Family Search for PF13870 (DUF4201)
PF13870 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
CF184_HUMAN / Q2M329 Cilia- and flagella-associated protein 184 from Homo sapiens (Human) (see paper)
Aligns to 365:541 / 555 (31.9%), covers 98.9% of PF13870, 170.1 bits
- function: In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC.
subunit: Forms a complex with CFAP263; the interaction is required for functional activity in cilia.
CG4970 uncharacterized protein from Drosophila melanogaster
Aligns to 496:672 / 690 (25.7%), covers 99.4% of PF13870, 160.2 bits
- Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster
Venugopal, BMC developmental biology 2020 - “...coding sequence (Fig. 1 h). However, they also deleted part of the neighboring annotated gene (CG4970). This gene is only expressed in testis and is very poorly conserved, with no known domains and no ortholog in other insect species. Trans-heterozygous between a Minos element inserted in...”
- “...we generated complement perfectly in terms of viability and fertility, indicating no essential function of CG4970 . We also obtained rescue of Dlg5 ex13 mutation lethality using a transgene with Dlg5 coding sequence under ubiquitin promoter and fused to GFP added in N-terminal (Ubi:GFP-Dlg5). Thus, we...”
- A comprehensive map of insulator elements for the Drosophila genome
Nègre, PLoS genetics 2010 - “...binding of CTCF, CP190, BEAF-32, and Mod(mdg4), is located between the divergent genes CG6509 and CG4970 which are separated by approximately 350 bp. CG6509 is transcribed as identified by its RNA level and have an active promoter, as identified by the presence of PolII and H3K4me3...”
- “...its TSS. CG4970, however, is inactive, thus suggesting that the presence of the insulator allows CG4970 to be activated independently of CG6509. (0.31 MB JPG) Click here for additional data file. Figure S12 Distribution of insulator binding sites around the TSS of genes dependent of their...”
I3LQX1 Coiled-coil domain containing 96 from Sus scrofa
Aligns to 365:541 / 555 (31.9%), covers 98.9% of PF13870, 157.0 bits
CF263_HUMAN / Q9H0I3 Cilia- and flagella-associated protein 263 from Homo sapiens (Human) (see paper)
Aligns to 178:354 / 377 (46.9%), covers 98.9% of PF13870, 156.5 bits
- function: Component of centriolar satellites contributing to primary cilium formation (PubMed:25074808). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity).
subunit: Forms a complex with CFAP184; the interaction is required for functional activity in cilia (By similarity). Interacts with HAP1 and PCM1 (PubMed:25074808). - Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
Soundararajan, Frontiers in cell and developmental biology 2022 - “...downregulated cellular proteins. Gene symbol Accession Description Fold change log 2 FC p -value CCDC113 Q9H0I3 Coiled-coil domain-containing protein 113 0.518 0.950 0.009 CCDC170 Q8IYT3 Coiled-coil domain-containing protein 170 0.53 0.910 0.028 RASSF3 Q86WH2 Ras association domain-containing protein 3 0.556 0.850 0.042 CASP8AP2 Q9UKL3 CASP8-associated protein...”
Q8C5T8 Cilia- and flagella-associated protein 263 from Mus musculus
Aligns to 178:354 / 377 (46.9%), covers 98.9% of PF13870, 155.5 bits
CG31231 uncharacterized protein from Drosophila melanogaster
Aligns to 487:663 / 679 (26.1%), covers 99.4% of PF13870, 153.7 bits
- Mixture modeling of transcript abundance classes in natural populations
Hsieh, Genome biology 2007 - “...TACs, we sequenced, from 43 of the NC lines, a short 1.8 kilobase (kb) gene (CG31231) that is sandwiched tightly between two other genes and that exhibits transcriptional bimodality in both populations. Three out of 16 common, independently segregating SNPs were observed to correlate with transcript...”
- “...control and nicotine diets. This SNP accounts for less than half of the bimodality of CG31231 expression and would not be detected in a genome scan for association with expression. Power to detect transcriptional abundance classes Many truly multimodal distributions will appear as skewed single normal...”
CG31784 uncharacterized protein from Drosophila melanogaster
Aligns to 551:727 / 763 (23.2%), covers 99.4% of PF13870, 151.5 bits
- Hawaiian picture-winged Drosophila exhibit adaptive population divergence along a narrow climatic gradient on Hawaii Island
Eldon, Ecology and evolution 2019 - “...ortholog symbols or functional domain annotations (if available) are as follows: (a) FBgn0130876; (b) FBgn0117568 (CG31784); (c) FBgn0119956 (GH12477, contains domain cytochrome b561/ferric reductase transmembrane); (d) FBgn0132691; (e) FBgn0123024 (transcriptional cofactor, nab); (f) FBgn0123345 (retininlike protein); (g) FBgn0120752 (CG17005); (h) FBgn0128660 (cuticle protein, Cpr49Ad); (i) FBgn0129493...”
- “...by bold font ANOVA Factor Comparative study Species Gene symbol PopulationxTemperature treatment n/a D.sproati bap, CG31784, GH12477, CG17005, Cpr49Ad, CG13029 a , CG171958 a , CG4956 a , FBgn0120752 (no gene symbol), CG9921 b , nab, SdhC c Population Leemans et al. ( 2000 ) D.melanogaster...”
- A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3
Cingolani, Fly 2012 - “...lethald CG31145 27L/* 764 ND a mew 752Q/* 1050 Lethala CG31784 1049Q/* 1078 NDa NFAT 12G/* 1420 NDd CG32115 468W/* 476 ND oc/otd 389Y/*, 453Y/* 543 Lethald LRP1...”
- Identification and investigation of Drosophila postsynaptic density homologs
Liebl, Bioinformatics and biology insights 2008 - “...JNK and regulates synaptic targeting of AMPARs (Ye et al. 2000; Ye et al. 2007) CG31784 25.2/47.3 GRIP NM_021150.1 Scaffolding protein that binds to GluR2 and GluR3 (Dong et al. 1997) GRIP 56.1/81.7 Hsp90 S45392.1 Required for constitutive cycling of AMPARs (Gerges et al. 2004b) Hsp83...”
CF184_TETTS / I7M6D6 Cilia- and flagella-associated protein 184 from Tetrahymena thermophila (strain SB210) (see paper)
TTHERM_00529650 hypothetical protein from Tetrahymena thermophila SB210
Aligns to 595:771 / 794 (22.3%), covers 98.3% of PF13870, 136.2 bits
- function: In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC.
subunit: Forms a complex with CFAP263; the interaction is required for functional activity in cilia.
disruption phenotype: Mutants swimming speed is reduced compared to wild-type with trajectories wavy and kinky. Cilia length is not affected. - Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link
Bazan, PLoS genetics 2021 - “...[ 33 ]. Regretfully, we were unable to identify the nature of Ccdc113 modification(s). Ccdc96 (TTHERM_00529650) is a larger ~94 kDa protein with poorly conserved N-terminal part but highly conserved C-terminal end ( S3 Fig ). 10.1371/journal.pgen.1009388.g002 Fig 2 Ccdc113 and Ccdc96 localize in cilia but...”
- “...DRC3-coDel Ccdc113 TTHERM_00312810 33/8 0 18/7 0 10/7 7/4 0 13/10 0 13/10 5/4 Ccdc96 TTHERM_00529650 39/16 3/2 31/16 0 21/15 15/9 0 21/12 0 21/12 8/7 Fap57A TTHERM_00105300 14/7 15/9 13/9 22/14 7/6 13/10 10/7 15/12 10/9 15/12 14/13 Actin TTHERM_00190950 186/16 148/16 96/16 91/14...”
CF263_BOVIN / Q3SZX9 Cilia- and flagella-associated protein 263 from Bos taurus (Bovine) (see paper)
Aligns to 178:368 / 391 (48.8%), covers 98.9% of PF13870, 126.5 bits
- function: Component of centriolar satellites contributing to primary cilium formation (By similarity). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity).
subunit: Forms a complex with CFAP184; the interaction is required for functional activity in cilia (By similarity). Interacts with HAP1 and PCM1 (By similarity).
CF263_TETTS / Q22KK0 Cilia- and flagella-associated protein 263 from Tetrahymena thermophila (strain SB210) (see paper)
TTHERM_00312810 flagellar associated protein from Tetrahymena thermophila SB210
Aligns to 166:347 / 361 (50.4%), covers 98.9% of PF13870, 113.0 bits
- function: In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC.
subunit: Forms a complex with CFAP184; the interaction is required for functional activity in cilia.
disruption phenotype: Mutants swimming speed is reduced compared to wild-type with trajectories wavy and kinky. Cilia length is not affected. - Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link
Bazan, PLoS genetics 2021 - “...Ccdc113 in motile cilia as potential N-DRC connectors may be conserved in evolution. Tetrahymena Ccdc113 (TTHERM_00312810) is a 43 kDa, likely post-translationally modified, protein (Figs 2A and S4A ). These data are in agreement with studies in Chlamydomonas suggesting that FAP263 is a phosphoprotein [ 33...”
- “...and mutant cells. Protein name Number in TGD WT CCDC113-KO WT CCDC96-coDel WT DRC3-coDel Ccdc113 TTHERM_00312810 33/8 0 18/7 0 10/7 7/4 0 13/10 0 13/10 5/4 Ccdc96 TTHERM_00529650 39/16 3/2 31/16 0 21/15 15/9 0 21/12 0 21/12 8/7 Fap57A TTHERM_00105300 14/7 15/9 13/9 22/14...”
T1HZ69 CCDC113/CCDC96 coiled-coil domain-containing protein from Rhodnius prolixus
Aligns to 54:190 / 231 (59.3%), covers 73.4% of PF13870, 59.1 bits
- Proteomic Mapping of Multifunctional Complexes Within Triatomine Saliva
Santiago, Frontiers in cellular and infection microbiology 2020 - “...class, which are: (i) actin, (ii) thioredoxin peroxidase, (iii) triabin; and (iv) an uncharacterized protein (T1HZ69) from the Unknown class. The hemocyanin/hexamerin, the heat shock protein and the histone PGs were identified in the majority of the species, except for T. dimidiata, T. infestans , and...”
- “...binding Dm 2 Uncharacterized protein (T1IAP4) Integral component of membrane Dm 3 UNKNOWN Uncharacterized protein (T1HZ69) - Ti 4; Td 6; Dm 1; Dm5; Rp1; Rp 3; Rp 4; Rn1 Uncharacterized protein (T1HNL8) - Dm 2 Uncharacterized protein (T1HS38) - Dm 2; Rn 3 Uncharacterized protein...”
Or search for genetic data about PF13870 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory