Family Search for PF13355 (DUF4101)
PF13355.6 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
all2707 hypothetical protein (NCBI ptt file) from Nostoc sp. PCC 7120
Aligns to 678:791 / 798 (14.3%), covers 100.0% of PF13355, 114.1 bits
ARC6_ARATH / Q9FIG9 Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see 13 papers)
AT5G42480 ARC6 (ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6); protein binding (RefSeq) from Arabidopsis thaliana
NP_199063 Chaperone DnaJ-domain superfamily protein from Arabidopsis thaliana
Aligns to 679:794 / 801 (14.5%), covers 100.0% of PF13355, 101.6 bits
- function: Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatorial positioning of PDV2 and ARC5. May contribute to gravitropism in stems and hypocotyls. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency.
subunit: Self-interacts. Part of a complex made of ARC3, ARC6, FTSZ1 and FTSZ2. Interacts with FTSZ2-1 and FTSZ2-2 (via C-terminus), but not with FTSZ1. Binds to CDT1A. Interacts (via C-terminus) with PDV2 (via C-terminus) in the chloroplast intermembrane space.
disruption phenotype: Defective in proplastid and plastid division, with only one or two grossly enlarged plastids per cell, sometimes exhibiting alteration in stromule length and frequency in non-green tissues (e.g. increase in the frequency of stromules in nearly all cells). Abnormal subplastidial localization of the key plastid division proteins FTSZ1 and FTSZ2 (numerous short and disorganized FtsZ filament fragments). Root cells statoliths, chloroplasts, and other plastids are also abnormally large. Impaired gravitropism of inflorescence stems and hypocotyls, but not of roots. Several mesophyll and stomatal guard cells contain chlorophyll-free plastids, probably missing chloroplastic DNA. - Computational identification of protein-protein interactions in model plant proteomes
Ding, Scientific reports 2019 - “...is plastid division protein PDV2 (AT2G16070) and protein accumulation and replication of chloroplasts 6 ARC6 (AT5G42480), which has been shown to interact in the intermembrane space to coordinate the division machinery of chloroplast membrane 88 . Our predicted PPIs also included some subunits of known complexes...”
- The chloroplast division protein ARC6 acts to inhibit disassembly of GDP-bound FtsZ2
Sung, The Journal of biological chemistry 2018 - “...under accession numbers At2g36250 (FtsZ2-1), AF089738 (FtsZ2-1 cDNA), AT5G42480 (ARC6), and AY150490 (ARC6 cDNA). 11. 12. 13. 14. 15. 16. 17. 18. 19. 20....”
- The plant cell cycle: Pre-Replication complex formation and controls
Brasil, Genetics and molecular biology 2017 - “...ORC1b (AT4G12620) ABAP1 2HD, PD Masuda et al. , 2008 ORC2 (AT2G37560), ORC5 (AT4G29910), ORC6 (AT5G42480) PD Diaz-Trivino et al. , 2005 ORC3 (AT5G16690) ORC2, ORC4, ORC5, ORC6 PD Diaz-Trivino et al. , 2005 ORC1A PD Masuda et al. , 2008 ABAP1 2HD, PD, IP Masuda...”
- Variations in chloroplast movement and chlorophyll fluorescence among chloroplast division mutants under light stress
Dutta, Journal of experimental botany 2017 - “...Large chloroplasts arc5-2 At3g19720 Col-0 36 giant chloroplasts, centrally constricted Miyagishima et al. (2006) arc6-5 At5g42480 Col-0 12 giant chloroplasts Crumpton-Taylor et al. (2012) arc12 At1g69390 Col-0 12 giant chloroplasts Glynn et al. (2007) pdv1-1 At5g53280 Col-0 25 giant chloroplasts, with constrictions Miyagishima et al. (2006)...”
- Prospective function of FtsZ proteins in the secondary plastid of chlorarachniophyte algae
Hirakawa, BMC plant biology 2015 - “...BAC87808 Chlamydomonas reinhardtii XP_001702420, XP_001690917 XP_001692722 XP_001697031 XP_001697195 XP_001702662 N/A N/A XP_001700508 Arabidopsis thaliana At2g36250, At5g42480 N/A At5g24020 At1g69390 At3g19720 At5g53280 (PDV) N/A At3g52750, At2g16070 (PDV) At5g55280 At1g75010 (ARC3) At1g20830 (MCD1) Thalassiosira pseudonana XP_002296337, N/A N/A XP_002291334 N/A XP_002290986 N/A N/A XP_002294718, XP_002293505 Phaeodactylum tricornutum XP_002182929,...”
- Uncovering the protein lysine and arginine methylation network in Arabidopsis chloroplasts
Alban, PloS one 2014 - “...of the inner envelope membrane (TIC62, At3g18890 and TIC110, At1g06950), translation (PRPL11), plastid division (ARC6, At5g42480) or stress signaling (PrxA, At3g11630) ( Table 2 ). The 23 chloroplastic methylproteins display 24 sites of Lys methylation and 7 sites of Arg methylation. Thus, most of them are...”
- “...TIC110 component of the translocon at the chloroplast inner envelope (At1g06950), and the ARC6 protein (At5g42480) that is involved in the assembly of the plastid-dividing FtsZ ring. Other studies have previously shown that chloroplastic methylproteins are components of transient or stable complexes, e.g. fructose bisphosphate aldolase...”
- Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity
Mazars, Plant signaling & behavior 2014 - “...0.510 proline-rich family protein P10797 AT5G38420 0.518 ribulose bisphosphate carboxylase small chain 2B Chaperones Q7XAR9 AT5G42480 0.346 chaperone DnaJ-domain containing protein P42763 AT1G76180 0.417 dehydrin ERD14 Miscellaneous Q9SSK7 AT1G70850 0.218 MLP-like protein 34 Q9SD07 AT3G51420 0.469 strictosidine synthase-like 4 protein Q9SJL9 AT2G36870 0.512 xyloglucan:xyloglucosyl transferase P25858...”
- A J-like protein influences fatty acid composition of chloroplast lipids in Arabidopsis
Ajjawi, PloS one 2011 - “...At3g53690 and At2g22100). Of the two proteins thought to be in the chloroplast (At2g35500 and At5g42480), At5g42480 (also known as ARC6) was the best candidate because six positive colonies encoding five different peptides were identified for ARC6 (see Table 2 for details) while only one positive...”
- “...10.1371/journal.pone.0025368.t002 Table 2 Clones retrieved by Yeast 2 hybrid screening. Locus Annotation Start Stop Localization At5g42480 ARC6 129 1020 Chloro IM (Exp) At5g42480 ARC6 159 1030 Chloro IM (Exp) At5g42480 ARC6 159 1030 Chloro IM (Exp) At5g42480 ARC6 174 1265 Chloro IM (Exp) At5g42480 ARC6 192...”
- More
- The Arabidopsis arc5 and arc6 mutations differentially affect plastid morphology in pavement and guard cells in the leaf epidermis.
Fujiwara, PloS one 2018 - GeneRIF: results support the notion that ARC5 is dispensable in the process of equal division of epidermal plastids, and indicate that dysfunctions in ARC5 and ARC6 differentially affect plastid replication among mesophyll cells, PCs, and GCs within a single leaf
- Structural insights into the coordination of plastid division by the ARC6-PDV2 complex.
Wang, Nature plants 2017 (PubMed)- GeneRIF: PDV2 inserts its carboxy terminus into a pocket formed in ARC6, and this interaction further induces the dimerization of the intermembrane space regions of two ARC6 molecules. A pdv2 mutant attenuating PDV2-induced ARC6 dimerization showed abnormal morphology of ARC6 rings and compromised chloroplast division in plant cells.
- ARC6-mediated Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
Irieda, Scientific reports 2017 - GeneRIF: Study shows that ARC6 is involved in mediating Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
- Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.
Kumar, Protein science : a publication of the Protein Society 2016 - GeneRIF: The ARC6 intermembrane space region bears a structurally uncharacterized domain of unknown function, DUF4101, that is highly conserved among ARC6 and Ftn2 proteins. This study reports the crystal structure of this domain.
- Single particle tracking analysis of the chloroplast division protein FtsZ anchoring to the inner envelope membrane.
Johnson, Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2013 (PubMed)- GeneRIF: These results suggest that besides ARC6-mediated anchoring, an additional FtsZ-anchoring mechanism is present in chloroplasts.
- In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
McAndrew, The Biochemical journal 2008 (PubMed)- GeneRIF: Results describe the in vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
- Arabidopsis ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.
Glynn, The Plant cell 2008 - GeneRIF: Data show that ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.
- Photosynthesis in Arabidopsis thaliana mutants with reduced chloroplast number.
Ii, Photosynthesis research 2005 (PubMed)- GeneRIF: The effect of reduced chloroplast number on the photosynthetic competence of leaves of A. thaliana with mutations at accumulation and replication of chloroplasts (ARC) sites ARC3, ARC5, and ARC6 are reported.
- More
- Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6
Kumar, Protein science : a publication of the Protein Society 2016 (secret)
CDP1_ARATH / Q8VY16 Plastid division protein CDP1, chloroplastic; ARC6-homolog protein; Protein CHLOROPLAST DIVISION SITE POSITIONING 1; AtCDP1; Protein PARALOG OF ARC6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
NP_188549 plastid division protein from Arabidopsis thaliana
AT3G19180 ARC6H (RefSeq) from Arabidopsis thaliana
Aligns to 693:811 / 819 (14.5%), covers 99.1% of PF13355, 100.6 bits
- function: Component of the plastid division machinery required for PDV1 localization to constriction sites. Involved in chloroplast division site placement. Seems to inhibit FtsZ assembly, functioning as an antagonistic regulator of FtsZ dynamics against ARC6.
subunit: Self-interacts. Interacts (via N-terminus) with ARC3.
disruption phenotype: Defects of chloroplast and FtsZ filament morphology (e.g. long FtsZ filaments formed by multiple rings or spirals); elongated chloroplasts with multiple division sites. - Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly.
Zhang, Plant physiology 2016 - GeneRIF: PARC6 role in coordination of the chloroplast division complex and negative regulation of FtsZ assembly.
- PARC6, a novel chloroplast division factor, influences FtsZ assembly and is required for recruitment of PDV1 during chloroplast division in Arabidopsis.
Glynn, The Plant journal : for cell and molecular biology 2009 (PubMed)- GeneRIF: PARC6 plays a role in coordinating the internal and external components of the chloroplast division complex and may function as an antagonistic regulator of Z-ring dynamics.
- CDP1, a novel component of chloroplast division site positioning system in Arabidopsis.
Zhang, Cell research 2009 (PubMed)- GeneRIF: Chloroplast division site positioning 1 (AtCDP1) is a novel chloroplast division protein involved in chloroplast division site placement in Arabidopsis. [CDP1]
- Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6
Kumar, Protein science : a publication of the Protein Society 2016 (secret) - Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis
Jiang, International journal of molecular sciences 2020 - “...leaves of sco2 have a normal green appearance [ 36 , 37 , 38 ]. AT3g19180 , encoding the paralog of accumulation and replication of chloroplast 6 ( PACR6 ), regulates chloroplast division, and its loss-of-function mutant shows abnormal chloroplast division [ 39 , 40 ]....”
- “...Ler ) plants were used in the study. The T-DNA insertion mutant lines (SALK_100009C, locus AT3g19180; SALK_076272, locus At3g19190; CS68145, locus AT3g19220) were obtained from the Arabidopsis Resource Center (Columbus, OH, USA). For soil-grown plants, sown seeds were cold-treated for two days and then transferred to...”
- Variations in chloroplast movement and chlorophyll fluorescence among chloroplast division mutants under light stress
Dutta, Journal of experimental botany 2017 - “...al. (2008) arc3-2 At1g75010 Col-0 ~11 irregularly globular, large chloroplasts Shimada et al. (2004) parc6-1 At3g19180 Col-0 ~7 heterogenous, irregular chloroplasts, some with constrictions Glynn et al. (2009) arc11/minD1 At5g24020 L er Heterogenous, giant chloroplasts with some small chloroplasts Marrison et al. (1999) minD1-1 At5g24020 Ws...”
- The chloroplast min system functions differentially in two specific nongreen plastids in Arabidopsis thaliana
Wang, PloS one 2013 - “...follows: arc3 (At1g75010, CS264), arc11 (At5g24020, CS281), arc12 (At1g69390, CS16472), mcd1 (At1g20830, CS65539) and parc6 (At3g19180, CS860043). Quantitative Real-time PCR For quantitative real-time PCR (qRT-PCR) analyses, total RNA was extracted using the Plant RNeasy Mini Kit (Omega). Five micrograms total RNA was used for cDNA synthesis...”
sll0169 unknown protein (NCBI ptt file) from Synechocystis sp. PCC 6803
Aligns to 589:705 / 714 (16.4%), covers 97.4% of PF13355, 96.5 bits
Synpcc7942_1943 cell division protein Ftn2-like (NCBI) from Synechococcus elongatus PCC 7942
Aligns to 512:625 / 631 (18.1%), covers 100.0% of PF13355, 94.1 bits
- Systematic Identification of Target Genes for Cellular Morphology Engineering in Synechococcus elongatus PCC7942
Zhang, Frontiers in microbiology 2020 - “...168 203 Elongated 98 3 114 91 WT 92 26 ZipN Synechocystis 42% (72%) ZipN Synpcc7942_1943 Filamentous Filamentous Filamentous 98 8 623 666 Elongated 104 6 Cdv3 Synechocystis 35% (75%) Cdv3 Synpcc7942_2006 542 732 Elongated 83 2 576 760 Elongated 89 3 SulA Synechocystis 56% (99%)...”
- “...Lutkenhaus, 2002 ). In cyanobacteria, FtsA is missing, while another protein termed as ZipN ( Synpcc7942_1943 in PCC7942), was discovered to work as an FtsA-like orchestrator for divisome assembly ( Koksharova and Wolk, 2002 ; Marbouty et al., 2009 ; Camargo et al., 2019 ). A...”
- Four New Genes of Cyanobacterium Synechococcus elongatus PCC 7942 Are Responsible for Sensitivity to 2-Nonanone
Koksharova, Microorganisms 2020 - “...( Synpcc7942_0558 ) is a conserved hypothetical protein, chaperone-like protein and the protein ABB57973.1 ( Synpcc7942_1943 ) is cell division protein Ftn2-like, which contains CbpA region. It is known that Curved DNA-binding protein CbpA, contains a DnaJ-like domain, which is characteristic of DnaJ/Hsp40 (heat shock protein...”
Or search for genetic data about PF13355 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory