Family Search for PF12372 (DUF3652)
PF12372.8 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q59FF4 Huntingtin variant (Fragment) from Homo sapiens
Aligns to 911:951 / 1147 (3.6%), covers 100.0% of PF12372, 77.5 bits
XP_006822985 huntingtin from Saccoglossus kowalevskii
Aligns to 1471:1511 / 2816 (1.5%), covers 100.0% of PF12372, 77.2 bits
XP_536221 huntingtin isoform X1 from Canis lupus familiaris
Aligns to 1503:1543 / 3130 (1.3%), covers 100.0% of PF12372, 76.5 bits
- Huntingtin facilitates polycomb repressive complex 2
Seong, Human molecular genetics 2010 - “...( 50 ). Huntingtin orthologues for the multiple sequence alignments: dog ( Canis familiaris ; XP_536221), mouse ( Mus musculus ; AAA89100), opossum ( Monodelphis domestica ; XP_001364862), chicken ( Gallus gallus ; XP_420822), zebrafish ( Danio rerio ; NP_571093); lancelet ( Branchiostoma floridae ; ABP04240)...”
XP_420822 huntingtin isoform X1 from Gallus gallus
Aligns to 1467:1507 / 3095 (1.3%), covers 100.0% of PF12372, 76.4 bits
- Huntingtin facilitates polycomb repressive complex 2
Seong, Human molecular genetics 2010 - “...Mus musculus ; AAA89100), opossum ( Monodelphis domestica ; XP_001364862), chicken ( Gallus gallus ; XP_420822), zebrafish ( Danio rerio ; NP_571093); lancelet ( Branchiostoma floridae ; ABP04240) and sea squirt ( Ciona intestinalis ; NP_001119700), were aligned using ClustalW2 (European Bioinformatics Institute: http://www.ebi.ac.uk/Tools/clustalw2/ ) (...”
P51111 Huntingtin from Rattus norvegicus
Aligns to 1484:1524 / 3110 (1.3%), covers 100.0% of PF12372, 76.4 bits
- Validation of protein carbonyl measurement: a multi-centre study.
Augustyniak, Redox biology 2015 - “...11 54.7 DO P12001 60S ribosomal protein L18 21.7 LPP Identified in 5 and 15min P51111 Huntingtin 343.8 DO P29994 Inositol 1,4,5-trisphosphate receptor type 1 313.3 DO Q63796 Mitogen-activated protein kinase kinase kinase 12 96.3 LPP Q6WAY2 Lipid phosphate phosphatase-related protein type 1 35.9 DO...”
- Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.
Baer, Brain : a journal of neurology 2009 - “...Heat shock cognate 71 kDa protein P63018 gi|51702273 70871 0 271 5 6 135 Huntingtin P51111 gi|1708162 343762 0 101 3 1 91 Hypoxanthine-guanine phosphoribosyltransferase P27605 gi|123501 24477 0 32 1 4 124 Junction plakoglobin Q6P0K8 gi|81885083 81801 0 105 4 5 41 LAMA-like protein 2...”
- The Urine Proteome as a Biomarker of Radiation Injury: Submitted to Proteomics- Clinical Applications Special Issue: "Renal and Urinary Proteomics (Thongboonkerd)"
Sharma, Proteomics. Clinical applications 2008 - Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae
Candiani, BMC developmental biology 2007 - “...carried out using the huntingtin sequences from Homo sapiens (P42858), Mus musculus (P42859), Rattus norvegicus (P51111), Sus scrofa (BAA36752), Danio rerio (AAC63983), Fugu rubripes (P51112), Tetraodon negroviridis (CAG03293), and Ciona intestinalis (AM162277). We also used the sequences of Xenopus tropicalis , Gallus gallus and Ciona savigny...”
- High-throughput identification of IMCD proteins using LC-MS/MS.
Pisitkun, Physiological genomics 2006
NP_077333 huntingtin from Rattus norvegicus
Aligns to 1494:1534 / 3120 (1.3%), covers 100.0% of PF12372, 76.4 bits
- BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.
Manfré, PloS one 2018 - GeneRIF: results indicate deficits in several parameters representative of sociability in rats with huntingtin mutation in a model of Huntington disease
- Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.
Chen, The Journal of biological chemistry 2018 - GeneRIF: Heat shock promotes inclusion body formation of mutant Htt and alleviates mutant Htt-induced HSF1 dysfunction.
- N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.
DeGuire, The Journal of biological chemistry 2018 - GeneRIF: results provide crucial insights into the role of phosphorylation in regulating Httex1 structure and function, and underscore the critical importance of identifying the enzymes responsible for regulating Htt phosphorylation, and their potential as therapeutic targets for managing Huntington's disease
- Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation.
Xu, PloS one 2017 - GeneRIF: the long HTT 3'UTR suppresses translation.
- Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.
Trajkovic, The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 - GeneRIF: We found that the protein is secreted via a late endosomal/lysosomal unconventional secretory pathway. Moreover, mHtt secretion can be reduced significantly by phosphatidylinositol 3-kinase and neutral sphingomyelinase inhibitors. Understanding and manipulating the secretion of mHtt is important because of its potentially harmful propagation in the brain.
- 17β-Estradiol modulates huntingtin levels in rat tissues and in human neuroblastoma cell line.
Nuzzo, Neuroscience research 2016 (PubMed)- GeneRIF: Huntingtin is an E2-inducible protein involved in the first steps of E2-induced signaling pathways committed to neuronal protection against oxidative stress.
- Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
Sahoo, PloS one 2016 - GeneRIF: Compared to other known markers of HTT toxicity, nuclear DNA damage appears to be a relatively early pathological event.
- Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.
Shen, eLife 2016 - GeneRIF: The N-terminal N17 promotes amyloid fibril formation, while the C-terminal Proline Rich Domain destabilizes fibrils and enhances oligomer formation.
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HD_MOUSE / P42859 Huntingtin; Huntington disease protein homolog; HD protein homolog from Mus musculus (Mouse) (see 4 papers)
Aligns to 1493:1533 / 3119 (1.3%), covers 100.0% of PF12372, 76.3 bits
- function: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.
function: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles.
subunit: Interacts with PFN1 (By similarity). Interacts through its N- terminus with PRPF40A (By similarity). Interacts with PQBP1 (By similarity). Interacts with SETD2 (By similarity). Interacts with SH3GLB1 (PubMed:12456676). Interacts with SYVN (By similarity). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (By similarity). - Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau
Chen, Journal of Alzheimer's disease : JAD 2018 - “...nucleotide exchange factor (GEF) 2(Arhgef2) Learning O88587 Catechol-O-methyltransferase(Comt) O35927 Catenin (cadherin associated protein), delta 2(Ctnnd2) P42859 Huntingtin(Htt) P31324 Protein kinase, cAMP dependent regulatory, type II beta(Prkar2b) Axon guidance P97427 Collapsin response mediator protein 1(Crmp1) Q9EQF6 Dihydropyrimidinase-like 5(Dpys15) O08917 Flotillin 1(Flot1) P06837 Growth associated protein 43(Gap43) P13595...”
- “...beta 2A class IIA(Tubb2a) Regulation of synaptic plasticity O35927 Catenin (cadherin associated protein), delta 2(Ctnnd2) P42859 Huntingtin(Htt) P13595 Neural cell adhesion molecule 1(Ncam1) CC Axon P63054 Purkinje cell protein 4(Pcp4) O88587 Catechol-O-methyltransferase(Comt) P48320 Glutamic acid decarboxylase 2(Gad2) P06837 Growth associated protein 43(Gap43) P42859 Huntingtin(Htt) P33173 Kinesin...”
- Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae
Candiani, BMC developmental biology 2007 - “...sequence alignments were carried out using the huntingtin sequences from Homo sapiens (P42858), Mus musculus (P42859), Rattus norvegicus (P51111), Sus scrofa (BAA36752), Danio rerio (AAC63983), Fugu rubripes (P51112), Tetraodon negroviridis (CAG03293), and Ciona intestinalis (AM162277). We also used the sequences of Xenopus tropicalis , Gallus gallus...”
NP_034544 huntingtin from Mus musculus
Aligns to 1494:1534 / 3120 (1.3%), covers 100.0% of PF12372, 76.3 bits
- Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration.
Sava, Nanomedicine : nanotechnology, biology, and medicine 2020 - GeneRIF: Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration.
- Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.
Cariulo, Biochemical and biophysical research communications 2020 (PubMed)- GeneRIF: Mutant huntingtin in Hdh primary neuronal cultures and mouse brain samples is hypophosphorylated on S13 residue.
- Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.
Yang, Nature communications 2020 - GeneRIF: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.
- Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington's Disease.
Goodliffe, PloS one 2020 - GeneRIF: Structural and functional features of medium spiny neurons in the BACHDDeltaN17 mouse model of Huntington's Disease.
- DNA methylation study of Huntington's disease and motor progression in patients and in animal models.
Lu, Nature communications 2020 - GeneRIF: DNA methylation study of Huntington's disease and motor progression in patients and in animal models.
- Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.
Petkau, Human molecular genetics 2019 (PubMed)- GeneRIF: We conclude that mHTT expression in microglia, though clearly affecting specific aspects of microglia function, does not alter disease pathogenesis in the BACHD mouse model. This may have implications for current or future therapeutic trials testing immune-modulating drugs in Huntington's disease patients
- Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks.
Mehler, The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 - GeneRIF: Study demonstrated that loss-of-huntingtin function in subpallial lineages not only differentially disrupts distinct interneuron species early in life, but also leads to a pattern of neurological deficits that are reminiscent of Huntington's Disease.
- Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Shen, Nature neuroscience 2019 - GeneRIF: Study shows Huntington as a key mediator of fragile X mental retardation protein regulation of mitochondria unveils a previously unknown cross-talk between these two human disease genes.
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XP_008248081 huntingtin from Oryctolagus cuniculus
Aligns to 1426:1466 / 3053 (1.3%), covers 100.0% of PF12372, 76.2 bits
NP_002102 huntingtin from Homo sapiens
Aligns to 1515:1555 / 3144 (1.3%), covers 100.0% of PF12372, 76.0 bits
HD_HUMAN / P42858 Huntingtin; Huntington disease protein; HD protein from Homo sapiens (Human) (see 24 papers)
Aligns to 1513:1553 / 3142 (1.3%), covers 100.0% of PF12372, 76.0 bits
- function: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function
function: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles.
subunit: Interacts with PFN1 (PubMed:18573880). Interacts through its N-terminus with PRPF40A (PubMed:9700202). Interacts with PQBP1 (PubMed:10332029). Interacts with SETD2 (PubMed:9700202, PubMed:10958656, PubMed:11461154). Interacts with SH3GLB1 (By similarity). Interacts with SYVN (PubMed:17141218). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (PubMed:15654337). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635, PubMed:28882895, PubMed:28757145). Interacts with F8A1/F8A2/F8A3 (PubMed:29466333, PubMed:16476778). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (PubMed:16476778). - PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins
Jarnot, Nucleic acids research 2020 - “...complexity regions play a role in preserving structure ( 46 ). Likewise, Huntingtin (UniProt AC P42858) contains a poly-glutamine (polyQ) homorepeat that causes the disease phenotype when there are more than 36 glutamines present. Huntingtin has a stretch of glutamines from residue 18 to 38 and...”
- Disentangling the complexity of low complexity proteins
Mier, Briefings in bioinformatics 2020 - “...Q38PT6), typical disordered proteins (cellular tumor antigen p53, P04637) and proteins related to diseases (huntingtin, P42858). With this selection, we aim at relating the concept of compositional bias in proteins to a variety of cellular processes, compartments and structural states. We note that associating function to...”
- “...autotransporter 1873 Acinetobacter baumannii P24928 RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 1970 H. sapiens P42858 HD_HUMAN Huntingtin 3142 H. sapiens In the following sections, a series of methods that are widely used to detect LC in protein sequences are introduced and applied to the dataset...”
- Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques.
Sora, Frontiers in cell and developmental biology 2020 - “...(HGF receptor) P08581 Y-type 1234-YYSV-1237 30786811 Histone acetyltransferase KAT2A (KAT2A) Q92830 Y-type 734-YTTL-737 31878840 Huntingtin P42858 W-type 3035-WVML-338 25385587 Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-A) O15111 W-type W-type 651-WHLL-654 740-WSWL-743 29717061 Junction-mediating and -regulatory protein (JMY) Q8N9B5 W-type 13-WVAV-16 26223951 Kelch repeat and...”
- Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1
Nataf, Frontiers in immunology 2019 - “...0 Detected GRN P28799 Detected Detected 0 0 HNRNPA1 P09651 Detected 0 0 Detected HTT P42858 Detected Detected Detected Detected LRRK2 Q5S007 Detected Detected Detected 0 MATR3 P43243 Detected Detected Detected Detected OPTN Q96CV9 Detected Detected 0 0 PARK7 Q99497 Detected Detected Detected Detected PFN1 P07737...”
- Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.
Carbo, International journal of molecular medicine 2019 - “...RASH_HUMAN (P01112) 2CL7 A GTP 1.25 Rap1A RAP1A_HUMAN (P62834) 1C1Y A GTP 1.9 Htt HD_HUMAN (P42858) 6EZ8 A - 4.0 Ubc9 UBC9_HUMAN (P63279) 5F6E A - 1.12 Htt, huntingtin; RHES, Ras Homolog Enriched in Striatum; Ubc9, ubiquitin carrier protein 9; DiRas1 and DiRas2, distinct subgroup of...”
- The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease
Rosas-Arellano, International journal of molecular sciences 2018 - “...19 , 20 ]. HTT, alternatively called Huntingtons disease protein or, simply, HD protein (UniProtKBID: P42858), in vertebrates, is a highly conserved soluble 348 kDa protein [ 21 ] ( Figure 1 A). There are few similarities in the sequence between humans and other species, which...”
- Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
Jiang, Chemical reviews 2018 - “...trafficking DHHC17 651 HMGCS2 P54868 C166, C305 Internal domain Enhance interaction with PPARalpha 652 Huntingtin P42858 C212 Internal domain Required for Huntingtin activity DHHC17 DHHC22 430 KChIP2 Q9NS61 C45, C46 Internal domain Required for cell surface protein expression 653 MAP3K12 Q12852 C127 Internal domain Regulates vesicle...”
- Urine-derived cells: a promising diagnostic tool in Fabry disease patients.
Slaats, Scientific reports 2018 - “...P35555 Fibrillin-1 FBN1 8,6 1,41710999 2,38675785 P39880 Homeobox protein cut-like 1 CUX1 6,4 1,7555979 1,62469578 P42858 Huntingtin HTT 45,7 1,37415071 1,02663898 P49755; G3V2K7 Transmembrane emp24 domain-containing protein 10 TMED10 28,7 1,60610264 2,37490463 P56134 ATP synthase subunit f, mitochondrial ATP5J2 24,5 1,46112134 1,74879551 P62745 Rho-related GTP-binding protein...”
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XP_001364862 huntingtin isoform X3 from Monodelphis domestica
Aligns to 1506:1546 / 3135 (1.3%), covers 100.0% of PF12372, 74.1 bits
- Huntingtin facilitates polycomb repressive complex 2
Seong, Human molecular genetics 2010 - “...Canis familiaris ; XP_536221), mouse ( Mus musculus ; AAA89100), opossum ( Monodelphis domestica ; XP_001364862), chicken ( Gallus gallus ; XP_420822), zebrafish ( Danio rerio ; NP_571093); lancelet ( Branchiostoma floridae ; ABP04240) and sea squirt ( Ciona intestinalis ; NP_001119700), were aligned using ClustalW2...”
XP_005160073 huntingtin isoform X5 from Danio rerio
Aligns to 1487:1527 / 3115 (1.3%), covers 100.0% of PF12372, 72.3 bits
NP_571093 huntingtin from Danio rerio
Aligns to 1487:1527 / 3121 (1.3%), covers 100.0% of PF12372, 72.3 bits
HD_TAKRU / P51112 Huntingtin; Huntington disease protein homolog; HD protein homolog from Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) (see paper)
Aligns to 1508:1548 / 3148 (1.3%), covers 100.0% of PF12372, 71.9 bits
- function: May play a role in microtubule-mediated transport or vesicle function
- Genetic Characteristic and RNA-Seq Analysis in Transparent Mutant of Carp-Goldfish Nucleocytoplasmic Hybrid.
Zhou, Genes 2019 - “...Up G_019763 Down P55918 MFAP4 miR-146a Up G_053967 Down P25291 GP2 miR-146a Up G_058480 Down P51112 htt miR-146a Up G_061471 Down O54951 Sema6b miR-146a Up G_084436 Down A2AAJ9 Obscn genes-10-00704-t006_Table 6 Table 6 Comparison of relative qPCR results with RNA-Seq results. Gene ID Gene Name FC...”
- Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae.
Candiani, BMC developmental biology 2007 - “...(P42858), Mus musculus (P42859), Rattus norvegicus (P51111), Sus scrofa (BAA36752), Danio rerio (AAC63983), Fugu rubripes (P51112), Tetraodon negroviridis (CAG03293), and Ciona intestinalis (AM162277). We also used the sequences of Xenopus tropicalis , Gallus gallus and Ciona savigny predicted from genomic sequences by Gissi et al ....”
NP_001263041 huntingtin, isoform B from Drosophila melanogaster
Aligns to 2717:2759 / 3583 (1.2%), covers 97.6% of PF12372, 65.0 bits
- Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity.
Xu, Cell reports 2019 - GeneRIF: Application of a behavioral platform to screen for clock-regulated Huntington's Disease suppressors, identifies a role for Heat Shock Protein 70/90 Organizing Protein (Hop). Hop knockdown paradoxically reduces mutant Htt aggregation and toxicity. This reveals a clock-regulated molecular and cellular pathway that links clock function to neurodegenerative disease.
- Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.
Xu, PLoS genetics 2019 - GeneRIF: Loss of CrebA also partially suppresses mHtt effects on behavior and cell loss and restoration of CrebA can suppress Atx2 effects. Our results indicate a prominent role of Atx2 in mediating mHtt pathology, specifically via its regulation of CrebA, defining a novel molecular pathway in Huntington's disease pathogenesis.
- The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway.
Calpena, Disease models & mechanisms 2018 - GeneRIF: Jp modifies the neuronal degeneration in a Drosophila model of Huntington's disease, and it has uncoveedr an unsuspected functional relationship with the Notch pathway.
- Loss of Huntingtin stimulates capture of retrograde dense-core vesicles to increase synaptic neuropeptide stores.
Bulgari, European journal of cell biology 2017 - GeneRIF: These results therefore identify native Htt as a regulator of synaptic capture and neuropeptide storage.
- Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima, Neuron 2017 - GeneRIF: Mutant HTT causes severe mislocalization and aggregation of nucleoporins and defective nucleocytoplasmic transport.
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
Gonzales, Human molecular genetics 2016 - GeneRIF: Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
- Altered lipid metabolism in Drosophila model of Huntington's disease.
Aditi, Scientific reports 2016 - GeneRIF: Data strongly suggest that mutant Htt expression exclusively in all the CNS and PNS neurons leads to fluctuation of body weight, carbohydrate and protein stores, global lipid levels along with the intracellular lipid deposits through its effect on the integrated process of metabolic homeostasis. These results also support the idea that lipid metabolism remains centrally affected in HD leading to altered body weight.
- The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development.
Dietz, Human molecular genetics 2015 (PubMed)- GeneRIF: Htt modulated histone H3K9 methylation levels at the heterochromatin-euchromatin boundary.
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XP_005093645 huntingtin from Aplysia californica
Aligns to 1375:1415 / 3024 (1.4%), covers 100.0% of PF12372, 57.4 bits
Or search for genetic data about PF12372 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory