Family Search for PF13826 (DUF4188)

PF13826 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SCO5551 hypothetical protein from Streptomyces coelicolor A3(2)
Aligns to 19:141 / 190 (64.7%), covers 100.0% of PF13826, 144.4 bits

• Structural and genomic DNA analysis of a putative transcription factor SCO5550 from Streptomyces coelicolor A3(2): regulating the expression of gene sco5551 as a transcriptional activator with a novel dimer shape
  Hayashi, Biochemical and biophysical research communications 2013 (PubMed)
  • “...coelicolor A3(2): Regulating the expression of gene sco5551 as a transcriptional activator with a novel dimer shape Biochemical and Biophysical Research...”
  • “...regulates the expression of the immediately upstream gene sco5551 encoding a putative protein, probably as a transcriptional activator. 0 false false SCO5550...”

An09g00500 uncharacterized protein from Aspergillus niger
Aligns to 86:210 / 874 (14.3%), covers 99.2% of PF13826, 116.5 bits

• Proteomic analysis of the secretory response of Aspergillus niger to D-maltose and D-xylose
  de, PloS one 2011
  • “...(5.2), Sp SPAC19G12.04 (4.3), Sc Cys4 (4.1) ROS defence An02g12940 (5.1/4.0) Nuclear Sc Nic96 (6.5), An09g00500 (4.6), Sc Nup170 (4.0) Unknown and others Hs CIRBP (5.5/9.4) Nc NCU03370 (10.7), Sp SPCC1450.12 (3.9) An12g05040 (7.9), An18g00950 (7.8) And : Aspergillus nidulans; Ao : Aspergillus oryzae; Hs :...”

fmaE / Q4WAZ2 prefumagillin monooxygenase from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see 3 papers)
FMAE_ASPFU / Q4WAZ2 Monooxygenase af470; Fumagillin biosynthesis antibiotic biosynthesis monooxygenase superfamily monooxygenase; Fma-ABM; EC 1.13.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 8 papers)
AFUA_8G00470, Afu8g00470 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 113:235 / 275 (44.7%), covers 100.0% of PF13826, 114.8 bits

• function: Monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283). Within the pathway, the monooxygenase af470 catalyzes the oxidative cleavage of prefumagillin to yield the final compound of the pathway, fumagillin (PubMed:24568283). The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane- bound beta-trans-bergamotene synthase af520. The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans- bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O- methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco- sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (Probable) (PubMed:24568283).
  catalytic activity: NADPH + 2 O2 + prefumagillin = acetaldehyde + fumagillin + H2O + NADP(+) (RHEA:74627)
  disruption phenotype: Completely abolishes the production of fumagillin but leads to the accumulation of the intermediate prefumagillin (PubMed:24082142, PubMed:24568283).
• Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
  Guruceaga, Toxins 2019
  • “...62 ] Afu8g00470 Afu8g00470 af470 fmaE Fma-ABM (Monooxygenase af470/Fumagillin biosynthesis antibiotic biosynthesis monooxygenase superfamily monooxygenase) Q4WAZ2 Fumagillin production abolished Prefumagillin accumulation [ 28 , 62 , 63 ] Afu8g00480 Afu8g00480 af480 fmaF Fma-C6H (Dioxygenase af480/Fumagillin biosynthesis cluster C-6 hydroxylase) Q4WAZ3 Fumagillin production abolished 6-demethoxy-fumagillin accumulation [...”
• Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
  Guruceaga, Toxins 2019
  • “...70 , 71 ] Afu8g00460 Afu8g00460 fpaI (Methionine aminopeptidase) Q4WAZ1 [ 28 , 62 ] Afu8g00470 Afu8g00470 af470 fmaE Fma-ABM (Monooxygenase af470/Fumagillin biosynthesis antibiotic biosynthesis monooxygenase superfamily monooxygenase) Q4WAZ2 Fumagillin production abolished Prefumagillin accumulation [ 28 , 62 , 63 ] Afu8g00480 Afu8g00480 af480 fmaF Fma-C6H...”
• Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus
  Lind, G3 (Bethesda, Md.) 2016
  • “..., Afu8g00390 , Afu8g00400 , Afu8g00410 , Afu8g00420 , Afu8g00430 , Afu8g00440 , Afu8g00460 , Afu8g00470 , Afu8g00480 , Afu8g00490 , Afu8g00500 , Afu8g00510 , Afu8g00520 Lin et al. (2013) Cluster 34 Pseurotin Afu8g00530 , Afu8g00540 , Afu8g00550 , Afu8g00560 , Afu8g00570 , Afu8g00580 Wiemann et...”
• RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus
  O'Keeffe, BMC genomics 2014
  • “...0.969 7.093 0.0005 AFUA_8G00440 psoF 0.005 0.998 5.426 0.0005 AFUA_8G00460 fpaI 0.301 0.919 0.282 0.633 AFUA_8G00470 fmaE 0.176 0.968 0.271 0.636 AFUA_8G00480 fmaF 0.427 0.919 7.258 0.0005 AFUA_8G00490 - 0.306 0.959 5.649 0.007 AFUA_8G00500 - 0.047 0.997 6.780 0.002 AFUA_8G00510 fmaG 0.793 0.820 8.101 0.0005 AFUA_8G00520...”
• The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus
  Dhingra, PloS one 2013
  • “...compared to the wild type at both time points tested ( Figure 5 ). Only Afu8g00470 showed slightly higher expression than the other genes in the cluster in fumR (20% and 36% at 48 h and 72 h post inoculation, respectively) as compared to wild-type levels....”
  • “...transcriptional pattern of the genes in the fumagillin cluster (Afu8g00370, Afu8g00520, Afu8g00370, Afu8g00510, Afu8g00500, Afu8g00480, Afu8g00470, Afu8g00440, Afu8g00430) was evaluated by qRT-PCR in the wild type (WT, TSD51.1) and fumR strains. Total RNA was extracted from Czapek-Dox stationary liquid cultures incubated for 48 h and 72...”
• Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae
  Inglis, BMC microbiology 2013
  • “...- Afu8g00370 Afu8g00490 - Afu8g00310 - n/a n/a This study Afu8g00620 cluster Afu8g00620 Afu8g00640 - Afu8g00470 Afu8g00720 - Afu8g00390 - n/a n/a This study Afu8g01640 cluster Afu8g01640 Afu8g01640 - Afu8g01640 Afu8g01600 - Afu8g01730 Afu8g01630 - Afu8g01640 ECS, IGD ECS, IGD This study Afu8g02350 cluster Afu8g02350 Afu8g02460...”

oxdA / P82604 phenylacetaldoxime dehydratase (EC 4.8.1.4) from Bacillus sp. (strain OxB-1) (see paper)
OXD_BACSX / P82604 Phenylacetaldoxime dehydratase; EC 4.8.1.4 from Bacillus sp. (strain OxB-1) (see paper)
A0A0A8JIJ3 aliphatic aldoxime dehydratase (EC 4.8.1.2) from Bacillus sp. OxB-1 (see paper)
P82604 phenylacetaldoxime dehydratase (EC 4.8.1.4) from Bacillus sp. (in: Bacteria) (see 2 papers)
Aligns to 220:329 / 351 (31.3%), covers 68.6% of PF13826, 46.9 bits

• function: Catalyzes the stoichiometric dehydration of Z- phenylacetaldoxime to phenylacetonitrile. Prefers the Z-form of phenylacetaldoxime over its E-isomer.
  catalytic activity: (Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile (RHEA:20069)
  cofactor: heme b
  subunit: Monomer.
• The genome of newly classified Ochroconis mirabilis: Insights into fungal adaptation to different living conditions
  Yew, BMC genomics 2016
  • “...Alignment of putative phenylacetaldoxime dehydratase of O. mirabilis UM 578 (UM578_4049) with Bacillus sp. OxB-1 (P82604). Identical and similar residues are black and gray shaded respectively. The haem-containing dehydratase region is indicated by asterisk. Figure S3. Putative aldoxime-nitrile pathway gene cluster of UM 578. The phyenylacetaldoxime...”
• Prediction of the functional class of metal-binding proteins from sequence derived physicochemical properties by support vector machine approach
  Lin, BMC bioinformatics 2006
  • “...- Q8GNT2 + P03697 + P31178 + P81605 - Q8VYR2 + P03825 + P32505 + P82604 + Q94702 + P12258 + P33353 + P83310 - Q95QY7 - P12608 - P33440 + Q00166 + Q9JJV3 + P14229 + P34806 + Q00167 - Q9LAI0 - P14633 + P39405...”

7f2zA / P82604 Crystal structure of oxdb e85a mutant (form ii) (see paper)
Aligns to 220:329 / 339 (32.4%), covers 68.6% of PF13826, 44.4 bits

• Ligand: protoporphyrin ix containing fe (7f2zA)

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