Family Search for PF12540 (DUF3736)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF12540 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

GSE1_HUMAN / Q14687 Genetic suppressor element 1 from Homo sapiens (Human) (see 2 papers)
Aligns to 732:873 / 1217 (11.7%), covers 100.0% of PF12540, 242.7 bits

• subunit: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
• Mitochondria-derived vesicles and their potential roles in kidney stone disease.
  Chaiyarit, Journal of translational medicine 2023
  • “...lectin 2) (S-Lac lectin 2) 93 GDAP1 Q8TB36 Ganglioside-induced differentiation-associated protein 1 (GDAP1) 94 GSE1 Q14687 Genetic suppressor element 1 95 FP565260.6 A0A0B4J2D5 Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (Keio novel protein-I) (KNP-I) (Protein GT335) (Protein HES1) 96 GLDC P23378 Glycine dehydrogenase (decarboxylating), mitochondrial...”
• Ubiquitylomes Analysis of the Whole blood in Postmenopausal Osteoporosis Patients and healthy Postmenopausal Women.
  Yang, Orthopaedic surgery 2019
  • “...ANK1 122.28 P16157 1.482 Up Ankyrin1 ANK1 239.87 P02649 0.183 Down Apolipoprotein E APOE 160.18 Q14687 0.598 Down Genetic suppressor element 1 GSE1 116.54 P20618 0.416 Down Proteasome subunit beta type1 PSMB1 132.13 P02671 0.805 Down Fibrinogen alpha chain FGA 81.017 P02671 0.554 Down Fibrinogen alpha...”
• Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells.
  Yamamoto, Oncotarget 2018
  • “...LC-MS/MS in HEL cells Rank Symbol Name UniProtKB number Unused ProtScore Peptides (95%) 1 GSE1 Q14687 101.90 55 2 KDM1A (LSD1) O60341 89.31 62 3 HSPD1 P10809 71.24 48 4 RCOR1 (CoREST) Q9UKL0 44.71 28 5 HDAC2 Q92769 31.70 23 6 HNRNPUL1 Q9BUJ2 21.59 11 7...”

XP_006531210 genetic suppressor element 1 isoform X3 from Mus musculus
Aligns to 1369:1510 / 1850 (7.7%), covers 100.0% of PF12540, 235.5 bits

• Gse1, a component of the CoREST complex, is required for placenta development in the mouse.
  Hiver, Developmental biology 2023 (PubMed)
  • GeneRIF: Gse1, a component of the CoREST complex, is required for placenta development in the mouse.
• Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth.
  Imai, Gene 2005 (PubMed)
  • GeneRIF: Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)

Or search for genetic data about PF12540 in the Fitness Browser