Family Search for PF13886 (DUF4203)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13886 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TM198_XENTR / Q6DFQ7 Transmembrane protein 198 from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 36:232 / 342 (57.6%), covers 100.0% of PF13886, 167.5 bits

• function: Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.
  subunit: Interacts with lrp6. Interacts with casein kinases.
  disruption phenotype: Morphants have defects in neural crest formation. At the tadpole stage, animals are often less pigmented with ventrally bent tails. Embryos develop smaller eyes and forebrain structures.

XP_012812209 transmembrane protein 198 isoform X1 from Xenopus tropicalis
Aligns to 48:244 / 354 (55.6%), covers 100.0% of PF13886, 167.3 bits

• Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.
  Liang, Molecular and cellular biology 2011
  • GeneRIF: these results identified TMEM198 as a membrane scaffold protein that promotes LRP6 phosphorylation and Wnt signaling activation.

TM198_HUMAN / Q66K66 Transmembrane protein 198 from Homo sapiens (Human) (see paper)
NP_001290027 transmembrane protein 198 from Homo sapiens
Aligns to 40:236 / 360 (54.7%), covers 99.5% of PF13886, 157.3 bits

• function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
  subunit: Interacts with LRP6.
• Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.
  Liang, Molecular and cellular biology 2011
  • GeneRIF: these results identified TMEM198 as a membrane scaffold protein that promotes LRP6 phosphorylation and Wnt signaling activation.
• Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases
  Jang, Biomaterials research 2023
  • “...HUMAN SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 Y N Cluster 3 Q66K66 HUMAN TMEM198 Transmembrane protein 198 N Y Cluster 1 P24821 HUMAN TNC Tenascin Y N Cluster 3 Q86YW5 HUMAN TREML1 Trem-like transcript 1 protein N Y Cluster 3 Discussion Exosomes...”
• Differential Expression of Serum Proteins in Chronic Obstructive Pulmonary Disease Assessed Using Label-Free Proteomics and Bioinformatics Analyses.
  Li, International journal of chronic obstructive pulmonary disease 2022
  • “...Stanniocalcin-2 0.33 DOWN P02768 ALB Albumin 0.32 DOWN Q9BWX5 GATA5 Transcription factor GATA-5 0.29 DOWN Q66K66 TMEM198 Transmembrane protein 198 0.27 DOWN Q9HCB6 SPON1 Spondin-1 0.26 DOWN Q07075 ENPEP Glutamyl aminopeptidase 0.24 DOWN Q5D862 FLG2 Filaggrin-2 0.23 DOWN P19440 GGT1 Glutathione hydrolase 1 proenzyme 0.22 DOWN...”
  • “...Number Protein-Coding Gene Name Protein Description FC UP P49913 CAMP Cathelicidin antimicrobial peptide 10.07 UP Q66K66 TMEM198 Transmembrane protein 198 9.27 UP P13611 VCAN Versican core protein 7.61 UP Q96EE4 CCDC126 Coiled-coil domain-containing protein 126 7.46 UP P08238 HSP90AB1 Heat shock protein HSP 90-beta 6.20 UP...”
• Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
  Birkelund, Clinical proteomics 2020
  • “...Q13790 Apolipoprotein F APOF 0.4627 3.02E03 Q96RL7 Vacuolar protein sorting-associated protein 13A VPS13A 0.5619 1.23E02 Q66K66 Transmembrane protein 198 TMEM198 0.5646 2.27E02 Correlation of proteins found changed/increased by proteomic in SF to regulatory pathways To identify underlying biological themes and pathways of the correlating proteins, a...”
• The Constitutive Proteome of Human Aqueous Humor and Race Specific Alterations.
  Kodeboyina, Proteomes 2020
  • “...P01593 IGKV1D-33 Immunoglobulin kappa variable 1D-33 77.27 2.93 P02679 FGG Fibrinogen gamma chain 76.14 4.92 Q66K66 TMEM198 Transmembrane protein 198 76.14 4.40 P02656 APOC3 Apolipoprotein C-III 76.14 3.19 P13671 C6 Complement component C6 76.14 2.96 Q99574 SERPINI1 Neuroserpin 76.14 2.38 P04264 KRT1 Keratin, type II cytoskeletal...”
• Proteomic analysis of human follicular fluid associated with successful in vitro fertilization.
  Shen, Reproductive biology and endocrinology : RB&E 2017
  • “...210 P21675 Transcription initiation factor TFIID subunit 1 TAF1 212,677 - - 7 1 211 Q66K66 Transmembrane protein 198 TMEM198 39,475 2.5 2 2.5 1 212 P02766 Transthyretin TTR 15,887 69.4 12 69.4 19 213 P13611 Versican core protein VCAN 372,820 - - 5.2 2 214...”

TM7S3_HUMAN / Q9NS93 Transmembrane 7 superfamily member 3; Seven span transmembrane protein from Homo sapiens (Human) (see 3 papers)
Aligns to 296:503 / 570 (36.5%), covers 100.0% of PF13886, 144.7 bits

• function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).

C9JXI5 Transmembrane protein 198 (Fragment) from Homo sapiens
Aligns to 40:227 / 227 (82.8%), covers 95.0% of PF13886, 144.6 bits

• Proteomics investigation of the changes in serum proteins after high- and low-flux hemodialysis.
  Han, Renal failure 2018
  • “...A0A0B4J1X8 Immunoglobulin heavy variable 343 13077 5.18 Decreased P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial 164939 5.92 C9JXI5 Transmembrane protein 198 (fragment) 24329 NS K7ER74 Protein APOC4-APOC2 20049 5.25 A0A0J9YXX1 Uncharacterized protein (fragment) 12773 8.62 K7ERI9 Apolipoprotein C-I (fragment) 8647 6.13 C9JEE0 Immunoglobulin lambda-like polypeptide 1 (fragment) 19227...”

TM7S3_MOUSE / Q9CRG1 Transmembrane 7 superfamily member 3; NARP1 from Mus musculus (Mouse) (see 2 papers)
Aligns to 291:498 / 565 (36.8%), covers 100.0% of PF13886, 135.9 bits

• function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
• SWATH-Based Comprehensive Determination of the Localization of Apical and Basolateral Membrane Proteins Using Mouse Liver as a Model Tissue.
  Hirano, Biomedicines 2022
  • “...Q8BH24 0.578 0.002 Potentially Abcg8 Q9DBM0 0.520 0.007 Yes Eno1 P17182 0.684 0.003 Yes Tm7sf3 Q9CRG1 0.662 0.012 Yes Slc2a8 Q9JIF3 0.524 0.017 Yes Lnpep Q8C129 0.690 0.005 Yes Slc46a1 Q6PEM8 0.530 0.005 Yes Park7 Q99LX0 0.702 0.006 Yes Abcb6 Q9DC29 0.532 0.001 Yes Pi4k2b Q8CBQ5...”

NP_080557 transmembrane 7 superfamily member 3 precursor from Mus musculus
Aligns to 291:498 / 565 (36.8%), covers 100.0% of PF13886, 135.8 bits

• The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
  Wu, Parasites & vectors 2021
  • GeneRIF: The NF-kappaB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
• An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
  Beck, Diabetologia 2011 (PubMed)
  • GeneRIF: Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.

XP_005253448 transmembrane 7 superfamily member 3 isoform X3 from Homo sapiens
2 alignments in 296:452 / 519 (30.3%), covering up to 45.8% of PF13886, 99.4 bits

• TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.
  Isaac, Cell death and differentiation 2017
  • GeneRIF: Lack of TM7SF3 activates nitric oxide production and the PKR-like ER kinase arm of the unfolded protein response that involves inhibition of eIF2alpha activity, enhanced expression of ATF4 and ATF3, and induction of CHOP that culminates in apoptosis.
• An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
  Beck, Diabetologia 2011 (PubMed)
  • GeneRIF: Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.
• A large-scale candidate gene association study of age at menarche and age at natural menopause.
  He, Human genetics 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)

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