Family Search for PF13664 (DUF4149)

Running HMMer for PF13664

PF13664 hits 23 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

F4IYB7 Late embryogenesis abundant protein (LEA) family protein from Arabidopsis thaliana
Aligns to 47:149 / 213 (48.4%), covers 100.0% of PF13664, 104.5 bits

• Deciphering the transcriptomic regulation of heat stress responses in Nothofagus pumilio
  Estravis-Barcala, PloS one 2021
  • “...protein 41 Q39084 Late embryogenesis abundant protein 46 Q9FG31 Late embryogenesis abundant protein family protein F4IYB7 Dehydrins Dehydrin Xero 1 P25863 Dehydrin Rab18 P30185 10.1371/journal.pone.0246615.t003 Table 3 Ubiquitin-ligases significantly more expressed at 34C. Name A. thaliana UniProt ID E3 ubiquitin-protein ligase Q9LHE6 E3 ubiquitin-protein ligase ATL41...”

F2DTQ3 Predicted protein from Hordeum vulgare subsp. vulgare
Aligns to 46:148 / 212 (48.6%), covers 100.0% of PF13664, 102.7 bits

• Multi-omics analysis reveals molecular mechanisms of shoot adaption to salt stress in Tibetan wild barley
  Shen, BMC genomics 2016
  • “...ATPase (M0XZ33), vacuolar ATP synthase subunit (M0V7E0), reticulon-like protein (F2DHE3) and a conserved hypothetical protein (F2DTQ3), considered as membrane proteins, were significantly up-regulated in XZ169 under high salinity, but not in XZ26 (Table 1 ). However, some ion transporters, including potassium transporter (M0UZZ1), MRP (M0X1H9)- and...”
  • “...1.18 0.85 F2D712 Apolipoprotein 66,668 9.35 15.4 124 1.27 1.45 1.40 1.64 1.05 0.96 0.93 F2DTQ3 Conserved hypothetical protein 27,453 9.79 10.4 43 1.21 1.30 1.60 1.68 1.27 0.96 0.98 F2DHE3 Reticulon-like protein 34,653 6.75 18.5 61 1.17 1.43 1.29 1.76 1.03 0.93 0.83 M0XZ33 ATPase,...”

TM205_HUMAN / Q6UW68 Transmembrane protein 205 from Homo sapiens (Human) (see paper)
TC 9.A.55.1.1 / Q6UW68 The probable cisplatin exporter, TMEM205. Genetic polymorphisms may alter chemotheraputic responses in lung cancer patients. from Homo sapiens (see 4 papers)
Aligns to 17:118 / 189 (54.0%), covers 95.1% of PF13664, 96.2 bits

• function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
• substrates: Cisplatin
  tcdb comment: The N- and C-termini may be extracellular (Attwood et al. 2016)
• A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion
  Gallenito, Metallomics : integrated biometal science 2020
  • “...E. coli A synthetic DNA (Genscript Inc.) coding for codon-optimized human TMEM205 (Uniprot accession number: Q6UW68) was cloned into a pET19b vector with an N-terminal hexa-histidine tag and was transformed into E. coli BL21(DE3) GOLD. For expression, an overnight pre-culture in Terrific Broth supplied with 0.8%...”
• Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import.
  Nguyen, Nature communications 2018
  • “...KLCIVGGILLVFQIIAFLVGGLI APGPTTAVSY 19.1 1.230 Q8TCJ2 */** STT3B *** 55 AGLSGGLSQP AGWQSLLSFTILFLAWLAGF SSRLFAVIRF + 14.3 1.225 Q6UW68 TMEM205 5 GNLGGLIKMV HLLVLSGAWGMQMWVTFVSGFLL FRSLPRHTFG 14.3 1.385 Q643R3 LPCAT4 30 HLSRLQRVKF CLLGALLAPIRVLLAFIVLFLLW PFAWLQVAGL + 8.7 2.387 P35610 SOAT1 130 DELLEVDHIR TIYHMFIALLILFILSTLVVDYI DEGRLVLEFS 0 2.542 Q9UIQ6 * LNPEP 102 ACSVPSA RTMVVCAFVIVVAVSVIMVIYLL...”
• Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens.
  Smith, Comparative biochemistry and physiology. Part D, Genomics & proteomics 2016
  • “...recognition particle receptor subunit beta 30 kDa 1 Q8WUY1 THEM6 Protein THEM6 24 kDa 1 Q6UW68 TMEM205 Transmembrane protein 205 21 kDa 1 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 67 kDa 1 Q9C040 TRIM2 Tripartite motif-containing protein 2 82 kDa 1 P43897 TSFM Elongation factor...”
  • “...protein Rab-39B 25 kDa 1 Q9H930 SP140L Nuclear body protein SP140-like protein 67 kDa 1 Q6UW68 TMEM205 Transmembrane protein 205 21 kDa 1 Q9NZR1 TMOD2 Tropomodulin-2 40 kDa 1 Q9NY65 TUBA8 Tubulin alpha-8 chain 50 kDa 1 GEN P03372 ESR1 Estrogen receptor 66 kDa 3 P55957...”
• The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.
  Suárez-Arroyo, American journal of cancer research 2016

Q91XE8 Transmembrane protein 205 from Mus musculus
Aligns to 17:119 / 189 (54.5%), covers 97.1% of PF13664, 95.0 bits

• Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
  Kitteringham, Journal of proteomics 2010
  • “...1.00 0.96 1.04 1.00 0.97 1.03 0.54 0.70 0.77 0.77 0.69 0.58 0.81 0.69 0.090 Q91XE8 Transmembrane protein 205 2 1.5 11.4 1.00 0.67 0.70 0.60 0.73 0.58 0.91 0.49 0.47 0.49 0.57 0.50 0.46 0.55 0.69 0.153 P15105 Glutamine synthetase 4 9.8 25.1 1.00 1.16...”

YP098_YEAST / Q06089 Uncharacterized mitochondrial outer membrane protein YPR098C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YPR098C Protein of unknown function, localized to the mitochondrial outer membrane from Saccharomyces cerevisiae
Aligns to 11:105 / 161 (59.0%), covers 99.0% of PF13664, 91.8 bits

• Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
  Hughes, eLife 2016
  • “...YGR012w Outer membrane MSP1 YGR028W Outer membrane TOM70 YNL121C Outer membrane TOM71 YHR117W Outer membrane YPR098C Outer membrane OM14 YBR230C Outer membrane SEN15 YMR059W Outer membrane PTH2 YBL057C Outer membrane MCP1 YOR228C Outer membrane SCM4 YGR049W Outer membrane MIR1 b YJR077C Inner membrane CTP1 b YBR291C...”
• Development of a cross-disciplinary investigative model for the introduction of microarray techniques at non-r1 undergraduate institutions
  Walker, CBE life sciences education 2008
  • “...MFa2 PUS7 IMP4 RHO1 YDR309C YLR413W YKL106C-A YFL039C YGR279C YML022W YPR098C YOR123C YLR293C YGL089C YOR243C YGR035C YNL075W YPR165W 16 15 7 14 7 12 16 15 13 7...”
  • “...YLR413W YJR117W YKL106C-A YFL039C YGR279C YML022W YGL089C YPR098C YOR123C YLR293C YKL019W YKL209C YGL089C YOR243C YOR219C YLR413W YJR117W YKL106C-A YFL039C...”
• Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis
  Rojas, BMC genomics 2008
  • “...OST3 SXM1 YKT6 ERG5 OPI3 VAP1 YOR280C YPL101W PCL1 TIF11 YLR009W ERG6 PBI2 VID24 YOR289W YPR098C PFS2 TIF34 YLR035C-A EXG1 PCL7 YAL053W YOR338W YSA1 PHO11 TIF35 YLR065C FBA1 PDC1 YBL049W YPL004C PHO12 TIP1 YLR106C FUN14 PDC5 YBL064C YPL066W PRE10 TPM1 YLR157C-B GCV1 PDH1 YBR006W YPL134C PRE2...”
• Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway
  Vylkova, Eukaryotic cell 2007
  • “...protein from Assembly 19; S. cerevisiae orthologue, YPR098C ATPase activity; protein targeting to the mitochondrion 0.26 0.24 Down-regulated genes Plasma...”
• Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins
  Zahedi, Molecular biology of the cell 2006
  • “...6.7 53.5 YBL057c 43 23.1 5.3 52.0 YAL048c 12 75.1 5.7 51.0 YPR098c YER004w 9 44 17.7 25.1 9.7 9.3 51.0 50.0 X X YGR012w YGR086c YMR110c 57 38 33 42.8 38.3 59.9...”
• Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii
  Brachat, Genome biology 2003
  • “...3' intron Intron 47 ++ ++ ++ ++ YPR090W/YPR089W Fusion FS ++ ++ ++ Resequenced YPR098C 5' intron Intron 53 ++ ++ *Extension, ORF extension. FS, frameshift; PS, premature STOP. Supporting evidence from other fungal sequences: ++ indicates that homology supports the corrected S. cerevisiae ORF;...”

AFUA_2G02630 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 60:167 / 223 (48.4%), covers 95.1% of PF13664, 90.4 bits

• The Aspergillus fumigatus SchA^SCH9 kinase modulates SakA^HOG1 MAP kinase activity and it is essential for virulence
  Alves, Molecular microbiology 2016
  • “...binding post-transcriptional regula- tor (Csx1) NI 1.62588 NI Unknown AFUA_1G04550 AFUB_004890 Uncharacterized NI 1.41957 NI AFUA_2G02630 AFUB_019730 Protein of unknown function NI NI 4.09779 AFUA_1G06780 AFUB_007160 Ortholog(s) have cytosol. nucleus localization NI 1.16415 NI AFUA_2G05670 AFUB_022700 Protein of unknown function NI 1.05243 NI AFUA_2G12580 AFUB_028240 Ortholog(s)...”

orf19.4947 putative uncharacterized protein from Candida albicans (see paper)
Aligns to 16:110 / 169 (56.2%), covers 99.0% of PF13664, 87.9 bits

• CharProtDB CGD description: Predicted ORF in Assemblies 19, 20 and 21

AT1G72100 late embryogenesis abundant domain-containing protein / LEA domain-containing protein from Arabidopsis thaliana
Aligns to 316:419 / 480 (21.7%), covers 97.1% of PF13664, 82.6 bits

• Glycerolipid synthesis and lipid trafficking in plant mitochondria
  Michaud, The FEBS journal 2017
  • “...MELL1 Moss OM/ER [ 70 , 77 ] MER Membrane tethering, mitochondria morphology At5g44310, At4g21020, At1g72100 Ups1 Yeast/mammals IMS [ 59 ] PA transfer between OM IM At5g13070 Mdm35 IMS At4g33100 Ups2 Yeast IMS [ 58 ] PL transfer between OMIM At5g13070 NDPK-D Mammals IMS [...”
• Genome-wide identification, structural analysis and new insights into late embryogenesis abundant (LEA) gene family formation pattern in Brassica napus
  Liang, Scientific reports 2016
  • “...0.7686 0.3935 At1g20450 BnLEA9 BnaA07g11450D Dehydrin 0.1357 0.6826 0.1988 BnLEA10 BnaC05g15780D Dehydrin 0.1605 0.7191 0.2232 At1g72100 BnLEA16 BnaA02g15750D LEA_4 0.1119 0.6431 0.1739 BnLEA17 BnaC02g21020D LEA_4 0.11 0.6099 0.1803 At2g18340 BnLEA25 BnaA08g15290D LEA_4 0.3728 3.4912 0.1068 BnLEA26 BnaC07g03410D LEA_4 0.2374 1.2281 0.1933 At2g23120 BnLEA27 BnaC08g34610D LEA_6 0.2586...”
• Global scale transcriptome analysis of Arabidopsis embryogenesis in vitro
  Wickramasuriya, BMC genomics 2015
  • “..., AT4G36600 , AT3G22500 , AT5G06760 , AT3G15670 , AT2G35300 , AT4G27400 , AT1G32560 and AT1G72100 as well as several other embryogenesis related genes i.e. EMBRYO SAC DEVELOPMENT 39 , SEED GENE 3 ( ATS3 ), AGL81 , RESPONSIVE TO ABSCISIC ACID 28 ( RAB28 ;...”
• Toward the identification and regulation of the Arabidopsis thaliana ABI3 regulon
  Mönke, Nucleic acids research 2012
  • “...methionin TP AT2G35300 LEA TP AT2G36640 ATECP63 TP AT2G42560 LEA TP AT1G80090 CBS family TP AT1G72100 LEA TP AT5G01300 ATPEBP CTP AT3G53040 LEA TP AT1G04560 AWPM19 family CP AT4G36600 LEA TP AT1G54860 Unknown CTPA AT2G18340 LEA TP AT4G18920 Unknown CTP AT1G73190 Alpha-TIP CTPA AT5G45690 Unknown CTP...”
• LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana
  Hundertmark, BMC genomics 2008
  • “...+ stress 8 At1g54410 dehydrin family protein dehydrin dehydrin -1.868 other Non-seed + stress 9 At1g72100 LEA domain-containing protein LEA_4 LEA_4 -0.46 secreted Seed 10 At1g76180 dehydrin ERD14 dehydrin dehydrin -1.265 other Non-seed 11 At2g03740 LEA domain-containing protein LEA_4 LEA_4 -0.703 Chloroplast Bud 12 At2g03850 LEA...”
  • “...Cytosol 216 87.8 1.00E-16 0.819 At1g52690 At3g15670 7 29 Cytosol Cytosol 453 179 7.00E-44 0.82 At1g72100 At1g22600 9 no LEA secreted secreted 317 126 2.00E-27 0.908 At2g18340 At4g36600 13 43 secreted Mitochondrion 483 190 7.00E-47 0.966 At2g21490 At4g39130 14 45 Cytosol Cytosol 146 60.8 4.00E-08 0.772...”

LOC102584616 uncharacterized protein LOC102584616 from Solanum tuberosum
Aligns to 206:309 / 402 (25.9%), covers 98.0% of PF13664, 81.5 bits

• Transcriptome Analysis of Two Tetraploid Potato Varieties under Water-Stress Conditions
  Alvarez-Morezuelas, International journal of molecular sciences 2022
  • “...kinase regulatory subunit gamma-like PV42a 48.76 3.16 10 14 LOC102592988 - 48.09 2.74 10 16 LOC102584616 - 42.46 2.71 10 13 LOC102591763 branched-chain-amino-acid aminotransferase 2, chloroplastic-like 39.31 1.50 10 8 ijms-23-13905-t003_Table 3 Table 3 List of genes showing highest significantly different expression in the comparison of...”

XAND_ASPFU / A4DA06 Xanthocillin biosynthesis cluster protein D from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
Aligns to 17:117 / 156 (64.7%), covers 88.2% of PF13664, 78.6 bits

• function: Part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112). The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112). Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112). Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112). Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).

LOC21391660 uncharacterized protein LOC21391660 from Morus notabilis
Aligns to 302:405 / 486 (21.4%), covers 98.0% of PF13664, 78.3 bits

• Transcriptome and DNA Methylome Reveal Insights Into Phytoplasma Infection Responses in Mulberry (Morus multicaulis Perr.)
  Liu, Frontiers in plant science 2021
  • “...14.6446 0.606895 4.97406952 0.0027701 GDSL esterase/lipase At5g45950-like LOC112092080 5.82597 0.200124 4.950610547 0.0002691 Glycine-rich protein 23-like LOC21391660 0.624074 0.0242434 4.877854205 0.0387887 Uncharacterized LOC21391660 LOC21401277 1.26248 0.0578608 4.877854205 0.010022 Isoprene synthase, chloroplastic LOC21399349 29.8954 1.0711 4.864222339 2.17E-05 Uncharacterized LOC21399349 LOC21385960 1.97066 0.0731959 4.827228132 0.0421538 Dehydration-responsive element-binding protein 2F...”

AT1G22600 hypothetical protein from Arabidopsis thaliana
Aligns to 199:302 / 385 (27.0%), covers 95.1% of PF13664, 72.9 bits

• LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana
  Hundertmark, BMC genomics 2008
  • “...216 87.8 1.00E-16 0.819 At1g52690 At3g15670 7 29 Cytosol Cytosol 453 179 7.00E-44 0.82 At1g72100 At1g22600 9 no LEA secreted secreted 317 126 2.00E-27 0.908 At2g18340 At4g36600 13 43 secreted Mitochondrion 483 190 7.00E-47 0.966 At2g21490 At4g39130 14 45 Cytosol Cytosol 146 60.8 4.00E-08 0.772 At2g36640...”
  • “...in expression, the other pair between a LEA and a non- LEA gene (#9 and At1g22600) shows a high correlation (r 2 = 0.908). Also the tandem repeat between a LEA and a non- LEA gene (#7 and At1g52680) shows a high diversification in expression (r...”

NGO0618 hypothetical protein from Neisseria gonorrhoeae FA 1090
Aligns to 11:105 / 146 (65.1%), covers 95.1% of PF13664, 63.9 bits

• Overproduction of the MtrCDE efflux pump in Neisseria gonorrhoeae produces unexpected changes in cellular transcription patterns
  Ohneck, Antimicrobial agents and chemotherapy 2015
  • “...of the mtr120 mutation NGO0218 NGO0585 NGO0593 NGO0618 NGO0650 NGO1058 NGO1246 NGO1248 NGO1360 NGO1368 NGO1481 NGO1857 NGO1917 NGO0218 NGO0585 clpP NGO0618...”
• Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae
  Isabella, BMC genomics 2011
  • “...2.1 Conserved hypothetical protein (possible transcriptional regulator) NGO0570 3.5 3.4 Possible DNA-binding CreA protein RpoH NGO0618 3.3 2.7 Neisseria-specific protein, uncharacterized DUF331 4.1 7.8 Uncharacterized protein family DUF331; the function of this family is unknown NGO0802 3.7 4.0 Hypothetical protein (possible Neisseria-specific protein) NGO0854 3.6 8.4...”

Q9JZ54 TMEM205-like domain-containing protein from Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Aligns to 11:105 / 146 (65.1%), covers 94.1% of PF13664, 62.7 bits

• Towards New Drug Targets? Function Prediction of Putative Proteins of Neisseria meningitidis MC58 and Their Virulence Characterization
  Shahbaaz, Omics : a journal of integrative biology 2015
  • “...Q9K057 Q9JZK6 Q9JZJ2 Q9JZJ0 Q9JZG5 Q7DDH4 P57062 Q9JZ68 Q9JZ54 Q7DDB9 Q9JYR8 Q9JYH4 Q9JY55 Q9JXY1 Q7DD60 Q7DD59 P67616 Q9JXE9 Q7DD46 Q9JXC4 Q9JXB6 Q9JXN2 Q9JYI6...”

XP_004923868 transmembrane protein 205 from Bombyx mori
Aligns to 120:222 / 285 (36.1%), covers 94.1% of PF13664, 61.8 bits

• Comparisons of Transcriptional Profiles of Gut Genes between Cry1Ab-Resistant and Susceptible Strains of Ostrinia nubilalis Revealed Genes Possibly Related to the Adaptation of Resistant Larvae to Transgenic Cry1Ab Corn
  Yao, International journal of molecular sciences 2017
  • “...0.41 6.66 0.33 J-ECB-33_G10 GH989292.1 transmembrane protein 205-like ( Bombyx mori ) 1.29 10 26 XP_004923868 2.66 0.20 3.41 0.12 J-ECB-35_F06 GH990233.1 heme oxygenase ( Bombyx mori ) 6.66 10 48 NP_001040361 2.29 0.10 2.22 0.03 J-ECB-38_B03 GH991444.1 inhibitor of growth protein 3-like ( Bombyx mori...”

HELPY_0294 hypothetical protein from Helicobacter pylori B38
Aligns to 11:118 / 157 (68.8%), covers 99.0% of PF13664, 59.5 bits

• Elevated levels of adaption in Helicobacter pylori genomes from Japan; a link to higher incidences of gastric cancer?
  Soto-Girón, Evolution, medicine, and public health 2015
  • “...(YP_002301307) ( P value: 0.001) H. protein HELPY_0735 (YP_003057482) ( P value: 0.003) H. protein HELPY_0294 * (YP_003057096.1) ( P value: 0.002) H. protein HP1405 (NP_207861) ( P value: 0.001) H. protein HP1405 (NP_208196) ( P value:0.000) H. protein HELPY_0206 (YP_003057019) ( P value: 8.70E 11)...”

WS0563 conserved hypothetical protein from Wolinella succinogenes DSM 1740
Aligns to 17:124 / 164 (65.9%), covers 98.0% of PF13664, 58.3 bits

• Molecular signatures (unique proteins and conserved indels) that are specific for the epsilon proteobacteria (Campylobacterales)
  Gupta, BMC genomics 2006
  • “...hits from -Proteobacteria WS0520 NP_906757.1 247 aa TonB domain protein All significant hits from -Proteobacteria WS0563 NP_906797 164 aa Putative integral membrane protein; identified by similarity to PIR:B71953 All significant hits from -Proteobacteria WS0575 NP_906809 217 aa Putative lipoprotein, The C. lari homolog is a secreted...”

HP0288 hypothetical protein from Helicobacter pylori 26695
Aligns to 11:118 / 157 (68.8%), covers 99.0% of PF13664, 57.6 bits

• A Biotin Biosynthesis Gene Restricted to Helicobacter
  Bi, Scientific reports 2016
  • “...based on the genome sequence of H. pylori strain 26695. The two ORFs, HP0287 and HP0288, were annotated as a hypothetical protein and a membrane protein, respectively. To test which of these genes functioned in the E. coli biotin synthetic pathway, derivatives of the arabinose promoter...”
  • “...indicating that high level expression of BioV is not toxic. In contrast expression of the HP0288 gene failed to support detectable growth of the E. coli bioH strain ( Fig. 2 ). Since the known BioH paralogues lack sufficient sequence similarity for alignment with the encoded...”
• Recombination-based in vivo expression technology identifies Helicobacter pylori genes important for host colonization
  Castillo, Infection and immunity 2008
  • “...and two hypothetical open reading frames, HP0287 and HP0288. ftsH (HP0286) encodes a putative ATP-dependent metalloprotease (33) and is essential for growth in...”
  • “...been identified yet. The products of HP0287 and HP0288, Downloaded from http://iai.asm.org/ on February 11, 2017 by University of California, Berkeley FIG. 4....”
• Requirement of histidine kinases HP0165 and HP1364 for acid resistance in Helicobacter pylori
  Loh, Infection and immunity 2006
  • “...(40) HP0192 HP0224 HP0229 (8, 24, 40) HP0259 HP0288 HP0362 HP0365 HP0454 HP0464 HP0523 HP0555 HP0579 HP0623 HP0633 HP0635 HP0637 (24) HP0656 HP0675 HP0700...”
  • “...0.4 0.4 0.6 0.7 0.5 HP0067 HP0192 HP0224 HP0259 HP0288 HP0362 HP0454 HP0464 HP0512 (40) HP0523 HP0555 HP0579 HP0633 HP0635 HP0656 HP0675 HP0700 HP0827 (40)...”

PVX_100835 hypothetical protein, conserved from Plasmodium vivax
Aligns to 42:161 / 210 (57.1%), covers 98.0% of PF13664, 39.6 bits

• Determination of the Plasmodium vivax schizont stage proteome
  Roobsoong, Journal of proteomics 2011
  • “...PVX_097625 Merozoite surface protein 8, putative PVX_099320 Acid phosphatase, putative PVX_099980 Merozoite surface protein 1 PVX_100835 Hypothetical protein, conserved PVX_110895 ADP/ATP transporter on adenylate translocase, putative PVX_113775 Membrane protein pf12 precursor, putative PVX_122545 COP-coated vesicle membrane protein p24 precursor, putative Table 4 Plasmodium vivax proteins recognized...”

PF3D7_1237700 conserved protein, unknown function from Plasmodium falciparum 3D7
Aligns to 42:161 / 210 (57.1%), covers 98.0% of PF13664, 36.5 bits

• Combining IP₃ affinity chromatography and bioinformatics reveals a novel protein-IP₃ binding site on Plasmodium falciparum MDR1 transporter
  Alves, Current research in microbial sciences 2023
  • “...Heat shock protein 40, type II 1 yes PF3D7_1252100 Rhoptry neck protein 3 3 Yes PF3D7_1237700 Conserved protein, unknown function 5 Yes PF3D7_0801800 Mannose-6-phosphate isomerase, putative 1 No PF3D7_0731300 Plasmodium exported protein (PHISTb), unknown function 1 Yes PF3D7_0702500 Plasmodium exported protein, unknown function 2 No PF3D7_1344800...”
• Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum
  Lamb, PloS one 2022
  • “...22 ] ( Table 1 ). Using these criteria, we selected five proteins for validation: PF3D7_1237700, PF3D7_0707400, PF3D7_1437700, and PF3D7_0514900, and PF3D7_0105500. Although this last protein was not in the final list of 122, we had identified PF3D7_0105500 early in our pilot experiments with proximity biotinylation...”
  • “...description a MitoProtII Score b PMC Score c Mutagenesis index score d IFA result e PF3D7_1237700 Conserved protein, unknown function 0.74 0.789 0.19 + PF3D7_0707400 AAA family ATPase, putative 0.63 0.747 0.13 + PF3D7_1437700 Succinyl-CoA ligase, putative 0.72 0.585 1 + PF3D7_0105500 Conserved protein, unknown function...”
• Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics
  Swearingen, PLoS pathogens 2016
  • “...PF3D7_1323700 glideosome associated protein with multiple membrane spans 1 (GAPM1) 3 Motility NO 6 TMs PF3D7_1237700 conserved protein, unknown function 3 Hypothetical NO 5 TMs PF3D7_1238000 COPI associated protein, putative 3 Vesicular Trafficking NO 4 TMs PF3D7_1011500 conserved Plasmodium membrane protein, unknown function 3 Hypothetical NO...”
• Proteomic analysis of detergent-resistant membrane microdomains in trophozoite blood stage of the human malaria parasite Plasmodium falciparum
  Yam, Molecular & cellular proteomics : MCP 2013
  • “...PF3D7_1410400 PF3D7_1410700 PF3D7_1212000 PF3D7_1222300 PF3D7_1237700 PF3D7_1115600 PF3D7_1116800 PF3D7_1121600 PF3D7_1129000 PF3D7_1130200 PF3D7_1132800...”

K7EM09 Transmembrane protein 205 (Fragment) from Homo sapiens
Aligns to 1:57 / 120 (47.5%), covers 50.0% of PF13664, 27.7 bits

• Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade
  Walker, Anticancer research 2021
  • “...Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2 - [GSHR_HUMAN] 522 56.221 1.290853 p <0.001 K7EM09 Transmembrane protein 205 (Fragment) OS=Homo sapiens GN=TMEM205 PE=1 SV=1 - [K7EM09_HUMAN] 120 13.3807 1.2885968 p <0.001 I3L3E4 Charged multivesicular body protein 6 (Fragment) OS=Homo sapiens GN=CHMP6 PE=1 SV=1 - [I3L3E4_HUMAN]...”

NVIE_014310 DUF4149 domain-containing protein from Nitrososphaera viennensis EN76
Aligns to 315:427 / 987 (11.4%), covers 95.1% of PF13664, 24.8 bits

• Genome wide transcriptomic analysis of the soil ammonia oxidizing archaeon Nitrososphaera viennensis upon exposure to copper limitation
  Reyes, The ISME journal 2020
  • “...as several of their genes were upregulated including: two copC/D genes, copC/D_a (NVIE_014300) and copC/D_b (NVIE_014310). Both proteins are fusions of CopC and CopD domains, and their genes together with neighboring genes form part of a larger cluster comprising 25 genes of which 15 were upregulated...”
  • “...a log 2 FC>1.5 found in close proximity to the two CopC/D genes (NVIE_014300 and NVIE_014310) in the genome, upregulated genes next to the highly upregulated MCO4_b (NVIE_019250), and genes specifically associated with Cu from the top 25 upregulated genes (see Dataset S 1 for a...”

PA14_62890 hypothetical protein from Pseudomonas aeruginosa UCBPP-PA14
Aligns to 10:107 / 135 (72.6%), covers 89.2% of PF13664, 24.7 bits

• Contribution of Veillonella parvula to Pseudomonas aeruginosa-mediated pathogenicity in a murine tumor model system
  Pustelny, Infection and immunity 2015
  • “...in expressionb Gene and/or producta PA14_29690 PA14_51430 PA14_62890 PA14_62960 10 10 10 8.17 Hypothetical protein pqsA, probable coenzyme A ligase Hypothetical...”

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