Family Search for PF13430 (DUF4112)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13430 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

HCBG_01665 uncharacterized protein from Histoplasma capsulatum G186AR
Aligns to 61:165 / 246 (42.7%), covers 99.0% of PF13430, 128.7 bits

• Extracellular Vesicle-Mediated RNA Release in Histoplasma capsulatum
  Alves, mSphere 2019
  • “...MR Protein kinase Protein modification process HCBG_01228 5F Oxidative stress-induced growth inhibitor 2 Peptidase activity HCBG_01665 MF MF pH domain-containing protein Protein modification process HCBG_03811 MR 3R Heat shock protein Hsp98 Hsp104 ATPase activity, peptidase activity HCBG_00544 MF Ubiquitin conjugating enzyme Ligase activity HCBG_02715 3F 3F...”

NCU07888 hypothetical protein from Neurospora crassa OR74A
Aligns to 62:167 / 272 (39.0%), covers 99.0% of PF13430, 127.5 bits

• Analyses of expressed sequence tags in Neurospora reveal rapid evolution of genes associated with the early stages of sexual reproduction in fungi
  Nygren, BMC evolutionary biology 2012
  • “...Hypothetical protein, signal peptide, 3 transmembrane domains - NCU07743 0.244 Taurine catabolism dioxygenase TauD 1e-81 NCU07888 0.198 Pleckstrin homology domain-containing protein 2e-40 NCU08435 0.379 RNA-dependent RNA polymerase 0 NCU08986 0.257 Hypothetical protein - NCU09099 0.267 Hypothetical protein, signal peptide, GPI-anchor - NCU09357 c 0.349 ATPase, DNA/RNA...”

AFUA_5G12410 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 63:167 / 257 (40.9%), covers 99.0% of PF13430, 125.4 bits

• Conservation of nucleosome positions in duplicated and orthologous gene pairs
  Nishida, TheScientificWorldJournal 2012
  • “...AFUA_1G00510 0.402217656 YML121W AFUA_5G09650 0.410825283 YFL060C AFUA_2G08580 0.411505108 YDR301W AFUA_8G04040 0.413112754 YJL221C AFUA_3G07380 0.413321446 YLR326W AFUA_5G12410 0.458648708 YBL108C-A AFUA_4G03360 0.487139446 YGR165W AFUA_5G08380 0.519339895 YKL157W AFUA_4G09030 0.604021491 YNL334C AFUA_2G08580 0.720610634...”

CNAG_01821 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 55:157 / 226 (45.6%), covers 99.0% of PF13430, 111.8 bits

• Cryptococcus neoformans Mar1 function links mitochondrial metabolism, oxidative stress, and antifungal tolerance
  Telzrow, Frontiers in physiology 2023
  • “...to Mar1, there are only two proteins in the C. neoformans proteome that contain DUF4112: CNAG_01821 and CNAG_04386. Like Mar1, both proteins are uncharacterized, harbor two transmembrane domains within DUF4112, and have a relatively high probability of mitochondrial import by MitoProt II prediction (CNAG_01821 = 72%,...”

MELLADRAFT_73507 uncharacterized protein from Melampsora larici-populina 98AG31
Aligns to 57:159 / 274 (37.6%), covers 99.0% of PF13430, 111.3 bits

• Multinuclei Occurred Under Cryopreservation and Enhanced the Pathogenicity of Melampsora larici-populina
  Zheng, Frontiers in microbiology 2021
  • “...in abnormal nuclear division. Transcriptome sequencing revealed that genes associated with fatty acid metabolism (MELLADRAFT_117759, MELLADRAFT_73507, MELLADRAFT_45837, and MELLADRAFT_27551) and trehalose biosynthesis process (MELLADRAFT_60322) were significantly upregulated ( Figure 7D ). Trehalose is widely noted in bacteria, fungi, and plants (Avonce et al., 2006 ). In...”

YL326_YEAST / Q06170 Uncharacterized membrane protein YLR326W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
YLR326W Ylr326wp from Saccharomyces cerevisiae
Aligns to 61:166 / 240 (44.2%), covers 98.1% of PF13430, 107.8 bits

• Comparative genomic analysis of clinical Candida glabrata isolates identifies multiple polymorphic loci that can improve existing multilocus sequence typing strategy
  Arastehfar, Studies in mycology 2021
  • “...CAGL0M09086g BUD4 YJR092W M09075/ CAGL0M09108g JSN1 YJR091C GVI51_A02255/ CAGL0A02486g 1 SEB2 YDR351W A00825/ CAGL0A01001g 1 YLR326W YLR326W A02431/ CAGL0A02651g EAF1 YDR359C C01617/ CAGL0C01859g RER1 YCL001W ARB1/ CAGL0C02343g ARB1 YER036C C02321/ CAGL0C02541g BDF1 YLR399C POP2/ CAGL0C03399g POP2 YNR052C ABP1/ CAGL0C03597g ABP1 YCR088W D02871/ CAGL0D02926g BRE2 YLR015W D05049/...”
• A Thi2p Regulatory Network Controls the Post-glucose Effect of Xylose Utilization in Saccharomyces cerevisiae
  Wei, Frontiers in microbiology 2019
  • “...ARV1, SYM1, YLR255C, TMA7, YLR264C-A, BOP2, CMG1, SMD2, YLR281C, YLR283W, YLR287C, COQ11, SPH1, NKP2, PEX30, YLR326W 16787 Hydrolase activity 14 out of 93 genes, 15.1% CCR4, POP5, PHO11, YIL082W-A, CDC42, GPN3, CDD1, IRC20, MCM5, DBP9, CTS1, TAD3, SFH1, YRF1-6 3677 DNA binding 11 out of 93...”
  • “...YAR023C, UIP3, YAR064W, YAR066W, YAR068W, RRT6, SPG1, YLR255C, YLR264C-A, BOP2, CMG1, YLR278C, YLR281C, YLR283W, YLR287C, YLR326W 51726 Regulation of cell cycle 9 out of 93 genes, 9.7% CCR4, LTE1, CLN3, BUD14, CDC42, RED1, YCS4, MEC3, SFH1 33043 Regulation of organelle organization 8 out of 93 genes,...”
• Chromosomal rearrangements as a major mechanism in the onset of reproductive isolation in Saccharomyces cerevisiae
  Hou, Current biology : CB 2014
  • “...was located between MCM6 (YGL200C) and EMP24 (YGL201C) on chromosome VII and the second between YLR326W and NMA1 (YLR328W) on chromosome XII. Considering the relative position of the centromeres on these two chromosomes, the translocation likely occurred between the left-arm of chromosome VII and the right-arm...”
• Lipidome and proteome of lipid droplets from the methylotrophic yeast Pichia pastoris
  Ivashov, Biochimica et biophysica acta 2013
  • “...the small (40S) ribosomal subunit Rps3p (82%) R Translation (RNA binding) F2QTD3 Uncharacterized membrane protein YLR326W Ylr326wp (28%) Unknown Unknown C4QV50 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e Rpp0p (71%) R Cytoplasmic translation, ribosomal large subunit assembly, translational elongation...”
• Widespread promoter-mediated coordination of transcription and mRNA degradation
  Dori-Bachash, Genome biology 2012
  • “...mRNA levels in the Swapped versus WT strains after transcriptional arrest of MRI1 (b) and YLR326W (d). Error bars reflect standard error among two or four biological replicates (see Materials and methods). (c,e) Differences in mRNA degradation rates estimated using the linear least square fits shown...”
  • “...reflects a promoter element that controls mRNA degradation. Next we analyzed the swap strains of YLR326W (Figure 2d,e ; Figure S3 in Additional file 1 ). Swapping of the entire 470 bp upstream region increased mRNA levels by approximately four-fold and mRNA degradation by approximately three-fold....”
• Conservation of nucleosome positions in duplicated and orthologous gene pairs
  Nishida, TheScientificWorldJournal 2012
  • “...0.970226227 726071 + chr12 YLR307W 0.962710223 0.990591743 745622 + chr12 YLR323C 0.953205594 0.975247431 778952 chr12 YLR326W 0.979769576 0.991583861 782174 + chr12 YLR355C 0.967858474 0.973834311 839252 chr12 YLR356W 0.968277882 0.974767083 840320 + chr12 YLR378C 0.974122358 0.977246394 877177 chr12 YLR380W 0.973258508 0.97821865 878282 + chr12 YLR410W-A 0.951545011 0.9529714...”
  • “...YDL174C AFUA_1G00510 0.402217656 YML121W AFUA_5G09650 0.410825283 YFL060C AFUA_2G08580 0.411505108 YDR301W AFUA_8G04040 0.413112754 YJL221C AFUA_3G07380 0.413321446 YLR326W AFUA_5G12410 0.458648708 YBL108C-A AFUA_4G03360 0.487139446 YGR165W AFUA_5G08380 0.519339895 YKL157W AFUA_4G09030 0.604021491 YNL334C AFUA_2G08580 0.720610634...”
• Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach
  Ambroset, G3 (Bethesda, Md.) 2011
  • “...2.58E06 0.002 Protein of unknown function YHR097C 0.7414 2.78E06 0.002 Putative protein of unknown function YLR326W 0.7409 2.84E06 0.002 Putative protein of unknown function YRF1-3 0.7209 7.01E06 0.004 Helicase encoded by the Y element of subtelomeric regions YOR289W 0.716 8.64E06 0.005 Putative protein of unknown function...”
  • “...subtelomeric regions YLL066C 0.6707 7.54E05 0.019 Putative protein of unknown function with similarity to helicases YLR326W 0.669 7.99E05 0.019 Putative protein of unknown function TMA23 0.6672 8.46E05 0.019 Nucleolar protein of unknown function implicated in ribosome biogenesis PHM7 0.6659 8.83E05 0.019 Protein of unknown function IES5...”
• Genomewide expression profile analysis of the Candida glabrata Pdr1 regulon
  Caudle, Eukaryotic cell 2011
  • “...0.34 0.31 Unknown NAd YBR242w NA SNG1c YLR326w NA YOR186w NA NA SUR7 YSC83 CAGL0I00550g CAGL0C01749g CAGL0I07777g CAGL0G09273g CAGL0A01001g CAGL0K00341g...”
• More
• PalmPred: an SVM based palmitoylation prediction method using sequence profile information.
  Kumari, PloS one 2014
  • “...7 *, 8* 7, 8 7, 8 TLG1 Q03322 205*, 206* 205, 206 205 YLR326W Q06170 79, 80, 81 80 79, 80, 81 SNA4 Q07549 2*, 3*, 5*, 7*, 8* 2, 3, 5, 7, 34 PSR1 Q07800 9 $ , 10 $ 10 10 9, 10...”
• CSS-Palm 2.0: an updated software for palmitoylation sites prediction
  Ren, Protein engineering, design & selection : PEDS 2008
  • “...P08466 P32867 P39926 Q12241 Q08144 P50108 P46985 A6ZMD0 Q06170 Amino acid permeases (AAPs) Agp1 P25376 Bap2 P38084 Gap1 P19145 Gnp1 P48813 Hip1 P06775 Sam3...”

F2QTD3 Uncharacterized protein from Komagataella phaffii (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1)
Aligns to 61:164 / 262 (39.7%), covers 99.0% of PF13430, 106.0 bits

• Lipidome and proteome of lipid droplets from the methylotrophic yeast Pichia pastoris.
  Ivashov, Biochimica et biophysica acta 2013
  • “...C4QVA2 Protein component of the small (40S) ribosomal subunit Rps3p (82%) R Translation (RNA binding) F2QTD3 Uncharacterized membrane protein YLR326W Ylr326wp (28%) Unknown Unknown C4QV50 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e Rpp0p (71%) R Cytoplasmic translation, ribosomal large...”

CNAG_04386 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 60:165 / 247 (42.9%), covers 99.0% of PF13430, 95.9 bits

• Cryptococcus neoformans Mar1 function links mitochondrial metabolism, oxidative stress, and antifungal tolerance
  Telzrow, Frontiers in physiology 2023
  • “...there are only two proteins in the C. neoformans proteome that contain DUF4112: CNAG_01821 and CNAG_04386. Like Mar1, both proteins are uncharacterized, harbor two transmembrane domains within DUF4112, and have a relatively high probability of mitochondrial import by MitoProt II prediction (CNAG_01821 = 72%, CNAG_04386 =...”

CNAG_06695 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 127:232 / 294 (36.1%), covers 96.2% of PF13430, 33.5 bits

• Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition
  Esher, PLoS pathogens 2018
  • “...growth on elevated salt concentrations. This strain had a mutation in a previously uncharacterized gene (CNAG_06695), which we have named MAR1 ( m acrophage a ctivating r egulator of cell wall-1). The encoded protein is predicted to contain two transmembrane domains, which comprise a larger domain...”

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