Family Search for PF13863 (DUF4200)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13863 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CP100_CHLRE / A8I4E9 Cilia- and flagella-associated protein 100; Flagella-associated protein 100; Modifier of inner arms 1 protein; Mia1p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 118:236 / 576 (20.7%), covers 99.2% of PF13863, 119.2 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
  subunit: Interacts with FAP73; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia1-1, mia1-2, mia1-3 and mia1-4 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.

CFA73_CHLRE / M1V4Y8 Cilia- and flagella-associated protein 73; Flagella-associated protein 73; Modifier of inner arms 2 protein; Mia2p from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 29:147 / 308 (38.6%), covers 99.2% of PF13863, 117.6 bits

• function: As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of inner dynein arm.
  subunit: Interacts with FAP100; form the modifier of inner arm (MIA) complex.
  disruption phenotype: The mia2 mutants do not express the protein in the axoneme and display slightly jerky, slow swimming phenotypes, reduced flagellar beat frequencies and defective phototaxis.

CCD42_MOUSE / Q5SV66 Coiled-coil domain-containing protein 42 from Mus musculus (Mouse) (see paper)
Aligns to 44:162 / 316 (37.7%), covers 99.2% of PF13863, 98.8 bits

• function: Required for sperm development.
  disruption phenotype: Mice develop normally without obvious somatic defects but males are sterile due to malformation of the sperm flagella. Sperm cells display defects in the number and location of the head-tail coupling apparatus and lack flagellated sperm.

CCD38_HUMAN / Q502W7 Coiled-coil domain-containing protein 38 from Homo sapiens (Human) (see paper)
Aligns to 112:230 / 563 (21.1%), covers 100.0% of PF13863, 93.4 bits

Or search for genetic data about PF13863 in the Fitness Browser