Family Search for PF13910 (DUF4209)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13910 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

EMARD_HUMAN / Q5T6L9 Endoplasmic reticulum membrane-associated RNA degradation protein; ER membrane-associated RNA degradation protein from Homo sapiens (Human) (see paper)
Aligns to 133:214 / 678 (12.1%), covers 98.9% of PF13910, 106.2 bits

• function: May play a role in neuronal migration during embryonic development.

EMARD_RAT / Q3B8R1 Endoplasmic reticulum membrane-associated RNA degradation protein; ER membrane-associated RNA degradation protein from Rattus norvegicus (Rat) (see paper)
Aligns to 133:214 / 678 (12.1%), covers 98.9% of PF13910, 97.6 bits

• function: May play a role in neuronal migration during embryonic development.
  disruption phenotype: RNAi-mediated knockdown of the protein, performed in utero by electroporation in lateral ventricle of 15 dpc embryos, results in a massive neuronal migration defect and in the development of heterotopic nodules along the walls of the lateral ventricles. At 20 dpc, a significant arrest of cells within the ventricular zone is observed, while, at this stage in control embryos, cells have reached the cortical plate.

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