Family Search for PF15167 (DUF4581)

PF15167 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MTURN_DANRE / P0C8M4 Maturin; Maturin neural progenitor differentiation regulator protein homolog from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
NP_001138278 UPF0452 protein C7orf41 homolog from Danio rerio
Aligns to 4:133 / 133 (97.7%), covers 100.0% of PF15167, 285.2 bits

• function: May be involved in early neuronal development (By similarity). May play a role in promoting megakaryocyte differentiation (By similarity).
• Maturin is a novel protein required for differentiation during primary neurogenesis.
  Martinez-De, Developmental biology 2013
  • GeneRIF: Maturin knockdown and overexpression studies showed that it is required for primary neurogenesis and regulates neural differentiation.
  • GeneRIF: Maturin functions during primary neurogenesis and is required for the proneural pathway to regulate neural differentiation.

MTURN_XENLA / Q7ZX36 Maturin; Maturin neural progenitor differentiation regulator protein from Xenopus laevis (African clawed frog) (see paper)
NP_001079626 maturin from Xenopus laevis
NP_001007923 maturin from Xenopus tropicalis
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 278.9 bits

• function: Involved in early neuronal development; required for cell cycle exit and differentiation of primary neurons (By similarity). Cooperates synergistically with pak3 to promote primary neural differentiation within the neural plate (PubMed:24095902). May play a role in promoting megakaryocyte differentiation (By similarity).
  disruption phenotype: Morpholino knockdown of the protein causes an accumulation of neuronal progenitor cells resulting in the neural plate expansion.
• Maturin is a novel protein required for differentiation during primary neurogenesis.
  Martinez-De, Developmental biology 2013
  • GeneRIF: Maturin knockdown and overexpression studies showed that it is required for primary neurogenesis and regulates neural differentiation.
  • GeneRIF: Maturin functions during primary neurogenesis and is required for the proneural pathway to regulate neural differentiation.
• Maturin is a novel protein required for differentiation during primary neurogenesis.
  Martinez-De, Developmental biology 2013
  • GeneRIF: Maturin knockdown and overexpression studies showed that it is required for primary neurogenesis and regulates neural differentiation.

MTURN_HUMAN / Q8N3F0 Maturin; Maturin neural progenitor differentiation regulator protein homolog; Protein Ells1 from Homo sapiens (Human) (see paper)
NP_690006 maturin from Homo sapiens
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 267.0 bits

• function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity).
• C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway.
  Zhou, BioMed research international 2021
  • GeneRIF: C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling Pathway.
• PKCα/ERK/C7ORF41 axis regulates epidermal keratinocyte differentiation through the IKKα nuclear translocation.
  Yan, The Biochemical journal 2021 (PubMed)
  • GeneRIF: PKCalpha/ERK/C7ORF41 axis regulates epidermal keratinocyte differentiation through the IKKalpha nuclear translocation.
• A three-platelet mRNA set: MAX, MTURN and HLA-B as biomarker for lung cancer.
  Liu, Journal of cancer research and clinical oncology 2019 (PubMed)
  • GeneRIF: High MTURN expression is associated with lung cancer.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

MTURN_MOUSE / Q8CGA4 Maturin; Maturin neural progenitor differentiation regulator protein homolog from Mus musculus (Mouse) (see 2 papers)
NP_001276669 maturin isoform a from Mus musculus
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 263.7 bits

• function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity).
• C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway.
  Zhou, BioMed research international 2021
  • GeneRIF: C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling Pathway.
• C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD.
  Yan, The Biochemical journal 2020 (PubMed)
  • GeneRIF: C7ORF41 overexpression significantly ameliorated hepatic inflammation and lipid accumulation in palmitic acid (PA)-treated hepatocytes, whereas C7ORF41 knockdown showed the opposite effects.
• Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice.
  Zhu, Frontiers in endocrinology 2023
  • “...adapter protein 1 Ldlrap1 0.703602688 1.392901081 Q8C147 Dedicator of cytokinesis protein 8 Dock8 0.789642671 1.517773691 Q8CGA4 Maturin Mturn 0.491145 1.578948145 Q8CHH9 Septin-8 Septin8 0.686151817 1.372095604 Q8JZK9 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Hmgcs1 0.641253478 1.406928093 Q8K3K8 Optineurin Optn 0.680041902 1.365399359 Q8R238 Serine dehydratase-like Sdsl 0.70692237 1.290868637 Q8VD33 Small glutamine-rich...”

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