Family Search for PF12509 (DUF3715)

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PF12509 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q5VWN6 Protein TASOR 2 from Homo sapiens
2 alignments in 552:1006 / 2430 (12.5%), covering up to 97.3% of PF12509, 195.6 bits

• Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.
  Ma, Cancer science 2021
  • “...ligand 1 Q9NZQ7 12.11 6 1.7 Polyadenylatebinding protein 4 Q13310 (+1) 8.57 3 Protein FAM208B Q5VWN6 7.70 7 6.0 Fragile X mental retardation syndromerelated protein 1 P51114 6.07 5 2.0 Spermspecific antigen 2 P28290 5.83 4 1.7 FilaminB O75369 5.2 4 2.9 DNA topoisomerase 2alpha P11388...”

TASOR_HUMAN / Q9UK61 Protein TASOR; CTCL tumor antigen se89-1; Retinoblastoma-associated protein RAP140; Transgene activation suppressor protein from Homo sapiens (Human) (see 4 papers)
Aligns to 166:319 / 1670 (9.2%), covers 100.0% of PF12509, 172.8 bits

• function: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity).
  subunit: Component of the HUSH complex; at least composed of TASOR, PPHLN1 and MPHOSPH8 (PubMed:26022416). Interacts with MORC2; the interaction associateS MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (PubMed:28581500). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (PubMed:30487602). Interacts with INPP5A, EML1, SV1L, GPSM2, ITGB3BP, CNTN1, ETFA, PSMD8, S100A10, MPHOSPH8, TMEM100, ALB, PARPBP, HCFC2, NCBP1 and SETDB1 (By similarity).
• Mass Spectrometry-Based Proteomics of Minor Species in the Bulk: Questions to Raise with Respect to the Untargeted Analysis of Viral Proteins in Human Tissue.
  Aziz, Life (Basel, Switzerland) 2023
  • “...I3L182). Major capsid protein L1 of HPV5 (R9QCH2, A9JPG1) matched 21.8% to human protein TASOR (Q9UK61). Thus, the sequence homology of viral and human proteins is one major limitation of the experiment. 2.3. Low-Intensity Signals Another problem is the fact that viral proteins do not dominate...”
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...(EC 3.1.4.11) OS=Homo sapiens PE=2 SV=1 - [B4E3H3_HUMAN] 0.80 2 1 1 1,132 132.7 6.51 Q9UK61 Uncharacterized protein C3orf63 OS=Homo sapiens GN=C3orf63 PE=1 SV=3 - [CC063_HUMAN] 0.84 1 1 1 1,670 188.9 5.80 Q0P6D6 Coiled-coil domain-containing protein 15 OS=Homo sapiens GN=CCDC15 PE=2 SV=2 - [CCD15_HUMAN] 0.74...”

TASOR_MOUSE / Q69ZR9 Protein TASOR; Transgene activation suppressor protein from Mus musculus (Mouse) (see 3 papers)
Aligns to 161:314 / 1610 (9.6%), covers 100.0% of PF12509, 171.3 bits

• function: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). Plays a crucial role in early embryonic development (PubMed:31112734, PubMed:24781204, PubMed:28839193). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (PubMed:31112734). Plays an important role in maintaining epiblast fitness or potency (PubMed:28839193).
  subunit: Component of the HUSH complex; at least composed of TASOR, PPHLN1 and MPHOSPH8 (By similarity). Interacts with MORC2; the interaction associateS MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (By similarity). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (By similarity). Interacts with INPP5A, EML1, SV1L, GPSM2, ITGB3BP, CNTN1, ETFA, PSMD8, S100A10, MPHOSPH8, TMEM100, ALB, PARPBP, HCFC2, NCBP1 and SETDB1 (PubMed:31112734).
  disruption phenotype: Embryonic lethality with robust developmentally delayed phenotype observed at 8.5 dpc, progressing through 9.5 dpc with full lethality by 12.5 dpc (PubMed:24781204, PubMed:28839193). RNAi- mediated knockdown in zygotes results in formation of multipolar spindles and increased ratio of arrested or incorrectly developed embryos (PubMed:28839193).

XP_006509039 testis-expressed protein 15 isoform X1 from Mus musculus
Aligns to 104:251 / 3059 (4.8%), covers 100.0% of PF12509, 151.4 bits

• TEX15 associates with MILI and silences transposable elements in male germ cells.
  Yang, Genes & development 2020
  • GeneRIF: TEX15 associates with MILI and silences transposable elements in male germ cells.
  • GeneRIF: Loss of TEX15 leads to DNA hypomethylation and de-silencing of transposable elements, at a level comparable to loss of MILI or DNMT3C but not MIWI2. TEX15 is associated with MILI in testis. piRNA biogenesis is intact in TEX15-deficient male germ cells.
• TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
  Schöpp, Nature communications 2020
  • GeneRIF: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
• Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
  Yang, The Journal of cell biology 2008
  • GeneRIF: Tex15 is essential for male meiosis and for chromosomal synapsis. DNA double-strand breaks (DSBs) are formed but not repaired in Tex15-deficient males.
  • GeneRIF: Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination.

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