Family Search for PF14739 (DUF4472)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF14739 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CCD78_XENLA / Q66KE8 Coiled-coil domain-containing protein 78; xCCDC78 from Xenopus laevis (African clawed frog) (see paper)
Aligns to 60:166 / 559 (19.1%), covers 100.0% of PF14739, 121.6 bits

• function: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for cep152 localization to the deuterosome.

I7LVY1 Kinesin motor catalytic domain protein from Tetrahymena thermophila (strain SB210)
Aligns to 448:554 / 1066 (10.0%), covers 100.0% of PF14739, 116.3 bits

• Molecular architecture of the ciliary tip revealed by cryo-electron tomography.
  Legal, bioRxiv : the preprint server for biology 2023
  • “...fourfold reduction in FAP256A/B-KO cilia ( Table S3 ). These proteins include a predicted kinesin (I7LVY1) that is likely to bind the CP microtubules in the cap complex. Based on these results, we believe these proteins are therefore likely to be part of the ciliary cap...”

CCD78_HUMAN / A2IDD5 Coiled-coil domain-containing protein 78; hsCCDC78 from Homo sapiens (Human) (see 2 papers)
Aligns to 54:165 / 438 (25.6%), covers 98.1% of PF14739, 100.9 bits

• function: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.
• Blood Plasma Circulating DNA-Protein Complexes: Involvement in Carcinogenesis and Prospects for Liquid Biopsy of Breast Cancer.
  Shefer, Journal of personalized medicine 2023
  • “...receptor ADRB1 60 + Q6Y288 Beta-1,3-glucosyltransferase B3GALTL 94 Q03060 cAMP-responsive element modulator CREM 56 + A2IDD5 Coiled-coil domain-containing protein 78 CCD78 70 Q7Z7J5 Developmental pluripotency-associated protein 2 DPPA2 71 A8MZ26 EF-hand calcium-binding domain-containing protein 9 EFCAB9 65 + Q9BY07 Electrogenic sodium bicarbonate cotransporter 4 SLC4A5 78...”
• The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles.
  do, Biochimica et biophysica acta. Molecular cell research 2022
  • “...0.87 45 Q8IX12 Cell division cycle and apoptosis regulator protein 1 70.35 0.7 2.09 46 A2IDD5 Coiled-coil domain-containing protein 78 70.09 0.3 1.47 47 Q9UGF2 C-Jun-amino-terminal kinase-interacting protein 1 69.90 0.8 2.75 48 O60583 Cyclin-T2 69.04 0.5 1.49 49 O15055 Period circadian protein homolog 2 68.37...”

XP_016878418 coiled-coil domain-containing protein 78 isoform X7 from Homo sapiens
2 alignments in 128:310 / 611 (20.0%), covering up to 66.4% of PF14739, 72.7 bits

• Dominant mutation of CCDC78 in a unique congenital myopathy with prominent internal nuclei and atypical cores.
  Majczenko, American journal of human genetics 2012
  • GeneRIF: Dominant mutation of CCDC78 in a unique congenital myopathy with prominent internal nuclei and atypical cores.
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila, Genes and immunity 2010 (PubMed)
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)

Or search for genetic data about PF14739 in the Fitness Browser