Family Search for PF13886 (TM7S3_TM198)
PF13886 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
TM198_XENTR / Q6DFQ7 Transmembrane protein 198 from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 38:232 / 342 (57.0%), covers 100.0% of PF13886, 165.3 bits
- function: Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.
subunit: Interacts with lrp6. Interacts with casein kinases.
disruption phenotype: Morphants have defects in neural crest formation. At the tadpole stage, animals are often less pigmented with ventrally bent tails. Embryos develop smaller eyes and forebrain structures.
XP_012812209 transmembrane protein 198 isoform X1 from Xenopus tropicalis
Aligns to 50:244 / 354 (55.1%), covers 100.0% of PF13886, 165.2 bits
TM198_HUMAN / Q66K66 Transmembrane protein 198 from Homo sapiens (Human) (see paper)
NP_001290027 transmembrane protein 198 from Homo sapiens
Aligns to 42:236 / 360 (54.2%), covers 100.0% of PF13886, 156.1 bits
- function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
subunit: Interacts with LRP6. - Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.
Liang, Molecular and cellular biology 2011 - GeneRIF: these results identified TMEM198 as a membrane scaffold protein that promotes LRP6 phosphorylation and Wnt signaling activation.
- Novel predictive biomarkers for atonic postpartum hemorrhage as explored by proteomics and metabolomics.
Qu, BMC pregnancy and childbirth 2025 - “...group Uniprot ID Protein name Gene name PPH vs. non-PPH P value Difference multiple Regulation Q66K66 Transmembrane protein 198 TMEM198 0.005 2.080 Up P25398 40S ribosomal protein S12 RPS12 0.023 2.037 Up Q9NZK5 Adenosine deaminase 2 ADA2 0.030 0.118 Down P01889 HLA class I histocompatibility antigen,...”
- A multi-omics study to monitor senescence-associated secretory phenotypes of Alzheimer's disease
Yang, Annals of clinical and translational neurology 2024 - “...0.46 0.09761194 Nucleus, Cytoplasm 25 P68871 Hemoglobin subunit beta HBB 0.444 0.080222037 Blood microparticle 26 Q66K66 Transmembrane protein 198 TMEM198 0.421 0.05588057 Membrane 27 P69905 Hemoglobin subunit alpha HBA1; HBA2 0.365 0.018902331 Blood microparticle 28 Q9Y623 Myosin4 MYH4 0.333 0.008978847 Cytoplasm 1 The subcellular location information...”
- Apolipoproteins have a major role in cellular tumor dormancy in triple negative breast cancer: In-silico study.
El-Gammal, Scientific reports 2024 - “...A1BG P04217 AF-P04217-F1 Clusterin CLUS P10909 AF-P10909-F1 Lumican LUM P51884 AF-P51884-F1 Transmembrane protein 198 TM198 Q66K66 AF-Q66K66-F1 Elongin-A2 ELOA2 Q8IYF1 AF-Q8IYF1-F1 Preparation of selected proteins Domain coverage, lack of mutations and gaps, resolution less than 3, and the experimental method of x-ray diffraction determine the best...”
- Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson's Disease.
Hwang, International journal of molecular sciences 2024 - “...LV147 P01700 Increased LC-MS/MS [ 89 ] KLKB1 P03952 Increased LC-MS/MS [ 89 ] TM198 Q66K66 Increased LC-MS/MS [ 89 ] CBPB2 Q96IY4 Increased LC-MS/MS [ 89 ] RET4 P02753 Increased LC-MS/MS [ 89 ] LSAMP Q13449 Increased MRM-LC-MS/MS [ 112 ] APOH P02749 Increased MRM-LC-MS/MS...”
- Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson's Disease.
Kim, International journal of molecular sciences 2024 - “...89 ] TGFB1 P01137 Increased Meta-analysis (ELISA) TGON2 O43493 Decreased LC-MS/MS [ 114 ] TM198 Q66K66 Increased LC-MS/MS [ 110 ] TNFA P01375 Increased Meta-analysis [ 89 ] TTHY P02766 Decreased LC-MS/MS [ 26 ] VEGFA P15692 Decreased Systematic review [ 89 ] VGF O15240 Decreased...”
- Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases
Jang, Biomaterials research 2023 - “...HUMAN SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 Y N Cluster 3 Q66K66 HUMAN TMEM198 Transmembrane protein 198 N Y Cluster 1 P24821 HUMAN TNC Tenascin Y N Cluster 3 Q86YW5 HUMAN TREML1 Trem-like transcript 1 protein N Y Cluster 3 Discussion Exosomes...”
- Differential Expression of Serum Proteins in Chronic Obstructive Pulmonary Disease Assessed Using Label-Free Proteomics and Bioinformatics Analyses.
Li, International journal of chronic obstructive pulmonary disease 2022 - “...Stanniocalcin-2 0.33 DOWN P02768 ALB Albumin 0.32 DOWN Q9BWX5 GATA5 Transcription factor GATA-5 0.29 DOWN Q66K66 TMEM198 Transmembrane protein 198 0.27 DOWN Q9HCB6 SPON1 Spondin-1 0.26 DOWN Q07075 ENPEP Glutamyl aminopeptidase 0.24 DOWN Q5D862 FLG2 Filaggrin-2 0.23 DOWN P19440 GGT1 Glutathione hydrolase 1 proenzyme 0.22 DOWN...”
- “...Number Protein-Coding Gene Name Protein Description FC UP P49913 CAMP Cathelicidin antimicrobial peptide 10.07 UP Q66K66 TMEM198 Transmembrane protein 198 9.27 UP P13611 VCAN Versican core protein 7.61 UP Q96EE4 CCDC126 Coiled-coil domain-containing protein 126 7.46 UP P08238 HSP90AB1 Heat shock protein HSP 90-beta 6.20 UP...”
- Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
Birkelund, Clinical proteomics 2020 - “...Q13790 Apolipoprotein F APOF 0.4627 3.02E03 Q96RL7 Vacuolar protein sorting-associated protein 13A VPS13A 0.5619 1.23E02 Q66K66 Transmembrane protein 198 TMEM198 0.5646 2.27E02 Correlation of proteins found changed/increased by proteomic in SF to regulatory pathways To identify underlying biological themes and pathways of the correlating proteins, a...”
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TM7S3_HUMAN / Q9NS93 Transmembrane 7 superfamily member 3; Seven span transmembrane protein from Homo sapiens (Human) (see 3 papers)
Aligns to 298:503 / 570 (36.1%), covers 99.5% of PF13886, 143.7 bits
- function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
C9JXI5 Transmembrane protein 198 (Fragment) from Homo sapiens
Aligns to 42:227 / 227 (81.9%), covers 95.5% of PF13886, 143.4 bits
- Proteomics investigation of the changes in serum proteins after high- and low-flux hemodialysis.
Han, Renal failure 2018 - “...A0A0B4J1X8 Immunoglobulin heavy variable 343 13077 5.18 Decreased P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial 164939 5.92 C9JXI5 Transmembrane protein 198 (fragment) 24329 NS K7ER74 Protein APOC4-APOC2 20049 5.25 A0A0J9YXX1 Uncharacterized protein (fragment) 12773 8.62 K7ERI9 Apolipoprotein C-I (fragment) 8647 6.13 C9JEE0 Immunoglobulin lambda-like polypeptide 1 (fragment) 19227...”
NP_080557 transmembrane 7 superfamily member 3 precursor from Mus musculus
Aligns to 293:498 / 565 (36.5%), covers 99.5% of PF13886, 135.5 bits
TM7S3_MOUSE / Q9CRG1 Transmembrane 7 superfamily member 3; NARP1 from Mus musculus (Mouse) (see 2 papers)
Aligns to 293:498 / 565 (36.5%), covers 99.5% of PF13886, 135.4 bits
- function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
- SWATH-Based Comprehensive Determination of the Localization of Apical and Basolateral Membrane Proteins Using Mouse Liver as a Model Tissue.
Hirano, Biomedicines 2022 - “...Q8BH24 0.578 0.002 Potentially Abcg8 Q9DBM0 0.520 0.007 Yes Eno1 P17182 0.684 0.003 Yes Tm7sf3 Q9CRG1 0.662 0.012 Yes Slc2a8 Q9JIF3 0.524 0.017 Yes Lnpep Q8C129 0.690 0.005 Yes Slc46a1 Q6PEM8 0.530 0.005 Yes Park7 Q99LX0 0.702 0.006 Yes Abcb6 Q9DC29 0.532 0.001 Yes Pi4k2b Q8CBQ5...”
XP_005253448 transmembrane 7 superfamily member 3 isoform X3 from Homo sapiens
2 alignments in 298:452 / 519 (29.9%), covering up to 46.2% of PF13886, 98.7 bits
- TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
Isaac, Cell metabolism 2024 - GeneRIF: TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
- TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.
Isaac, Cell death and differentiation 2017 - GeneRIF: Lack of TM7SF3 activates nitric oxide production and the PKR-like ER kinase arm of the unfolded protein response that involves inhibition of eIF2alpha activity, enhanced expression of ATF4 and ATF3, and induction of CHOP that culminates in apoptosis.
- An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
Beck, Diabetologia 2011 (PubMed)- GeneRIF: Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.
- A large-scale candidate gene association study of age at menarche and age at natural menopause.
He, Human genetics 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
Or search for genetic data about PF13886 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory