Family Search for PF12372 (Htt_N-HEAT)

PF12372 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

HD_MOUSE / P42859 Huntingtin; Huntington disease protein homolog; HD protein homolog from Mus musculus (Mouse) (see 4 papers)
Aligns to 736:1612 / 3119 (28.1%), covers 99.9% of PF12372, 1126.8 bits

• function: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.
  function: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles.
  subunit: Interacts with PFN1 (By similarity). Interacts through its N- terminus with PRPF40A (By similarity). Interacts with PQBP1 (By similarity). Interacts with SETD2 (By similarity). Interacts with SH3GLB1 (PubMed:12456676). Interacts with SYVN (By similarity). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (By similarity).

HD_HUMAN / P42858 Huntingtin; Huntington disease protein; HD protein from Homo sapiens (Human) (see 24 papers)
Aligns to 756:1632 / 3142 (27.9%), covers 99.9% of PF12372, 1096.4 bits

• function: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function
  function: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles.
  subunit: Interacts with PFN1 (PubMed:18573880). Interacts through its N-terminus with PRPF40A (PubMed:9700202). Interacts with PQBP1 (PubMed:10332029). Interacts with SETD2 (PubMed:10958656, PubMed:11461154, PubMed:9700202). Interacts with SH3GLB1 (By similarity). Interacts with SYVN (PubMed:17141218). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (PubMed:15654337). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635, PubMed:28757145, PubMed:28882895). Interacts with F8A1/F8A2/F8A3 (PubMed:16476778, PubMed:29466333). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (PubMed:16476778).

HD_TAKRU / P51112 Huntingtin; Huntington disease protein homolog; HD protein homolog from Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) (see paper)
Aligns to 714:1627 / 3148 (29.0%), covers 99.8% of PF12372, 1003.1 bits

• function: May play a role in microtubule-mediated transport or vesicle function

Or search for genetic data about PF12372 in the Fitness Browser