Family Search for PF13778 (DUF4174)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13778 hits 25 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CCD80_CHICK / Q8AXP2 Coiled-coil domain-containing protein 80; Equarin from Gallus gallus (Chicken) (see paper)
3 alignments in 141:910 / 958 (41.4%), covering up to 100.0% of PF13778, 347.6 bits

• function: Promotes cell adhesion and matrix assembly (By similarity). May play a role in eye formation.
  subunit: Binds to various extracellular matrix proteins.

CCD80_HUMAN / Q76M96 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes protein 1; Up-regulated in BRS-3 deficient mouse homolog from Homo sapiens (Human) (see 3 papers)
3 alignments in 141:902 / 950 (41.8%), covering up to 100.0% of PF13778, 346.3 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.

CCD80_RAT / Q6QD51 Coiled-coil domain-containing protein 80; Down-regulated by oncogenes 1 protein; Steroid-sensitive gene 1 protein; SSG-1 from Rattus norvegicus (Rat) (see 2 papers)
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 344.4 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.

CCD80_MOUSE / Q8R2G6 Coiled-coil domain-containing protein 80; Up-regulated in BRS-3 deficient mouse from Mus musculus (Mouse) (see 3 papers)
3 alignments in 141:901 / 949 (41.8%), covering up to 100.0% of PF13778, 344.0 bits

• function: Promotes cell adhesion and matrix assembly.
  subunit: Binds to various extracellular matrix proteins.

SRPX2_HUMAN / O60687 Sushi repeat-containing protein SRPX2; Sushi-repeat protein upregulated in leukemia from Homo sapiens (Human) (see 6 papers)
Aligns to 334:453 / 465 (25.8%), covers 99.2% of PF13778, 136.3 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
  subunit: Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.

SRPX2_RAT / B5DF94 Sushi repeat-containing protein SRPX2 from Rattus norvegicus (Rat) (see paper)
Aligns to 335:454 / 466 (25.8%), covers 99.2% of PF13778, 136.1 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF (By similarity). Promotes synapse formation.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.

SRPX2_MOUSE / Q8R054 Sushi repeat-containing protein SRPX2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 337:456 / 468 (25.6%), covers 99.2% of PF13778, 135.2 bits

• function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations.
  subunit: Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF (By similarity).

SRPX_HUMAN / P78539 Sushi repeat-containing protein SRPX from Homo sapiens (Human) (see paper)
Aligns to 332:451 / 464 (25.9%), covers 99.2% of PF13778, 120.3 bits

• function: May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction

Or search for genetic data about PF13778 in the Fitness Browser