Family Search for PF15139 (CFAP95)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15139 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CFA95_HUMAN / Q5VTT2 Cilia- and flagella-associated protein 95 from Homo sapiens (Human) (see 2 papers)
Aligns to 28:220 / 229 (84.3%), covers 100.0% of PF15139, 318.7 bits

• function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
  subunit: Interacts with MYH9 (PubMed:28345668). Interacts with MYH10 (PubMed:28345668).
• C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells.
  Zhou, Scientific reports 2017
  • “...we chose to explore the functions of isoform 1 and its encoded protein (Swiss-Prot ID: Q5VTT2) in hESCs. C9ORF135 protein localizes to the cytoplasm and plasma membrane in hESCs C9ORF135 is not expressed in HEK293A cells. Hence, we exogenously expressed full-length C9ORF135 (isoform 1) with an...”

CFA95_BOVIN / Q32L77 Cilia- and flagella-associated protein 95 from Bos taurus (Bovine) (see paper)
Aligns to 28:221 / 232 (83.6%), covers 99.5% of PF15139, 315.4 bits

• function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
  subunit: Interacts with MYH9. Interacts with MYH10.

CFA95_MOUSE / Q9CQC3 Cilia- and flagella-associated protein 95 from Mus musculus (Mouse) (see paper)
NP_080464 cilia- and flagella-associated protein 95 from Mus musculus
Aligns to 28:219 / 228 (84.2%), covers 99.5% of PF15139, 298.6 bits

• function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
  subunit: Interacts with MYH9. Interacts with MYH10.
• Tissue expression patterns identify mouse cilia genes.
  McClintock, Physiological genomics 2008 (PubMed)
  • GeneRIF: 1700028P14Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.

XP_011516532 cilia- and flagella-associated protein 95 isoform X2 from Homo sapiens
Aligns to 28:178 / 187 (80.7%), covers 65.1% of PF15139, 180.7 bits

• A Bayesian approach to genetic association studies with family-based designs.
  Naylor, Genetic epidemiology 2010
  • GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

7ung0 / Q5VTT2 7ung0 (see paper)
Aligns to 1:44 / 52 (84.6%), covers 22.6% of PF15139, 82.9 bits

• Ligand: peptide (7ung0)

Or search for genetic data about PF15139 in the Fitness Browser