Family Search for PF12478 (UBAP2-Lig)
PF12478 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
LIG_DROME / Q86S05 Protein lingerer from Drosophila melanogaster (Fruit fly) (see 3 papers)
Aligns to 575:610 / 1375 (2.6%), covers 100.0% of PF12478, 71.3 bits
- function: Acts in the nervous system to mediate the control of copulatory organs during courtship.
disruption phenotype: Male flies exhibit abnormal copulation. They fail to successfully withdraw their genitalia upon termination of copulation so end up 'stuck' to the female, tugging to separate. There is also a 'non-copulating' behavioral phenotype. There are no morphological defects in the male genitalia. Females can mate successfully but have reduced fertility. Complete loss of lig function results in lethality during early pupal stages. - Rasputin functions as a positive regulator of orb in Drosophila oogenesis
Costa, PloS one 2013 - “...ct % Cov Seq ct Spec ct % Cov Lingerer (CNS; behavior; Grk signaling) (CG8715) Q86S05 74 329 41.3% 25 55 23.7% Drosophila Fragile X Mental Retardation (dFMR1) (CNS: translation factor; Orb regultor) (CG6203) Q9NFU0 31 65 41.2% 5 9 11.1% CG5726 (RNAi) Q7JRH5 30 62...”
LIG_AEDAE / Q16VD3 Protein lingerer from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see paper)
Aligns to 538:572 / 1250 (2.8%), covers 100.0% of PF12478, 71.3 bits
- function: Acts in the nervous system to mediate the control of copulatory organs during courtship.
NP_995778 lingerer, isoform C from Drosophila melanogaster
Aligns to 575:610 / 1343 (2.7%), covers 100.0% of PF12478, 71.3 bits
UBAP2_HUMAN / Q5T6F2 Ubiquitin-associated protein 2; UBAP-2; RNA polymerase II degradation factor UBAP2 from Homo sapiens (Human) (see 2 papers)
NP_060919 ubiquitin-associated protein 2 isoform 1 from Homo sapiens
Aligns to 512:544 / 1119 (2.9%), covers 100.0% of PF12478, 64.0 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050).
subunit: May interact with ANXA2. - A systematic review and meta-analysis of proteomic and metabolomic alterations in anaphylaxis reactions
Gallizzi, Frontiers in immunology 2024 - “...TRIM4 NA P40222 TXLNA TXLNA Alpha-taxilin NA A0AVT1 UBA6 UBA6 Ubiquitin-like modifier-activating enzyme 6 NA Q5T6F2 UBAP2 UBAP2 Ubiquitin-associated protein 2 NA Q14157 UBP2L UBAP2L Ubiquitin-associated protein 2-like NA Q9C0C9 UBE2O UBE2O (E3-independent) E2 ubiquitin-conjugating enzyme NA Q5T4S7 UBR4 UBR4 E3 ubiquitin-protein ligase UBR4 NA Q9Y5K5...”
- Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells.
Yang, International journal of nanomedicine 2023 - “...2-C H2A2C Down Q8NDX5 Polyhomeotic-like protein 3 PHC3 Down Q14671 Pumilio homolog 1 PUM1 Down Q5T6F2 Ubiquitin-associated protein 2 UBAP2 Down Q9UK53 Inhibitor of growth protein 1 ING1 Down P22736 Nuclear receptor subfamily 4 group A member 1 NR4A1 Down High Dose vs Control Q9H4H8 Protein...”
- Recent Advances in Molecular and Cellular Functions of S100A10.
Okura, Biomolecules 2023 - “...TTLL13 Tubulin polyglutamylase TTLL13 A6NNM8 Cytoplasm PL-MS 3 [ 43 ] UBAP2 Ubiquitin-associated protein 2 Q5T6F2 Cytoplasm; Nucleus Co-fractionation [ 44 ] ULK1 Serine/threonine-protein kinase ULK1 O75385 Cytoplasm Co-IP 4 [ 244 ] UQCRB Cytochrome b-c1 complex subunit 7 P14927 Cytoplasm AC-MS 1 [ 52 ,...”
- Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach.
Thirumal, Advances in protein chemistry and structural biology 2022 - “...605898 Q9NYU1 TRIM59 TRIM59 ENSG00000213186 30834 286827 616148 Q8IWR1 UBAP2 UBAP2 ENSG00000137073 14185 55833 NA Q5T6F2 TYSND1 TYSND1 ENSG00000156521 28531 219743 611017 Q2T9J0 UBAP2L UBAP2L ENSG00000143569 29877 9898 616472 Q14157 UPF1 UPF1 ENSG00000005007 9962 5976 601430 Q92900 ITGB1 ITGB1 ENSG00000150093 6153 3688 135630 P05556 PUSL1 PUSL1...”
- Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function.
Campbell, PLoS pathogens 2022 - “...[ 47 ] Q14674 ESPL1 0 60|44 1 0.02453 Q9Y697 NFS1 0 53|74 2.7 0.13895 Q5T6F2 UBAP2 0 41|52 5.9 0.04155 SG [ 47 ] Q9Y5X1 SNX9 0 40|57 2.3 0.08151 Q8TD19 HNEK9 0 38|38 3.4 0.03882 Q9HCJ0 TNRC6C 0 38|17 1 0.01627 SG and PB...”
- The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02.
Mukherjee, Frontiers in immunology 2021 - “...TPASSSSAL 9 Q9NPG3 Ubinuclein-1 Nucleus HLA-B*07:02 5 875-883 CS, ( 26 ) 51 KPPTSQSSVL 10 Q5T6F2 Ubiquitin-associated protein 2 Nucleus, Cytoplasm HLA-B*07:02 32 411420 CS, ( 26 ) 52 VPVgSSASEL 9 Q7Z2W4-3 Zinc finger CCCH-type, antiviral 1 Nucleus, Cytoplasm HLA-B*07:02 36 596603 ( 26 ) 53...”
- Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.
Llabrés, PloS one 2020 - “...P62820 0.289 0.761 Q99471 Q8N6S5 Q9UQN3 O43633 0.932 0.885 O43447 Q9H2H8 0.723 0.929 0.694 P46379 Q5T6F2 0.799 0.102 Q9H000 Q96IZ5 0.188 0.733 Q92802 O95391 0.811 0.209 P98161 O75592 0.379 0.725 0.596 (b) Non-structural protein nsp12 (NP_828869, P0DTD1-PRO_0000449629) SARS-CoV-1 SARS-CoV-2 BPO CCO MFO P20290 P51148 0.521 0.666...”
- Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.
Malaker, Cancer immunology research 2017 - “...Q06413 AML, ALL, CLL1, JY, S, To Myocyte-specific enhancer factor 2C 15 f KPP(ts)QSSVL 411420 Q5T6F2 ALL Ubiquitin associated protein 2 16 g KPPVsFFSL 95103 Q6PKC3 ALL Thioredoxin domain containing protein 11 17 h KPTLLYnVSL 373381 P04220 CLL1, CLL2 Ig Mu heavy chain disease protein 18...”
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- Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
Lv, Protein and peptide letters 2024 (PubMed)- GeneRIF: Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
- PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
Chou, Molecular cell 2023 (PubMed)- GeneRIF: PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
- UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
Herlihy, DNA repair 2022 (PubMed)- GeneRIF: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
- Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression.
Wang, Cancer medicine 2021 - GeneRIF: Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression.
- Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells.
Xiong, Human cell 2021 (PubMed)- GeneRIF: Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells.
- circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.
Xu, Journal of ovarian research 2020 - GeneRIF: circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.
- Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
Xiong, FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 - GeneRIF: Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
- Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.
Wang, Biochemical and biophysical research communications 2018 (PubMed)- GeneRIF: The circ-UBAP2 plays a vital regulatory role in triple-negative breast cancer (TNBC) via the miR-661/MTA1 axis and may serve as a promising therapeutic target for TNBC patients.
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XP_006538287 ubiquitin-associated protein 2 isoform X2 from Mus musculus
Q91VX2 Ubiquitin-associated protein 2 from Mus musculus
Aligns to 512:544 / 1132 (2.9%), covers 100.0% of PF12478, 61.1 bits
Q4V8A7 Atp8b2 protein from Rattus norvegicus
Aligns to 520:551 / 580 (5.5%), covers 97.0% of PF12478, 59.7 bits
UBP2L_MOUSE / Q80X50 Ubiquitin-associated protein 2-like; RNA polymerase II degradation factor Ubap2l from Mus musculus (Mouse) (see 2 papers)
Aligns to 515:546 / 1107 (2.9%), covers 97.0% of PF12478, 58.8 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (By similarity). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (PubMed:25185265). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:35977029). Required for proper brain development and neocortex lamination (PubMed:35977029).
subunit: Interacts with BMI1. Part of a complex consisting of UBAP2L, BMI1 and RNF2. Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation.
disruption phenotype: Ubap2l knockout results in a lethal phenotype in a majority of embryos. Mice with heterozygous Ubap2l deletion have cognitive impairment and behavioral abnormalities, including lower preference for social novelty, mild repetitive behavior, anxious-like behavior, and abnormal spatial working memory compared to wild-type mice. Stress granule intensity and numbers are reduced in developing brains of Ubap2l-deficient mice compared to controls, and neocortex development and lamination is abnormal. - The amyloid peptide β disrupts intercellular junctions and increases endothelial permeability in a NADPH oxidase 1-dependent manner.
Tarafdar, Redox biology 2022 - “...cobalamin transport escort protein LMBD1 Lmbrd1 0.038995409 Q9R0P9 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Uchl1 0.044148581 Q80X50 Ubiquitin-associated protein 2-like Ubap2l 0.044849063 Cytoskeleton and transport O35098 Dihydropyrimidinase-related protein 4 Dpysl4 9.41366E-05 Q3UVL4 Vacuolar protein sorting-associated protein 51 homolog Vps51 0.000644658 Q9D898 Actin-related protein 2/3 complex subunit 5-like...”
- “...Q8K0B2 Lysosomal cobalamin transport escort protein LMBD1 Lmbrd1 0.0095729 Q8BGQ7 Alanine--tRNA ligase, cytoplasmic Aars1 0.0102687 Q80X50 Ubiquitin-associated protein 2-like Ubap2l 0.0116174 Q8BJW6 Eukaryotic translation initiation factor 2A Eif2a 0.0116343 Q69ZR2 E3 ubiquitin-protein ligase HECTD1 Hectd1 0.0119589 Q9JK81 MYG1 exonuclease Myg1 0.0143308 Q9CQJ6 Density-regulated protein Denr 0.0216944...”
- Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus
Parente, Molecular genetics and metabolism 2016 - “...Ctnna2 0.048 -3.44 catenin (cadherin associated protein), alpha 2 Q9D7X8 Ggct 0.046 -3.46 gamma-glutamyl cyclotransferase Q80X50 Ubap2l 0.049 -3.49 ubiquitin associated protein 2-like P28740 Kif2a 0.011 -3.52 kinesin family member 2A P21619 Lmnb2 0.042 -3.60 lamin B2 P28271 Aco1 0.020 -3.61 aconitase 1 P60469 Ppfia3 0.021...”
- Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation
Nagel, Molecular & cellular proteomics : MCP 2013 - “...kinase WNK1 Q8BT14 Q61191 P48678 Q8BFW7 Q811L6 Q80X50 P83741 Q99K90 Q02614 Q689Z5 Q8CF89 Q02780 Q6PIJ4 Q02819 P81117 Q80U93 Q6ZPK0 Q9DBG5 Q6NXI6...”
- The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects.
Oliveira, The Journal of experimental medicine 2010 - “...22 FQVTHTVAL 113-121 361 Q9QYA2 Mitochondrial import receptor subunit TOM40 homologue 23 GGPINPATA 1036-1044 1107 Q80X50 Ubiquitin-associated protein 2-like 24 GLGVLLAF 5-12 113 Q8QZT4 Crumbs protein homologue 3 25 HSIQNSQDM 61-69 210 Q91YN9 BAG family molecular chaperone regulator 2 26 IQKTPQIQVY 21-30 119 P01887 Beta-2-microglobulin 27...”
NP_001019969 ubiquitin-associated protein 2-like from Rattus norvegicus
Aligns to 515:546 / 1105 (2.9%), covers 97.0% of PF12478, 58.8 bits
NP_001120792 ubiquitin-associated protein 2-like isoform b from Homo sapiens
Aligns to 495:526 / 983 (3.3%), covers 97.0% of PF12478, 58.8 bits
NP_705693 ubiquitin-associated protein 2-like isoform 2 from Mus musculus
Aligns to 495:526 / 1067 (3.0%), covers 97.0% of PF12478, 58.8 bits
F8W726 Ubiquitin associated protein 2 like from Homo sapiens
Aligns to 506:537 / 1079 (3.0%), covers 97.0% of PF12478, 58.7 bits
UBP2L_HUMAN / Q14157 Ubiquitin-associated protein 2-like; Protein NICE-4; RNA polymerase II degradation factor UBAP2L from Homo sapiens (Human) (see 6 papers)
Aligns to 495:526 / 1087 (2.9%), covers 97.0% of PF12478, 58.7 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity).
subunit: Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2 (PubMed:25185265). Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation (PubMed:32302570). - A systematic review and meta-analysis of proteomic and metabolomic alterations in anaphylaxis reactions
Gallizzi, Frontiers in immunology 2024 - “...A0AVT1 UBA6 UBA6 Ubiquitin-like modifier-activating enzyme 6 NA Q5T6F2 UBAP2 UBAP2 Ubiquitin-associated protein 2 NA Q14157 UBP2L UBAP2L Ubiquitin-associated protein 2-like NA Q9C0C9 UBE2O UBE2O (E3-independent) E2 ubiquitin-conjugating enzyme NA Q5T4S7 UBR4 UBR4 E3 ubiquitin-protein ligase UBR4 NA Q9Y5K5 UCHL5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5...”
- Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.
Li, Animal cells and systems 2024 - “...Q13247 Serine/arginine-rich splicing factor 6 (SRSF6) 39586.34 11.42 1 1 0.0262 1 1 0.0262 37 Q14157 Ubiquitin-associated protein 2-like (UBAP2L) 114533.12 6.61 10 9 0.1058 5 5 0.0589 38 Q14694 Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 87132.74 5.19 3 3 0.0426 1 1 0.0113 39 Q15058 Kinesin-like...”
- Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach.
Thirumal, Advances in protein chemistry and structural biology 2022 - “...NA Q5T6F2 TYSND1 TYSND1 ENSG00000156521 28531 219743 611017 Q2T9J0 UBAP2L UBAP2L ENSG00000143569 29877 9898 616472 Q14157 UPF1 UPF1 ENSG00000005007 9962 5976 601430 Q92900 ITGB1 ITGB1 ENSG00000150093 6153 3688 135630 P05556 PUSL1 PUSL1 ENSG00000169972 26914 126789 NA Q8N0Z8 PVR PVR ENSG00000073008 9705 5817 173850 P15151 RAB2A RAB2A...”
- Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function.
Campbell, PLoS pathogens 2022 - “...95|51 10.1 0.02521 SG [ 47 , 49 ] Q8N6T3 ARFGAP1 0 74|86 6.4 0.19704 Q14157 UBAP2L 0 71|81 10.4 0.06992 SG [ 47 , 49 ] O60573 EIF4E2 0 71|59 8.6 0.26531 SG and PB [ 47 ] Q14674 ESPL1 0 60|44 1 0.02453 Q9Y697...”
- Protein and Signaling Pathway Responses to rhIL-6 Intervention Before Lobaplatin Treatment in Osteosarcoma Cells
Wang, Frontiers in oncology 2021 - “...fosB FOSB P01100 Proto-oncogene c-Fos FOS Fragile X mental retardation syndrome-related protein 1 (two connected) Q14157 Ubiquitin-associated protein 2-like UBAP2L P51114 Fragile X mental retardation syndroame-related protein 1 FXR1 STRING Ras GTPase-activating protein-binding protein 1 (five connected) P51114 Fragile X mental retardation syndrome-related protein 1 FXR1...”
- “...retardation syndrome-related protein 1 FXR1 Q13283 Ras GTPase-activating protein-binding protein 1 G3BP1 Q14444 Caprin-1 CAPRIN1 Q14157 Ubiquitin-associated protein 2-like UBAP2L Fragile X mental retardation syndromerelated protein 1 (three connected) Q13283 Ras GTPase-activating protein-binding protein 1 G3BP1 Q9UN86 Ras GTPase-activating protein-binding protein 2 G3BP2 Q14444 Caprin-1 CAPRIN1...”
- Quantification of FAM20A in human milk and identification of calcium metabolism proteins
Patel, Physiological reports 2021 - “...protein 4 [T22D4_HUMAN] MFGM CID TTC1 Q99614 Tetratricopeptide repeat protein 1 [TTC1_HUMAN] MFGM CID UBAP2L Q14157 Ubiquitinassociated protein 2like [UBP2L_HUMAN] MFGM CID UBTD2 Q8WUN7 Ubiquitin domaincontaining protein 2 [UBTD2_HUMAN] MFGM CID UQCRB P14927 Cytochrome bc1 complex subunit 7 [QCR7_HUMAN] MFGM CID UQCRFS1 P47985 Cytochrome bc1 complex...”
- Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
Zhang, Cancer cell international 2021 - “...kinase 13 MAPK13 Q15759 Mitogen-activated protein kinase 11 MAPK11 P53778 Mitogen-activated protein kinase 12 MAPK12 Q14157 Mitogen-activated protein kinase 14 MAPK14 P78527 DNA-dependent protein kinase catalytic subunit PRKDC P68400 Casein kinase II subunit alpha CSNK2A1 P49840 Glycogen synthase kinase-3 alpha GSK3A P49841 Glycogen synthase kinase-3 beta...”
- The human olfactory cleft mucus proteome and its age-related changes.
Yoshikawa, Scientific reports 2018 - “...1 P13693 19697 Translationally-controlled tumor protein 0.54 0.0061 4.9 0.3 2.8 0.1 3.8 0.1 2 Q14157 114579 Ubiquitin-associated protein 2-like 0.53 0.0082 0.2 0.0 0.0 0.0 0.1 0.0 3 Q8TD33 10578 Secretoglobin family 1C member 1 0.52 0.0085 5.0 0.2 0.0 0.0 2.5 0.1 4 P08185...”
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W5NVV3 Uncharacterized protein from Ovis aries
Aligns to 495:526 / 1087 (2.9%), covers 97.0% of PF12478, 58.7 bits
NP_001076535 ubiquitin-associated protein 2-like from Danio rerio
Aligns to 534:565 / 1144 (2.8%), covers 93.9% of PF12478, 56.6 bits
- Deep RNA sequencing of the skeletal muscle transcriptome in swimming fish
Palstra, PloS one 2013 - “...(herpes virus-associated) [X. laevis] 537 NP_001121282 6.28E58 RefSeq W ubiquitin-associated protein 2-like [D. rerio] 520 NP_001076535 1.37E50 Drerio W ubiquitin-conjugating enzyme E2 E3 [D. rerio] 598 NP_957215 1.21E14 Drerio R, W ubiquitin-like modifier-activating enzyme 1 [D. rerio] 815 NP_998227 1.34E127 Drerio W ubiquitin-protein ligase E3A [D....”
K1RJ91 Ubiquitin-associated protein 2 from Crassostrea gigas
Aligns to 527:556 / 1396 (2.1%), covers 78.8% of PF12478, 46.2 bits
Or search for genetic data about PF12478 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory