Family Search for PF13863 (DUF4200)

PF13863.6 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CP100_CHLRE / A8I4E9 Cilia- and flagella-associated protein 100; Flagella-associated protein 100; Modifier of inner arms 1 protein; Mia1p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
FAP100 flagellar associated protein from Chlamydomonas reinhardtii
Aligns to 118:236 / 576 (20.7%), covers 99.2% of PF13863, 119.6 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
  subunit: Interacts with FAP73; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia1-1, mia1-2, mia1-3 and mia1-4 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.
• FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia
  Lin, Molecular biology of the cell 2019
  • “...the 1 and 1 DHCs, several I1 intermediate chains, the two MIA proteins (FAP73 and FAP100) implicated in the regulation of I1 dynein ( Yamamoto et al. , 2013 ), and the three T/TH proteins, FAP43, FAP44, and FAP244, mentioned above. All subunits of the N-DRC,...”
  • “...et al. (2013) described FAP57 as one of a few polypeptides that coimmunoprecipitated with the FAP100 subunit of the MIA complex, the IC138 and two DHCs of I1 dynein, and the FAP44 subunit of the I1 dynein tether head after chemical cross-linking. FAP57 has also been...”
• Ciliary Motility: Regulation of Axonemal Dynein Motors
  Viswanadha, Cold Spring Harbor perspectives in biology 2017
  • “...light chains MIA1 MIA2 DHC6 DHC5 IDA9 DHC2 DHC8 DHC7 FAP100 DHC6 DHC5 DHC9 DHC2 DHC8 DHC7 FLA14 FAP73 LC8 Tctex2b LC7a, LC7 LC7b ODA15 DIC4 BOP5 IC97, IC110...”
  • “...Inner dynein arms (IDAs) and associated proteins Associates with FAP100 in the MIA complex and with IC138 Associates with FAP73 in the MIA complex and with...”
• Sperm dysfunction and ciliopathy
  Inaba, Reproductive medicine and biology 2016 (secret)
• The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility
  Yamamoto, The Journal of cell biology 2013
  • “...(AttributionNoncommercialShare Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ ). The MIA complex, composed of FAP100 and FAP73, interacts with I1 dynein components and is required for normal ciliary beat frequency. Axonemal dyneins must be precisely regulated and coordinated to produce ordered ciliary/flagellar motility, but how...”
  • “...flagellar beat frequency. We found that the MIA1 and MIA2 genes encode conserved coiled-coil proteins, FAP100 and FAP73, respectively, which form the modifier of inner arms (MIA) complex in flagella. Cryoelectron tomography of mia mutant axonemes revealed that the MIA complex was located immediately distal to...”
• A solid-state control system for dynein-based ciliary/flagellar motility
  King, The Journal of cell biology 2013
  • “...of the I1/f inner arm dynein. This structure consists of two coiled-coil proteins (FAP73 and FAP100), and mutants lacking these components exhibit altered waveform, decreased beat frequency, and abnormal photobehavior that is evidence of defects in flagella control pathways ( King and Dutcher, 1997 ). Furthermore,...”

CFA73_CHLRE / M1V4Y8 Cilia- and flagella-associated protein 73; Flagella-associated protein 73; Modifier of inner arms 2 protein; Mia2p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 29:147 / 308 (38.6%), covers 99.2% of PF13863, 118.9 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of inner dynein arm.
  subunit: Interacts with FAP100; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia2 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.

XP_006713686 cilia- and flagella-associated protein 100 isoform X1 from Homo sapiens
Q494V2 Cilia- and flagella-associated protein 100 from Homo sapiens
Aligns to 151:269 / 611 (19.5%), covers 100.0% of PF13863, 114.2 bits

• Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.
  Kwon, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012 (PubMed)
  • GeneRIF: We confirmed that the expression of CCDC37 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region.
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...mitochondrial OS=Homo sapiens GN=ATP5O PE=1 SV=1 - [ATPO_HUMAN] 5.16 2 1 1 213 23.3 9.96 Q494V2 Coiled-coil domain-containing protein 37 OS=Homo sapiens GN=CCDC37 PE=1 SV=1 - [CCD37_HUMAN] 1.96 1 1 1 611 71.1 7.11 Q7Z4R8 UPF0669 protein C6orf120 OS=Homo sapiens GN=C6orf120 PE=1 SV=1 - [CF120_HUMAN] 3.14...”
• Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells
  Villeneuve, Molecular biology of the cell 2011
  • “...O60911 Cathepsin L2 precursor Human 1 4.2 O00257 E3 SUMO-protein ligase CBX4 Human 2 2.3 Q494V2 Coiled-coil domaincontaining protein 37 Human 1 1 Q16610 Extracellular matrix protein 1 precursor Human 1 2.4 P02765 Alpha-2-HS-glycoprotein precursor (Fetuin-A) Human 4 7 Q14254 Flotillin-2 Human 3 7.1 P42167 Lamina-associated...”

CCD42_MOUSE / Q5SV66 Coiled-coil domain-containing protein 42 from Mus musculus (Mouse) (see paper)
NP_808447 coiled-coil domain-containing protein 42 from Mus musculus
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 94.9 bits

• function: Required for sperm development.
  disruption phenotype: Mice develop normally without obvious somatic defects but males are sterile due to malformation of the sperm flagella. Sperm cells display defects in the number and location of the head-tail coupling apparatus and lack flagellated sperm.
• Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.
  Pasek, Developmental biology 2016
  • GeneRIF: Data indicate that mutations in the gene Coiled-coil domain containing 42 (Ccdc42) is associated with malformation of the sperm flagella.
• CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton.
  Tapia, Frontiers in cell and developmental biology 2019
  • “...et al., 1961 ). However, three putative CCDC42 isoforms have been reported in mice (UniProtKB Q5SV66) produced by alternative splicing ( Figure 10 ). The longest isoform 203 (Q5SV66) consists of 316 amino acids (aa). In isoform 201 (Q5SV65) the sequence encoded by exon 5 is...”
  • “...in red). FIGURE 10 Amino acid alignment of reported CCDC42 isoforms. The longest isoform 203 (Q5SV66) consists of 316 aa. In isoform 201 (Q5SV65) the sequence encoded by exon 5 is missing resulting in a putative protein of 238 aa. Isoform 202 (Q5SV66-2) has a postulated...”

CCD38_HUMAN / Q502W7 Coiled-coil domain-containing protein 38 from Homo sapiens (Human) (see paper)
NP_872302 coiled-coil domain-containing protein 38 from Homo sapiens
Aligns to 112:230 / 563 (21.1%), covers 100.0% of PF13863, 93.6 bits

• Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.
  Wain, PLoS genetics 2014
  • GeneRIF: strongest signal of association with smoking resistance for a non-synonymous SNP in CCDC38, a gene which has previously been reported to show association with FEV1/FVC, and we demonstrate moderate expression of CCDC38 in bronchial epithelial cells
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Q8CDN8 Coiled-coil domain-containing protein 38 from Mus musculus
Aligns to 112:230 / 563 (21.1%), covers 100.0% of PF13863, 90.0 bits

• Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice.
  Chen, Food science & nutrition 2020
  • “...LP10treated mouse liver Description ProteinID Abbrev. Vehicle LP10 p value Fold Coiledcoil domaincontaining protein 38 Q8CDN8 CCD38 6.4352.994 00 .005 Vehicle only E3 ubiquitinprotein ligase TTC3 O88196 TTC3 0.9640.658 00 .026 Vehicle only Peroxisomal 2,4dienoylCoA reductase Q9WV68 DECR2 2.8792.064 00 .032 Vehicle only Dehydrogenase/reductase SDR family...”

XP_006513691 coiled-coil domain-containing protein 38 isoform X1 from Mus musculus
Aligns to 112:230 / 624 (19.1%), covers 100.0% of PF13863, 89.7 bits

• Identification and characteristics of the testes-specific gene, Ccdc38, in mice.
  Lin, Molecular medicine reports 2016 (PubMed)
  • GeneRIF: these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis.

Smp_147450 serine/threonine kinase from Schistosoma mansoni
Aligns to 259:377 / 550 (21.6%), covers 99.2% of PF13863, 88.9 bits

• A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability
  Swierczewski, PLoS neglected tropical diseases 2009
  • “...schistosomes or that the predicted coding sequences are incorrect. Other putative S. mansoni PKA sequences (Smp_147450 and Smp_194610) appear to lack a functional kinase domain or are missing amino acid residues that are critical for PKA function. Thus the extent to which adult schistosomes express multiple...”

NP_653282 coiled-coil domain-containing protein 42 isoform 1 from Homo sapiens
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 87.3 bits

• HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B
  Lechtreck, Cell motility and the cytoskeleton 2009
  • “...3e-30 C_630058 EDP05376 FAP52 5062 1567 3495 AAH25392 1e-161 C_650031 EDO98890 FAP73 3842 1720 2122 NP_653282 4e-17 C_60149 EDO99770 FAP295 4254 340 3914 NP_006250 5e-90 The gene numbers in version 2.0 of the C. reinhardtii genome (JGI), the protein names, details of the PCR products, putative...”

CG17564 uncharacterized protein from Drosophila melanogaster
Aligns to 54:172 / 335 (35.5%), covers 98.3% of PF13863, 69.2 bits

• Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies
  Zur, Frontiers in genetics 2019
  • “...Gene Name Chlamydomonas Human Ch neuron expression Testis expression Expression summary Expression corroboration MIA COMPLEX CG17564 MIA2/FAP73 CCDC43A/B 78.21 12 (909) Ch + Testis CG10750 MIA2/FAP73 CCDC43B 6.56 14 (783) Ch + Testis No ortholog MIA1/FAP100 CCDC38 na na na T/TH COMPLEX CG17687 CFAP43 CFAP43 3.2...”
  • “...(Yamamoto et al., 2013 ; Figure 1A ). Drosophila has two orthologs of MIA2/FAP73 ( CG17564 and CG10750 ), and these are expressed in both testes and Ch neurons ( Table 3 ; Figure 2A ). The MIA transcripts are particularly highly enriched in Ch neurons...”
• Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila
  Damulewicz, Genes 2018
  • “...to ER Stress CG42678 Septate Junction Tsp2A Unknown CG13742 CG43894 CG43391 scpr-C abd-A CG3611 CG43816 CG17564 CG15186 CG15140 CG32413 CG34279 CG13337 CG12688 CG44437 CG13449 CG4998 CG12321 CG44158 CG42869 CG11905 CG10051 CG32548 CG45060 G6P CG44163 CG31415 CG13058 Osi24 CG13332 CG12034 CG43117 CG15728 pyd3 Sfp77F pre-mod(mdg4)-B CG17777 CG42272...”
• Spermatogenesis Drives Rapid Gene Creation and Masculinization of the X Chromosome in Stalk-Eyed Flies (Diopsidae)
  Baker, Genome biology and evolution 2016
  • “...paralogs belonging to a gene family clade with five duplicates of the D. melanogaster genes CG17564 and CG10750 (the pair represent tandem duplicates within Drosophila ) acquired expression in the male carcass and ovaries, and a T. dalmanni duplicate of the D. melanogaster genes CG32086 and...”
• Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs
  Whyard, Parasites & vectors 2015
  • “...CG9313 Yes No No AAEL012096 CG18472 Yes No No AAEL012446 CG6303 No Yes Yes AAEL013621 CG17564 Yes Yes No AAEL013723 CG31000 ( heph ) Yes Yes Yes AAEL013737 CG6971 Yes No No AAEL014067 CG5048 Yes Yes No AAEL014408 CG4965 ( twe ) Yes No Yes Genes...”

Q9VIY1 CG10750 protein from Drosophila melanogaster
Aligns to 54:172 / 331 (36.0%), covers 99.2% of PF13863, 68.4 bits

• Satellite DNA-like elements associated with genes within euchromatin of the beetle Tribolium castaneum
  Brajković, G3 (Bethesda, Md.) 2012
  • “...5 4278 Q9W3N7 FBgn0029971 Transposon 635 D6WII2 100142263 Putative uncharacterized protein 3 20 3 18,585 Q9VIY1 FBgn0032769 Transposon 635 D6WFT8 657535 WD repeat-containing protein 47 3 21 Inside Q960Y9 FBgn0026427 Satellite 604 1.7 D6WDY2 656125 Kynurenine aminotransferase 3 22 5 10,696 Q8SXC2 FBgn0037955 Transposon 1000 D6WDY4...”

TGME49_053340 hypothetical protein from Toxoplasma gondii ME49
Aligns to 55:163 / 202 (54.0%), covers 88.2% of PF13863, 68.3 bits

• The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation
  Walker, Molecular microbiology 2013
  • “...2.179 3.501 TGME49_052640 plasma-membrane proton-ATPase 2.167 3.086 TGME49_053330 rhoptry kinase family protein, truncated 2.137 5.634 TGME49_053340 Hypothetical 2.063 4.578 * TGME49_120190 (SRS9) is a known bradyzoite marker ( Van, 2007 ), despite the lack of strong up-regulation in pH 8.2-stressed wild type parasites in this experiment....”

D6WII2 Coiled-coil domain-containing protein 42A-like Protein from Tribolium castaneum
Aligns to 57:175 / 335 (35.5%), covers 98.3% of PF13863, 64.0 bits

• Satellite DNA-like elements associated with genes within euchromatin of the beetle Tribolium castaneum
  Brajković, G3 (Bethesda, Md.) 2012
  • “...687 1.9 D6WII0 100141571 NADH dehydrogenase, putative 3 20 5 4278 Q9W3N7 FBgn0029971 Transposon 635 D6WII2 100142263 Putative uncharacterized protein 3 20 3 18,585 Q9VIY1 FBgn0032769 Transposon 635 D6WFT8 657535 WD repeat-containing protein 47 3 21 Inside Q960Y9 FBgn0026427 Satellite 604 1.7 D6WDY2 656125 Kynurenine aminotransferase...”

ETH_00013980 Flagellar associated protein, related from Eimeria tenella
Aligns to 1:78 / 314 (24.8%), covers 63.9% of PF13863, 54.9 bits

• RNA Seq analysis of the Eimeria tenella gametocyte transcriptome reveals clues about the molecular basis for sexual reproduction and oocyst biogenesis
  Walker, BMC genomics 2015
  • “...chain alpha axoneme ETH_00030810 115.85 flagellar associated protein flagella ETH_00023960 55.80 flagellar associated protein flagella ETH_00013980 53.78 flagellar associated protein flagella ETH_00023965 50.49 flagellar associated protein flagella ETH_00019365 42.87 flagellar associated related flagella ETH_00004845 41.61 flagellar associated protein flagella ETH_00019370 31.03 flagellar associated related flagella ETH_00002895...”

PF3D7_1023600 conserved protein, unknown function from Plasmodium falciparum 3D7
Aligns to 138:256 / 512 (23.2%), covers 96.6% of PF13863, 31.4 bits

• Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions
  Cabral, Memorias do Instituto Oswaldo Cruz 2017
  • “...5 PF3D7_0818900 organism=Plasmodium_falciparum_3D7 | product=heat shock protein 70 (Hsp70) TTPSYVAFTDTER 1 5 73.9/45 5.67/3.5 6 PF3D7_1023600 organism=Plasmodium_falciparum_3D7 | product=conserved Plasmodium protein, unknown function KEKTINNLNK 1 2 25.5/40 9.85/4.5 8 PF3D7_1007800 organism=Plasmodium_falciparum_3D7 | product=conserved Plasmodium protein, unknown function NDKEEIPDIVNK 1 3 125.2/40 8.5/4.0 10 PF3D7_0918400 organism=Plasmodium_falciparum_3D7 |...”
  • “...analysis showed that these are putative membrane proteins ( Table IV ). Two other proteins, PF3D7_1023600 and PF3D7_1007800, were identified and are annotated as proteins with unknown function. GO analysis revealed that these proteins are cytoplasmic proteins ( Table IV ). TABLE IV Gene ontology (GO),...”

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