Family Search for PF13863 (DUF4200)

PF13863 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CP100_CHLRE / A8I4E9 Cilia- and flagella-associated protein 100; Flagella-associated protein 100; Modifier of inner arms 1 protein; Mia1p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 118:236 / 576 (20.7%), covers 99.2% of PF13863, 119.2 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
  subunit: Interacts with FAP73; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia1-1, mia1-2, mia1-3 and mia1-4 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.

CFA73_CHLRE / M1V4Y8 Cilia- and flagella-associated protein 73; Flagella-associated protein 73; Modifier of inner arms 2 protein; Mia2p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 29:147 / 308 (38.6%), covers 99.2% of PF13863, 117.6 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of inner dynein arm.
  subunit: Interacts with FAP100; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia2 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.

Q494V2 Cilia- and flagella-associated protein 100 from Homo sapiens
Aligns to 151:269 / 611 (19.5%), covers 100.0% of PF13863, 115.0 bits

• The Protective Effect of Liquiritin in Hypoxia/Reoxygenation-Induced Disruption on Blood Brain Barrier.
  Li, Frontiers in pharmacology 2021
  • “...NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Q9H3P7 ACBD3 Golgi resident protein GCP60 Q494V2 CFAP100 Cilia- and flagella-associated protein 100 P08670 VIM Vimentin P00558 PGK1 Phosphoglycerate kinase 1 P31689 DNAJA1 DnaJ homolog subfamily a member 1 P26583 HMGB2 High mobility group protein B2 Q9UKA9...”
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...mitochondrial OS=Homo sapiens GN=ATP5O PE=1 SV=1 - [ATPO_HUMAN] 5.16 2 1 1 213 23.3 9.96 Q494V2 Coiled-coil domain-containing protein 37 OS=Homo sapiens GN=CCDC37 PE=1 SV=1 - [CCD37_HUMAN] 1.96 1 1 1 611 71.1 7.11 Q7Z4R8 UPF0669 protein C6orf120 OS=Homo sapiens GN=C6orf120 PE=1 SV=1 - [CF120_HUMAN] 3.14...”
• Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells
  Villeneuve, Molecular biology of the cell 2011
  • “...O60911 Cathepsin L2 precursor Human 1 4.2 O00257 E3 SUMO-protein ligase CBX4 Human 2 2.3 Q494V2 Coiled-coil domaincontaining protein 37 Human 1 1 Q16610 Extracellular matrix protein 1 precursor Human 1 2.4 P02765 Alpha-2-HS-glycoprotein precursor (Fetuin-A) Human 4 7 Q14254 Flotillin-2 Human 3 7.1 P42167 Lamina-associated...”

A6QQM8 Coiled-coil domain-containing protein 42 from Bos taurus
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 102.8 bits

• Establishment of a repertoire of fertility associated sperm proteins and their differential abundance in buffalo bulls (Bubalus bubalis) with contrasting fertility
  Kumaresan, Scientific reports 2023
  • “...(Sm-D1) (snRNP core protein D1) 2.59 Q3ZBU7 TUBB4A Tubulin beta-4A chain (tubulin beta-4 chain) 2.92 A6QQM8 CCDC42 Coiled-coil domain-containing protein 42 3.9 Figure 6 Heat map indicating the extent of differential expression of top 30 dysregulated proteins (15 upregulated and 15 downregulated) between high- and low-fertile...”

CCD42_MOUSE / Q5SV66 Coiled-coil domain-containing protein 42 from Mus musculus (Mouse) (see 5 papers)
NP_808447 coiled-coil domain-containing protein 42 from Mus musculus
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 98.8 bits

• function: Essential for male fertility (PubMed:26945718). Required for sperm development (PubMed:26945718).
  subunit: Interacts with ODF1 and ODF2 (PubMed:31475146). Interacts with CCDC38 (PubMed:35587122). Interacts with CCDC146 (PubMed:38038747). Interacts with CFAP53 (PubMed:34124066).
  disruption phenotype: Mice develop normally without obvious somatic defects but males are sterile due to malformation of the sperm flagella. Sperm cells display defects in the number and location of the head-tail coupling apparatus and lack flagellated sperm.
• CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton.
  Tapia, Frontiers in cell and developmental biology 2019
  • “...et al., 1961 ). However, three putative CCDC42 isoforms have been reported in mice (UniProtKB Q5SV66) produced by alternative splicing ( Figure 10 ). The longest isoform 203 (Q5SV66) consists of 316 amino acids (aa). In isoform 201 (Q5SV65) the sequence encoded by exon 5 is...”
  • “...in red). FIGURE 10 Amino acid alignment of reported CCDC42 isoforms. The longest isoform 203 (Q5SV66) consists of 316 aa. In isoform 201 (Q5SV65) the sequence encoded by exon 5 is missing resulting in a putative protein of 238 aa. Isoform 202 (Q5SV66-2) has a postulated...”
• Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.
  Pasek, Developmental biology 2016
  • GeneRIF: Data indicate that mutations in the gene Coiled-coil domain containing 42 (Ccdc42) is associated with malformation of the sperm flagella.

CCD38_HUMAN / Q502W7 Coiled-coil domain-containing protein 38 from Homo sapiens (Human) (see paper)
NP_872302 coiled-coil domain-containing protein 38 from Homo sapiens
Aligns to 112:230 / 563 (21.1%), covers 100.0% of PF13863, 93.4 bits

• function: Essential for male fertility. Required for sperm flagellum biogenesis. Also required for acrosome biogenesis. Required for the attachment of developing acrosomes to the nucleus during spermiogenesis and may be involved in the transport of fibrous sheath components.
  subunit: Interacts with CCDC42, CFAP53, IFT88 and ODF2. Interacts with CCDC146. Interacts with TEKT3. Interacts with ubiquitinated histone H2A.
• Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.
  Wain, PLoS genetics 2014
  • GeneRIF: strongest signal of association with smoking resistance for a non-synonymous SNP in CCDC38, a gene which has previously been reported to show association with FEV1/FVC, and we demonstrate moderate expression of CCDC38 in bronchial epithelial cells
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

NP_653282 coiled-coil domain-containing protein 42 isoform 1 from Homo sapiens
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 91.4 bits

• HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B
  Lechtreck, Cell motility and the cytoskeleton 2009
  • “...3e-30 C_630058 EDP05376 FAP52 5062 1567 3495 AAH25392 1e-161 C_650031 EDO98890 FAP73 3842 1720 2122 NP_653282 4e-17 C_60149 EDO99770 FAP295 4254 340 3914 NP_006250 5e-90 The gene numbers in version 2.0 of the C. reinhardtii genome (JGI), the protein names, details of the PCR products, putative...”

CCD38_MOUSE / Q8CDN8 Coiled-coil domain-containing protein 38 from Mus musculus (Mouse) (see 4 papers)
Aligns to 112:230 / 563 (21.1%), covers 100.0% of PF13863, 88.6 bits

• function: Essential for male fertility (PubMed:35587122, PubMed:37709195). Required for sperm flagellum biogenesis (PubMed:35587122, PubMed:37709195). Also required for acrosome biogenesis (PubMed:37709195). Required for the attachment of developing acrosomes to the nucleus during spermiogenesis and may be involved in the transport of fibrous sheath components (PubMed:37709195).
  subunit: Interacts with CCDC42, CFAP53, IFT88 and ODF2 (PubMed:35587122). Interacts with CCDC146 (PubMed:38038747). Interacts with TEKT3 (PubMed:37709195). Interacts with ubiquitinated histone H2A (PubMed:27278724).
  disruption phenotype: Mutant males are infertile (PubMed:35587122, PubMed:37709195). They exhibit normal mounting behaviors and produce coital plugs but fail to produce any offspring after mating with wild- type adult females (PubMed:35587122, PubMed:37709195). Significantly reduced sperm count and motility with spermatozoa displaying morphological abnormalities including short or absent flagella, abnormal nuclei, disordered filaments, abnormally long manchettes and abnormal sperm heads (PubMed:35587122, PubMed:37709195). Impaired fibrous sheaths and disorganized axonemes in sperm flagella (PubMed:37709195). Sperm heads display acrosomal dysplasia (PubMed:37709195). Significantly reduced levels of Cfap53, Ift88, Ift20 and Odf2 in the testis (PubMed:35587122). Significantly decreased levels of Tekt3, Tssk6, Bsg, Akap3 and Cabyr in the testis (PubMed:37709195). Mislocalization of Odf2 with no expression detected in the sperm flagellum (PubMed:35587122). Aberrant localization of Tekt3, Akap3 and Cabyr (PubMed:37709195). Testis size and ratio of testis weight to body weight are unaffected (PubMed:35587122, PubMed:37709195). Fertility of knockout females is normal (PubMed:35587122).
• Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice.
  Chen, Food science & nutrition 2020
  • “...LP10treated mouse liver Description ProteinID Abbrev. Vehicle LP10 p value Fold Coiledcoil domaincontaining protein 38 Q8CDN8 CCD38 6.4352.994 00 .005 Vehicle only E3 ubiquitinprotein ligase TTC3 O88196 TTC3 0.9640.658 00 .026 Vehicle only Peroxisomal 2,4dienoylCoA reductase Q9WV68 DECR2 2.8792.064 00 .032 Vehicle only Dehydrogenase/reductase SDR family...”

XP_006513691 coiled-coil domain-containing protein 38 isoform X1 from Mus musculus
Aligns to 112:230 / 624 (19.1%), covers 100.0% of PF13863, 88.3 bits

• Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.
  Wang, Journal of genetics and genomics = Yi chuan xue bao 2024 (PubMed)
  • GeneRIF: Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.
• CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
  Zhang, Development (Cambridge, England) 2022 (PubMed)
  • GeneRIF: CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
• Identification and characteristics of the testes-specific gene, Ccdc38, in mice.
  Lin, Molecular medicine reports 2016 (PubMed)
  • GeneRIF: these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis.

CG17564 uncharacterized protein from Drosophila melanogaster
Aligns to 54:172 / 335 (35.5%), covers 99.2% of PF13863, 87.5 bits

• Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies
  Zur, Frontiers in genetics 2019
  • “...Gene Name Chlamydomonas Human Ch neuron expression Testis expression Expression summary Expression corroboration MIA COMPLEX CG17564 MIA2/FAP73 CCDC43A/B 78.21 12 (909) Ch + Testis CG10750 MIA2/FAP73 CCDC43B 6.56 14 (783) Ch + Testis No ortholog MIA1/FAP100 CCDC38 na na na T/TH COMPLEX CG17687 CFAP43 CFAP43 3.2...”
  • “...(Yamamoto et al., 2013 ; Figure 1A ). Drosophila has two orthologs of MIA2/FAP73 ( CG17564 and CG10750 ), and these are expressed in both testes and Ch neurons ( Table 3 ; Figure 2A ). The MIA transcripts are particularly highly enriched in Ch neurons...”
• Spermatogenesis Drives Rapid Gene Creation and Masculinization of the X Chromosome in Stalk-Eyed Flies (Diopsidae)
  Baker, Genome biology and evolution 2016
  • “...paralogs belonging to a gene family clade with five duplicates of the D. melanogaster genes CG17564 and CG10750 (the pair represent tandem duplicates within Drosophila ) acquired expression in the male carcass and ovaries, and a T. dalmanni duplicate of the D. melanogaster genes CG32086 and...”
• Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs
  Whyard, Parasites & vectors 2015
  • “...CG9313 Yes No No AAEL012096 CG18472 Yes No No AAEL012446 CG6303 No Yes Yes AAEL013621 CG17564 Yes Yes No AAEL013723 CG31000 ( heph ) Yes Yes Yes AAEL013737 CG6971 Yes No No AAEL014067 CG5048 Yes Yes No AAEL014408 CG4965 ( twe ) Yes No Yes Genes...”

Smp_147450 serine/threonine kinase from Schistosoma mansoni
Aligns to 259:377 / 550 (21.6%), covers 100.0% of PF13863, 86.3 bits

• A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability
  Swierczewski, PLoS neglected tropical diseases 2009
  • “...schistosomes or that the predicted coding sequences are incorrect. Other putative S. mansoni PKA sequences (Smp_147450 and Smp_194610) appear to lack a functional kinase domain or are missing amino acid residues that are critical for PKA function. Thus the extent to which adult schistosomes express multiple...”

Q9VIY1 CG10750 protein from Drosophila melanogaster
Aligns to 54:172 / 331 (36.0%), covers 99.2% of PF13863, 84.3 bits

• Satellite DNA-like elements associated with genes within euchromatin of the beetle Tribolium castaneum
  Brajković, G3 (Bethesda, Md.) 2012
  • “...5 4278 Q9W3N7 FBgn0029971 Transposon 635 D6WII2 100142263 Putative uncharacterized protein 3 20 3 18,585 Q9VIY1 FBgn0032769 Transposon 635 D6WFT8 657535 WD repeat-containing protein 47 3 21 Inside Q960Y9 FBgn0026427 Satellite 604 1.7 D6WDY2 656125 Kynurenine aminotransferase 3 22 5 10,696 Q8SXC2 FBgn0037955 Transposon 1000 D6WDY4...”

D6WII2 Coiled-coil domain-containing protein 42A-like Protein from Tribolium castaneum
Aligns to 57:175 / 335 (35.5%), covers 98.3% of PF13863, 71.6 bits

• Satellite DNA-like elements associated with genes within euchromatin of the beetle Tribolium castaneum
  Brajković, G3 (Bethesda, Md.) 2012
  • “...687 1.9 D6WII0 100141571 NADH dehydrogenase, putative 3 20 5 4278 Q9W3N7 FBgn0029971 Transposon 635 D6WII2 100142263 Putative uncharacterized protein 3 20 3 18,585 Q9VIY1 FBgn0032769 Transposon 635 D6WFT8 657535 WD repeat-containing protein 47 3 21 Inside Q960Y9 FBgn0026427 Satellite 604 1.7 D6WDY2 656125 Kynurenine aminotransferase...”

TGME49_053340 hypothetical protein from Toxoplasma gondii ME49
Aligns to 55:162 / 202 (53.5%), covers 87.4% of PF13863, 66.4 bits

• The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation
  Walker, Molecular microbiology 2013
  • “...2.179 3.501 TGME49_052640 plasma-membrane proton-ATPase 2.167 3.086 TGME49_053330 rhoptry kinase family protein, truncated 2.137 5.634 TGME49_053340 Hypothetical 2.063 4.578 * TGME49_120190 (SRS9) is a known bradyzoite marker ( Van, 2007 ), despite the lack of strong up-regulation in pH 8.2-stressed wild type parasites in this experiment....”

ETH_00013980 Flagellar associated protein, related from Eimeria tenella
Aligns to 1:78 / 314 (24.8%), covers 63.9% of PF13863, 54.0 bits

• RNA Seq analysis of the Eimeria tenella gametocyte transcriptome reveals clues about the molecular basis for sexual reproduction and oocyst biogenesis
  Walker, BMC genomics 2015
  • “...chain alpha axoneme ETH_00030810 115.85 flagellar associated protein flagella ETH_00023960 55.80 flagellar associated protein flagella ETH_00013980 53.78 flagellar associated protein flagella ETH_00023965 50.49 flagellar associated protein flagella ETH_00019365 42.87 flagellar associated related flagella ETH_00004845 41.61 flagellar associated protein flagella ETH_00019370 31.03 flagellar associated related flagella ETH_00002895...”

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