Family Search for PF12239 (DUF3605)

Running HMMer for PF12239

PF12239 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

GIG1_CANAL / Q59VM7 N-acetylglucosamine-induced protein 1; GlcNAc-Induced Gene from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 55:226 / 254 (67.7%), covers 100.0% of PF12239, 162.2 bits

• function: N-acetylglucosamine-induced protein which plays a role in the N-acetylglucosamine metabolic pathway.
  disruption phenotype: Leads to increased resistance to the chitin synthase inhibitor nikkomycin Z.

YP067_YEAST / Q02754 Uncharacterized protein YPL067C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
YPL067C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene from Saccharomyces cerevisiae
Aligns to 17:171 / 198 (78.3%), covers 99.4% of PF12239, 136.6 bits

• The N-Acetylglucosamine Kinase from Yarrowia lipolytica Is a Moonlighting Protein
  Flores, International journal of molecular sciences 2021
  • “...GIG1 have been found in yeast species that lack NAGA catabolic genes, except for the YPL067C ( HTC1 ) gene of S. cerevisiae [ 25 ]. The protein Htc1 belongs to a family named HTC (for histidine triad with channel) [ 34 ]. It has been...”
  • “..., NAGA transporter 25.6 YALI0F04466g Similar to GIG1 from C. albicans and to HTC1 ( YPL067C ) from S. cerevisiae 12.5 Glycogen catabolism YALI0F04169g Similar to S. cerevisiae YPR160w GPH1 3.4 Cell wall organization YALI0D01331g Weakly similar to uniprot|Q12303 S. cerevisiae YLR121c YPS3 GPI-anchored aspartyl protease...”
• Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms
  Van, Developmental cell 2018
  • “...+ c + + NRG2 Negative Regulator of Glucose-controlled genes + + + c + YPL067C Histidine Triad with Channel + + + + SRM1 Suppressor of Receptor Mutations + + + + + CTS1 ChiTinaSe + + + c + PCM1 PhosphoaCetylglucosamine Mutase + +...”
• Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins
  Sauerwald, Molecular and cellular biology 2015
  • “...strain hit1 strain jlp2 strain ngr1 strain yfl034w strain ypl067c strain SGA crd1 GFP-OM14 strain SGA fmp32 GFP-OM14 strain SGA fmp33 GFP-OM14 strain SGA hit1...”
  • “...SGA ngr1 GFP-OM14 strain SGA yfl034w GFP-OM14 strain SGA ypl067c GFP-OM14 strain MATa MATa MATa MATa MATa MATa MATa MATa MATa MATa S288C his31 leu20 met150...”
• Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification
  Lardenois, Molecular genetics and genomics : MGG 2015
  • “...CDC6 ) and three genes of unknown function ( YBR056W - A , YLR462W , YPL067C ) that may play roles in the cellular starvation response. The genes in the fifth and sixth categories are detected only in ume6 cells and reflect the progressive breakdown of...”
• Functional studies of the yeast med5, med15 and med16 mediator tail subunits
  Larsson, PloS one 2013
  • “...mating YER124C DSE1 Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways YPL067C NA Putative protein of unknown function YOR178C GAC1 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) YLR377C FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway YPL036W PMA2 Plasma membrane...”
• Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae
  McIsaac, Molecular biology of the cell 2011
  • “...The transcriptional response of the GAL genes from (A). (C) Transcriptional response of YPL066W and YPL067C in (A). (D) The 10 most strongly repressed genes in (A). Clusters in (B) and (D) were hierarchically clustered. GEV induction results in strong activation of GAL2 and GAL7 and...”
  • “...slight induction of GAL10 over the course of the experiment. We found two genes ( YPL067C and YPL066W ) that are divergently transcribed in response to GEV induction ( Figure 6C ). These genes are reminiscent of GAL1 and GAL10 , which are divergently transcribed in...”
• Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac
  van, Applied and environmental microbiology 2011
  • “...YPS3, YCR101C, YGL258W-A, YAL067W-A, YNR066C, ADH2, CSM4, YPL067C, PRM5 YOR387C, ADH4, VEL1, ZPS1, YIL169C, ZAP1, CHA1, YLL053C, YGK3, HPF1 YOR378C, ADH4,...”
• Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z
  Gunasekera, Eukaryotic cell 2010
  • “...The detection of a Gig1 ortholog in S. cerevisiae (YPL067c) was interesting, since this yeast lacks GlcNAc catabolic genes. Although this could suggest that the...”
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UMAG_01716 uncharacterized protein from Ustilago maydis 521
2 alignments in 67:287 / 289 (68.2%), covering up to 64.3% of PF12239, 99.8 bits

• Acid pH Strategy Adaptation through NRG1 in Ustilago maydis
  Sánchez-Arreguin, Journal of fungi (Basel, Switzerland) 2021
  • “...1,3 -Glucan chains of cell wall proteins (UMAG_01640), N -acetylglucosamine ( NAG1 ) synthesis pathway (UMAG_01716, UMAG_01718 and UMAG_04983) and chitin synthase 1 (UMAG_10718) are overexpressed. We believe that NAG elevation in the cell wall could function as a shell to protect against high anionic concentrations...”

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