Family Search for PF13778 (DUF4174)

PF13778.6 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q90X49 Coiled-coil domain-containing protein 80 from Danio rerio
B7SDQ7 CL2 from Danio rerio
NP_001007199 coiled-coil domain-containing protein 80 precursor from Danio rerio
3 alignments in 125:830 / 867 (45.9%), covering up to 100.0% of PF13778, 353.9 bits

• Comparative proteome and peptidome analysis of the cephalic fluid secreted by Arapaima gigas (Teleostei: Osteoglossidae) during and outside parental care
  Torati, PloS one 2017
  • “...member of group I collagen (fibrillar forming collagen) F, M 0.05, 0.03 [ 71 ] Q90X49 Coiled-coil domain-containing protein 80 Promotes cell adhesion and matrix assembly F, PM 0.04, 0.04 [ 72 ] Discussion The lateral line of A . gigas is an open system like...”
• Proteomics analysis of the zebrafish skeletal extracellular matrix
  Kessels, PloS one 2014
  • “...[44] F1QXC6 Tgfb2l 1.14* 0.07 1.21* 1.42** 0.28 1.70** 0.01 [54] , [55] Cartilage-related proteins B7SDQ7 Ccdc80 a 1.74** 0.15 1.89** 0.06 0.28 0.21 0.00 [29] F1Q775 Cilp a 0.48 0.25 0.23 1.24** 1.29 2.53** n.s. [29] F1Q924 Col6a6 a 0.47 0.51 0.98* 1.53** 0.32 1.21**...”
• The Coiled-Coil Domain Containing 80 (ccdc80) gene regulates gadd45β2 expression in the developing somites of zebrafish as a new player of the hedgehog pathway.
  Della, Journal of cellular physiology 2015 (PubMed)
  • GeneRIF: investigated the functional effects of Coiled-Coil Domain Containing 80-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
• Ccdc80-l1 Is involved in axon pathfinding of zebrafish motoneurons.
  Brusegan, PloS one 2012
  • GeneRIF: analysis of zebrafish Ccdc80 and Ccdc80-like1 (Ccdc80-l1) proteins; Ccdc80-l1 is involved in axon pathfinding of zebrafish motoneurons

CCD80_CHICK / Q8AXP2 Coiled-coil domain-containing protein 80; Equarin from Gallus gallus (Chicken) (see paper)
NP_989762 coiled-coil domain-containing protein 80 precursor from Gallus gallus
3 alignments in 141:910 / 958 (41.4%), covering up to 100.0% of PF13778, 349.5 bits

• function: Promotes cell adhesion and matrix assembly (By similarity). May play a role in eye formation.
  subunit: Binds to various extracellular matrix proteins.
• Multiple roles of Equarin during lens development.
  Song, Development, growth & differentiation 2014 (PubMed)
  • GeneRIF: As lens development proceeds, Equarin is strongly expressed in the lens equatorial region with a high-dorsal-to-low-ventral gradient.
• Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development.
  Song, Developmental dynamics : an official publication of the American Association of Anatomists 2013 (PubMed)
  • GeneRIF: Equarin is involved in cell adhesion during fiber differentiation and development.
• Equarin is involved as an FGF signaling modulator in chick lens differentiation.
  Song, Developmental biology 2012 (PubMed)
  • GeneRIF: Data show that endogenous Equarin is required for chick lens cell differentiation.
• A balance of FGF and BMP signals regulates cell cycle exit and Equarin expression in lens cells.
  Jarrin, Molecular biology of the cell 2012
  • GeneRIF: Equarin gene expression is regulated by a balance of FGF and BMP signals in lens cells of the developing eye.

CCD80_HUMAN / Q76M96 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes protein 1; Up-regulated in BRS-3 deficient mouse homolog from Homo sapiens (Human) (see 3 papers)
NP_955806 coiled-coil domain-containing protein 80 precursor from Homo sapiens
3 alignments in 141:902 / 950 (41.8%), covering up to 100.0% of PF13778, 348.5 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.
  Zhou, Scientific reports 2018
  • GeneRIF: The authors identified that CCDC80 has genetic and functional relevance to Intracranial Aneurysm pathogenesis in the French-Canadian population.
• Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis.
  Liu, Molecular medicine reports 2018
  • GeneRIF: LINC01279 and MSC-AS1 were upregulated in endometriosis. LINC01279 may be associated with the pathogenesis of endometriosis.
• Adipose tissue and serum CCDC80 in obesity and its association with related metabolic disease.
  Osorio-Conles, Molecular medicine (Cambridge, Mass.) 2017
  • GeneRIF: Our finding of upregulated CCDC80 expression in the visceral adipose tissue of obese patients indicates that it may be a component of the obesity-altered secretome in this depot. Furthermore, the presence of CCDC80 protein in human serum and its association with systemic metabolic dysfunction suggests that it may be linked to metabolic changes in other organs.
• Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
  Walczak, Molecular endocrinology (Baltimore, Md.) 2014
  • GeneRIF: Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
• Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis.
  Ferraro, The Journal of clinical endocrinology and metabolism 2013 (PubMed)
  • GeneRIF: Data suggest that CCDC80 expression is down-regulated in many thyroid carcinomas; loss of heterozygosity partially accounts for CCDC80 down-regulation in thyroid carcinoma; CCDC80 expression positively regulates expression of E-cadherin.
• Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells.
  Wang, The Journal of biological chemistry 2013
  • GeneRIF: activation of PKGI with cGMP regulated SSG1 intracellular distribution.
• Transcriptional repression of the tumor suppressor DRO1 by AIB1.
  Ferragud, FEBS letters 2011 (PubMed)
  • GeneRIF: Results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis.
• URB is abundantly expressed in adipose tissue and dysregulated in obesity.
  Okada, Biochemical and biophysical research communications 2008 (PubMed)
  • GeneRIF: In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes.
• More
• Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.
  Hathout, Scientific reports 2019
  • “...specific biomarkers that responded to GC treatment. Uniprot_ID Abbreviated protein name P_age_adj P_GC_adj P_interaction_adj Conclusion Q76M96 CCDC80 0.008 0.015 0.024 Both Q96KN2 CNDP1 0.584 <0.001 0.161 Only GC P01019 ANGT 0.545 <0.001 0.170 Only GC Q9BU40 CRDL1 0.100 0.0187 0.161 Only GC P04278 SHBG 0.582 0.002...”
• Comparison of secretome from osteoblasts derived from sclerotic versus non-sclerotic subchondral bone in OA: A pilot study.
  Sanchez, PloS one 2018
  • “...0,64 O43707 5 ACTN4_HUMAN Alpha-actinin-4 9,34 1,47 P00736 5 C1R_HUMAN Complement C1r subcomponent 9,01 0,59 Q76M96 5 CCD80_HUMAN Coiled-coil domain-containing protein 80 8,81 1,62 O00391 5 QSOX1_HUMAN Sulfhydryl oxidase 1 8,72 0,64 P11216 3 PYGB_HUMAN Glycogen phosphorylase, brain form 8,27 0,38 Q05707 3 COEA1_HUMAN Collagen alpha-1(XIV)...”
• Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes.
  Britton, Cellular and molecular gastroenterology and hepatology 2018
  • “...Q9NQH7 XPNPEP3 Probable Xaa-Pro aminopeptidase 3 0.076 0.004 .001 P07996 THBS1 Thrombospondin-1 0.083 0.047 .001 Q76M96 CCDC80 Coiled-coil domain-containing protein 80 0.090 0.031 .001 P78539 SRPX Sushi repeat-containing protein SRPX 0.096 0.620 .001 Q9UHI8 ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 0.114 0.090 .002...”
• Identification of serum protein biomarkers for utrophin based DMD therapy.
  Guiraud, Scientific reports 2017
  • “...serine/threonine-protein kinase AKT1 AKT2 AKT3 P31749 2 2.7 0.0007 36 Coiled-coil domain-containing protein 80 CCDC80 Q76M96 2 2.7 0.0002 ++ 37 Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Q06124 5 2.6 0.001 ++ 38 40S ribosomal protein S7 RPS7 P62081 5 2.5 0.0009 +++ 39 Heat shock...”
• Integrated proteomic and N-glycoproteomic analyses of doxorubicin sensitive and resistant ovarian cancer cells reveal glycoprotein alteration in protein abundance and glycosylation.
  Ji, Oncotarget 2017
  • “...LAMB1 MEMPSTPQQIQN(1)ITEDIR 1566 2.64 1.70 1.21 0.17 2.19 GTN(1)YTVR 701 3.24 0.13 1.21 0.17 2.68 Q76M96 CCDC80 IIGVGEEVGGVIEIFPIN(1)GSSVVEREDVPAHIVK 835 3.21 1.29 1.42 0.25 2.26 P15144 ANPEP GPSTPIPEDPNWN(1)VTEFHTTPK 265 3.68 2.96 1.84 0.18 2.00 4 C9J5X1 IGF1R N(1)GSQSMYCIPCEGPCPK 314 2.11 1.03 1.11 0.39 1.91 Q6UY14 ADAMTSL4 IGTEFN(1)VTSPSN(1)CSHIPRPPAIQPCQGQACQDR...”
• Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension.
  Sasagawa, Frontiers in pharmacology 2016
  • “...(PAH/C) FDR AGR2 095994 1.17 0.01 0.87 0.01 1.26 0.03 0.35 0.00 1.19 0.00 CCDC80 Q76M96 0.71 0.14 0.61 0.06 1.02 0.08 0.17 0.00 1.15 0.00 GZMA P12544 0.61 0.06 4.18 0.00 0.77 0.17 0.16 0.04 0.71 0.00 SMAD6 043541 1.12 0.00 0.51 0.16 1.18 0.03...”
• Circulating Proteomic Signatures of Chronological Age.
  Menni, The journals of gerontology. Series A, Biological sciences and medical sciences 2015
  • “...(0.002) 2.310 12 0.012 (0.001) 1.910 33 0.013 (0.001) 3.6610 46 Coiled-coil domain-containing protein 80 Q76M96 CCDC80 0.31 [0, 0.71] 0.015 (0.002) 1.710 9 0.007 (0.001) 5.110 29 0.011 (0.004) 2.5510 43 Pleiotrophin P21246 PTN 0.52 [0, 0.67] 0.018 (0.002) 3.610 15 0.007 (0.001) 1.210 24...”
• A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine
  Calamia, Scientific reports 2014
  • “...3,25 96,46 73,1 P36222 Chitinase-3-like protein 1 CHI3L1 236 3,38 * 3,19 4,33 18,32 10,2 Q76M96 Coiled-coil domain-containing protein 80 CCDC80 9 2,63 1,61 2,40 19,37 9,9 P20908 Collagen alpha-1(V) chain COL5A1 17 1,72 1,17 * 1,96 45,04 28,6 P12109 Collagen alpha-1(VI) chain COL6A1 55 2,68...”
  • “...3,37 0,000 P21810 Biglycan BGN 1,80 0,003 P49747 Cartilage oligomeric matrix protein COMP 1,74 0,035 Q76M96 Coiled-coil domain-containing protein 80 CCDC80 1,47 0,023 P02452 Collagen alpha-1(I) chain COL1A1 1,51 0,055 P02461 Collagen alpha-1(III) chain COL3A1 1,71 0,056 P20908 Collagen alpha-1(V) chain COL5A1 1,66 0,020 Q99715 Collagen...”
• More

CCD80_RAT / Q6QD51 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes 1 protein; Steroid-sensitive gene 1 protein; SSG-1 from Rattus norvegicus (Rat) (see 2 papers)
NP_071988 coiled-coil domain-containing protein 80 precursor from Rattus norvegicus
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 347.0 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein.
  O'Leary, Molecular endocrinology (Baltimore, Md.) 2013
  • GeneRIF: Ccdc80 preferentially binds activated, tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2.
• DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.
  Bommer, The Journal of biological chemistry 2005 (PubMed)
  • GeneRIF: DRO1 may have a role in the development of colorectal and pancreatic cancers

CCD80_MOUSE / Q8R2G6 Coiled-coil domain-containing protein 80; Up-regulated in BRS-3 deficient mouse from Mus musculus (Mouse) (see 3 papers)
XP_006522563 coiled-coil domain-containing protein 80 isoform X1 from Mus musculus
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 346.3 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.
• Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.
  Knebel, International journal of molecular sciences 2017
  • “...26S protease regulatory subunit 10B P62334 Psmc6 1.89 6.65 10 5 Coiled-coil domain-containing protein 80 Q8R2G6 Ccdc80 1.89 2.33 10 4 Pentraxin-related protein PTX3 P48759 Ptx3 1.87 3.35 10 2 Tenascin Q80YX1 Tnc 1.86 6.09 10 5 Inositol polyphosphate 1-phosphatase P49442 Inpp1 1.52 1.24 10 5...”
  • “...1.15 10 6 -Amylase 1 P00687 Amy1 3.64 1.84 10 5 Coiled-coil domain-containing protein 80 Q8R2G6 Ccdc80 3.47 2.67 10 7 Tissue - l -fucosidase Q99LJ1 Fuca1 3.28 9.84 10 7 Ganglioside GM2 activator Q60648 Gm2a 3.26 2.29 10 6 Actin-related protein 2/3 complex subunit 3...”
• The proteome of mouse cerebral arteries
  Badhwar, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 (secret)
• Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development
  Wilson, Molecular & cellular proteomics : MCP 2012
  • “...Q8VHI5 O35103 D3Z7H8 0.003841 0.000306 10.7 10.0 P61750 Q8R2G6 0.00273 9.3 E0CZ58 0.000531 0.005008 0.000328 0.00195 0.00048 0.00044 0.005544 0.000123 8.6 7.0...”
• Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.
  Drake, Journal of proteome research 2012
  • “...N221 4 3 Protease CTSL2 CATL2_HUMAN O60911 Cathepsin L2 N221 3 2 Protease CCDC80 CCD80_HUMAN Q8R2G6 Coiled-coil domain-containing protein 80 N667 3 1 Adhesion molecule CCDC80 CCD80_HUMAN Q8R2G6 Coiled-coil domain-containing protein 80 N668 4 3 Adhesion molecule CD109 CD109_HUMAN Q6YHK3 CD109 antigen e N68 3 1...”
• Identification of astrocyte secreted proteins with a combination of shotgun proteomics and bioinformatics
  Dowell, Journal of proteome research 2009
  • “...B P10605 Yes 56 3 Acyltransferase-like 1-A Q8BYI6 membrane 7 3 Coiled-coil domain-containing protein 80 Q8R2G6 Yes 7 3 Serine protease inhibitor A3C P29621 Yes 6 3 Serine protease inhibitor A3F Q80X76 Yes 6 3 Serine protease inhibitor A3K P07759 Yes 6 3 Metallothionein-3 P28184 Yes...”
• Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression.
  Gong, European journal of pharmacology 2019 (PubMed)
  • GeneRIF: Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a.
• Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.
  Grill, Carcinogenesis 2018 (PubMed)
  • GeneRIF: The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease.
• Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation.
  Grill, Molecular and cellular endocrinology 2017 (PubMed)
  • GeneRIF: DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells.
• The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias.
  Leone, Cancer letters 2015 (PubMed)
  • GeneRIF: Data indicate that embryonic fibroblasts from cl2/coiled-coil domain-containing protein 80 (ccdc80) knock-out mice showed higher proliferation rate and lower susceptibility to apoptosis.
• Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
  Walczak, Molecular endocrinology (Baltimore, Md.) 2014
  • GeneRIF: Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
• DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
  Grill, Molecular cancer research : MCR 2014 (PubMed)
  • GeneRIF: This report characterizes a new mouse model for the study of colorectal cancer and establishes DRO1 (CCDC80) as a tumor suppressor via a mechanism involving ERK phosphorylation.
• Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
  Tremblay, Endocrinology 2012 (PubMed)
  • GeneRIF: Results suggest that Ccdc80 is a novel modulator of glucose and energy homeostasis during diet-induced obesity.
• Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.
  Tremblay, The Journal of biological chemistry 2009
  • GeneRIF: Ccdc80 plays dual roles in adipogenesis by mechanisms that involve at least in part down-regulation of Wnt/beta-catenin signaling and induction of C/EBPalpha and peroxisome proliferator-activated receptor gamma.
• More

A5PKA3 CCDC80 protein from Bos taurus
3 alignments in 141:906 / 954 (41.6%), covering up to 100.0% of PF13778, 346.2 bits

• How to dig deeper? Improved enrichment methods for mucin core-1 type glycopeptides
  Darula, Molecular & cellular proteomics : MCP 2012
  • “...File S2 Uniprot ID A2I7N2 A4IFA5 A5D7R6 A5PK77 A5PKA3 A6QLD8 E1BB91 E1BCW0 E1BI67 E1BKQ9 F1MER7 F1MMK9 F1N1I6 O18977 (F1MPK6) P00735 P00743 P00744 P01030 P01044...”

NP_001014348 sushi repeat-containing protein SRPX precursor from Danio rerio
Aligns to 318:437 / 448 (26.8%), covers 99.2% of PF13778, 122.4 bits

• Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses
  Gong, Journal of neuroinflammation 2020
  • “...No. Accession Gene Symbol Description Control vs model Model vs FA Model vs FB 1 NP_001014348 srpx Sushi repeat-containing protein SRPX precursor ## ** * 2 NP_001028768 mrps7 28S ribosomal protein S7, mitochondrial precursor ### *** *** 3 NP_001077285 zgc:162509 Uncharacterized protein LOC553299 ## ** **...”

SRPX2_HUMAN / O60687 Sushi repeat-containing protein SRPX2; Sushi-repeat protein upregulated in leukemia from Homo sapiens (Human) (see 6 papers)
NP_055282 sushi repeat-containing protein SRPX2 precursor from Homo sapiens
Aligns to 334:453 / 465 (25.8%), covers 99.2% of PF13778, 121.5 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
  subunit: Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.
• Exploring the association between SRPX2 variants and neurodevelopment: How causal is it?
  Schirwani, Gene 2019 (PubMed)
  • GeneRIF: We explore the contribution of SRPX2 variants to clinical phenotype in our patients and conclude that these variants at least partially explain the phenotype. Further studies are necessary to establish and confirm the association between SRPX2 and neurodevelopment particularly speech and language development.
• SRPX2 knockdown inhibits cell proliferation and metastasis and promotes chemosensitivity in esophageal squamous cell carcinoma.
  He, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 (PubMed)
  • GeneRIF: Knockdown of SRPX2 inhibits cell proliferation and metastasis, and promotes chemosensitivity in esophageal squamous cell carcinoma cells.
• SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma.
  Lin, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 (PubMed)
  • GeneRIF: SRPX2 potentially acts as an independent prognostic predictor and a drug-target for hepatocellular carcinoma patients.
• Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer.
  Liu, Medical oncology (Northwood, London, England) 2015 (PubMed)
  • GeneRIF: Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer.
• Impact of overexpression of Sushi repeat-containing protein X-linked 2 gene on outcomes of gastric cancer.
  Yamada, Journal of surgical oncology 2014 (PubMed)
  • GeneRIF: High SRPX2 expression is associated with gastric cancer.
• Analysis of ELP4, SRPX2, and interacting genes in typical and atypical rolandic epilepsy.
  Reinthaler, Epilepsia 2014 (PubMed)
  • GeneRIF: In rolandic epilepsy patients no major role was found for an association with SRPX2 or ELP4 genes.
• Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer.
  Øster, International journal of cancer 2013 (PubMed)
  • GeneRIF: Hypomethylation of SRPX2 appeared at the transition from adenoma to carcinoma, and was correlated with adenocarcinoma histology, microsatellite stability, and poor differentiation.
• The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice.
  Sia, Science (New York, N.Y.) 2013
  • GeneRIF: SRPX2 is an epilepsy- and language-associated gene that is a target of the foxhead box protein P2 (FoxP2) transcription factor.
• More
• Biobtree: A tool to search, map and visualize bioinformatics identifiers and special keywords
  Gur, F1000Research 2019
  • “...3 Q9Y5S8 NADPH oxidase 1 ## 4 P33240 Cleavage stimulation factor subunit 2 ## 5 O60687 Sushi repeat-containing protein SRPX2 ## 6 Q96C24 Synaptotagmin-like protein 4 ## 7 Q8TAB3 Protocadherin-19 ## 8 Q5H913 ADP-ribosylation factor-like protein 13A ## 9 Q6PP77 XK-related protein 2 usecase-3 Map all...”
• Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat.
  Li, Stem cell research & therapy 2019
  • “...0.36 Laminin subunit alpha-5 Angiogenesis E9PEP6 196 0.29 Neuropilin Angiogenesis P98160 1080 0.23 HSPG Angiogenesis O60687 119 0.19 Sushi repeat-containing protein SRPX2 Angiogenesis P29279 76 0.17 CTGF Angiogenesis O00622 95 0.16 CYR61 Intussusceptive angiogenesis, wound healing, spreading of cells Q14118 109 0.14 Dystroglycan Angiogenesis involved in...”
• Elucidating the Molecular Composition of Cartilage by Proteomics
  Hsueh, Journal of proteome research 2016
  • “...37.86 0.122 0.030 0.589 0.104 P00734 THRB Prothrombin 70.0 11 23.31 0.748 0.042 0.267 0.151 O60687 SRPX2 Sushi repeat-containing protein SRPX2 52.9 15 44.73 0.764 0.044 0.046 0.054 O75339 CILP1-2 Cartilage intermediate layer protein 1 132.5 40 38.85 0.012 0.046 0.155 0.025 Q9H3U7 SMOC2 SPARC-related modular...”
• Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis.
  Wu, PloS one 2015
  • “...Heterogeneous nuclear ribonucleoprotein K 0.6 51 kDa O43491 Band 4.1-like protein 2 0.6 113 kDa O60687 Sushi repeat-containing protein SRPX2 2.4 53 kDa P14543 Nidogen-1 0.6 136 kDa Q13740 CD166 antigen 1.9 65 kDa P06702 Protein S100-A9 1.75 13 kDa P98095 Fibulin-2 0.6 127 kDa P06748...”
• Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2.
  Pimienta, PloS one 2015
  • “...Q96HQ2 RBM19 0.43 0.87 0.88 Q9Y4C8 RAI1 0.37 0.99 1.15 Q7Z5J4 SRPUL 0.11 - - O60687 NUP93 0.08 1.06 1.04 Q8N1F7 NXNL2 0.04 - - Q5VZ03 STRBP 0.03 1.53 1.47 Q96SI9 LRRC14B 0.01 1.36 1.32 A6NHZ5 * FCRLA and FCRL1 were identified as a protein group...”
• Glycoproteomic analysis of the secretome of human endothelial cells.
  Yin, Molecular & cellular proteomics : MCP 2013
  • “...Plasma membrane Serum deprivation-response protein SDPR_HUMAN O95810 SDPR Plasma membrane Sushi repeat-containing protein SRPX2 SRPX2_HUMAN O60687 SRPX2 Extracellular Erythrocyte band 7 integral membrane protein STOM_HUMAN P27105 STOM Plasma membrane Miscellaneous secreted proteins Peptidyl-glycine alpha-amidating monooxygenase AMD_HUMAN P19021 PAM Extracellular Glycoprotein Angiopoietin-2 ANGP2_HUMAN O15123 ANGPT2 Extracellular Glycoprotein...”
• Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroups
  Önnerfjord, The Journal of biological chemistry 2012
  • “...0.91 4.53 2.13 4.36 1.81 1.47 0.24 0.56 ND O60687 Q7Z7G0 P24821 P22105 P05452 Q6ZMP0 P07996 P49476 Q15582 O00300 P13611 Q6UXI7 P04004 0.70 0.15 0.73 0.48 1.19...”
  • “...P02743 P09486 Q9H3U7 Q13813 O76061 P48061 P08254 P00441 O60687 Q7Z7G0 P24821 P22105 P05452 Q6ZMP0 P07996 P49476 P35443 P37837 Q15582 Q01995 P29401 P13693 Q14C87...”
• Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage.
  Rosenthal, Arthritis and rheumatism 2011
  • “...protein Hox-A4 (Hox-1D) (Hox-1.4) 2 55 6.250 9.764 Other P62988 Ubiquitin 2 73 32.895 6.603 O60687 Sushi repeat-containing protein SRPX2 precursor. 7 81 20.215 6.888 O75340 Probable calcium-binding protein ALG-2 3 80 17.801 5.17 O43293 Death-associated protein kinase 3 (EC 2.7.1.37) 2 4 5.947 6.501 Q7Z7G0...”
  • “...Cartilage intermediate layer protein 2 precursor (CILP-2) 8 7.87 70 60 0.33 1.62 2.49E-08 2.91E-06 O60687 Sushi repeat-containing protein SRPX2 precursor 7 20.22 60 30 0.32 1.65 1.37E-06 1.52E-04 P49747 Cartilage oligomeric matrix protein precursor (COMP) 18 26.29 100 90 0.27 1.90 5.21E-142 0 P02751 Fibronectin...”

SRPX2_RAT / B5DF94 Sushi repeat-containing protein SRPX2 from Rattus norvegicus (Rat) (see paper)
Aligns to 335:454 / 466 (25.8%), covers 99.2% of PF13778, 121.1 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF (By similarity). Promotes synapse formation.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.

XP_006528669 sushi repeat-containing protein SRPX2 isoform X1 from Mus musculus
Aligns to 314:433 / 445 (27.0%), covers 99.2% of PF13778, 120.5 bits

• The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
  Cong, Nature neuroscience 2020
  • GeneRIF: The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
• Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
  Anwer, Neuroscience 2019 (PubMed)
  • GeneRIF: Unsupervised hierarchical clustering using SRPX2 expression did not identify genotype or injury-specific clusters. Data demonstrate that SRPX2 expression in the hypothalamus is resistant to genetic deficiencies in the urokinase-system or to the hypothalamus-affecting TBI.
• Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene.
  Soteros, PloS one 2018
  • GeneRIF: we show that mice lacking SRPX2 show a specific reduction in excitatory VGlut2 synapses in the cerebral cortex, while VGlut1 and inhibitory synapses were largely unaffected. SRPX2 KO mice also exhibit an abnormal ultrasonic vocalization ontogenetic profile in neonatal pups, and reduced preference for social novelty.

SRPX2_MOUSE / Q8R054 Sushi repeat-containing protein SRPX2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 337:456 / 468 (25.6%), covers 99.2% of PF13778, 120.3 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF (By similarity).
• Long Non-Coding RNA Myoparr Regulates GDF5 Expression in Denervated Mouse Skeletal Muscle.
  Hitachi, Non-coding RNA 2019
  • “...P46412 14778 0.448922444 4.822510417 C3 P01027 12266 0.445172583 4.782304504 C1qtnf3 Q9ES30 81799 0.445104367 4.781573094 Srpx2 Q8R054 68792 0.436334685 4.687544788 Lifr P42703 16880 0.429117336 4.610160558 Sorl1 O88307 20660 0.414098638 4.449130463 Col14a1 Q80X19 12818 0.386271994 4.1507739 Postn Q62009 50706 0.370968623 3.986691548 Svep1 A2AVA0 64817 0.370316314 3.979697508 Pi16 Q9ET66...”
• Global proteome profiling of dental cementum under experimentally-induced apposition
  Salmon, Journal of proteomics 2016
  • “...Q640N1 Isoform 1 of Adipocyte enhancer-binding protein 1 4.62 6.73 10.57 7.28 0.033 0.634 0.062 Q8R054 Uncharacterized protein 0.00 0.00 0.40 0.66 0.033 0.524 0.524 P21550 Beta-enolase 0.00 0.00 0.83 1.01 0.039 0.810 0.810 P12023 Isoform APP770 of Amyloid beta A4 protein (Fragment) 1.53 1.26 3.19...”

F1NX90 Sushi repeat-containing protein SRPX2 from Gallus gallus
Aligns to 317:436 / 448 (26.8%), covers 99.2% of PF13778, 118.0 bits

• Alternative Splicing Profile and Sex-Preferential Gene Expression in the Female and Male Pacific Abalone Haliotis discus hannai.
  Kim, Genes 2017
  • “...5 hypothetical protein LOTGIDRAFT_214098 Lottia gigantea NP_001116989.1 F_Cluster00011 6791 5 hypothetical protein AC249_AIPGENE2795 Exaiptasia pallida F1NX90 F_Cluster10316 2268 5 PREDICTED: Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like Biomphalaria glabrata XP_414851.3 F_Cluster12757 1916 5 - - - genes-08-00099-t005_Table 5 Table 5 List of top-ranked genes containing over five isoforms...”

Q63769 Sushi repeat-containing protein SRPX from Rattus norvegicus
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 109.3 bits

• Advanced proteomics procedure as a detection tool for predictive screening in type 2 pre-Diabetes.
  Koehn, The EPMA journal 2010
  • “...51.2 Hep. CLUS_RAT P05371 Sec. Clusterin precursor (Sulfated glycoprotein 2) (SGP-2) 51.3 Hep.; Sup. SRPX_RAT Q63769 Sec. Sushi repeat-containing protein SRPX prec. 51.5 Hep. ANT3_MOUSE P32261 Sec. Antithrombin-III precursor (ATIII). 52.0 Hep. LIPL_RAT Q06000 Sec. Lipoprotein lipase precursor (EC 3.1.1.34) (LPL). 53.0 Hep. SG3_MOUSE P47867 Sec....”
• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...Sushi-repeat-containing protein SRPX precursor Q9R0M3 Mus musculus 92 95 464 Sushi repeat-containing protein SRPX precursor Q63769 Rattus norvegicus 93 95 464 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus 94 97 460 Hypothetical protein Q32KV1 Bos taurus 90 94 459...”
  • “...protein) (Down- regulated by v-SRC). UPI0000504722 Rattus norvegicus 91 93 449 Splice isoform 2 of Q63769 Q63769-2 Rattus norvegicus 89 92 444 PREDICTED: similar to Sushi repeat-containing protein SRPX precursor, partial UPI00005C0986 Bos taurus 89 93 358 Acknowledgments This work was supported by NIH grants: R01EY16112,...”

Q9R0M3 Sushi-repeat-containing protein SRPX from Mus musculus
NP_058607 sushi-repeat-containing protein SRPX isoform 1 precursor from Mus musculus
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 107.0 bits

• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...100 464 Sushi-repeat-containing protein, X-linked Q4VX66 Homo sapiens 100 100 464 Sushi-repeat-containing protein SRPX precursor Q9R0M3 Mus musculus 92 95 464 Sushi repeat-containing protein SRPX precursor Q63769 Rattus norvegicus 93 95 464 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus...”
• Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
  Inoue, Acta neuropathologica 2017 (PubMed)
  • GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
• The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
  Tambe, Molecular carcinogenesis 2016 (PubMed)
  • GeneRIF: drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells.
• Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.
  Tambe, Cancer letters 2012 (PubMed)
  • GeneRIF: Drs suppresses viral replication via mTOR-dependent pathway.
• The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
  Tambe, Cancer letters 2009 (PubMed)
  • GeneRIF: drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes
• Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
  Tambe, Carcinogenesis 2007 (PubMed)
  • GeneRIF: Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs
• Isolation of a novel mouse variant of the drs tumor suppressor gene.
  Kawai, Cancer letters 2002 (PubMed)
  • GeneRIF: Isolation of a novel variant of the tumor suppressor gene (mDRS-2)

E7F8X0 Sushi repeat-containing protein SRPX2 from Danio rerio
Aligns to 329:448 / 460 (26.1%), covers 99.2% of PF13778, 106.6 bits

• Proteomics analysis of the zebrafish skeletal extracellular matrix
  Kessels, PloS one 2014
  • “...0.76 0.55 [59] , [60] F1Q5C3 Itih6 1.61** 0.44 1.16 0.00 0.55 0.55 n.s. [29] E7F8X0 Srpx2 0.82 0.72 1.55* 0.83* 0.39 1.22** 0.88* [29] E7F1S4 Thbs2b 0.80 0.11 0.90 1.07** 0.31 0.75 0.75 [29] E7EXE8 Tnxb 2.24** 0.50 2.74** 0.73 0.58 1.31* 0.56 [29] Bone-...”

NP_001164221 sushi repeat-containing protein SRPX isoform 2 precursor from Homo sapiens
Aligns to 312:431 / 444 (27.0%), covers 99.2% of PF13778, 105.0 bits

• SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma.
  Liu, Oncology reports 2019 (PubMed)
  • GeneRIF: the findings of the present study suggest that targeting the Cancerassociated fibroblasts genes, SRPX and HMCN1, can inhibit ovarian cancer migration and invasion.
• Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
  Inoue, Acta neuropathologica 2017 (PubMed)
  • GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
• Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
  Burnicka-Turek, BMC cell biology 2010
  • GeneRIF: PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
• Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
  Shimakage, Oncology reports 2009 (PubMed)
  • GeneRIF: Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
• ETX1 is over-expressed in the glaucomatous trabecular meshwork.
  Iragavarapu, Molecular vision 2009
  • GeneRIF: This is the first report demonstrating overexpression of ETX1 in glaucomatous trabecular meshwork.
• A novel apoptotic pathway induced by the drs tumor suppressor gene.
  Tambe, Oncogene 2004 (PubMed)
  • GeneRIF: An apoptosis-inducing protein localized in the endoplasmic reticulum which increases efficiency of apoptosis
• Down-regulation of drs mRNA in human prostate carcinomas.
  Kim, Human pathology 2003 (PubMed)
  • GeneRIF: Down-regulation of drs mRNA is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer.
• Expression of drs mRNA in human lung adenocarcinomas.
  Shimakage, Human pathology 2002 (PubMed)
  • GeneRIF: expression of drs mRNA in well-differentiated, moderately differentiated, and poorly differentiated lung adenocarcinoma tissues (drs; down-regulated by v-scr)
• More

P78539 Sushi repeat-containing protein SRPX from Homo sapiens
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 104.8 bits

• β2-Adrenergic Signalling Promotes Cell Migration by Upregulating Expression of the Metastasis-Associated Molecule LYPD3
  Gruet, Biology 2020
  • “...Q96S19 2.699 PPT1 P50897 1.175 CYTS P01037 1.180 TSP1 P07996 1.230 CYTN P01037 1.298 SRPX P78539 1.345 HUWE1 Q7Z6Z7 1.454 ITIH2 P19823 1.509 FINC P02751 1.510 ANR28 O15084 1.930 KI13B Q9NQT8 2.080 Log2 fold change represents the increase/decrease in protein expression relative to untreated samples (UT)....”
• Combination of laser microdissection, 2D-DIGE and MALDI-TOF MS to identify protein biomarkers to predict colorectal cancer spread.
  Kirana, Clinical proteomics 2019
  • “...0.06 9 22 6 14-3-3- P31946 14-3-3 protein beta/alpha 0.67 0.05 9 37 7 SRPX P78539 Sushi repeat-containing protein SRPX 1.5 0.02 14 26 8 NME2 P22392 Nucleoside diphosphate kinase B (nm23H2) 1.6 0.005 8 38 9 MRLC 3 P19105 Myosin regulatory light chain MRLC3 0.67...”
• Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes.
  Britton, Cellular and molecular gastroenterology and hepatology 2018
  • “...P07996 THBS1 Thrombospondin-1 0.083 0.047 .001 Q76M96 CCDC80 Coiled-coil domain-containing protein 80 0.090 0.031 .001 P78539 SRPX Sushi repeat-containing protein SRPX 0.096 0.620 .001 Q9UHI8 ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 0.114 0.090 .002 Q92538 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor...”
• Proteomic analysis of bone proteins adsorbed onto the surface of titanium dioxide.
  Sugimoto, Biochemistry and biophysics reports 2016
  • “...20 F1N152 Serine protease HTRA1 0.85 21 P32262 Antithrombin-III 0.85 22 P0C225 Osteocalcin 0.79 23 P78539 Sushi repeat-containing protein SRPX 0.51 24 P19879 Mimecan 0.51 25 O01305 Calcium vector protein 0.46 G2S proteins immobilized on TiO 2 , as detected by LC/MS/MS Accesion no Protein emPAI...”
• Histology-directed and imaging mass spectrometry: An emerging technology in ectopic calcification
  Taverna, Bone 2015
  • “...SPP24 Secreted phosphoprotein 24 Q13103 CO6A6 Collagen alpha-6(VI) chain A6NMZ7 SRPX Sushi repeat-containing protein SRPX P78539 FILA Filaggrin P20930 THRB Prothrombin P00734 H7C2N1 Prothymosin alpha (Fragment) H7C2N1 Proteins identified in the non-mineralized dermis AATM Aspartate aminotransferase, mitochondrial P00505 IMMT Mitochondrial inner membrane protein Q16891 ACON Aconitate...”
• Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis.
  Wu, PloS one 2015
  • “...chain 1.6 40 kDa P05109 Protein S100-A8 1.55 11 kDa Q01995 Transgelin 0.3 23 kDa P78539 Sushi repeat-containing protein SRPX 2.05 52 kDa P31943 Heterogeneous nuclear ribonucleoprotein H 0.6 49 kDa P55795 Heterogeneous nuclear ribonucleoprotein H2 0.5 49 kDa O94832 Unconventional myosin-Id 0.6 116 kDa P12107...”
• Computational prediction of human salivary proteins from blood circulation and application to diagnostic biomarker identification.
  Wang, PloS one 2013
  • “...1531 0.632 CD163 Q86VB7 1539 0.628 NCAM1 P13591 1681 0.640 LTF P02788 1693 1.583 SRPX P78539 1959 0.556 FBN1 P35555 2192 0.625 CFH P08603 2400 0.550 VWF P04275 2518 0.537 CD99 P14209 2867 0.623 TF P02787 2907 0.578 As of now, very little data is available...”
• Secreted proteins as a fundamental source for biomarker discovery.
  Stastna, Proteomics 2012
  • “...] Sulfhydryl oxidase 1 (Quiescin Q6) QSCN6_HUMAN (O00391) SMCs yes Sushi repeat-containing protein SRPX SRPX_HUMAN (P78539) SMCs yes Testican-1 (Protein SPOCK) TICN1_HUMAN (Q08629) SMCs yes cancer [ 117 ] Thrombospondin-2 TSP2_HUMAN (P35442) SMCs yes yes Tissue factor pathway inhibitor 2 (TFPI-2) TFPI2_HUMAN (P48307) SMCs yes cancer...”
• More

PSPTO_5640 hypothetical protein (NCBI) from Pseudomonas syringae pv. tomato str. DC3000
Aligns to 26:144 / 177 (67.2%), covers 100.0% of PF13778, 102.5 bits

• Transcriptome analysis of Pseudomonas syringae identifies new genes, noncoding RNAs, and antisense activity
  Filiatrault, Journal of bacteriology 2010
  • “...PSPTO_5636 PSPTO_5635 PSPTO_5637 PSPTO_5638 PSPTO_5639 PSPTO_5640 PSPTO_5641 PSPTO_5642, PSPTO_5643c PSPTO_5644 PSPTO_5645, PSPTO_5646 a Protein descriptions...”

F1MQX1 Sushi repeat containing protein X-linked from Bos taurus
Aligns to 327:446 / 459 (26.1%), covers 99.2% of PF13778, 97.9 bits

• A tissue-specific, injectable acellular gel for the treatment of chronic vocal fold scarring
  Xu, Acta biomaterialia 2019
  • “...Actin, alpha skeletal muscle P68138 42 Histone H1.2 P02253 21 Sushi repeat containing protein X-linked F1MQX1 51 Heterogeneous nuclear ribonucleoprotein K Q3T0D0 51 Keratin, type I cytoskeletal 19 P08728 44 Myosin-10 Q27991 229 Other Uncharacterized protein E1BHG5 33 Uncharacterized protein M0QVY0 61 Uncharacterized protein E1BDK6 196...”

Q32KV1 Sushi-repeat-containing protein, X-linked from Bos taurus
Aligns to 327:446 / 459 (26.1%), covers 99.2% of PF13778, 96.6 bits

• ETX1 is over-expressed in the glaucomatous trabecular meshwork
  Iragavarapu, Molecular vision 2009
  • “...precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504721 Rattus norvegicus 94 97 460 Hypothetical protein Q32KV1 Bos taurus 90 94 459 Sushi repeat-containing protein SRPX precursor (DRS protein) (Down- regulated by v-SRC). UPI0000504720 Rattus norvegicus 94 97 452 Splice isoform 2 of P78539 P78539-2 Homo sapiens...”

Dshi_0724 Methylmalonyl-CoA epimerase (EC 5.1.99.1) from Dinoroseobacter shibae DFL-12
Aligns to 38:140 / 149 (69.1%), covers 99.2% of PF13778, 73.2 bits

• mutant phenotype: Specifically important for utilizing Sodium propionate. Automated validation from mutant phenotype: the predicted function (METHYLMALONYL-COA-EPIM-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.

Or search for genetic data about PF13778 in the Fitness Browser