Family Search for PF14780 (NEPRO_N)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF14780 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NEPRO_MOUSE / Q8R2U2 Nucleolus and neural progenitor protein; Neural progenitor protein from Mus musculus (Mouse) (see 2 papers)
NP_666084 nucleolus and neural progenitor protein isoform 1 from Mus musculus
Aligns to 12:202 / 564 (33.9%), covers 99.5% of PF14780, 207.3 bits

• function: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors (PubMed:19906856). May also play a role in preimplentation embryo development (PubMed:26178919).
  disruption phenotype: Knockout embryos die before preimplantation.
• Nepro is localized in the nucleolus and essential for preimplantation development in mice.
  Hashimoto, Development, growth & differentiation 2015 (PubMed)
  • GeneRIF: The Nepro is a nucleolus-associated protein, and its loss leads to the apoptosis before blastocyst formation in mice.

CG14174 uncharacterized protein from Drosophila melanogaster
Aligns to 7:191 / 347 (53.3%), covers 99.5% of PF14780, 205.5 bits

• Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster
  Sun, Scientific reports 2024
  • “...GL00570 STERILE 76, 1 NDJ Lethal CG13773 Polr1F TWISTNB Twistnb HMC05572 STERILE 167, 0 NDJ CG14174 CG14174 NEPRO Nepro HMJ30042 STERILE STERILE MVD1, Mat Lethal CG14230 CG14230 NOL8 Nol8 GLC01782 257, 1 NDJ STERILE Mat Lethal CG14303 qin TDRD5 Tdrd5 GL01398 52, 0 NDJ 468, 0...”
  • “...produced no mature oocytes with mat . This phenotype with mat , such as CG3430, CG14174, CG16838, CG33217, and CG6540 , suggests a role in growth of the oocyte during the meiotic prophase arrest. We also identified several genes with a reduced fertility phenotype. This could...”
• A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila
  Gao, Proceedings of the National Academy of Sciences of the United States of America 2008 (secret)

NEPRO_HUMAN / Q6NW34 Nucleolus and neural progenitor protein from Homo sapiens (Human) (see 3 papers)
Aligns to 12:202 / 567 (33.7%), covers 100.0% of PF14780, 192.9 bits

• function: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.
• Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.
  Greenwood, Cell reports 2019
  • “...CWC25 yes yes yes Q86Y91 KIF18B yes yes yes yes Q6P4F7 ARHGAP11A yes yes yes Q6NW34 NEPRO yes yes yes Q9BVJ6 UTP14A yes yes yes Q9NVN8 GNL3L yes yes yes yes Q5QJE6 DNTTIP2 yes yes yes Q69YH5 CDCA2 yes yes yes Q96BK5 PINX1 yes yes yes...”
  • “...ZNF512B yes 3 4/4 0/1 2/2 1/1 Q9Y4B6 DCAF1 yes 3 4/4 0/1 2/2 1/1 Q6NW34 NEPRO yes 3 4/4 1/1 2/2 0/1 Q8N3Z6 ZCCHC7 3 3/4 0/1 1/2 1/1 Q8NDF8 PAPD5 3 2/4 0/1 1/2 1/1 Q8TF76 HASPIN yes 2 4/4 0/1 0/2 1/1 Q9NXE8...”
• Semantic Analysis of Posttranslational Modification of Proteins Accumulated in Thyroid Cancer Cells Exposed to Simulated Microgravity.
  Bauer, International journal of molecular sciences 2018
  • “...Zinc finger FYVE domain-containing protein 26 (Q68DK2) 0 0.22 0.05 0.16 C3orf17 Uncharacterized protein C3orf17 (Q6NW34) 0 1.01 0.05 0.25 FASTKD5 FAST kinase domain-containing protein 5 (Q7L8L6) 0 1.02 0 0.46 HS2ST1 Heparan sulfate 2- O -sulfotransferase 1 (Q7LGA3) 0 3.13 0 0.37 SZRD1 SUZ domain-containing...”

AT1G50910 hypothetical protein from Arabidopsis thaliana
Aligns to 2:167 / 500 (33.2%), covers 83.2% of PF14780, 49.6 bits

• Differential Alternative Splicing Genes and Isoform Regulation Networks of Rapeseed (Brassica napus L.) Infected with Sclerotinia sclerotiorum
  Ma, Genes 2020
  • “...II degradation factor-like protein (DUF1296) BnaA06n0344 AT1G48840 50.79 Plant protein of unknown function (DUF639) BnaC06g04140D AT1G50910 79.28 Hypothetical protein BnaA02g12910D AT1G67170 69.08 Sarcolemmal membrane-associated protein BnaA07g24840D AT1G68010 T23K23.14 96.90 Hydroxypyruvate reductase BnaCnng00710D AT2G04560 82.68 Transferases BnaCnng63360D AT2G19480 F3P11.8 84.7 Nucleosome assembly protein 1;2 BnaC04g33610D AT2G21270 80.73...”
• GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essential for female gametogenesis and male competence in Arabidopsis
  Wang, PloS one 2012
  • “...the RNases P/MRP complexes were found: At2G47300 (AtPOP1), At2G43190 (AtPOP4), AT1G04635 (AtPOP5), At5G41270 (AtRPR2), and At1G50910 (AtRMP1). In Arabidopsis , none of the homologues has been studied. To investigate whether these homologues have similar interaction in Arabidopsis as in yeast and human, we checked the protein-protein...”

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