Family Search for PF14988 (DUF4515)

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PF14988 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BBOF1_MOUSE / Q3V079 Basal body-orientation factor 1; Coiled-coil domain-containing protein 176 from Mus musculus (Mouse) (see paper)
Aligns to 83:276 / 533 (36.4%), covers 100.0% of PF14988, 161.0 bits

• function: Plays an essential role in sperm motility and male fertility by stabilizing the sperm flagellar axonemal structure. May be required for the stability of ODF2 and MANS1 proteins. Dispensable for the assembly and function of motile cilia.
  subunit: Interacts with MNS1 and ODF2.
  disruption phenotype: Mice show reduced sperm motility and male subfertility without obvious sperm morphological defects. Abnormalities in sperm flagellar axoneme seen, with an absence of one to three microtubule doublets in the principal piece and end piece of the sperm flagellum. Motile cilia are normally distributed on the epithelial cells of the trachea and the axonemal structure of cilia is intact.
• Liver proteome of mice with different genetic susceptibilities to the effects of fluoride
  Khan, Journal of applied oral science : revista FOB 2016
  • “...+ - Q8R1G2 Cmbl Carboxymethylenebutenolidasehomolog 73.2 + - Q61686 Cbx5 Chromoboxproteinhomolog 5 96.9 + - Q3V079 Ccdc176 Coiled-coil domain-containing protein 176 66.5 + - P50172 Hsd11b1 Corticosteroid 11-beta-dehydrogenase isozyme 1 100.4 + - Cth Q8VCN5 Cystathioninegamma-lyase 100.5 - + P48771 Cox7a2 Cytochrome c oxidase subunit 7A2,...”

XP_030102806 basal body-orientation factor 1 isoform X1 from Mus musculus
Aligns to 83:230 / 361 (41.0%), covers 67.0% of PF14988, 127.4 bits

• BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.
  Cao, Cellular and molecular life sciences : CMLS 2023 (PubMed)
  • GeneRIF: BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.
• CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement.
  Liu, Current biology : CB 2023 (PubMed)
  • GeneRIF: CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement.

BBOF1_XENLA / A0JMY4 Basal body-orientation factor 1; Coiled-coil domain-containing protein 176 from Xenopus laevis (African clawed frog) (see paper)
Aligns to 80:273 / 531 (36.5%), covers 98.1% of PF14988, 82.7 bits

• function: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
  disruption phenotype: Cilia in multiciliate cells are motile but fail to produce flow. Multiciliated cells are present in the normal number, cilia of normal length and of normal density. They are however misoriented.

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