Family Search for PF15091 (DUF4554)

Running HMMer for PF15091

PF15091 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TO6BL_HUMAN / Q8N6T0 Type 2 DNA topoisomerase 6 subunit B-like; TOP6B like initiator of meiotic double strand breaks; Type 2 DNA topoisomerase VI subunit B-like; TOPOVIBL from Homo sapiens (Human) (see 2 papers)
Aligns to 54:505 / 511 (88.5%), covers 100.0% of PF15091, 929.4 bits

• function: [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
  subunit: [Isoform 3]: Heterotetramer of SPO11 and 2 TOP6BL chains. Interacts with SPO11.
• Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation
  Singh, Microbiology spectrum 2023
  • “...musculus , and Homo sapiens were O05207 , Q8ID53 , A0A509AMZ8 , J3QMY9 , and Q8N6T0 , respectively. A multiple-sequence alignment was performed using ClustalV ( 25 ). The structures of PfTopoVIB and HsTopoVIBL were retrieved from the AlphaFold database ( 26 ). Structure alignment was...”
• The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna.
  Schedina, BMC genomics 2018
  • “...sequence 11 protein Q8IYF3 43 53 46 TOP6BL Type 2 DNA topoisomerase 6 subunit B-like Q8N6T0 18 43 9 trip13 Pachytene checkpoint protein 2 homolog Q15645 5 2 7 wWee2 Wee1-like protein kinase 2 Q66JT0 10 36 12 xrcc1 DNA repair protein XRCC1 Q60596 3 2...”

NP_078926 type 2 DNA topoisomerase 6 subunit B-like isoform a from Homo sapiens
Aligns to 171:622 / 628 (72.0%), covers 100.0% of PF15091, 927.2 bits

• Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities.
  Prieto, Translational psychiatry 2016
  • GeneRIF: Top association findings suggested that the bipolar disorder risk allele at SNP rs10896235 in C11orf80 may be associated with increased risk of headache, including migraine.

TO6BL_MOUSE / J3QMY9 Type 2 DNA topoisomerase 6 subunit B-like; TOP6B like initiator of meiotic double strand breaks; Type 2 DNA topoisomerase VI subunit B-like; TOPOVIBL from Mus musculus (Mouse) (see paper)
Aligns to 120:573 / 579 (78.4%), covers 100.0% of PF15091, 818.7 bits

• function: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
  subunit: Heterotetramer of SPO11 and 2 TOP6BL chains (Probable). Interacts with SPO11 (PubMed:26917764).
  disruption phenotype: Male mice develop normally and reach adulthood but have smaller testes. Spermatogonia are present at the periphery of tubules but are strongly depleted and spermatids are absent, due to defects during meiotic prophase.
• Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation
  Singh, Microbiology spectrum 2023
  • “...berghei , Mus musculus , and Homo sapiens were O05207 , Q8ID53 , A0A509AMZ8 , J3QMY9 , and Q8N6T0 , respectively. A multiple-sequence alignment was performed using ClustalV ( 25 ). The structures of PfTopoVIB and HsTopoVIBL were retrieved from the AlphaFold database ( 26 )....”

NP_001028619 type 2 DNA topoisomerase 6 subunit B-like from Mus musculus
Aligns to 120:566 / 599 (74.6%), covers 96.7% of PF15091, 794.9 bits

• TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
  Nore, Nature communications 2022
  • GeneRIF: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.

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