Family Search for PF12480 (DUF3699)
PF12480 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
GAR3_HUMAN / Q8TC56 Golgi-associated RAB2 interactor protein 3 from Homo sapiens (Human) (see 2 papers)
Aligns to 116:186 / 605 (11.7%), covers 98.6% of PF12480, 102.8 bits
F1RQD7 Golgi associated RAB2B interactor family member 3 from Sus scrofa
Aligns to 120:190 / 593 (12.0%), covers 98.6% of PF12480, 101.2 bits
- Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa
Xu, Frontiers in cell and developmental biology 2021 - “...Family with sequence similarity 71, member A Thr115, Ser399/Ser405, Ser182, Ser405 Down RNA biogenesis 85 F1RQD7 FAM71B Family with sequence similarity 71, member B Ser184, Ser518, Ser494, Ser181/Ser183/Ser184, Ser494/Ser495, Ser183/Ser184, Ser24 Down RNA biogenesis 86 A0A286ZY95 FN1 Fibronectin Ser2378 Down Sperm maturation 87 F1RYK8 FSIP2 Fibrous...”
GAR3_MOUSE / Q5STT6 Golgi-associated RAB2B interactor protein 3; Protein FAM71B from Mus musculus (Mouse) (see 2 papers)
Aligns to 123:192 / 665 (10.5%), covers 91.5% of PF12480, 99.7 bits
- function: May be involved in RNA biogenesis.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (PubMed:18256213). Interacts with FRG1.
Q5VWN6 Protein TASOR 2 from Homo sapiens
Aligns to 94:167 / 2430 (3.0%), covers 98.6% of PF12480, 98.3 bits
- Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.
Ma, Cancer science 2021 - “...ligand 1 Q9NZQ7 12.11 6 1.7 Polyadenylatebinding protein 4 Q13310 (+1) 8.57 3 Protein FAM208B Q5VWN6 7.70 7 6.0 Fragile X mental retardation syndromerelated protein 1 P51114 6.07 5 2.0 Spermspecific antigen 2 P28290 5.83 4 1.7 FilaminB O75369 5.2 4 2.9 DNA topoisomerase 2alpha P11388...”
F1S2W0 Family with sequence similarity 71 member A from Sus scrofa
Aligns to 117:187 / 597 (11.9%), covers 98.6% of PF12480, 98.3 bits
- Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa
Xu, Frontiers in cell and developmental biology 2021 - “...A0A287AEH4 FAM205C Family with sequence similarity 205 member C Ser28, Ser22 Down RNA biogenesis 84 F1S2W0 FAM71A Family with sequence similarity 71, member A Thr115, Ser399/Ser405, Ser182, Ser405 Down RNA biogenesis 85 F1RQD7 FAM71B Family with sequence similarity 71, member B Ser184, Ser518, Ser494, Ser181/Ser183/Ser184, Ser494/Ser495,...”
Q96KD3 Golgi-associated RAB2 interactor protein 1B from Homo sapiens
Aligns to 140:208 / 344 (20.1%), covers 98.6% of PF12480, 89.9 bits
- Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response.
Turck, Frontiers in molecular neuroscience 2017 - “...activity Q96PY6 Serine/threonine-protein kinase Nek1 NEK1 >5.00 Cell communication Serine/threonine kinase Protein serine/threonine kinase activity Q96KD3 Protein FAM71F1 FAM71F1 >5.00 Unknown Unclassified Molecular function unknown Q92750 Transcription initiation factor TFIID subunit 4B TAF4B >5.00 Cell growth and maintenance Transcription factor Transcription factor activity P12814 Alpha-actinin-1 ACTN1...”
GAR1A_MOUSE / B2RXB0 Golgi-associated RAB2 interactor protein 1A from Mus musculus (Mouse) (see 2 papers)
Aligns to 107:175 / 297 (23.2%), covers 98.6% of PF12480, 89.4 bits
- function: RAB2B effector protein required for accurate acrosome formation and normal male fertility.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
disruption phenotype: Mutant male fertility is significantly impaired compared with that of the controls (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal acrosome morphology (PubMed:34714330).
GAR4_HUMAN / Q8IYT1 Golgi-associated RAB2 interactor protein 4; Golgi-associated Rab2B interactor-like 4; GARI-L4; GARI-like 4 from Homo sapiens (Human) (see paper)
NP_705834 protein FAM71A from Homo sapiens
Aligns to 115:184 / 594 (11.8%), covers 97.2% of PF12480, 87.6 bits
GAR1B_MOUSE / Q3UZD7 Golgi-associated RAB2 interactor protein 1B; Golgi-associated RAB2 interactor-like 1; GARI-L1 from Mus musculus (Mouse) (see paper)
Aligns to 140:208 / 341 (20.2%), covers 98.6% of PF12480, 86.1 bits
- function: RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330). In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330).
disruption phenotype: Mutant males are sterile (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal swollen acrosome morphology and impaired acrosome reaction (PubMed:34714330).
Q6NXP2 Golgi-associated RAB2 interactor protein 1A from Homo sapiens
Aligns to 117:185 / 309 (22.3%), covers 98.6% of PF12480, 85.9 bits
XP_030111331 protein FAM71F1 isoform X7 from Mus musculus
Aligns to 108:176 / 310 (22.3%), covers 98.6% of PF12480, 85.7 bits
NP_001138874 protein FAM71E2 from Homo sapiens
Q8N5Q1 Golgi-associated RAB2 interactor protein 5B from Homo sapiens
Aligns to 97:167 / 922 (7.7%), covers 95.8% of PF12480, 85.5 bits
GAR2_MOUSE / D3YV92 Golgi-associated RAB2 interactor protein 2 from Mus musculus (Mouse) (see paper)
Aligns to 114:184 / 440 (16.1%), covers 98.6% of PF12480, 83.4 bits
- function: Seems to play a role in sperm motility.
subunit: Interacts with CALM1. - Identification of tissue-enriched novel transcripts and novel exons in mice.
Hong, BMC genomics 2014 - “...Different 5UTR tNE-3 Skp2 chr15:9082539-9082780 242 - Q9Z0Z3 Different 5UTR tNE-4 Fam71d chr12:79824797-79824939 143 + D3YV92 26 shorter AA, different C term tNE-5 Fam71d chr12:79796826-79797030 205 + D3YV92 Different 5UTR tNE-6 Rfx1 chr8:86608465-86608794 330 + tNE-7 Fam71d chr12:79823117-79823280 164 + D3YV92 tNE-8 Pfkm chr15:97925522-97925641 120 +...”
GAR2_HUMAN / Q8N9W8 Golgi-associated RAB2 interactor protein 2 from Homo sapiens (Human) (see paper)
XP_011534805 protein FAM71D isoform X1 from Homo sapiens
Aligns to 115:185 / 422 (16.8%), covers 97.2% of PF12480, 83.3 bits
GAR5A_MOUSE / A1L3C1 Golgi-associated RAB2 interactor protein 5A; Golgi-associated RAB2B interactor-like 5; GARIL5 from Mus musculus (Mouse) (see paper)
Aligns to 93:160 / 212 (32.1%), covers 85.9% of PF12480, 61.9 bits
- function: RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
XP_030098915 protein FAM71E1 isoform X10 from Mus musculus
Aligns to 1:63 / 175 (36.0%), covers 84.5% of PF12480, 61.7 bits
NP_001269718 protein FAM71F1 isoform 3 from Homo sapiens
Aligns to 57:109 / 243 (21.8%), covers 63.4% of PF12480, 57.6 bits
NP_612420 protein FAM71E1 isoform 2 from Homo sapiens
Aligns to 159:225 / 231 (29.0%), covers 78.9% of PF12480, 53.1 bits
Q6IPT2 Golgi-associated RAB2 interactor protein 5A from Homo sapiens
Aligns to 175:241 / 247 (27.1%), covers 78.9% of PF12480, 52.9 bits
- Predicting Functions of Uncharacterized Human Proteins: From Canonical to Proteoforms.
Poverennaya, Genes 2020 - “...was assigned for the largest number of proteins (24 proteins). For 10 proteins (A2RUT3, A6PVS8, Q6IPT2, Q6IPT2-2, Q7Z5L2, Q8N3J3, Q8N3J3-3, Q8TD91, Q8TD91-2, Q9HA90), a combination of biological processes including proteolysis (GO:0006508), cognition (GO:0050890), and regulation of cell migration (GO:0030334) was predicted. For 19 proteins (rightmost column),...”
- “...for 93 uPE1 proteins. * denotes the following set of proteins: A2RUT3, A6PVS8, Q2NL68, Q4KMZ1, Q6IPT2, Q6IPT2-2, Q7Z5L2, Q8N3J3, Q8N3J3-3, Q8TD91, Q8TD91-2, Q9H741, Q9HA90, Q9NWQ9. ** denotes the following set of proteins: Q0P6D6, Q2M3V2, Q53LP3, Q68CR1, Q6P995, Q6ZRI6-2, Q86X40, Q8IV32, Q8IW50, Q8N6V9, Q8NCJ5, Q8NCT3, Q8NCU4, Q8NEF3,...”
Or search for genetic data about PF12480 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory