Family Search for PF12158 (DUF3592)

PF12158 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

ABO_0637 hypothetical protein (NCBI) from Alcanivorax borkumensis SK2
Aligns to 13:476 / 573 (81.0%), covers 100.0% of PF12158, 210.2 bits

• Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis
  Schneiker, Nature biotechnology 2006
  • “...the uptake systems for glutamate ( glt P, ABO_1478, glt S, ABO_1616) and choline/betaine (ABO_0232, ABO_0637 and ABO_0808), the A. borkumensis SK2 genome contains the genetic determinants for the biosynthesis of glutamate ( glt A, ABO_1501, glt B, ABO_2229, glt D, ABO_2228 and glt X, ABO_1509),...”

bll1416 bll1416 (NCBI ptt file) from Bradyrhizobium japonicum USDA 110
2 alignments in 7:335 / 335 (98.2%), covering up to 96.6% of PF12158, 146.4 bits

• Bradyrhizobium diazoefficiens USDA110 PhaR functions for pleiotropic regulation of cellular processes besides PHB accumulation
  Nishihata, BMC microbiology 2018
  • “...protein bll0805 CGCAACGCACAA 185.17 76.29 2.43 hypothetical protein blr0806 CGCAACGCACAA 52.09 23.58 2.21 hypothetical protein bll1416 TGCGCGGCAGCA 52.49 20.56 2.55 unknown protein blr2204 TGCAGTCCAGAA 19.07 9.05 2.11 transcriptional regulatory protein AraC family bll2446 TTCGCCGCAGAA 275.72 129.25 2.13 hypothetical protein bsr2601 TGCACCGCAGCC 32.44 15.65 2.07 unknown protein...”

TSI4_PSEAE / Q9I068 Immune protein Tsi4 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
PA2775 hypothetical protein (NCBI) from Pseudomonas aeruginosa PAO1
Aligns to 8:134 / 145 (87.6%), covers 98.6% of PF12158, 58.3 bits

• function: Immunity protein that plays a role in preventing early activation of toxin Tse4.
  disruption phenotype: Deletion mutant together with deletion of toxin Tse4 leads to a significant loss of fitness advantage when placed in competition with parental strains.
• Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients
  Qu, Cell & bioscience 2022
  • “...in LYSZa6, including clpV1 , PA3904 (PAAR4), PA2702 ( tse2 ), PA2774 ( tse4 ), PA2775 ( tsi4 ), vgrG1 , PA0093 ( tse6 ), PA3905 ( tecT ), PA0082 ( tssA1 ), PA2703 ( tsi2 ), PA0094 ( eagT6 ), PA3484 ( tse3 ), PA5266...”
  • “...631.67 PA2702 Tse2 280.90 4.35 2.50E29 419.33 117.33 PA2774 Tse4 296.61 4.37 4.85E26 461.67 122.33 PA2775 Tsi4 133.81 4.71 7.24E19 212.67 52.33 vgrG1 VgrG1 2637.35 4.74 1.56E50 3969.33 1016.67 PA0093 Tse6 947.79 4.91 3.88E-46 1469.00 360.00 PA3905 Type VI effector chaperone for Tox-Rease, TecT 1073.56 4.95...”
• Pf4 Phage Variant Infection Reduces Virulence-Associated Traits in Pseudomonas aeruginosa
  Tortuel, Microbiology spectrum 2022
  • “...tse1 Tse1 2.06 PA2685 vgrG4 VgrG4 2.63 PA2703 tsi2 Tsi2 2.79 PA2774 tse4 Tse4 2.76 PA2775 tsi4 Tsi4 3.38 PA3291 tli1 Tli1 2.64 PA3294 vgrG4a VgrG4a 2.34 PA3485 tsi3 Tsi3 3.24 PA3486 vgrG4b VgrG4b 2.28 PA3487 tle5 Tle5 3.09 PA3488 tli5 Tli5 2.40 PA5086 tli5b1 Type...”
• NosocomialPseudomonas aeruginosaregulates alginate biosynthesis and Type VI secretion system during adaptive and convergent evolution for coinfection in critically ill COVID-19 patients
  Qu, 2021
• Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions
  Morgan, PLoS pathogens 2019
  • “...3.4 0.007 178 PA1544 anr 736 5.3 0.007 0.050.03 PA2239 pslI 1256 9.0 0.007 nt PA2775 - 2407 17.4 0.007 nt PA5041 pilP 1730 12.6 0.007 nt PA5490 cc4 1842 13.7 0.007 nt PA3763 purL 1200 9.1 0.008 nt PA2645 nuoJ 1579 12.3 0.008 nt PA4223...”
• The Small RNA ErsA of Pseudomonas aeruginosa Contributes to Biofilm Development and Motility through Post-transcriptional Modulation of AmrZ
  Falcone, Frontiers in microbiology 2018
  • “...TssA1 1,424308 2,6838574 PA0093 tse6 , Tse6 1,500855 2,8301039 PA0509 nirN , NirN 2,22837 4,6860424 PA2775 tsi4 , Tsi4 1,314079 2,4864355 PA3872 narI , respiratory nitrate reductase gamma chain 3,080462 8,4588527 PA3873 narJ , respiratory nitrate reductase delta chain 2,190598 4,5649467 PA3874 narH , respiratory nitrate...”
• The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting
  Sana, Frontiers in cellular and infection microbiology 2016
  • “...al., 2011 ; Lu et al., 2013 ; Silverman et al., 2013 Tse4 PA2774 Tsi4 (PA2775) Bacteria Periplasm ? 4 transmembrane segments Hcp1 (PA0085)- dependent Whitney et al., 2015 Tse5 (RhsP1) PA2684 Tsi5 (PA2684.1) Bacteria Periplasm/ membrane RetS repression ? RHS/YD repeat, toxicity VgrG1c (PA2685)- dependent...”
• Genetically distinct pathways guide effector export through the type VI secretion system
  Whitney, Molecular microbiology 2014
  • “...Fig. 1B ). Based on these observations, we hypothesized that the open reading frame (ORF), PA2775, encodes a PA2774-specific immunity determinant. To test whether PA2774PA2775 constitute an effectorimmunity (EI) pair, we generated an in-frame deletion of the PA2774PA2775 bicistron and assessed the ability of this strain...”
  • “...strains possessing PA2774 and a functional T6SS display a significant fitness advantage against the PA2774 PA2775 recipient ( Fig. 2A ). In agreement with the hypothesis that PA2774 functions as an antibacterial effector delivered by the H1-T6SS, deletion of PA2774 or inactivation of the T6SS in...”
• Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa
  McPhee, Journal of bacteriology 2006
  • “...observe any Mg2 regulation for PA1851, PA3925, PA0918, PA2775, or PA0297 (spuA). Similarly, we examined but did not observe Mg2 regulation for PA0327, PA0545,...”

YmfA / b1122 putative inner membrane protein YmfA from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ymfA / ECOCYC|G6579-MONOMER inner membrane protein ymfA from Escherichia coli K12 (see paper)
Aligns to 5:140 / 153 (88.9%), covers 95.3% of PF12158, 53.5 bits

c1397 Hypothetical protein ymfA (NCBI ptt file) from Escherichia coli CFT073
Aligns to 19:154 / 167 (81.4%), covers 95.3% of PF12158, 48.7 bits

• Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
  Tesina, The EMBO journal 2020 (secret)

Q4A237 Putative membrane protein from Emiliania huxleyi virus 86 (isolate United Kingdom/English Channel/1999)
Aligns to 16:156 / 180 (78.3%), covers 95.3% of PF12158, 43.6 bits

• Proteomic analysis of the EhV-86 virion
  Allen, Proteome science 2008
  • “...Q4A2C3 ehv356 Unknown 2 81.0 39 Q4A2C1 ehv358 > 4 h p.i. 1 17.2 45 Q4A237 ehv442 > 4 h p.i. 1 19.4 58 Q4A225 ehv454 24 h p.i. 3 74.4 119 Q4A218 ehv461 12 h p.i. 4 32.9 36 a Data from Allen et al...”

lpl0118 hypothetical protein (NCBI) from Legionella pneumophila str. Lens
Aligns to 12:157 / 159 (91.8%), covers 98.0% of PF12158, 40.4 bits

• Three antagonistic cyclic di-GMP-catabolizing enzymes promote differential Dot/Icm effector delivery and intracellular survival at the early steps of Legionella pneumophila infection
  Allombert, Infection and immunity 2014
  • “...of the GGDEF/EAL domains of Lpl0780, Lpl0922, and Lpl0118 in efficient Legionella multiplication in host cells. Thus, Lpl0780, Lpl0922, and Lpl1118 proteins,...”

QU43_RS49180 DUF3592 domain-containing protein from Burkholderia cenocepacia J2315
BCAL2505 hypothetical protein (RefSeq) from Burkholderia cenocepacia J2315
Aligns to 1:123 / 126 (97.6%), covers 91.9% of PF12158, 37.6 bits

• Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
  Spiewak, MicrobiologyOpen 2019
  • “...BCAL2276 (QU43_RS48010), BCAL2274 (QU43_RS48000), BCAL2272 (QU43_RS47990) BCAL2504 (QU43_RS49175) 1 BCAL2503 c (QU43_RS49165) Poreforming Tse4 BCAL2505 (QU43_RS49180) BCAM1464 (QU43_RS74705) 2 N/A d Peptidoglycan hydrolase Tae4 BCAM1465 (QU43_RS61680) BCAM0046 (QU43_RS54630) 2 BCAM0043 (QU43_RS54615) Phospholipase Tle1/DUF2235 (PF09994) BCAM0045 (QU43_RS54625) BCAM0149 (QU43_RS55145) 2 BCAM0148 (QU43_RS55140) Phospholipase Tle5/PLDc_SF (cl15239) BCAM0150 (QU43_RS55150),...”
• Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
  Spiewak, MicrobiologyOpen 2019
  • “...& Brodersen, 2018 ), and two homologues of the antibacterial poreforming toxin Tse4 (BCAL1292 and BCAL2505; Whitney et al., 2014 ; LaCourse et al., 2018 ) were also identified. An additional putative T6SS effector was identified by using homologues of the Tae peptidoglycan hydrolase T6SS effector...”
  • “...(PF11678) BCAL2276 (QU43_RS48010), BCAL2274 (QU43_RS48000), BCAL2272 (QU43_RS47990) BCAL2504 (QU43_RS49175) 1 BCAL2503 c (QU43_RS49165) Poreforming Tse4 BCAL2505 (QU43_RS49180) BCAM1464 (QU43_RS74705) 2 N/A d Peptidoglycan hydrolase Tae4 BCAM1465 (QU43_RS61680) BCAM0046 (QU43_RS54630) 2 BCAM0043 (QU43_RS54615) Phospholipase Tle1/DUF2235 (PF09994) BCAM0045 (QU43_RS54625) BCAM0149 (QU43_RS55145) 2 BCAM0148 (QU43_RS55140) Phospholipase Tle5/PLDc_SF (cl15239) BCAM0150...”
• Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment
  O'Grady, Frontiers in cellular and infection microbiology 2011
  • “...surface antigen 3.1 BCAL2468 Putative membrane protein 1.9 BCAL2482 Putative OmpC outer membrane protein 3.1 BCAL2505 Putative membrane protein 1.5 BCAL2552 Putative membrane protein 1.5 BCAL2553 Putative membrane protein 1.8 BCAL3033 Probable outer membrane lipoprotein carrier 1.5 BCAL3203 Putative periplasmic TolB protein 1.6 BCAL3204 Putative OmpA...”
  • “...BCAL2486 Putative ironsulfur oxidoreductase 2.11 BCAL2488 Lysr family regulatory protein 2.07 BCAL2500 Hypothetical protein 1.67 BCAL2505 Putative membrane protein 1.55 BCAL2507 Conserved hypothetical protein 1.93 c BCAL2516 Hypothetical protein 1.70 BCAL2529 Putative transcriptional regulator 1.53 BCAL2541 Putative hydrolase 1.53 BCAL2552 Putative membrane protein 1.53 BCAL2553 Putative...”

BCAL1291 hypothetical protein (RefSeq) from Burkholderia cenocepacia J2315
QU43_RS42950 DUF3592 domain-containing protein from Burkholderia cenocepacia J2315
Aligns to 1:121 / 125 (96.8%), covers 91.9% of PF12158, 36.1 bits

• Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
  Spiewak, MicrobiologyOpen 2019
  • “...(PF01551), SH3_3 (PF08239), Lysozymelike CTD (cl00222) BCAL1167 (QU43_RS73515) BCAL1292 (QU43_RS42955) 1 BCAL1294 (QU43_RS42965) Poreforming Tse4 BCAL1291 (QU43_RS42950) BCAL1296 (QU43_RS42975) 1 BCAL1294 (QU43_RS42965) Phospholipase PAAR_like/DUF4150 (PF13665), Lipase_3 (cd00519) BCAL1297 (QU43_RS42980) BCAL1298 (QU43_RS75480) 1 BCAL1294 (QU43_RS42965) Nuclease GHE HNH/ENDO VII nuclease (PF14410) BCAL1299 (QU43_RS42990) BCAL1358 (QU43_RS43285) 1 BCAL1355...”
• Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment
  O'Grady, Frontiers in cellular and infection microbiology 2011
  • “...Hsp20-related protein 1.65 BCAL1273 Phosphate ABC transporter ATP-binding protein 1.55 BCAL1282 Putative membrane protein 2.39 BCAL1291 Putative membrane protein 1.54 BCAL1292 Putative membrane protein 1.75 BCAL1299 Conserved hypothetical protein 1.51 BCAL1300 Conserved hypothetical protein 1.98 BCAL1316 Conserved hypothetical protein 1.56 BCAL1326 Conserved hypothetical protein 8.68 BCAL1357...”
• Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia
  Bernier, Journal of bacteriology 2005
  • “...ZP_00282303 YP_109966g ZP_00213820 ZP_00222251 ZP_00222248 BCAL1291 BCAL1292 BCAL1172 BCAL1122 pBCA044 pBCA032 pBCA033 BCAM0327 BCAM0340 BCAM0514 BCAM0524...”
• Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
  Spiewak, MicrobiologyOpen 2019
  • “...SH3_3 (PF08239), Lysozymelike CTD (cl00222) BCAL1167 (QU43_RS73515) BCAL1292 (QU43_RS42955) 1 BCAL1294 (QU43_RS42965) Poreforming Tse4 BCAL1291 (QU43_RS42950) BCAL1296 (QU43_RS42975) 1 BCAL1294 (QU43_RS42965) Phospholipase PAAR_like/DUF4150 (PF13665), Lipase_3 (cd00519) BCAL1297 (QU43_RS42980) BCAL1298 (QU43_RS75480) 1 BCAL1294 (QU43_RS42965) Nuclease GHE HNH/ENDO VII nuclease (PF14410) BCAL1299 (QU43_RS42990) BCAL1358 (QU43_RS43285) 1 BCAL1355 (QU43_RS43270)...”

BCAM1200 hypothetical protein (RefSeq) from Burkholderia cenocepacia J2315
Aligns to 16:138 / 152 (80.9%), covers 92.6% of PF12158, 33.4 bits

• A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence
  Bernier, Infection and immunity 2008
  • “...in BCAS0225; Tpr K56-2 with pGSVTp-luxCDABE inserted in BCAM1200; Tpr 32 This This This This IncP plasmid expressing TraR; Tcr pUCD2 with traI-lacZ fusion;...”
  • “...BCAS0225; Tpr pGSVTp-lux with 343-bp EcoRI fragment of BCAM1200; Tpr pUCP26 with 1.7-kb PstI-BamHI fragment containing BCAS0225 and upstream region; Tcr 61 23...”

BB0794 putative exported protein (NCBI) from Bordetella bronchiseptica RB50
Aligns to 6:135 / 137 (94.9%), covers 79.1% of PF12158, 25.9 bits

• Diversity of secretion systems associated with virulence characteristics of the classical bordetellae
  Park, Microbiology (Reading, England) 2015
  • “...are five proteins encoded within the locus [TssA (BB0794), TssN (BB0808), TssP (BB0811), TssQ (BB0812) and TssV (BB0818)] that have neither known T6SS...”
• Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes
  Diavatopoulos, Journal of bacteriology 2006
  • “...was obtained by PCR, using one primer inside the IUI, in BB0794, and one primer outside the IUI, in BB0795, which was not detected in B. holmesii by CGH. The...”

Or search for genetic data about PF12158 in the Fitness Browser