Family Search for PF14951 (DUF4503)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF14951 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

SPIDR_HUMAN / Q14159 DNA repair-scaffolding protein; Scaffolding protein involved in DNA repair from Homo sapiens (Human) (see 6 papers)
Aligns to 521:906 / 915 (42.2%), covers 99.7% of PF14951, 662.4 bits

• function: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.
  subunit: Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts (via C-terminal region) with BLM; the interaction is direct. Interacts with RAD51; the interaction is direct. Interacts (via the C-terminal region) with FIGNL1 (via N-terminal one-half region); the interaction is direct.

Or search for genetic data about PF14951 in the Fitness Browser