Family Search for PF12263 (DUF3611)

PF12263 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

all4113 hypothetical protein from Nostoc sp. PCC 7120
Aligns to 16:192 / 194 (91.2%), covers 98.9% of PF12263, 239.4 bits

• Cell surface-associated proteins in the filamentous cyanobacterium Anabaena sp. strain PCC 7120
  Yoshimura, Microbes and environments 2012
  • “...2e-64), Alr1722 toTic32 (E value of 2e-31), All4804 to Tic20 (E value of 1e-08) and All4113 and All3977 to Tic21 (E values of 9e-15 and 2e-13, respectively). These homologues were not found in the outer membrane fraction ( 23 ) and our fraction of cell surface-associated...”

all3977 hypothetical protein from Nostoc sp. PCC 7120
Aligns to 1:168 / 170 (98.8%), covers 93.2% of PF12263, 215.1 bits

• Cell surface-associated proteins in the filamentous cyanobacterium Anabaena sp. strain PCC 7120
  Yoshimura, Microbes and environments 2012
  • “...toTic32 (E value of 2e-31), All4804 to Tic20 (E value of 1e-08) and All4113 and All3977 to Tic21 (E values of 9e-15 and 2e-13, respectively). These homologues were not found in the outer membrane fraction ( 23 ) and our fraction of cell surface-associated proteins. The...”

sll1656 unknown protein from Synechocystis sp. PCC 6803
Aligns to 13:190 / 191 (93.2%), covers 99.4% of PF12263, 198.0 bits

• Regulation of Iron Homeostasis and Use in Chloroplasts
  Kroh, International journal of molecular sciences 2020
  • “...the inner-membrane-localized Permease In Chloroplast 1 (PIC1) ( Figure 3 c). PIC1 and its homologue, sll1656 from Synechocystis PCC 6803, complemented a yeast Fe uptake deficient mutant, suggesting a role in Fe import for both transporters [ 103 ]. Arabidopsis pic1 mutants had severely underdeveloped chloroplasts...”
  • “...A. thaliana C. reinhardtii Synechocyst Is PCC 6803 Transport FRO7 AT5G49740 Cre04.g227400.t1.2 PIC1 AT2G15290 Cre10.g454734.t2.1 sll1656 [ 103 ] ATP-Binding Cassette I11 (ABCI11)/NAP14 AT5G14100 PNW71978/Cre16.g687550.t1.1 [ 107 ] slr0354 [ 107 ] ABCI10 AT4G33460 XP_001703542/Cre03.g164150.t1.1 [ 107 ] sll1623 [ 107 ] ABCI12 AT3G21580 PNW75614/Cre12.g533950.t1.1 [...”
• Chloroplast Iron Transport Proteins - Function and Impact on Plant Physiology
  López-Millán, Frontiers in plant science 2016
  • “...( Duy et al., 2007b ). The ortholog of PIC1/Tic21 in Synechocystis sp. PCC 6803, Sll1656, can functionally complement pic1 / tic21 loss-of-function plants ( Lv et al., 2009 ) and the growth of Fe uptake-deficient yeast mutants ( Duy et al., 2007b ). In contrast,...”
• The ins and outs of algal metal transport
  Blaby-Haas, Biochimica et biophysica acta 2012
  • “...iron transport. A pic1 mutant exhibits defective chloroplast development, and both PIC1 and an ortholog, sll1656 from the cyanobacterium Synechocystis sp PCC 6803, rescue a yeast mutant defective in iron uptake [ 126 , 127 ], but how PIC1 affects iron concentration in the chloroplast is...”

TIC21_ARATH / Q9SHU7 Protein TIC 21, chloroplastic; Protein CHLOROPLAST IMPORT APPARATUS 5; AtCIA5; Protein PERMEASE IN CHLOROPLASTS 1; AtPIC1; Translocon at the inner envelope membrane of chloroplasts 21; AtTIC21 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
TC 3.A.9.1.2 / Q9SHU7 Protein TIC 21, chloroplastic, component of The chloroplast envelope TIC translocase (TIC) complex. Tic21, Tic20-I, Tic214, Tic100 and Tic56 plus Toc components comprise a 1 Md complex in the membrane with each component being present in stoichiometric amounts from Arabidopsis thaliana
AT2G15290 TIC21 (TRANSLOCON AT INNER MEMBRANE OF CHLOROPLASTS 21); copper uptake transmembrane transporter/ iron ion transmembrane transporter/ protein homodimerization from Arabidopsis thaliana
NP_565372 translocon at inner membrane of chloroplasts 21 from Arabidopsis thaliana
Aligns to 107:283 / 296 (59.8%), covers 98.9% of PF12263, 179.4 bits

• function: Involved in chloroplast protein import across the inner envelope membrane. Acts also as a chloroplast permease regulating the iron transport and homeostasis. Involved in the uptake and sequestration of iron in plastids.
  subunit: Homomultimer. Part of the translocon complex.
  disruption phenotype: Seedling lethal when grown on soil. Albino or chlorotic dwarfed plants that accumulate unprocessed precursor proteins and chloroplast ferritin clusters when grown in vitro.
• substrates: proteins
  tcdb comment: A 1-megadalton complex consisting of Tic21, Tic20, Tic56, Tic100, and Tic214 has been identified in the chloroplast inner membrane (Nakai 2015)
• Black sheep, dark horses, and colorful dogs: a review on the current state of the Gene Ontology with respect to iron homeostasis in Arabidopsis thaliana
  Mai, Frontiers in plant science 2023
  • “...short description Direct evidence Metal or compound transporters At1g15960 NRAMP6 ( Li etal., 2019 ) At2g15290 PIC1/TIC21 ( Duy etal., 2007 ) At5g13740 ZIF1 ( Long etal., 2010 ) Regulators At3g23210 BHLH034/IDT1 ( Li etal., 2016 ) At4g14410 BHLH104 ( Li etal., 2016 ; Wang etal.,...”
• Live-cell imaging of the chloroplast outer envelope membrane using fluorescent dyes
  Ichikawa, Plant direct 2022
  • “...used for plasmid construction are listed in Table S1 . The DNA fragment encoding TIC21 (At2g15290) was PCRamplified from A. thaliana genomic DNA using the primers TIC21SalIF and TIC21EcoRVR (Table S1 ). The DNA fragment for mVenus was PCRamplified from a synthetic doublestranded DNA (Integrated DNA...”
• A forward genetics approach integrating genome-wide association study and expression quantitative trait locus mapping to dissect leaf development in maize (Zea mays)
  Miculan, The Plant journal : for cell and molecular biology 2021
  • “...encodes a Tic21 translocon component that is localized in the chloroplast inner membrane. Tic21 ( AT2G15290 ) null mutants in Arabidopsis thaliana suggest that it might be important in later stages of leaf development due to its crucial function as part of the inner membrane proteinconducting...”
• HS1 Is Involved in Hygromycin Resistance Through Facilitating Hygromycin Phosphotransferase Transportation From Cytosol to Chloroplast
  Luo, Frontiers in plant science 2020
  • “...encoded selected proteins as follows: HS1 (AT5G55210), TOC75 (AT3G46740), TIC40 (AT5G16620), TOC34 (AT5G05000), and TIC21 (AT2G15290). We also performed a bimolecular fluorescence complementation (BiFC) assay to further examine the interaction between HS1 and HPT. The N -terminus (aa 1177) of GFP (NGFP) was fused with HS1,...”
• The developmental and iron nutritional pattern of PIC1 and NiCo does not support their interdependent and exclusive collaboration in chloroplast iron transport in Brassica napus
  Pham, Planta 2020
  • “...genes To identify putative homologs the genes of interest in Brassica napus , AtPIC1 ( At2g15290 ), AtNiCo ( At2g16800 ) and AtMAR1 ( At5g26820 ) sequences were used as initial protein queries against Brassica Database ( https://brassicadb.org/brad ) to blast protein sequences. Reciprocal blasts of...”
  • “...strand]; reciprocal best hit: At5g26820 . 1 ; score: 365; 3e 99 ) orthologues of At2g15290 , At2g16800 and At5g26820 , respectively. According to the target sequences, specific primers were designed at exonexon border sites to avoid genomic contamination. Expression analysis For accurate representation and reliable...”
• A Thylakoid Membrane Protein Functions Synergistically with GUN5 in Chlorophyll Biosynthesis
  Zhang, Plant communications 2020
  • “...expression assay, theCDS fragments of CBD1 , CBD2 , PAA2 ( AT5G21930 ), PIC1 ( AT2G15290 ), OEP7 ( AT3G52420 ), and RBCS1 ( AT1G67090 ) deprived of stop codons were amplified and cloned into the PEZS-NL-GFP vector. The CDS fragments of PAA2 , PIC1 ,...”
• Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses
  Kruse, BMC plant biology 2020
  • “...L 2 FC RNA =1.02), translocons TIC55-II (AT2G24820, L 2 FC RNA =1.01), and TIC21 (AT2G15290, L 2 FC RNA =1.03), as well as OUTER ENVELOPE PROTEIN 16 (OEP16) (AT2G28900, L 2 FC RNA =1.57), PLASTIDIC TYPE I SIGNAL PEPTIDASE 1 (PLSP1) (AT3G24590, L 2 FC...”
• Regulation of Iron Homeostasis and Use in Chloroplasts
  Kroh, International journal of molecular sciences 2020
  • “...Gene Name A. thaliana C. reinhardtii Synechocyst Is PCC 6803 Transport FRO7 AT5G49740 Cre04.g227400.t1.2 PIC1 AT2G15290 Cre10.g454734.t2.1 sll1656 [ 103 ] ATP-Binding Cassette I11 (ABCI11)/NAP14 AT5G14100 PNW71978/Cre16.g687550.t1.1 [ 107 ] slr0354 [ 107 ] ABCI10 AT4G33460 XP_001703542/Cre03.g164150.t1.1 [ 107 ] sll1623 [ 107 ] ABCI12 AT3G21580...”
• More
• The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron.
  Duy, Plant physiology 2011
  • GeneRIF: By mediating iron uptake and sequestering processes in plastids, PIC1 is crucial for plant growth and development in general and in particular for fruit maturation.
• PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport.
  Duy, The Plant cell 2007
  • GeneRIF: PIC1 functions in iron transport across the inner envelope of chloroplasts and hence in cellular metal homeostasis. [PIC1] [PERMEASE INCHLOROPLASTS1]
• Tic21 is an essential translocon component for protein translocation across the chloroplast inner envelope membrane.
  Teng, The Plant cell 2006
  • GeneRIF: Tic21 functions as part of the inner membrane protein-conducting channel and may be more important for later stages of leaf development. [Tic21] [CIA5]

LOC100273175 uncharacterized protein LOC100273175 from Zea mays
Aligns to 89:265 / 296 (59.8%), covers 99.4% of PF12263, 174.6 bits

• Comparative proteomics of chloroplasts envelopes from bundle sheath and mesophyll chloroplasts reveals novel membrane proteins with a possible role in c4-related metabolite fluxes and development
  Manandhar-Shrestha, Frontiers in plant science 2013
  • “...erythrocyte binding activity (Singh et al., 2004 ). Their function in plants is unknown. PIC/TIC LOC100273175 4 Contains a DUF3611. Similarity to the A.t . TIC21. Is predicted to be involved in copper homeostasis and protein import into chloroplasts. PEPC LOC100191762 0 Phosphoenolpyruvate carboxylase; initial carbon...”

YP_002048795 hypothetical protein from Paulinella chromatophora
Aligns to 4:189 / 192 (96.9%), covers 98.3% of PF12263, 141.2 bits

• Protein import into the photosynthetic organelles of Paulinella chromatophora and its implications for primary plastid endosymbiosis
  Mackiewicz, Symbiosis (Philadelphia, Pa.) 2012
  • “...bacterial PipA, peptidyl-prolyl cis-trans isomerase A (rotamase A) passage of proteins through the intermembrane space YP_002048795 homolog to plant Tic21, protein-conducting channel in the inner organelle membrane protein translocation across the inner organelle membrane YP_002049520 homolog to plant Tic32, short-chain dehydrogenase redox regulation of the protein...”

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