Family Search for PF13320 (GH123_cat)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13320 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

5l7vA / A6L2E5 Crystal structure of bvgh123 with bond transition state analog galthiazoline. (see paper)
Aligns to 206:516 / 563 (55.2%), covers 100.0% of PF13320, 394.7 bits

• Ligand: (3ar,5r,6r,7r,7ar)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol (5l7vA)

BACPLE_01933 hypothetical protein from Bacteroides plebeius DSM 17135
Aligns to 231:542 / 592 (52.7%), covers 100.0% of PF13320, 379.1 bits

• Investigating host-microbiome interactions by droplet based microfluidics
  Tauzin, Microbiome 2020
  • “...sequence encoding the GH123 enzyme (named Uhgb_GH123) shares 100% identity (and full sequence coverage) with BACPLE_01933 (GenBank ID: WP_007561385.1), a gene encoding a DUF4091 domain-containing protein from B. plebeius DSM 17135. Its sequence similarity with the three characterized GH123 members is low, with 53% identity with...”

B2UQA1 Coagulation factor 5/8 type domain protein from Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)
Aligns to 345:658 / 712 (44.1%), covers 100.0% of PF13320, 365.2 bits

• The evolution and competitive strategies of Akkermansia muciniphila in gut
  Kim, Gut microbes 2022
  • “...1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 B2UQA1 Figure 3. Comparison of functional categories of Akkermansia muciniphila . The ordinate axis represents the percentages of genes in each functional category. The pan-genome from the 27 A. muciniphila genomes...”

CD2547 hypothetical protein from Clostridium difficile 630
Aligns to 181:525 / 582 (59.3%), covers 100.0% of PF13320, 334.1 bits

• Modulation of toxin production by the flagellar regulon in Clostridium difficile
  Aubry, Infection and immunity 2012
  • “...0.11 0.003 63.7 68 58.1 8.8 5 5.4 CD1803 CD2547 CD2672 126700383 126700402 126700403 Not observed in 630erm CD0240::erm Not observed in 630erm CD0240::erm 0.16...”

BBPR_1596 glycoside hydrolase domain-containing protein from Bifidobacterium bifidum PRL2010
Aligns to 440:766 / 1810 (18.1%), covers 100.0% of PF13320, 282.9 bits

• Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium-host cell crosstalk
  Ishikawa, iScience 2021
  • “...MSLTGVTAAQASDDNLALNQTVTASSYEVATTA V 1576 AKTG RKRRI BBPR_nagZ2 BF1_0115 1,722 186,027 Sialidase MMLATVMGPHFAGMRAQA L 1694 SATG AALALAKR BBPR_1596 BF1_0151 1,139 123,735 -N-Acetylglucosaminidase MRANGNSTHEILGKIVTAIASIAMTAAFA L 1107 SNTG RKRIG BBPR_1635 BF1_0172 739 78,939 Hypothetical protein MALALVASLVFAAMPAA L 706 SHTG RRRSRR BBPR_1657 BF1_0251 1338 138218.53 Minor extracellular serine protease MAGSLPGTALAAPAQGDAAST V...”

BF1_0115 glycoside hydrolase domain-containing protein from Bifidobacterium bifidum
Aligns to 455:781 / 1743 (18.8%), covers 100.0% of PF13320, 282.2 bits

• Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium-host cell crosstalk
  Ishikawa, iScience 2021
  • “...I 1926 SKTG RRRREV BBPR_1514 BF1_0056 1606 174333.12 -N-Hexosaminidase MSLTGVTAAQASDDNLALNQTVTASSYEVATTA V 1576 AKTG RKRRI BBPR_nagZ2 BF1_0115 1,722 186,027 Sialidase MMLATVMGPHFAGMRAQA L 1694 SATG AALALAKR BBPR_1596 BF1_0151 1,139 123,735 -N-Acetylglucosaminidase MRANGNSTHEILGKIVTAIASIAMTAAFA L 1107 SNTG RKRIG BBPR_1635 BF1_0172 739 78,939 Hypothetical protein MALALVASLVFAAMPAA L 706 SHTG RRRSRR BBPR_1657...”

E9RH20 beta-N-acetylgalactosaminidase (EC 3.2.1.53) from Paenibacillus sp. (see paper)
BAJ83606.1 glycosphingolipid β-N-acetylgalactosaminidase (NgaP) (EC 3.2.1.53|3.2.1.-) (see protein)
Aligns to 449:770 / 1034 (31.1%), covers 100.0% of PF13320, 280.6 bits

ABG82546.1 glycolipid exo-β-N-acetylgalactosaminidase (CpNga123;CPF_1473) (EC 3.2.1.53|3.2.1.-) (see protein)
CPF_1473 hypothetical protein from Clostridium perfringens ATCC 13124
Aligns to 180:519 / 587 (57.9%), covers 99.7% of PF13320, 252.9 bits

• The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens
  Noach, Journal of molecular biology 2016 (PubMed)
  • “...from C. perfringens strain ATCC 13124 (locus tag CPF_1473) is a -N-acetylgalactosaminidase, similar to NgaP from Paenibacillus sp. TS12. Like NgaP, CpNga123 was...”
  • “...from C. perfringens strain ATCC 13124 (locus tag CPF_1473) is a - N -acetylgalactosaminidase, similar to NgaP from Paenibacillus sp. TS12. Like NgaP, CpNga123...”

5fqgA / A0A0H2YNR7 The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from clostridium perfringens (see paper)
Aligns to 176:515 / 583 (58.3%), covers 99.7% of PF13320, 248.8 bits

• Ligand: beta-d-galactopyranose (5fqgA)

HMPREF9448_00112 DUF4091 domain-containing protein from Barnesiella intestinihominis YIT 11860
Aligns to 190:460 / 503 (53.9%), covers 72.8% of PF13320, 77.0 bits

• Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host-microbe cross talk
  Steimle, STAR protocols 2021
  • “...BC Bacteroides caccae ATCC 43185 NCBI:txid411901 NZ_AAVM02000002 BACCAC_01370 BI Barnesiella intestinihominis YIT 11860 NCBI:txid742726 ADLE01000001 HMPREF9448_00112 BO Bacteroides ovatus ATCC 8483 NCBI:txid411476 NZ_AAXF02000051 BACOVA_03510 BT Bacteroides thetaiotaomicron VPI-5482 NCBI:txid226186 NC_004663 BT4272 BU Bacteroides uniformis ATCC 8492 NCBI:txid411479 NZ_AAYH02000049 BACUNI_04564 CA Collinsella aerofaciens ATCC 25986 NCBI:txid411903 NZ_AAVN02000001...”

Or search for genetic data about PF13320 in the Fitness Browser