Family Search for PF13778 (DUF4174)

Running HMMer for PF13778

PF13778 hits 24 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NP_001007199 coiled-coil domain-containing protein 80 precursor from Danio rerio
B7SDQ7 Coiled-coil domain-containing protein 80 from Danio rerio
Q90X49 Coiled-coil domain-containing protein 80 from Danio rerio
3 alignments in 125:830 / 867 (45.9%), covering up to 100.0% of PF13778, 350.6 bits

• The Coiled-Coil Domain Containing 80 (ccdc80) gene regulates gadd45β2 expression in the developing somites of zebrafish as a new player of the hedgehog pathway.
  Della, Journal of cellular physiology 2015 (PubMed)
  • GeneRIF: investigated the functional effects of Coiled-Coil Domain Containing 80-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
• Ccdc80-l1 Is involved in axon pathfinding of zebrafish motoneurons.
  Brusegan, PloS one 2012
  • GeneRIF: analysis of zebrafish Ccdc80 and Ccdc80-like1 (Ccdc80-l1) proteins; Ccdc80-l1 is involved in axon pathfinding of zebrafish motoneurons
• Proteomics analysis of the zebrafish skeletal extracellular matrix.
  Kessels, PloS one 2014
  • “...[44] F1QXC6 Tgfb2l 1.14* 0.07 1.21* 1.42** 0.28 1.70** 0.01 [54] , [55] Cartilage-related proteins B7SDQ7 Ccdc80 a 1.74** 0.15 1.89** 0.06 0.28 0.21 0.00 [29] F1Q775 Cilp a 0.48 0.25 0.23 1.24** 1.29 2.53** n.s. [29] F1Q924 Col6a6 a 0.47 0.51 0.98* 1.53** 0.32 1.21**...”
• Comparative proteome and peptidome analysis of the cephalic fluid secreted by Arapaima gigas (Teleostei: Osteoglossidae) during and outside parental care
  Torati, PloS one 2017
  • “...member of group I collagen (fibrillar forming collagen) F, M 0.05, 0.03 [ 71 ] Q90X49 Coiled-coil domain-containing protein 80 Promotes cell adhesion and matrix assembly F, PM 0.04, 0.04 [ 72 ] Discussion The lateral line of A . gigas is an open system like...”

NP_989762 coiled-coil domain-containing protein 80 precursor from Gallus gallus
3 alignments in 141:910 / 958 (41.4%), covering up to 100.0% of PF13778, 347.6 bits

• Multiple roles of Equarin during lens development.
  Song, Development, growth & differentiation 2014 (PubMed)
  • GeneRIF: As lens development proceeds, Equarin is strongly expressed in the lens equatorial region with a high-dorsal-to-low-ventral gradient.
• Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development.
  Song, Developmental dynamics : an official publication of the American Association of Anatomists 2013 (PubMed)
  • GeneRIF: Equarin is involved in cell adhesion during fiber differentiation and development.
• Equarin is involved as an FGF signaling modulator in chick lens differentiation.
  Song, Developmental biology 2012 (PubMed)
  • GeneRIF: Data show that endogenous Equarin is required for chick lens cell differentiation.
• A balance of FGF and BMP signals regulates cell cycle exit and Equarin expression in lens cells.
  Jarrin, Molecular biology of the cell 2012
  • GeneRIF: Equarin gene expression is regulated by a balance of FGF and BMP signals in lens cells of the developing eye.

CCD80_CHICK / Q8AXP2 Coiled-coil domain-containing protein 80; Equarin from Gallus gallus (Chicken) (see paper)
3 alignments in 141:910 / 958 (41.4%), covering up to 100.0% of PF13778, 347.6 bits

• function: Promotes cell adhesion and matrix assembly (By similarity). May play a role in eye formation.
  subunit: Binds to various extracellular matrix proteins.

CCD80_HUMAN / Q76M96 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes protein 1; Up-regulated in BRS-3 deficient mouse homolog from Homo sapiens (Human) (see 3 papers)
NP_955806 coiled-coil domain-containing protein 80 precursor from Homo sapiens
3 alignments in 141:902 / 950 (41.8%), covering up to 100.0% of PF13778, 346.3 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer.
  Yu, BMC cancer 2024
  • GeneRIF: Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer.
• The expression of long non-coding RNA LINC01279 in gastric adenocarcinoma and its clinical significance.
  Meng, Asian journal of surgery 2022 (PubMed)
  • GeneRIF: The expression of long non-coding RNA LINC01279 in gastric adenocarcinoma and its clinical significance.
• Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.
  Christian, Oncotarget 2022
  • GeneRIF: Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.
• Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease.
  Wang, Physiological research 2021
  • GeneRIF: Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease.
• Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.
  Zhou, Scientific reports 2018
  • GeneRIF: The authors identified that CCDC80 has genetic and functional relevance to Intracranial Aneurysm pathogenesis in the French-Canadian population.
• Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis.
  Liu, Molecular medicine reports 2018
  • GeneRIF: LINC01279 and MSC-AS1 were upregulated in endometriosis. LINC01279 may be associated with the pathogenesis of endometriosis.
• Adipose tissue and serum CCDC80 in obesity and its association with related metabolic disease.
  Osorio-Conles, Molecular medicine (Cambridge, Mass.) 2017
  • GeneRIF: Our finding of upregulated CCDC80 expression in the visceral adipose tissue of obese patients indicates that it may be a component of the obesity-altered secretome in this depot. Furthermore, the presence of CCDC80 protein in human serum and its association with systemic metabolic dysfunction suggests that it may be linked to metabolic changes in other organs.
• Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
  Walczak, Molecular endocrinology (Baltimore, Md.) 2014
  • GeneRIF: Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
• More
• Differential Expression of Proteins Associated with Bipolar Disorder as Identified Using the PeptideShaker Software
  Seregin, International journal of molecular sciences 2023
  • “...protein ig-h3 TGFBI 0.005941 0.001980 0.0342 Q5VWQ8 Disabled homolog 2-interacting protein DAB2IP 0.000014 0.004689 0.01055 Q76M96 Coiled-coil domain-containing protein 80 CCDC80 0.000015 0.001359 0.01064 O00512 B-cell CLL/lymphoma 9 protein BCL9 0.018721 0.000029 0.01092 Q9Y678 Coatomer subunit gamma-1 COPG1 0.000018 0.002829 0.01281 P46940 Ras GTPase-activating-like protein IQGAP1...”
• Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan.
  Dillon, Anesthesia and analgesia 2023
  • “...Gene Symbol UniProt FC (blood) p-value FC (CSF) p-value Upregulated Coiled-coil domain-containing protein 80 CCDC80 Q76M96 1.38 0.007 1.27 < 0.001 * Periostin POSTN Q15063 1.36 < 0.001 * 1.20 0.046 Thrombospondin-4 THBS4 P35443 1.21 < 0.01 1.37 < 0.01 * Bone sialoprotein 2 IBSP P21815...”
• Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype.
  Donlon, GeroScience 2023
  • “...Desmocollin-2 DSC2 Q02487 1 4.80E02 0.739 4.30E02 0 4.80E01 1.079 Coiled-coil domain-containing protein 80 CCDC80 Q76M96 1 6.00E02 0.748 4.30E02 0 4.00E01 1.093 Alpha-parvin PARVA Q9NVD7 1 5.80E02 0.744 4.50E02 0 4.40E01 1.086 Vascular endothelial growth factor D VEGFA O43915 1 4.70E02 0.755 4.60E02 0 4.80E01...”
• Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies.
  Beusch, Cellular and molecular life sciences : CMLS 2023
  • “...P53396 ACLY ATP-citrate synthase 2.5510 4 0.59 P10301 RRAS Ras-related protein R-Ras 5.1810 5 0.61 Q76M96 CCDC80 Coiled-coil domain-containing protein 80 0.0032 0.62 O14498 ISLR Immunoglobulin superfamily containing leucine-rich repeat protein 0.0099 0.65 Q00341 HDLBP Vigilin 5.3910 6 0.66 P21926 CD9 CD9 antigen 0.0014 0.74 P16112...”
• Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome.
  Mengeste, Frontiers in physiology 2022
  • “...resident protein 44 8,20E-03 3,1 Q14767 LTBP2 Latent-transforming growth factor beta-binding protein 2 4,40E-06 2,9 Q76M96 CCDC80 Coiled-coil domain-containing protein 80 1,38E-04 2,3 Q05707 COL14A1 Collagen alpha-1(XIV) chain 1,10E-02 2,3 Q15582 TGFBI Transforming growth factor-beta-induced protein ig-h3 6,20E-04 2,3 O95967 EFEMP2 EGF-containing fibulin-like extracellular matrix protein...”
• Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs.
  Wang, Cells 2022
  • “...UniProt Protein Names Gene Names EVs_D28-35 /EVs_D0 Ratio Q8IUX7 Adipocyte enhancer-binding protein 1 AEBP1 100 Q76M96 Coiled-coil domain-containing protein 80 CCDC80 100 P05090 Apolipoprotein D APOD 8.375 Q9NRY6 Phospholipid scramblase 3 PLSCR3 2.635 cells-11-02491-t004_Table 4 Table 4 The expression/level ratio of selected proteins involved in ECM...”
• Plasma proteomic signature of decline in gait speed and grip strength.
  Liu, Aging cell 2022
  • “...0.0027 0.0006 2.21E05 343810 SL009324 O95633 FSTL3 Follistatinrelated protein 3 0.0027 0.0007 3.70E05 323423 SL010390 Q76M96 URB Coiledcoil domaincontaining protein 80 0.0026 0.0006 4.74E05 11514196 SL004557 P13987 CD59 CD59 glycoprotein 0.0028 0.0007 5.18E05 1309475 SL018509 Q9BXY4 RSPO3 Rspondin3 0.0026 0.0007 5.87E05 Note : Estimates were from...”
• Using plasma proteomics to investigate viral infections of the central nervous system including patients with HIV-associated neurocognitive disorders.
  Ahmed, Journal of neurovirology 2022
  • “...2.11 1.19 ADIPOQ Q15848 0.0088 1.57 2.06 1.25 A1BG P04217 0.0106 0.58 1.97 0.76 CCDC80 Q76M96 0.0149 1.39 1.83 1.18 F13A1 P00488 0.0149 13.53 1.83 3.68 F5 P12259 0.0262 4.15 1.58 2.04 EMILIN2 Q9BXX0 0.027 1.39 1.57 1.18 FGB P02675 0.0271 0.59 1.57 0.77 SLC8A1 P324185...”
• More

CCD80_RAT / Q6QD51 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes 1 protein; Steroid-sensitive gene 1 protein; SSG-1 from Rattus norvegicus (Rat) (see 2 papers)
NP_071988 coiled-coil domain-containing protein 80 precursor from Rattus norvegicus
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 344.4 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein.
  O'Leary, Molecular endocrinology (Baltimore, Md.) 2013
  • GeneRIF: Ccdc80 preferentially binds activated, tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2.
• DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.
  Bommer, The Journal of biological chemistry 2005 (PubMed)
  • GeneRIF: DRO1 may have a role in the development of colorectal and pancreatic cancers

A5PKA3 Coiled-coil domain-containing protein 80 from Bos taurus
3 alignments in 141:906 / 954 (41.6%), covering up to 100.0% of PF13778, 344.3 bits

• How to dig deeper? Improved enrichment methods for mucin core-1 type glycopeptides
  Darula, Molecular & cellular proteomics : MCP 2012
  • “...File S2 Uniprot ID A2I7N2 A4IFA5 A5D7R6 A5PK77 A5PKA3 A6QLD8 E1BB91 E1BCW0 E1BI67 E1BKQ9 F1MER7 F1MMK9 F1N1I6 O18977 (F1MPK6) P00735 P00743 P00744 P01030 P01044...”

CCD80_MOUSE / Q8R2G6 Coiled-coil domain-containing protein 80; Up-regulated in BRS-3 deficient mouse from Mus musculus (Mouse) (see 3 papers)
XP_006522563 coiled-coil domain-containing protein 80 isoform X1 from Mus musculus
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 344.0 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Ovariectomy Interferes with Proteomes of Brown Adipose Tissue in Rats.
  Chou, International journal of medical sciences 2022
  • “...Q8VHY0 CSPG4 12.83 8.27 27.17 5.84 0.0336 +2.12 6.699 2.141 0.973 Coiled-coil domain-containing protein 80 Q8R2G6 CCD80 0.23 0.46 1.06 0.07 0.0348 +4.61 0.307 2.701 0.999 Lactotransferrin P08071 TRFL 3.47 2.97 9.35 3.38 0.0403 +2.70 2.973 1.980 0.946 Stress-induced-phosphoprotein 1 Q60864 STIP1 8.29 3.22 13.79 2.90...”
• Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.
  Knebel, International journal of molecular sciences 2017
  • “...26S protease regulatory subunit 10B P62334 Psmc6 1.89 6.65 10 5 Coiled-coil domain-containing protein 80 Q8R2G6 Ccdc80 1.89 2.33 10 4 Pentraxin-related protein PTX3 P48759 Ptx3 1.87 3.35 10 2 Tenascin Q80YX1 Tnc 1.86 6.09 10 5 Inositol polyphosphate 1-phosphatase P49442 Inpp1 1.52 1.24 10 5...”
  • “...1.15 10 6 -Amylase 1 P00687 Amy1 3.64 1.84 10 5 Coiled-coil domain-containing protein 80 Q8R2G6 Ccdc80 3.47 2.67 10 7 Tissue - l -fucosidase Q99LJ1 Fuca1 3.28 9.84 10 7 Ganglioside GM2 activator Q60648 Gm2a 3.26 2.29 10 6 Actin-related protein 2/3 complex subunit 3...”
• The proteome of mouse cerebral arteries
  Badhwar, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 (secret)
• Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development
  Wilson, Molecular & cellular proteomics : MCP 2012
  • “...Q8VHI5 O35103 D3Z7H8 0.003841 0.000306 10.7 10.0 P61750 Q8R2G6 0.00273 9.3 E0CZ58 0.000531 0.005008 0.000328 0.00195 0.00048 0.00044 0.005544 0.000123 8.6 7.0...”
• Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.
  Drake, Journal of proteome research 2012
  • “...N221 4 3 Protease CTSL2 CATL2_HUMAN O60911 Cathepsin L2 N221 3 2 Protease CCDC80 CCD80_HUMAN Q8R2G6 Coiled-coil domain-containing protein 80 N667 3 1 Adhesion molecule CCDC80 CCD80_HUMAN Q8R2G6 Coiled-coil domain-containing protein 80 N668 4 3 Adhesion molecule CD109 CD109_HUMAN Q6YHK3 CD109 antigen e N68 3 1...”
• Identification of astrocyte secreted proteins with a combination of shotgun proteomics and bioinformatics
  Dowell, Journal of proteome research 2009
  • “...B P10605 Yes 56 3 Acyltransferase-like 1-A Q8BYI6 membrane 7 3 Coiled-coil domain-containing protein 80 Q8R2G6 Yes 7 3 Serine protease inhibitor A3C P29621 Yes 6 3 Serine protease inhibitor A3F Q80X76 Yes 6 3 Serine protease inhibitor A3K P07759 Yes 6 3 Metallothionein-3 P28184 Yes...”
• Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression.
  Gong, European journal of pharmacology 2019 (PubMed)
  • GeneRIF: Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a.
• Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.
  Grill, Carcinogenesis 2018 (PubMed)
  • GeneRIF: The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease.
• Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation.
  Grill, Molecular and cellular endocrinology 2017 (PubMed)
  • GeneRIF: DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells.
• The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias.
  Leone, Cancer letters 2015 (PubMed)
  • GeneRIF: Data indicate that embryonic fibroblasts from cl2/coiled-coil domain-containing protein 80 (ccdc80) knock-out mice showed higher proliferation rate and lower susceptibility to apoptosis.
• Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
  Walczak, Molecular endocrinology (Baltimore, Md.) 2014
  • GeneRIF: Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
• DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
  Grill, Molecular cancer research : MCR 2014 (PubMed)
  • GeneRIF: This report characterizes a new mouse model for the study of colorectal cancer and establishes DRO1 (CCDC80) as a tumor suppressor via a mechanism involving ERK phosphorylation.
• Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
  Tremblay, Endocrinology 2012 (PubMed)
  • GeneRIF: Results suggest that Ccdc80 is a novel modulator of glucose and energy homeostasis during diet-induced obesity.
• Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.
  Tremblay, The Journal of biological chemistry 2009
  • GeneRIF: Ccdc80 plays dual roles in adipogenesis by mechanisms that involve at least in part down-regulation of Wnt/beta-catenin signaling and induction of C/EBPalpha and peroxisome proliferator-activated receptor gamma.
• More

G1T0T4 Sushi repeat-containing protein SRPX2 from Oryctolagus cuniculus
Aligns to 334:453 / 465 (25.8%), covers 99.2% of PF13778, 140.1 bits

• Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
  Pinto-Pinho, Animals : an open access journal from MDPI 2024
  • “...3 TM PM G1T4W3 SLC9A6 Sodium/hydrogen exchanger SP+TM PM G1SLC9 SLC9A7 Sodium/hydrogen exchanger SP+TM PM G1T0T4 SRPX2 Sushi repeat containing protein X-linked 2 SP CS, PM, ES G1SN13 TENM1 Teneurin transmembrane protein 1 TM PM, ICPM O62852 TRPC5 Short transient receptor potential channel 5 TM PM...”

NP_001014348 sushi repeat-containing protein SRPX precursor from Danio rerio
Aligns to 318:437 / 448 (26.8%), covers 99.2% of PF13778, 137.7 bits

• Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO₄-induced inflammation in zebrafish by metabolomic and proteomic analyses
  Gong, Journal of neuroinflammation 2020
  • “...No. Accession Gene Symbol Description Control vs model Model vs FA Model vs FB 1 NP_001014348 srpx Sushi repeat-containing protein SRPX precursor ## ** * 2 NP_001028768 mrps7 28S ribosomal protein S7, mitochondrial precursor ### *** *** 3 NP_001077285 zgc:162509 Uncharacterized protein LOC553299 ## ** **...”

XP_038955648 sushi repeat-containing protein SRPX2 isoform X2 from Rattus norvegicus
Aligns to 301:420 / 432 (27.8%), covers 99.2% of PF13778, 136.3 bits

• Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
  Anwer, Journal of neurotrauma 2020 (PubMed)
  • GeneRIF: Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.

SRPX2_HUMAN / O60687 Sushi repeat-containing protein SRPX2; Sushi-repeat protein upregulated in leukemia from Homo sapiens (Human) (see 6 papers)
NP_055282 sushi repeat-containing protein SRPX2 precursor from Homo sapiens
Aligns to 334:453 / 465 (25.8%), covers 99.2% of PF13778, 136.3 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
  subunit: Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.
• SRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer.
  Guo, Clinical and experimental medicine 2023
  • GeneRIF: SRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer.
• Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
  Wang, Theranostics 2021
  • GeneRIF: Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
• Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma.
  Sasahira, International journal of molecular sciences 2020
  • GeneRIF: Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma.
• SRPX2 promotes cell proliferation and invasion via activating FAK/SRC/ERK pathway in non-small cell lung cancer.
  Li, Acta biochimica Polonica 2020 (PubMed)
  • GeneRIF: SRPX2 promotes cell proliferation and invasion via activating FAK/SRC/ERK pathway in non-small cell lung cancer.
• Exploring the association between SRPX2 variants and neurodevelopment: How causal is it?
  Schirwani, Gene 2019 (PubMed)
  • GeneRIF: We explore the contribution of SRPX2 variants to clinical phenotype in our patients and conclude that these variants at least partially explain the phenotype. Further studies are necessary to establish and confirm the association between SRPX2 and neurodevelopment particularly speech and language development.
• SRPX2 knockdown inhibits cell proliferation and metastasis and promotes chemosensitivity in esophageal squamous cell carcinoma.
  He, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 (PubMed)
  • GeneRIF: Knockdown of SRPX2 inhibits cell proliferation and metastasis, and promotes chemosensitivity in esophageal squamous cell carcinoma cells.
• SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma.
  Lin, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 (PubMed)
  • GeneRIF: SRPX2 potentially acts as an independent prognostic predictor and a drug-target for hepatocellular carcinoma patients.
• Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer.
  Liu, Medical oncology (Northwood, London, England) 2015 (PubMed)
  • GeneRIF: Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer.
• More
• Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
  Pinto-Pinho, Animals : an open access journal from MDPI 2024
  • “...Small integral membrane protein 9 SP+TM PM P78539 SRPX Sushi repeat-containing protein SRPX SP CS O60687 SRPX2 Sushi repeat-containing protein SRPX2 SP CS, PM, ES P08842 STS Steryl-sulfatase SP+TM PM P08247 SYP Synaptophysin TM PM P51864 TDGF1P3 Putative teratocarcinoma-derived growth factor 3 SP CS, PM, ES...”
• Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy.
  Nakagawa, Scientific reports 2023
  • “...P02671 238.9 Hemoglobin subunit alpha HBA1 ENSG00000206172 P69905 208.3 Sushi repeat-containing protein SRPX2 SRPX2 ENSG00000102359 O60687 154.8 Tenascin TNC ENSG00000041982 P24821 142.6 Hemoglobin subunit delta HBD ENSG00000223609 P02042 115.8 Keratin, type II cytoskeletal 7 KRT7 ENSG00000135480 P08729 115.4 Tubulin alpha-1A chain TUBA1A ENSG00000167552 Q71U36 109.3 Histone...”
• Human Codon Usage: The Genetic Basis of Pathogen Latency
  Kanduc, Global medical genetics 2021
  • “...C. neoformans (NCBI:txid214684). The ORF of the human protein Sushi repeat-containing protein SRPX2 (SRPX2; UniProt: O60687; SRPX2_HUMAN; NCBI Reference Sequence: NM_014467.3) was analyzed as a control. Codon usage of the Homo sapiens ORFeome was obtained from the international DNA sequence database ( http://www.kazusa.or.jp/codon/ ). 49 Codon...”
• CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells
  Suárez, Journal of extracellular vesicles 2021
  • “...SV=2 H14 P10412 58.18 1.01 0.22 Histone H1.4 OS=Homo sapiens OX=9606 GN=HIST1H1E PE=1 SV=2 SRPX2 O60687 23.31 1.17 1.93 Sushi repeatcontaining protein SRPX2 OS=Homo sapiens OX=9606 GN=SRPX2 PE=1 SV=1 NCL P19338 50.66 1.23 2.68 Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3 PSMA1 P25786 23.38 1.27 0.62...”
• Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis.
  Wangler, Stem cell research & therapy 2021
  • “...P48061 Traumatic, Degenerative, L-1 B2M P61769 Traumatic, Degenerative, IL-1 FNDC1 Q4ZHG4 Traumatic, Degenerative, IL-1 SRPX2 O60687 Traumatic, Degenerative SEMA7A O75326 Traumatic, Degenerative TIMP1 P01033 Traumatic, Degenerative FGG P02679 Traumatic, Degenerative ALB P02768 Traumatic, Degenerative SERPINE2 P07093 Traumatic, Degenerative CLU P10909 Traumatic, Degenerative CDH2 P19022 Traumatic, Degenerative...”
• Biobtree: A tool to search, map and visualize bioinformatics identifiers and special keywords
  Gur, F1000Research 2019
  • “...3 Q9Y5S8 NADPH oxidase 1 ## 4 P33240 Cleavage stimulation factor subunit 2 ## 5 O60687 Sushi repeat-containing protein SRPX2 ## 6 Q96C24 Synaptotagmin-like protein 4 ## 7 Q8TAB3 Protocadherin-19 ## 8 Q5H913 ADP-ribosylation factor-like protein 13A ## 9 Q6PP77 XK-related protein 2 usecase-3 Map all...”
• Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat.
  Li, Stem cell research & therapy 2019
  • “...0.36 Laminin subunit alpha-5 Angiogenesis E9PEP6 196 0.29 Neuropilin Angiogenesis P98160 1080 0.23 HSPG Angiogenesis O60687 119 0.19 Sushi repeat-containing protein SRPX2 Angiogenesis P29279 76 0.17 CTGF Angiogenesis O00622 95 0.16 CYR61 Intussusceptive angiogenesis, wound healing, spreading of cells Q14118 109 0.14 Dystroglycan Angiogenesis involved in...”
• Elucidating the Molecular Composition of Cartilage by Proteomics
  Hsueh, Journal of proteome research 2016
  • “...37.86 0.122 0.030 0.589 0.104 P00734 THRB Prothrombin 70.0 11 23.31 0.748 0.042 0.267 0.151 O60687 SRPX2 Sushi repeat-containing protein SRPX2 52.9 15 44.73 0.764 0.044 0.046 0.054 O75339 CILP1-2 Cartilage intermediate layer protein 1 132.5 40 38.85 0.012 0.046 0.155 0.025 Q9H3U7 SMOC2 SPARC-related modular...”
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SRPX2_RAT / B5DF94 Sushi repeat-containing protein SRPX2 from Rattus norvegicus (Rat) (see paper)
Aligns to 335:454 / 466 (25.8%), covers 99.2% of PF13778, 136.1 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF (By similarity). Promotes synapse formation.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.

XP_006528669 sushi repeat-containing protein SRPX2 isoform X1 from Mus musculus
Aligns to 314:433 / 445 (27.0%), covers 99.2% of PF13778, 135.4 bits

• C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex.
  Cong, Glia 2022
  • GeneRIF: C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex.
• The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
  Cong, Nature neuroscience 2020
  • GeneRIF: The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
• Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
  Anwer, Neuroscience 2019 (PubMed)
  • GeneRIF: Unsupervised hierarchical clustering using SRPX2 expression did not identify genotype or injury-specific clusters. Data demonstrate that SRPX2 expression in the hypothalamus is resistant to genetic deficiencies in the urokinase-system or to the hypothalamus-affecting TBI.
• Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene.
  Soteros, PloS one 2018
  • GeneRIF: we show that mice lacking SRPX2 show a specific reduction in excitatory VGlut2 synapses in the cerebral cortex, while VGlut1 and inhibitory synapses were largely unaffected. SRPX2 KO mice also exhibit an abnormal ultrasonic vocalization ontogenetic profile in neonatal pups, and reduced preference for social novelty.

SRPX2_MOUSE / Q8R054 Sushi repeat-containing protein SRPX2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 337:456 / 468 (25.6%), covers 99.2% of PF13778, 135.2 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF (By similarity).
• Comparative Proteomic Analysis of tPVAT during Ang II Infusion.
  Liang, Biomedicines 2021
  • “...Q8CHD8 RAB11FIP3 Rab11-family interacting protein 3 Q14DH7 ACSS3 Acyl-CoA synthetase short-chain family member 3, mitochondrial Q8R054 SRPX2 Sushi repeat-containing protein SRPX2 Q00898 SERPINA1E Alpha-1-antitrypsin 15 Q3UVG3 FAM91A1 Protein FAM91A1 Q9JJF9 SPPL2a Signal peptide peptidase-like 2A O89017 LGMN Legumain Q9CS72 FILIP1 Filamin-A-interacting protein 1 Q8R1R3 StarD7 StAR-related...”
  • “...Q9WVH9, P97429, Q8K4G1, Q62009, P97384, A2ASQ1, C0HKD8, P06797, P41317, Q8BPB5, Q80YX1, O08746, P82198, P18406, Q61704, Q8R054, Q60754, O70503, P09242, Q9CXD9 KEGG (kyoto encyclopedia of genes and genomes) pathways Fatty acid biosynthesis 4 0.0069 0.5894 0.2857 Q5SWU9, Q8JZR0, Q8R3F5, Q91WC3 EGFR tyrosine kinase inhibitor resistance 6 0.0076...”
• Long Non-Coding RNA Myoparr Regulates GDF5 Expression in Denervated Mouse Skeletal Muscle.
  Hitachi, Non-coding RNA 2019
  • “...P46412 14778 0.448922444 4.822510417 C3 P01027 12266 0.445172583 4.782304504 C1qtnf3 Q9ES30 81799 0.445104367 4.781573094 Srpx2 Q8R054 68792 0.436334685 4.687544788 Lifr P42703 16880 0.429117336 4.610160558 Sorl1 O88307 20660 0.414098638 4.449130463 Col14a1 Q80X19 12818 0.386271994 4.1507739 Postn Q62009 50706 0.370968623 3.986691548 Svep1 A2AVA0 64817 0.370316314 3.979697508 Pi16 Q9ET66...”
• Global proteome profiling of dental cementum under experimentally-induced apposition
  Salmon, Journal of proteomics 2016
  • “...Q640N1 Isoform 1 of Adipocyte enhancer-binding protein 1 4.62 6.73 10.57 7.28 0.033 0.634 0.062 Q8R054 Uncharacterized protein 0.00 0.00 0.40 0.66 0.033 0.524 0.524 P21550 Beta-enolase 0.00 0.00 0.83 1.01 0.039 0.810 0.810 P12023 Isoform APP770 of Amyloid beta A4 protein (Fragment) 1.53 1.26 3.19...”

Q63769 Sushi repeat-containing protein SRPX from Rattus norvegicus
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 124.5 bits

• Advanced proteomics procedure as a detection tool for predictive screening in type 2 pre-Diabetes.
  Koehn, The EPMA journal 2010
  • “...51.2 Hep. CLUS_RAT P05371 Sec. Clusterin precursor (Sulfated glycoprotein 2) (SGP-2) 51.3 Hep.; Sup. SRPX_RAT Q63769 Sec. Sushi repeat-containing protein SRPX prec. 51.5 Hep. ANT3_MOUSE P32261 Sec. Antithrombin-III precursor (ATIII). 52.0 Hep. LIPL_RAT Q06000 Sec. Lipoprotein lipase precursor (EC 3.1.1.34) (LPL). 53.0 Hep. SG3_MOUSE P47867 Sec....”
• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...Sushi-repeat-containing protein SRPX precursor Q9R0M3 Mus musculus 92 95 464 Sushi repeat-containing protein SRPX precursor Q63769 Rattus norvegicus 93 95 464 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus 94 97 460 Hypothetical protein Q32KV1 Bos taurus 90 94 459...”
  • “...protein) (Down- regulated by v-SRC). UPI0000504722 Rattus norvegicus 91 93 449 Splice isoform 2 of Q63769 Q63769-2 Rattus norvegicus 89 92 444 PREDICTED: similar to Sushi repeat-containing protein SRPX precursor, partial UPI00005C0986 Bos taurus 89 93 358 Acknowledgments This work was supported by NIH grants: R01EY16112,...”

Q9R0M3 Sushi-repeat-containing protein SRPX from Mus musculus
NP_058607 sushi-repeat-containing protein SRPX isoform 1 precursor from Mus musculus
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 122.6 bits

• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...100 464 Sushi-repeat-containing protein, X-linked Q4VX66 Homo sapiens 100 100 464 Sushi-repeat-containing protein SRPX precursor Q9R0M3 Mus musculus 92 95 464 Sushi repeat-containing protein SRPX precursor Q63769 Rattus norvegicus 93 95 464 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus...”
• Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
  Inoue, Acta neuropathologica 2017 (PubMed)
  • GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
• The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
  Tambe, Molecular carcinogenesis 2016 (PubMed)
  • GeneRIF: drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells.
• Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.
  Tambe, Cancer letters 2012 (PubMed)
  • GeneRIF: Drs suppresses viral replication via mTOR-dependent pathway.
• The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
  Tambe, Cancer letters 2009 (PubMed)
  • GeneRIF: drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes
• Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
  Tambe, Carcinogenesis 2007 (PubMed)
  • GeneRIF: Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs
• Isolation of a novel mouse variant of the drs tumor suppressor gene.
  Kawai, Cancer letters 2002 (PubMed)
  • GeneRIF: Isolation of a novel variant of the tumor suppressor gene (mDRS-2)

XP_051682971 sushi repeat-containing protein SRPX from Oryctolagus cuniculus
Aligns to 302:421 / 434 (27.6%), covers 99.2% of PF13778, 121.8 bits

• Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
  Pinto-Pinho, Animals : an open access journal from MDPI 2024
  • “...protein 4 98.1 Unplaced NP_001156408 XP_051691991 SMIM9 small integral membrane protein 9 69.7 Unplaced XP_016885382 XP_051682971 SRPX sushi repeat-containing protein SRPX, partial 94.6 X XP_047298063 XP_008247483 STS steryl-sulfatase 65.1 Unplaced NP_003170 XP_051682874 SYP synaptophysin 79.8 X NP_004606 XP_017205349 TSPAN7 tetraspanin-7 99.2 X XP_011529490 XP_002722247 VAMP7 vesicle-associated...”

E7F8X0 Sushi repeat-containing protein SRPX2 from Danio rerio
Aligns to 329:448 / 460 (26.1%), covers 99.2% of PF13778, 121.6 bits

• Proteomics analysis of the zebrafish skeletal extracellular matrix.
  Kessels, PloS one 2014
  • “...0.76 0.55 [59] , [60] F1Q5C3 Itih6 1.61** 0.44 1.16 0.00 0.55 0.55 n.s. [29] E7F8X0 Srpx2 0.82 0.72 1.55* 0.83* 0.39 1.22** 0.88* [29] E7F1S4 Thbs2b 0.80 0.11 0.90 1.07** 0.31 0.75 0.75 [29] E7EXE8 Tnxb 2.24** 0.50 2.74** 0.73 0.58 1.31* 0.56 [29] Bone-...”

NP_001164221 sushi repeat-containing protein SRPX isoform 2 precursor from Homo sapiens
Aligns to 312:431 / 444 (27.0%), covers 99.2% of PF13778, 120.5 bits

• A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
  Jiao, International journal of molecular sciences 2023
  • GeneRIF: A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
• SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma.
  Liu, Oncology reports 2019 (PubMed)
  • GeneRIF: the findings of the present study suggest that targeting the Cancerassociated fibroblasts genes, SRPX and HMCN1, can inhibit ovarian cancer migration and invasion.
• Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
  Inoue, Acta neuropathologica 2017 (PubMed)
  • GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
• Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
  Burnicka-Turek, BMC cell biology 2010
  • GeneRIF: PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
• Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
  Shimakage, Oncology reports 2009 (PubMed)
  • GeneRIF: Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
• ETX1 is over-expressed in the glaucomatous trabecular meshwork.
  Iragavarapu, Molecular vision 2009
  • GeneRIF: This is the first report demonstrating overexpression of ETX1 in glaucomatous trabecular meshwork.
• A novel apoptotic pathway induced by the drs tumor suppressor gene.
  Tambe, Oncogene 2004 (PubMed)
  • GeneRIF: An apoptosis-inducing protein localized in the endoplasmic reticulum which increases efficiency of apoptosis
• Down-regulation of drs mRNA in human prostate carcinomas.
  Kim, Human pathology 2003 (PubMed)
  • GeneRIF: Down-regulation of drs mRNA is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer.
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SRPX_HUMAN / P78539 Sushi repeat-containing protein SRPX from Homo sapiens (Human) (see paper)
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 120.3 bits

• function: May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction
• Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
  Pinto-Pinho, Animals : an open access journal from MDPI 2024
  • “...and NTRK-like protein 4 SP+TM PM A6NGZ8 SMIM9 Small integral membrane protein 9 SP+TM PM P78539 SRPX Sushi repeat-containing protein SRPX SP CS O60687 SRPX2 Sushi repeat-containing protein SRPX2 SP CS, PM, ES P08842 STS Steryl-sulfatase SP+TM PM P08247 SYP Synaptophysin TM PM P51864 TDGF1P3 Putative...”
  • “...transporter B(0+) Q92581 SLC9A6 * Sodium/hydrogen exchanger 6 Q9H156 SLITRK2 SLIT and NTRK-like protein 2 P78539 SRPX * Sushi repeat-containing protein SRPX P08842 STS Steryl-sulfatase P08247 SYP * Synaptophysin Q9UKZ4 TENM1 * Teneurin-1 P41732 TSPAN7 * Tetraspanin-7 P51809 VAMP7 Vesicle-associated membrane protein 7 Q86XK7 VSIG1 *...”
• Surgical treatment and muscle protein analysis of V-pattern exotropia in craniosynostosis
  Liu, Scientific reports 2022
  • “...organization Cytoplasm Metal ion binding 13.67 Q6NVY1 3-Hydroxyisobutyryl-CoA hydrolase Metabolic process Mitochondrion Catalytic activity 11.14 P78539 Sushi repeat-containing protein SRPX Cell organization Cell surface NA 6.46 Q16363 Laminin subunit alpha-4 Cell organization Cytoskeleton Catalytic activity 4.91 P39023 60S ribosomal protein L3 Cell organization Cytoplasm Protein binding...”
• Proteomic analysis of the umbilical cord in fetal growth restriction and preeclampsia.
  Conrad, PloS one 2022
  • “...-2.39 P49746 Thrombospondin-3 -2.16 Q12884 Prolyl endopeptidase FAP -2.14 P62263 40S ribosomal protein S14 -2.06 P78539 Sushi repeat-containing protein SRPX -2.00 A1L4H1 Soluble scavenger receptor -1.88 Q13421 Mesothelin -1.85 P55287 Cadherin-11 -1.57 Q14257 Reticulocalbin-2 -1.36 P01861 Immunoglobulin heavy constant gamma 4 -1.27 Q07092 Collagen alpha-1(XVI) chain...”
• Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.
  Gurke, Biomedicines 2022
  • “...Brain and bone marrow Chromatin organization SRP14 SRP14 P37108 Skin N/A Non-specific Mitochondria SRPX SRPX P78539 Skin Unknown Adipose tissue ECM organization STAT3 STAT3 P40763 mRNA N/A Non-specific Mitochondria and proteasome STAT6 STAT6 P42226 mRNA N/A Macrophages Immune response STIP1 STIP1 P31948 Serum N/A Non-specific Unknown...”
• CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells
  Suárez, Journal of extracellular vesicles 2021
  • “...treated cells Gene Name Accession Significance Ratio CD9vpep/Sc pep Ratio CD63 pep/Sc pep Description SRPX P78539 112.75 0.29 0.52 Sushi repeatcontaining protein SRPX OS=Homo sapiens OX=9606 GN=SRPX PE=1 SV=1 C1QBP Q07021 200 0.33 2.71 Complement component 1 Q subcomponentbinding protein mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1...”
• A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.
  Kang, Molecular & cellular proteomics : MCP 2021
  • “...KG1 0.298 0.759 0.421 <0.01 HL60 0.905 0.292 THP1 0.250 0.888 Sushi repeat-containing protein SRPX P78539 SRPX KG1 0.484 0.318 0.394 <0.01 HL60 0.299 0.550 THP1 0.515 0.339 Lysosome membrane protein 2 Q14108 SCAR-B2 KG1 0.381 0.319 0.380 0.043 HL60 0.402 0.427 THP1 0.303 0.450 Pappalysin-1...”
• Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis.
  Wangler, Stem cell research & therapy 2021
  • “...Traumatic, Degenerative CLU P10909 Traumatic, Degenerative CDH2 P19022 Traumatic, Degenerative LUM P51884 Traumatic, Degenerative SRPX P78539 Traumatic, Degenerative COL7A1 Q02388 Traumatic, Degenerative SPOCK1 Q08629 Traumatic, Degenerative LTBP1 Q14766 Traumatic, Degenerative TGFBI Q15582 Traumatic, Degenerative SBSN Q6UWP8 Traumatic, Degenerative FAM3C Q92520 Traumatic, Degenerative PXDN Q92626 Traumatic, Degenerative...”
• Expanding the Chondroitin Sulfate Glycoproteome - But How Far?
  Noborn, Frontiers in cell and developmental biology 2021
  • “...et al., 2015 Secretogranin-3 Q8WXD2 CS 37 Noborn et al., 2015 Sushi repeat-containing protein SRPX P78539 CS 34* Toledo et al., 2020 B. Novel proteoglycans identified in different model systems through glycoproteomics. Protein name Uniprot ID/Accession number Modification b Site(s) b References Caenorabditis elegans CLE-1A protein/CPG-10...”
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Q32KV1 Sushi-repeat-containing protein, X-linked from Bos taurus
Aligns to 327:446 / 459 (26.1%), covers 99.2% of PF13778, 110.8 bits

• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus 94 97 460 Hypothetical protein Q32KV1 Bos taurus 90 94 459 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504720 Rattus norvegicus 94 97 452 Splice isoform 2 of P78539 P78539-2 Homo sapiens...”

PSPTO_5640 hypothetical protein from Pseudomonas syringae pv. tomato str. DC3000
Aligns to 26:144 / 177 (67.2%), covers 100.0% of PF13778, 103.7 bits

• Transcriptome analysis of Pseudomonas syringae identifies new genes, noncoding RNAs, and antisense activity
  Filiatrault, Journal of bacteriology 2010
  • “...PSPTO_5636 PSPTO_5635 PSPTO_5637 PSPTO_5638 PSPTO_5639 PSPTO_5640 PSPTO_5641 PSPTO_5642, PSPTO_5643c PSPTO_5644 PSPTO_5645, PSPTO_5646 a Protein descriptions...”

PP_2396 hypothetical protein from Pseudomonas putida KT2440
Aligns to 36:158 / 193 (63.7%), covers 98.3% of PF13778, 71.0 bits

• Genome-Wide Analysis of Targets for Post-Transcriptional Regulation by Rsm Proteins in Pseudomonas putida
  Huertas-Rosales, Frontiers in molecular biosciences 2021
  • “...protein - YD repeat domain Repeats may bind carbohydrates PP_2219 Hypothetical protein PP_2345 Hypothetical protein PP_2396 Hypothetical protein Periplasmic protein PP_3007 Hypothetical protein PP_3010 Hypothetical protein Putative lipoprotein PP_3130 Hypothetical protein Glycoside hydrolase family (EPS turnover?) PP_3580 Hypothetical protein PP_3662 Hypothetical protein Nucleotide 5-monophosphate nucleosidase YgdH-like...”

XP_016885382 sushi repeat-containing protein SRPX isoform X1 from Homo sapiens
Aligns to 332:406 / 419 (17.9%), covers 59.2% of PF13778, 60.3 bits

• Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
  Pinto-Pinho, Animals : an open access journal from MDPI 2024
  • “...NTRK-like protein 4 98.1 Unplaced NP_001156408 XP_051691991 SMIM9 small integral membrane protein 9 69.7 Unplaced XP_016885382 XP_051682971 SRPX sushi repeat-containing protein SRPX, partial 94.6 X XP_047298063 XP_008247483 STS steryl-sulfatase 65.1 Unplaced NP_003170 XP_051682874 SYP synaptophysin 79.8 X NP_004606 XP_017205349 TSPAN7 tetraspanin-7 99.2 X XP_011529490 XP_002722247 VAMP7...”

Or search for genetic data about PF13778 in the Fitness Browser