Family Search for PF15021 (DUF4521)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15021 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SHLD1_HUMAN / Q8IYI0 Shieldin complex subunit 1; RINN1-REV7-interacting novel NHEJ regulator 3; Shield complex subunit 1 from Homo sapiens (Human) (see paper)
Aligns to 1:203 / 205 (99.0%), covers 100.0% of PF15021, 367.9 bits

• function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
  subunit: Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus.

XP_011527479 shieldin complex subunit 1 isoform X2 from Homo sapiens
Aligns to 14:216 / 218 (93.1%), covers 100.0% of PF15021, 367.6 bits

• Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.
  Isobe, Cell reports 2021
  • GeneRIF: Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.
• MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
  de, Nature communications 2021
  • GeneRIF: MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.

NP_001345189 shieldin complex subunit 1 from Mus musculus
Aligns to 1:204 / 206 (99.0%), covers 100.0% of PF15021, 334.9 bits

• The dystonia gene THAP1 controls DNA double-strand break repair choice.
  Shinoda, Molecular cell 2021
  • GeneRIF: The dystonia gene THAP1 controls DNA double-strand break repair choice.

XP_015329669 shieldin complex subunit 1 isoform X5 from Bos taurus
Aligns to 1:62 / 63 (98.4%), covers 28.9% of PF15021, 84.4 bits

• An OB-fold complex controls the repair pathways for DNA double-strand breaks.
  Gao, Nature communications 2018
  • GeneRIF: An OB-fold complex controls the repair pathways for DNA double-strand breaks.

Or search for genetic data about PF15021 in the Fitness Browser