Family Search for PF14713 (DUF4464)

PF14713 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CF299_MOUSE / Q810M1 Cilia- and flagella-associated protein 299 from Mus musculus (Mouse) (see paper)
Aligns to 12:232 / 233 (94.8%), covers 99.6% of PF14713, 311.1 bits

• function: May be involved in spermatogenesis.

CG14013 uncharacterized protein from Drosophila melanogaster
Aligns to 10:240 / 241 (95.9%), covers 99.6% of PF14713, 276.9 bits

• A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
  Dobbelaere, The EMBO journal 2023
  • “...this figure. Unique role for CFAP299 in ciliary membrane deposition and ciliogenesis CG8138/CFAP299 along with CG14013, CG14017, and CG3528 is one of four Drosophila orthologs of vertebrate C4orf22/CFAP299 (Fig 6A ), a largely uncharacterized protein reported to be testisenriched and tentatively linked to spermatogenesis (Li etal...”
  • “...aberrant axonemes lacking ninefold symmetry (Fig 6B ). CG8138 shares extensive homology with its paralogs CG14013, CG14017, and CG3528, also putatively expressed in neurons and sperm, raising the possibility of functional redundancy. Consistent with this, weaker phenotypes were also observed for CG14013 and CG3528 (see Dataset...”
• A Phylogenetic Profiling Approach Identifies Novel Ciliogenesis Genes InDrosophilaAndC. elegans
  Dobbelaere, 2022

CG3528 uncharacterized protein from Drosophila melanogaster
Aligns to 1:234 / 235 (99.6%), covers 99.1% of PF14713, 271.1 bits

• A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
  Dobbelaere, The EMBO journal 2023
  • “...role for CFAP299 in ciliary membrane deposition and ciliogenesis CG8138/CFAP299 along with CG14013, CG14017, and CG3528 is one of four Drosophila orthologs of vertebrate C4orf22/CFAP299 (Fig 6A ), a largely uncharacterized protein reported to be testisenriched and tentatively linked to spermatogenesis (Li etal , 2019a ),...”
  • “...ninefold symmetry (Fig 6B ). CG8138 shares extensive homology with its paralogs CG14013, CG14017, and CG3528, also putatively expressed in neurons and sperm, raising the possibility of functional redundancy. Consistent with this, weaker phenotypes were also observed for CG14013 and CG3528 (see Dataset EV3 A). How...”
• A Phylogenetic Profiling Approach Identifies Novel Ciliogenesis Genes InDrosophilaAndC. elegans
  Dobbelaere, 2022
• Small Maf functions in the maintenance of germline stem cells in the Drosophila testis
  Tan, Redox biology 2018
  • “...LATS2 1.51 0.02603 18145258 CG33307 N/A 5.99 0.0268 18188101 sosie; CR45216 N/A 1.53 0.016607 18141312 CG3528 C4orf22 5.62 0.004053 18171734 CG33217 PELP1 1.54 0.023726 18162277 CG2736 SCARB2 5.57 0.006617 18188937 CG11897 ABCC4 1.54 0.045327 18138530 CG43402 N/A 4.75 0.010525 18162274 Phk-3 N/A 1.55 0.033 18156218 gsb-n...”
• Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci
  Talsma, Molecular brain 2014
  • “...Galectin Galactoside binding [ 45 ] CJ10 Suppressor ** 21A1-21B1 Galectin CJ5 Suppressor *** 22F4-22F4 CG3528 Unknown DTS1 Enhancer * 22F4-22F4 CG3528 CJ10 Suppressor * 22F4-22F4 CG3528 CJ5 Suppressor * 27E-28B1 Ndae1 Na+driven anion exchanger [ 47 ] CJ5 Enhancer * 29B4-29E4 Glt Cell surface glycoprotein...”

TTHERM_00427460 flagellar/basal body protein, putative from Tetrahymena thermophila SB210
Aligns to 13:241 / 242 (94.6%), covers 99.6% of PF14713, 266.9 bits

• Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link
  Bazan, PLoS genetics 2021
  • “...37/26 Cfap251 TTHERM_01262850 39/14 25/13 36/16 56/26 32/17 15/9 27/15 32/21 29/19 32/21 17/11 Cfap299 TTHERM_00427460 22/7 2/2 13/5 0 4/3 4/2 0 6/4 0 6/4 3/3 Table shows the numbers (X/Y) of all the identified peptides (X, in a Mascot program, all significant matches) and...”

CG8138 uncharacterized protein from Drosophila melanogaster
Aligns to 4:232 / 233 (98.3%), covers 99.6% of PF14713, 266.8 bits

• A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
  Dobbelaere, The EMBO journal 2023
  • “...in Drosophila with distinct tissue expression patterns. Characterized here is the most closely related ortholog, CG8138, hereafter CFAP299. Accession numbers: HsCFAP97 (NP_065878.1); DrCFAP97 (NP_997943.1); CrFAP97 (XP_042919651.1); DmCFAP97/Hemingway (NP_650714.1); HsCFAP97D1 (NP_001129955.1); HsCFAP97D2 (XP_016876399.1); DrCFAP97D1 (XP_697280.2); DrCFAP97D2 (XP_005167838.1); DmCFAP97D1/CG14551 (NP_651462.1); HsCFAP299 (XP_047305931.1); DrCFAP299 (NP_001108596.1); CrFAP299 (XP_001697404.2); DmCFAP299/CG8138 (NP_650260.1);...”
  • “...the Human Protein Atlas also expressed in other ciliated tissues including the lung and oviduct. CG8138 initially presented with a strong phenotype in male fertility in the primary and secondary screen. Ultrastructural analysis of both RNAidepleted and mutant animals revealed what to our knowledge is a...”
• A Phylogenetic Profiling Approach Identifies Novel Ciliogenesis Genes InDrosophilaAndC. elegans
  Dobbelaere, 2022
• Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila
  Ma, Genetics 2012
  • “...Df(3R)Exel6167 (CG8476, CG8483, CG14380, CG8508, CG8141, CG8138, CG42573, CG34308, timeout, pic, sim) Df(3R)Exel6211 (Pkc98E, Slu7, Cpsf100, beta4GalNAcTB,...”

GL50803_21110 hypothetical protein from Giardia intestinalis
Aligns to 11:232 / 233 (95.3%), covers 99.1% of PF14713, 264.9 bits

• Microtubule organelles in Giardia
  Hagen, Advances in parasitology 2020
  • “...None X GFP Dawsonlab (GiardiaDB) GL50803_9427 Conserved hypothetical protein None None X GFP Dawsonlab (GiardiaDB) GL50803_21110 dpy-30 domain protein dpy-30 domain protein PF05186 X X X GFP Dawsonlab (GiardiaDB) GL50803_4538 dpy-30 domain protein dpy-30 domain protein PF05186 X Plasma membrane GFP Dawsonlab (GiardiaDB) GL50803_3582 DUF390 domain...”

CG14017 uncharacterized protein from Drosophila melanogaster
Aligns to 18:237 / 238 (92.4%), covers 97.4% of PF14713, 229.1 bits

• Versatile Endogenous Editing of GluRIIA in Drosophila melanogaster
  Beckers, Cells 2024
  • “...and affect a region larger than the GluRIIA locus [ 8 ]. For example, the CG14017 and Oscillin genes are deleted in the SP16 null mutant ( Figure 1 A). Here, we chose a previously described CRISPR/Cas9-based editing approach [ 18 ] to enable the precise...”
• A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
  Dobbelaere, The EMBO journal 2023
  • “...figure. Unique role for CFAP299 in ciliary membrane deposition and ciliogenesis CG8138/CFAP299 along with CG14013, CG14017, and CG3528 is one of four Drosophila orthologs of vertebrate C4orf22/CFAP299 (Fig 6A ), a largely uncharacterized protein reported to be testisenriched and tentatively linked to spermatogenesis (Li etal ,...”
  • “...axonemes lacking ninefold symmetry (Fig 6B ). CG8138 shares extensive homology with its paralogs CG14013, CG14017, and CG3528, also putatively expressed in neurons and sperm, raising the possibility of functional redundancy. Consistent with this, weaker phenotypes were also observed for CG14013 and CG3528 (see Dataset EV3...”
• A Phylogenetic Profiling Approach Identifies Novel Ciliogenesis Genes InDrosophilaAndC. elegans
  Dobbelaere, 2022

9fgpA / Q6V702 Cilia and flagella associated protein 299
Aligns to 1:140 / 140 (100.0%), covers 63.5% of PF14713, 205.1 bits

• Ligand: zinc ion (9fgpA)

PBANKA_083240 conserved protein, unknown function from Plasmodium berghei ANKA
Aligns to 6:214 / 250 (83.6%), covers 89.6% of PF14713, 105.4 bits

• Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor
  Kaneko, PLoS pathogens 2015
  • “...putative PBANKA_082100 0.269 Yes* chaperone protein, putative PBANKA_133660 0.271 Yes conserved Plasmodium protein, unknown function PBANKA_083240 0.276 Yes conserved Plasmodium protein, unknown function PBANKA_113810 0.281 Yes 14-3-3 protein, putative PBANKA_090980 0.284 Yes* conserved Plasmodium protein, unknown function PBANKA_145080 0.324 Yes conserved Plasmodium protein, unknown function PBANKA_071830...”

XP_016863465 cilia- and flagella-associated protein 299 isoform X3 from Homo sapiens
Aligns to 30:130 / 170 (59.4%), covers 43.5% of PF14713, 104.7 bits

• Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
  Uhl, Archives of general psychiatry 2008
  • GeneRIF: Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

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