Family Search for PF14916 (CCDC92)

PF14916 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CCD92_HUMAN / Q53HC0 Coiled-coil domain-containing protein 92; Limkain beta-2 from Homo sapiens (Human) (see 3 papers)
Aligns to 24:80 / 331 (17.2%), covers 96.5% of PF14916, 84.3 bits

• function: Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface.
  subunit: Interacts with CEP164.
  subunit: (Microbial infection) Interacts with ebolavirus protein NP; this interaction sequesters NP in the cytoplasm.
• Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
  Cheng, Frontiers in oncology 2021
  • “...Q86X45 Protein tilB homolog LRRC6 2.50 0.04 A7KAX9 Rho GTPase-activating protein 32 ARHGAP32 2.33 0.01 Q53HC0 Coiled-coil domain-containing protein 92 CCDC92 2.29 0.02 Q9UBU7 Protein DBF4 homolog A DBF4 2.26 0.03 Q8IZ40 REST corepressor 2 RCOR2 2.25 0.00 Q8WWT9 Solute carrier family 13 member 3 SLC13A3...”
• Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2.
  Bernatik, Molecular biology of the cell 2020
  • “...and S5), protein identifiers used are as follows: CEP164 (Q9UPV0), CEP83 (Q9Y592), CEP89 (Q96ST8), CCDC92 (Q53HC0), Rabin8 (Q96QF0), DVL3 (Q92997), TTBK2 (Q6IQ55), MPP9 (Q99550), KIF2a (O00139), Tau (P10636), and CEP97 (Q8IW35). Prediction of protein disorder was performed by PONDR ( http://www.pondr.com/ ) algorithms VSL-2 ( Peng...”

NP_001291890 coiled-coil domain-containing protein 92 isoform 2 from Homo sapiens
Aligns to 7:63 / 314 (18.2%), covers 96.5% of PF14916, 84.3 bits

• Association between single nucleotide polymorphism rs11057401 of CCDC92 gene and the risk of coronary heart disease (CHD).
  Xiao, Lipids in health and disease 2018
  • GeneRIF: The genotypic and allelic frequencies of the rs11057401 SNP of CCDC92 gene were significantly different between the patients with coronary heart disease and controls.
• The Genetic Link Between Diabetes and Atherosclerosis.
  Ross, The Canadian journal of cardiology 2018 (PubMed)
  • GeneRIF: Novel genetic variants of CCDC92 were associated with both Diabetes and Coronary Artery Disease .
• Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
  Lotta, Nature genetics 2017
  • GeneRIF: Mutation in CCDC92 gene is associated with insulin-resistant cardiometabolic disease.
• Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
  Klarin, Nature genetics 2017
  • GeneRIF: Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.
• Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
  Chasman, PLoS genetics 2009
  • GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

Q96AQ1 Coiled-coil domain-containing protein 74A from Homo sapiens
Aligns to 47:102 / 378 (14.8%), covers 87.7% of PF14916, 68.2 bits

• Biological pathways modulated by antipsychotics in the blood plasma of schizophrenia patients and their association to a clinical response.
  Martins-de-Souza, NPJ schizophrenia 2015
  • “...26 49,759 32.45 Up 4.607 2 Coiled-coil domain-containing protein 71 Unknown Unclassified Molecular function unknown Q96AQ1 CC74A_HUMAN CCDC74A 31 41,808 12.33 Up 1.079 2 Coiled-coil domain-containing protein 74A Unknown Unclassified Molecular function unknown Q6IPU0 CENPP_HUMAN CENPP 38 33,429 20.20 Up 1.001 2 Centromere protein P Unknown...”

S7P578 Clustered mitochondria protein homolog from Myotis brandtii
Aligns to 7:63 / 1381 (4.1%), covers 94.7% of PF14916, 67.7 bits

• Deciphering the evolution of composite-type GSKIP in mitochondria and Wnt signaling pathways
  Tsai, PloS one 2022
  • “...[ Lingula anatina (XP_013383658.1)], and seven Chordata [ Branchiostoma lanceolatum (XP_002595966.1), Myotis brandtii (Brandts bat, S7P578), Danio rerio (E7FE02), Gallus gallus (XP_015151355.1), Mus musculus (NP_001074627.1), Rattus norvegicus (NP_001292142.1), and Homo sapiens (NP_056044.3)]. Additionally, ClustalW was combined with the T-Coffee web-based program and MEGA-X to ensure a...”

Q96LY2 Coiled-coil domain-containing protein 74B from Homo sapiens
Aligns to 47:102 / 380 (14.7%), covers 87.7% of PF14916, 66.9 bits

• Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NFκB, and Hypoxia).
  Tang, Evidence-based complementary and alternative medicine : eCAM 2013
  • “...1.22 1.32 18 P04083 Annexin A1 1.52 1.54 1.42 1.43 1.64 1.43 1.43 1.43 19 Q96LY2 Coiled-coil domain-containing protein 74B 1.47 1.34 1.47 1.46 1.33 1.33 1.36 1.57 20 P31943 Heterogeneous nuclear ribonucleoprotein H 1.47 1.33 1.35 1.21 1.44 1.56 1.43 1.53 21 P09211 Glutathione S-transferase...”

NP_001245236 coiled-coil domain-containing protein 74B isoform 2 from Homo sapiens
Aligns to 47:103 / 314 (18.2%), covers 87.7% of PF14916, 64.9 bits

• CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.
  Zhou, BMC biology 2019
  • GeneRIF: The authors characterized CCDC74A and CCDC74B as microtubule-associated proteins that localize to spindles and are important K-fiber crosslinkers required for bipolar spindle formation and chromosome alignment.

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