Family Search for PF12463 (DUF3689)

PF12463 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TP4AP_HUMAN / Q8TEL6 Short transient receptor potential channel 4-associated protein; Trp4-associated protein; Trpc4-associated protein; Protein TAP1; TNF-receptor ubiquitous scaffolding/signaling protein; Protein TRUSS from Homo sapiens (Human) (see 4 papers)
Aligns to 407:714 / 797 (38.6%), covers 99.7% of PF12463, 439.7 bits

• function: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity).
  subunit: Component of the DCX(TRPC4AP) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1 (PubMed:19966799, PubMed:20551172). Interacts with MYC (PubMed:20551172). Constitutively associated with TNFRSF1A (By similarity). Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG (By similarity). Interacts with TRPC1, TRPC4 and TRPC5 (By similarity).
  subunit: (Microbial infection) Interacts with Hepatitis B virus (HBV) protein X; leading to prevent ubiquitination of TRPC4AP by SKP2.

NP_062802 short transient receptor potential channel 4-associated protein isoform 2 from Mus musculus
Aligns to 399:706 / 789 (39.0%), covers 99.7% of PF12463, 439.7 bits

• TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response.
  Zhu, Biochemical and biophysical research communications 2019 (PubMed)
  • GeneRIF: TRUSS ablation alleviates high fat diet -induced cognitive impairments and metabolic disorder.
• TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.
  Yu, Hepatology (Baltimore, Md.) 2018 (PubMed)
  • GeneRIF: Hepatocyte TRUSS promotes pathological stimuli-induced non alcoholic fatty liver disease and metabolic disorders, through activation of NF-kappaB by promoting ubiquitination and degradation of IkappaBalpha
• TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
  Soond, Molecular and cellular biology 2003
  • GeneRIF: cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)

TP4AP_MOUSE / Q9JLV2 Short transient receptor potential channel 4-associated protein; Trp4-associated protein; Trpc4-associated protein; Protein TAP1; Rabex-5/Rin2-interacting protein; TNF-receptor ubiquitous scaffolding/signaling protein; Protein TRUSS from Mus musculus (Mouse) (see 3 papers)
Aligns to 407:714 / 797 (38.6%), covers 99.7% of PF12463, 439.7 bits

• function: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (PubMed:14585990). Involved in JNK activation via its interaction with TRAF2 (PubMed:16876162). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (PubMed:20458742).
  subunit: Component of the DCX(TRPC4AP) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1 (By similarity). Interacts with MYC (By similarity). Constitutively associated with TNFRSF1A (PubMed:14585990). Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG (PubMed:14585990, PubMed:16876162). Interacts with TRPC1, TRPC4 and TRPC5 (PubMed:20458742).

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