Family Search for PF12530 (DUF3730)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF12530 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
RST1_ARATH / Q7XZF5 Protein RST1; Protein RESURRECTION 1 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
AT3G27670 RST1 (RESURRECTION1); binding from Arabidopsis thaliana
NP_189404 ARM repeat superfamily protein from Arabidopsis thaliana
2 alignments in 82:750 / 1841 (27.3%), covering up to 99.1% of PF12530, 393.7 bits
- function: Involved in cuticular wax formation (PubMed:16183838, PubMed:19625635). Required for the synthesis of alkanes from wax precursors (PubMed:16183838, PubMed:19625635). May play a role in acyl- CoA reduction to aldehydes (PubMed:16183838). Is repressed by FREE1 and functions downstream of FREE1 to negatively regulate multivesicular body (MVB) biogenesis and vacuolar transport (PubMed:31221737). Together with CER16/RIPR, acts as a cofactor of the cytoplasmic exosome and connects the cytosolic RNA exosome to the SKI complex (PubMed:31455787). Acts as a post-transcriptional gene silencing (PTGS) suppressor (PubMed:31455787, PubMed:31076735). RST1 can, like CER16/RIPR, suppress the production of small interfering RNAs (siRNAs) from the CER3 locus, which is involved in cuticule membrane and wax production, and in the typhine and sporopollenin biosynthesis of pollen (PubMed:31455787).
subunit: Interacts with CER16/RIPR.
disruption phenotype: Shrunken non viable seeds due to arrested embryo development when homozygous (PubMed:16183838). Alteration in cuticular waxes with elevated amounts of cutin monomers in leaves (PubMed:16183838, PubMed:19625635). Susceptibility to the obligate biotrophic fungus E.cichoracearum and increased resistance to the necrotrophic fungi B.cinerea and A.brassicicola (PubMed:19625635). - Positive selection and heat-response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica
Eshel, The New phytologist 2022 - “...heat stress, pathogen defense Nekrasov etal .( 2009 ); Yamamoto etal .( 2020 ) RST1 (At3g27670) ARMrepeat protein; RNA exosome cofactor, vacuolar trafficking, cuticular wax production, embryo development, pathogen defense Chen etal .( 2005 ); Mang etal .( 2009 ); Lange etal .( 2019 ); Zhao...”
- Catalytic activities, molecular connections, and biological functions of plant RNA exosome complexes
Lange, The Plant cell 2022 - “...Binds to Exo9 and the SKI complex, has a GTPase domain of unknown function RST1 At3g27670 FOCAD No homolog ARM repeats, associated with EXO9 and RIPR RIPR At5g44150 Not conserved No known domains, associated with RST1, SKI7, and the Ski complex The exosome core complex Plant...”
- Fusarium graminearum DICER-like-dependent sRNAs are required for the suppression of host immune genes and full virulence
Werner, PloS one 2021 - “...ethylene biosynthetic process AT4G02680 EOL1 ETO1-like 1 protein binding HvRST1 HORVU3Hr1G016630 integral component of membrane AT3G27670 RST1 Resurrection 1 membrane HvPIX7 HORVU3Hr1G051080 protein serine/threonine kinase activity AT5G15080 PIX7 Putative interactor of XopAC 7 ATP binding protein kinase activity Hvemb2726 HORVU5Hr1G024470 translation elongation factor activity AT4G29060 emb2726...”
- General Control Non-derepressible 1 (AtGCN1) Is Important for Flowering Time, Plant Growth, Seed Development, and the Transcription/Translation of Specific Genes in Arabidopsis
Cui, Frontiers in plant science 2021 - “...1.73 291.31 208.08 1.40 CYSTEINE SYNTHASE C1 (CYSC1) Embryonic development ending in seed dormancy 7 AT3G27670 7.04 4.32 1.63 5.70 4.44 1.28 RESURRECTION1 (RST1) AT4G24660 11.93 7.44 1.60 16.07 13.14 1.22 HOMEOBOX PROTEIN 22 (HB22) AT2G41720 18.60 11.66 1.59 17.28 13.98 1.24 EMBRYO DEFECTIVE 2654 (EMB2654)...”
- Analysis of QTL DM4.1 for Downy Mildew Resistance in Cucumber Reveals Multiple subQTL: A Novel RLK as Candidate Gene for the Most Important subQTL
Berg, Frontiers in plant science 2020 - “...pathway genes PR1 (AT2G14610), PR2 (AT3G57260), PR3 (AT3G12500), PAD4 (AT3G52430), EDS1 (AT3G48090), NPR1 (AT1G64280), RST1 (AT3G27670), and PGIP2 (AT5G06870) were retrieved from The Arabidopsis Information Resource (TAIR) on www.arabidopsis.org [accessed on 13-03-2019]. Protein sequences were used as queries for BLASTp searches against reference genomes of cucumber...”
- RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Lange, Nature communications 2019 - “...plants with T-DNAs inserted in the RRP45B / CER7 ( AT3G60500 ) and RST1 ( AT3G27670 ) loci have glossy green stems indicating wax deficiency 47 , 49 (Fig. 1a ). Gas chromatography followed by mass spectrometry (GC-MS) analysis of extracts obtained from the stem surface...”
- “...rst1-4 mutation suppresses the developmental phenotype induced by a MIM156 transgene. b Diagram of the AT3G27670 gene encoding the RST1 protein. Boxes represent exons, lines represent introns. Triangles indicate the position of the T-DNA insertions in rst1-2 and rst1-3 lines. Vertical lines indicate the point mutations...”
- Transcriptome Analysis of Four Arabidopsis thaliana Mediator Tail Mutants Reveals Overlapping and Unique Functions in Gene Regulation
Dolan, G3 (Bethesda, Md.) 2018 - “...20.4 AT4G01290 chorismate synthase chorismate synthase 20.5 AT2G26780 ARM repeat ARM repeat superfamily protein 22.4 AT3G27670 RST1 ARM repeat superfamily protein 22.9 AT2G17930 Phosphatidylinositol 3- and 4-kinase Phosphatidylinositol 3- and 4-kinase family protein with FAT domain 23.8 AT1G20960 b emb1507 U5 small nuclear ribonucleoprotein helicase, putative...”
- Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana
Wan, Genome biology 2015 - “...AT3G49600, AT5G06265, AT5G11030, AT5G12980, AT5G24740, AT5G40740, AT5G42770, AT5G51290, AT2G19390, AT1G55540, AT3G15120, AT5G10340, AT5G48120, AT1G77460, AT4G13750, AT3G27670, AT4G32200, AT4G04970, AT3G19630, AT4G18600, AT1G11060, AT4G02070, AT1G67140 [ 18 , 21 , 40 , 47 51 ] Protein phosphorylation or histone acetylation AT1G13320, AT1G16710, AT1G49340, AT5G04510, AT5G18525, AT5G49470, AT3G46920, AT1G31860,...”
- More
- A genetics screen highlights emerging roles for CPL3, RST1 and URT1 in RNA metabolism and silencing.
Li, Nature plants 2019 (PubMed)- GeneRIF: role in RNA metabolism and silencing
- RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis.
Zhao, The Plant cell 2019 - GeneRIF: RST1 is a negative regulator controlling membrane protein homeostasis and FREE1-mediated functions in plants.
- RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.
Lange, Nature communications 2019 - GeneRIF: RST1 and RST1 INTERACTING PROTEIN (RIPR) connect the cytosolic Arabidopsis RNA exosome to the Ski complex. rst1 and ripr mutants accumulate RNA quality control siRNAs produced by the post-transcriptional gene silencing machinery when mRNA degradation is compromised. Study biochemical and genetic data establish RST1 and RIPR as cofactors of the cytoplasmic exosome and the Ski complex in plants.
- The Arabidopsis RESURRECTION1 gene regulates a novel antagonistic interaction in plant defense to biotrophs and necrotrophs.
Mang, Plant physiology 2009 - GeneRIF: A mutation in RST1 defines a unique combination of disease responses to biotrophic and necrotrophic fungi in that it antagonizes salicylic acid-dependent defense and enhances JA-mediated defense through a mechanism that also controls cuticle synthesis.
FOCAD_HUMAN / Q5VW36 Focadhesin from Homo sapiens (Human) (see 3 papers)
NP_060264 focadhesin isoform 1 from Homo sapiens
Aligns to 490:714 / 1801 (12.5%), covers 100.0% of PF12530, 260.8 bits
- function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (PubMed:35864190). Potential tumor suppressor in gliomas.
subunit: Interacts with VCL. - FOCAD Indel in a Family With Juvenile Polyposis Syndrome.
MacFarland, Journal of pediatric gastroenterology and nutrition 2022 (PubMed)- GeneRIF: FOCAD Indel in a Family With Juvenile Polyposis Syndrome.
- Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis.
Moreno, Nature genetics 2022 (PubMed)- GeneRIF: Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis.
- FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.
Brand, Acta neuropathologica 2020 (PubMed)- GeneRIF: FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.
- Inter-tissue coexpression network analysis reveals DPP4 as an important gene in heart to blood communication.
Long, Genome medicine 2016 - GeneRIF: Results identified cardiac FOCAD expression to be correlated with protein biosynthetic processes in the lung. mediator of this process between the heart and lung.
- Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
Weren, The Journal of pathology 2015 - GeneRIF: The data suggests that nonallelic germline deletions in the tumor suppressor gene FOCAD underlie moderate genetic predisposition to the development of polyposis and CRC
- KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.
Brockschmidt, Brain : a journal of neurology 2012 (PubMed)- GeneRIF: This stduy showed that frequently deleted KIAA1797 gene encodes a novel focal adhesion complex protein with tumour suppressor function in gliomas.
- Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study.
Melton, Human molecular genetics 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- GeneRIF: KIAA1797 genetic variation is associated with heart rate.
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis, Molecular psychiatry 2009 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- More
- Deciphering the mechanoresponsive role of β-catenin in keratoconus epithelium.
Amit, Scientific reports 2020 - “...40 Bromodomain-containing protein BRD4 200 O60885 40 SOX-2 SOX2 35 P48431 39 Focadhesin FOCAD 200 Q5VW36 39 Alpha-enolase ENO1 47 P06733 37 Sialic acid binding IgG like lectin 11 SIGLEC11 76 Q96RL6 36 Interleukin-18 receptor IL18RAP 68 O95256 35 Contactin-1 CNTN1 113 Q12860 34 Pappalysin-1 PAPPA...”
- Urine-derived cells: a promising diagnostic tool in Fabry disease patients.
Slaats, Scientific reports 2018 - “...1,46114676 1,25552082 Q5T0F9; H7C1U3; H0Y517 Coiled-coil and C2 domain-containing protein 1B CC2D1B 3 1,72296639 1,61854792 Q5VW36 Focadhesin FOCAD 20 1,47918405 1,46710634 Q8N0X7 Spartin SPG20 12,8 1,8590069 1,45174217 Q8NB90 Spermatogenesis-associated protein 5 SPATA5 37,5 1,89352886 1,84231853 Q8NBN7; G8JLA1 Retinol dehydrogenase 13 RDH13 10,1 1,36431703 1,03176403 Q9BVG9; E9PS47;...”
FOCAD_MOUSE / A2AKG8 Focadhesin from Mus musculus (Mouse) (see paper)
Aligns to 490:714 / 1798 (12.5%), covers 100.0% of PF12530, 259.2 bits
- function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (By similarity). Potential tumor suppressor in gliomas.
subunit: Interacts with VCL.
F1LU27 Focadhesin from Rattus norvegicus
Aligns to 490:714 / 1798 (12.5%), covers 100.0% of PF12530, 255.8 bits
FOCAD_DANRE / E7FGT5 Focadhesin from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 492:716 / 1806 (12.5%), covers 100.0% of PF12530, 249.0 bits
- function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex.
disruption phenotype: Gene knockdown results in decreased overall survival and growth retardation. Mutant fishes have pathological liver features, including swollen hepatocytes, steatosis, fibrosis, and hepatocyte apoptosis.
CG3520 uncharacterized protein from Drosophila melanogaster
Aligns to 475:694 / 1204 (18.3%), covers 99.6% of PF12530, 184.6 bits
Or search for genetic data about PF12530 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory