Family Search for PF13320 (GH123_cat)

PF13320 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

5l7vA / A6L2E5 Crystal structure of bvgh123 with bond transition state analog galthiazoline. (see paper)
Aligns to 206:516 / 563 (55.2%), covers 100.0% of PF13320, 394.7 bits

• Ligand: (3ar,5r,6r,7r,7ar)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol (5l7vA)

8k2mA Crystal structure of group 4 monosaccharide-releasing beta-n- acetylgalactosaminidase ngap2 from paenibacillus sp. Ts12 in complex with galnac-thiazoline (see paper)
Aligns to 178:508 / 559 (59.2%), covers 100.0% of PF13320, 384.8 bits

• Ligand: (3ar,5r,6r,7r,7ar)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol (8k2mA)

BACPLE_01933 hypothetical protein from Bacteroides plebeius DSM 17135
Aligns to 231:542 / 592 (52.7%), covers 100.0% of PF13320, 379.1 bits

• Investigating host-microbiome interactions by droplet based microfluidics
  Tauzin, Microbiome 2020
  • “...sequence encoding the GH123 enzyme (named Uhgb_GH123) shares 100% identity (and full sequence coverage) with BACPLE_01933 (GenBank ID: WP_007561385.1), a gene encoding a DUF4091 domain-containing protein from B. plebeius DSM 17135. Its sequence similarity with the three characterized GH123 members is low, with 53% identity with...”

B2UQA1 Coagulation factor 5/8 type domain protein from Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)
Aligns to 345:658 / 712 (44.1%), covers 100.0% of PF13320, 365.2 bits

• The evolution and competitive strategies of Akkermansia muciniphila in gut
  Kim, Gut microbes 2022
  • “...1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 B2UQA1 Figure 3. Comparison of functional categories of Akkermansia muciniphila . The ordinate axis represents the percentages of genes in each functional category. The pan-genome from the 27 A. muciniphila genomes...”

CD2547 hypothetical protein from Clostridium difficile 630
Aligns to 181:525 / 582 (59.3%), covers 100.0% of PF13320, 334.1 bits

• Modulation of toxin production by the flagellar regulon in Clostridium difficile
  Aubry, Infection and immunity 2012
  • “...0.11 0.003 63.7 68 58.1 8.8 5 5.4 CD1803 CD2547 CD2672 126700383 126700402 126700403 Not observed in 630erm CD0240::erm Not observed in 630erm CD0240::erm 0.16...”

BBPR_1596 glycoside hydrolase domain-containing protein from Bifidobacterium bifidum PRL2010
Aligns to 440:766 / 1810 (18.1%), covers 100.0% of PF13320, 282.9 bits

• Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium-host cell crosstalk
  Ishikawa, iScience 2021
  • “...MSLTGVTAAQASDDNLALNQTVTASSYEVATTA V 1576 AKTG RKRRI BBPR_nagZ2 BF1_0115 1,722 186,027 Sialidase MMLATVMGPHFAGMRAQA L 1694 SATG AALALAKR BBPR_1596 BF1_0151 1,139 123,735 -N-Acetylglucosaminidase MRANGNSTHEILGKIVTAIASIAMTAAFA L 1107 SNTG RKRIG BBPR_1635 BF1_0172 739 78,939 Hypothetical protein MALALVASLVFAAMPAA L 706 SHTG RRRSRR BBPR_1657 BF1_0251 1338 138218.53 Minor extracellular serine protease MAGSLPGTALAAPAQGDAAST V...”

BF1_0115 glycoside hydrolase domain-containing protein from Bifidobacterium bifidum
Aligns to 455:781 / 1743 (18.8%), covers 100.0% of PF13320, 282.2 bits

• Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium-host cell crosstalk
  Ishikawa, iScience 2021
  • “...I 1926 SKTG RRRREV BBPR_1514 BF1_0056 1606 174333.12 -N-Hexosaminidase MSLTGVTAAQASDDNLALNQTVTASSYEVATTA V 1576 AKTG RKRRI BBPR_nagZ2 BF1_0115 1,722 186,027 Sialidase MMLATVMGPHFAGMRAQA L 1694 SATG AALALAKR BBPR_1596 BF1_0151 1,139 123,735 -N-Acetylglucosaminidase MRANGNSTHEILGKIVTAIASIAMTAAFA L 1107 SNTG RKRIG BBPR_1635 BF1_0172 739 78,939 Hypothetical protein MALALVASLVFAAMPAA L 706 SHTG RRRSRR BBPR_1657...”

E9RH20 beta-N-acetylgalactosaminidase (EC 3.2.1.53) from Paenibacillus sp. (see paper)
BAJ83606.1 glycosphingolipid β-N-acetylgalactosaminidase (NgaP) (EC 3.2.1.53|3.2.1.-) (see protein)
Aligns to 449:770 / 1034 (31.1%), covers 100.0% of PF13320, 280.6 bits

ABG82546.1 glycolipid exo-β-N-acetylgalactosaminidase (CpNga123;CPF_1473) (EC 3.2.1.53|3.2.1.-) (see protein)
CPF_1473 hypothetical protein from Clostridium perfringens ATCC 13124
Aligns to 180:519 / 587 (57.9%), covers 99.7% of PF13320, 252.9 bits

• The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens
  Noach, Journal of molecular biology 2016 (PubMed)
  • “...from C. perfringens strain ATCC 13124 (locus tag CPF_1473) is a -N-acetylgalactosaminidase, similar to NgaP from Paenibacillus sp. TS12. Like NgaP, CpNga123 was...”
  • “...from C. perfringens strain ATCC 13124 (locus tag CPF_1473) is a - N -acetylgalactosaminidase, similar to NgaP from Paenibacillus sp. TS12. Like NgaP, CpNga123...”

5fqgA / A0A0H2YNR7 The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from clostridium perfringens (see paper)
Aligns to 176:515 / 583 (58.3%), covers 99.7% of PF13320, 248.8 bits

• Ligand: beta-d-galactopyranose (5fqgA)

8k2kA Crystal structure of group 3 oligosaccharide/monosaccharide-releasing beta-n-acetylgalactosaminidase ngadssm in complex with galnac- thiazoline (see paper)
Aligns to 174:488 / 529 (59.5%), covers 96.0% of PF13320, 199.7 bits

• Ligand: (3ar,5r,6r,7r,7ar)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol (8k2kA)

HMPREF9448_00112 DUF4091 domain-containing protein from Barnesiella intestinihominis YIT 11860
Aligns to 190:460 / 503 (53.9%), covers 72.8% of PF13320, 77.0 bits

• Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host-microbe cross talk
  Steimle, STAR protocols 2021
  • “...BC Bacteroides caccae ATCC 43185 NCBI:txid411901 NZ_AAVM02000002 BACCAC_01370 BI Barnesiella intestinihominis YIT 11860 NCBI:txid742726 ADLE01000001 HMPREF9448_00112 BO Bacteroides ovatus ATCC 8483 NCBI:txid411476 NZ_AAXF02000051 BACOVA_03510 BT Bacteroides thetaiotaomicron VPI-5482 NCBI:txid226186 NC_004663 BT4272 BU Bacteroides uniformis ATCC 8492 NCBI:txid411479 NZ_AAYH02000049 BACUNI_04564 CA Collinsella aerofaciens ATCC 25986 NCBI:txid411903 NZ_AAVN02000001...”

8k2hB / Q7Y231 Crystal structure of group 2oligosaccharide/monosaccharide-releasing beta-n-acetylhexosaminidase ngaat from arabidopsis thaliana in complex with galnac-thiazoline (see paper)
Aligns to 239:518 / 563 (49.7%), covers 70.3% of PF13320, 75.5 bits

• Ligand: (3ar,5r,6r,7r,7ar)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol (8k2hB)

Or search for genetic data about PF13320 in the Fitness Browser