) Genomic and genetic contexts of the Gemin5 gene locus. The CG13436 gene is nested within intron 4 of the Gemin5 gene. Locations of two P -element insertions in the 5 UTR, Gem5 P and Gem5 W , as well as, Gem5...”

CHLREDRAFT_171124 uncharacterized protein from Chlamydomonas reinhardtii
Aligns to 256:560 / 691 (44.1%), covers 79.0% of PF12018, 68.3 bits

• FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c
  Vasudevan, Molecular biology of the cell 2015
  • “...an apparent molecular weight of 80 kDa were found to contain the Chlamydomonas FAP206 homologue (CHLREDRAFT_171124). (D) Immunoprecipitates obtained with the anti-FAP91/CaM-IP2 antibodies from the radial spokeenriched supernatant of Chlamydomonas axonemes that were either wild type or spokeless pf14 mutant. Note the absence of the FAP206...”

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