Family Search for PF15249 (GLTSCR1)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF15249 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
XP_030098415 BRD4-interacting chromatin-remodeling complex-associated protein isoform X4 from Mus musculus
Aligns to 1020:1121 / 1497 (6.8%), covers 98.0% of PF15249, 124.1 bits
BICRA_MOUSE / F8VPZ9 BRD4-interacting chromatin-remodeling complex-associated protein; Glioma tumor suppressor candidate region gene 1 protein from Mus musculus (Mouse) (see paper)
Aligns to 1101:1202 / 1578 (6.5%), covers 98.0% of PF15249, 124.0 bits
- function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (By similarity).
subunit: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (By similarity).
I3LLE2 BRD4 interacting chromatin remodeling complex associated protein from Sus scrofa
Aligns to 1103:1204 / 1555 (6.6%), covers 98.0% of PF15249, 123.9 bits
BICRA_HUMAN / Q9NZM4 BRD4-interacting chromatin-remodeling complex-associated protein; Glioma tumor suppressor candidate region gene 1 protein from Homo sapiens (Human) (see 4 papers)
NP_056526 BRD4-interacting chromatin-remodeling complex-associated protein from Homo sapiens
Aligns to 1091:1192 / 1560 (6.5%), covers 98.0% of PF15249, 123.3 bits
- function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).
subunit: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:21555454). - Sifting Through the Noise: A Computational Pipeline for Accurate Prioritization of Protein-Protein Binding Candidates in High-Throughput Protein Libraries.
Mondal, bioRxiv : the preprint server for biology 2024 - “...protein that as the name implies is already known to bind BET proteins (Uniprot ID: Q9NZM4) [ 27 , 42 , 43 ] . Its detection as a binding partner provides a validation of the AF-CBP method. However, it is unknown which region of BICRA is...”
- Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development.
El, International journal of molecular sciences 2019 - “...(BICRA), also known as glioma tumor suppressor candidate region gene 1 protein GLTSCR1 (UniProt ID: Q9NZM4), is a 1560-residue-long component of the SWI/SNF chromatin remodeling subcomplex GBAF and an ncBAF complex subunit encoded by the BICRA gene. GLTSCR1/BICRA is shown to play a role in BRD4-mediated...”
- “...ID: P60709). Figure 23 Structural and functional analysis of the human GLTSCR1/BICRA protein (UniProt ID: Q9NZM4). ( A ) Intrinsic disorder profile of human GLTSCR1/BICRA protein generated by six commonly used predictors of intrinsic disorder (PONDR VLXT, PONDR VL3, PONDR VSL2, PONDR FIT, IUPred_short, and IUPred_long)....”
- A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation.
Michel, Nature cell biology 2018 - “...obtained from PFAM regions defined for the following UNIPROT identifiers: BRD9 : Q9H8M2, BICRA : Q9NZM4, BRD7 : Q9NPI1, SMARCA2 : P51531, SMARCA4 : Q9HBD4, SMARCB1 : G5E975, SMARCC1 : Q92922, SMARCC2 : Q8TAQ2, SMARCD1 : Q96GM5, SMARCD2 : Q92925, SMARCE1 : Q969G3, SS18 : Q15532,...”
- Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, Nature 2015 - “...P04745 Alpha-amylase 1 OS=Homo sapiens GN=AMY1A PE=1 SV=2 43 57731 1 1 2.3 6.47 175 Q9NZM4 Glioma tumor suppressor candidate region gene 1 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 42 158393 2 1 0.5 6.17 176 P10643 Complement component C7 OS=Homo sapiens GN=C7 PE=1 SV=2 42...”
- Identification of a novel BICRA variant leading to the newly described Coffin-Siris syndrome 12.
Asadauskaitė, Brain & development 2023 (PubMed)- GeneRIF: Identification of a novel BICRA variant leading to the newly described Coffin-Siris syndrome 12.
- GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.
Han, Journal of molecular cell biology 2022 - GeneRIF: GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.
- BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
Barish, American journal of human genetics 2020 - GeneRIF: BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
- Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA.
Walker, Leukemia 2019 - GeneRIF: Identifies an acute myeloid leukemia susceptibility locus near BICRA.
- GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.
Yin, Current medical science 2018 (PubMed)- GeneRIF: No significant association of GLTSCR1 rs1035938 and lung cancer was found in five genetic models in Chinese population. Haplotypes consisting of PPP1R13L, CD3EAP and GLTSCR1 SNPs on Chr19q13.3 may associate with lung cancer risk in the Chinese population.
- DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
Rajaraman, Neuro-oncology 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas.
Yang, Cancer 2005 (PubMed)- GeneRIF: Polymorphisms in GLTSCR1 are associated with the development of oligodendrogliomas.
- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
XP_005159309 glioma tumor suppressor candidate region gene 1 protein isoform X1 from Danio rerio
Aligns to 1159:1261 / 1823 (5.7%), covers 98.0% of PF15249, 114.9 bits
BICRL_HUMAN / Q6AI39 BRD4-interacting chromatin-remodeling complex-associated protein-like; Glioma tumor suppressor candidate region gene 1 protein-like from Homo sapiens (Human) (see paper)
Aligns to 711:811 / 1079 (9.4%), covers 100.0% of PF15249, 113.9 bits
- function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner.
subunit: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A. - Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development.
El, International journal of molecular sciences 2019 - “...(BICRAL) also known as glioma tumor suppressor candidate region gene 1 protein-like (GLTSCR1; UniProt ID: Q6AI39), is a 1079-residue-long component of the SWI/SNF chromatin remodeling subcomplex GBAF encoded by the BICRAL gene. The currently available information about this protein is very limited. It is known that...”
- “...Figure 24 D 2 P 2 functional disorder profile of human GLTSCR1L/BICRAL protein (UniProt ID: Q6AI39)....”
BICRL_MOUSE / Q8CHH5 BRD4-interacting chromatin-remodeling complex-associated protein-like from Mus musculus (Mouse) (see paper)
Aligns to 708:808 / 1074 (9.4%), covers 100.0% of PF15249, 111.2 bits
- function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner.
subunit: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A.
AT5G17510 hypothetical protein from Arabidopsis thaliana
Aligns to 138:253 / 369 (31.4%), covers 99.0% of PF15249, 98.4 bits
- Linkage and association mapping of ovule number per ovary (ON) in oilseed rape (Brassica napus L.)
Ahmad, Molecular breeding : new strategies in plant improvement 2023 - “...BnaA10g16530D (AT5G18310), BnaA10g17120D (AT5G17620), BnaA10g17220D (AT5G17510), BnaA10g17250D (AT3G03341), and BnaA10g17390D (AT5G17280). Mol Breeding (2023)...”
- Telomerase Interaction Partners-Insight from Plants
Fulnečková, International journal of molecular sciences 2021 - “...observed for two putative paralogs of the mediator of RNA polymerase II transcription subunit-like protein (AT5G17510, AT3G03460, Figure 6 A). Among proteins with presumed functions in the signaling and regulation of RNA transcription, we found that WDR26 (WD-40 REPEAT 26) protein interacted with POT1a. Also, two...”
- “...La1 (AT4G32720), MCM2 (AT1G44900), KRS (AT3G11710), COG5 (AT1G67930), RCC1 (AT1G19880), AT1G15790, CSP1 (AT4G36020), WDR26 (AT5G08560), AT5G17510, AT5G11980, AT4G27640 were prepared using cDNA from 7-day-old seedlings of Arabidopsis thaliana (Col-0), specific primers and Advantage 2 Polymerase Mix (Clontech, Mountain View, CA, USA) followed by BP clonase reaction...”
- BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes
Yu, Nature plants 2020 (PubMed)- “...Unique peptide Coverage (%) AT3G03460 BRIP1 7 23.2 11 42.4 AT5G17510 BRIP2 29 53.1 21 52.8 127 1 128 BD BRIP2-BD GLTSCR GLTSCR 265 266 369 BRIP2-G e BRIP1-BD...”
- “...and BRIP2, that are encoded by AT3G03460 and AT5G17510, respectively (Fig. 1a). They were selected as candidates for core subunits of plant SWI/SNF complexes...”
- A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies
McWhite, Cell 2020 - “...2014 ), 2) SWI/SNF components with LEAF AND FLOWER RELATED (LFR) and the uncharacterized protein AT5G17510 ( Vercruyssen et al., 2014 ), and 3) two uncharacterized pentatricopeptide repeat proteins PPR59 and PPR351 ( Arabidopsis Interactome Mapping, 2011 ). To further independently validate our derived protein complexes...”
F6HEA6 GLTSCR protein conserved domain-containing protein from Vitis vinifera
Aligns to 145:260 / 381 (30.4%), covers 99.0% of PF15249, 97.3 bits
- Grape ASR-Silencing Sways Nuclear Proteome, Histone Marks and Interplay of Intrinsically Disordered Proteins
Atanassov, International journal of molecular sciences 2022 - “...F6H824 (F6H824_VITVI) CBI23432.3 VIT_00s0250g00040.t01 DNA-binding protein 1.21 D7SU28 (D7SU28_VITVI) CBI20777.3 VIT_04s0008g02590.t01 Selenium binding protein 1.22 F6HEA6 (F6HEA6_VITVI) CBI26439.3 VIT_16s0039g01020.t01 Adenylate cyclase, terminal-differentiation specific 1.30 D7TIR0 (D7TIR0_VITVI) CBI30136.3 Not available Arginine/serine-rich coiled-coil protein 2 isoform X2 1.43 F6H1I0 (F6H1I0_VITVI) CBI19683.3 VIT_18s0001g12350.t01 Protein ESSENTIAL FOR POTEXVIRUS ACCUMULATION X1...”
AGABI1DRAFT_112712 uncharacterized protein from Agaricus bisporus var. burnettii JB137-S8
Aligns to 24:138 / 274 (42.0%), covers 96.1% of PF15249, 95.0 bits
- Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components
Hernández-García, Communications biology 2022 - “...irregularis , PKK68317) BRD1, BRD2, BRD13 SMARCJ BCL7A, BCL7B, BCL7C - BDH1, BDH2 SMARCK GLTSCR1/1L AGABI1DRAFT_112712 ( A. bisporus , K5W2I3), UMAG_10422 ( U. maydis , A0A0D1DVN6), RhiirC2_747354 ( R. irregularis , PKK70026) BRIP1, BRIP2 SMARCL SS18, CREST, SS18L2 RiSS18/RirG_105530 ( R. irregularis , A0A015JMG5) GIF1,...”
AT3G03460 hypothetical protein from Arabidopsis thaliana
Aligns to 129:244 / 354 (32.8%), covers 99.0% of PF15249, 90.4 bits
- C2-methyladenosine in tRNA promotes protein translation by facilitating the decoding of tandem m2A-tRNA-dependent codons
Duan, Nature communications 2024 - “...found in protein-coding genes (CAA-CGU-CGC-CGU from AT2G18500 , CAG-CGU-CAA-CAA from AT2G33640 , and CAA-CAG-CGU-CAA-CAA-CAG from AT3G03460 ) into the dual-luciferase reporter construct as shown in Fig. 6c (termed as S1, S2, and S3, respectively). As a negative control, a sequence without m 2 A-tRNA-dependent codons (GUG-GUG-ACA-ACA,...”
- Telomerase Interaction Partners-Insight from Plants
Fulnečková, International journal of molecular sciences 2021 - “...for two putative paralogs of the mediator of RNA polymerase II transcription subunit-like protein (AT5G17510, AT3G03460, Figure 6 A). Among proteins with presumed functions in the signaling and regulation of RNA transcription, we found that WDR26 (WD-40 REPEAT 26) protein interacted with POT1a. Also, two closely...”
- BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes
Yu, Nature plants 2020 (PubMed)- “...Replicate 1 Unique peptide Coverage (%) Unique peptide Coverage (%) AT3G03460 BRIP1 7 23.2 11 42.4 AT5G17510 BRIP2 29 53.1 21 52.8 127 1 128 BD BRIP2-BD GLTSCR...”
- “...we named BRIP1 and BRIP2, that are encoded by AT3G03460 and AT5G17510, respectively (Fig. 1a). They were selected as candidates for core subunits of plant...”
NP_001263051 BRD4 interacting chromatin remodeling complex associated protein, isoform B from Drosophila melanogaster
Aligns to 2173:2272 / 3003 (3.3%), covers 99.0% of PF15249, 83.1 bits
MIG38_CAEEL / A6ZJ71 Abnormal cell migration protein 38 from Caenorhabditis elegans (see paper)
NP_001255569 Abnormal cell migration protein 38 from Caenorhabditis elegans
Aligns to 685:783 / 1607 (6.2%), covers 90.2% of PF15249, 54.5 bits
- function: During gonad development, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody which allows for the formation of gonad arms. Role in gonad DTC migration may be in association with integrin related proteins ina-1 and mig-15.
disruption phenotype: Embryonic lethal. RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis. RNAi-mediated knockdown specifically in gonad DTCs also result in a DTC migration defect in which DTCs migrate away from the hermaphrodite midbody on the dorsal basement membrane. RNAi-mediated knockdown in a unc-6 mutant background results in failed gonad DTC migration to the midbody of the hermaphrodite. RNAi-mediated knockdown with ina-1, mig- 15 or talin in an rrf-3 mutant background results in enhanced gonad DTC migration. - mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.
Martynovsky, Developmental biology 2012 - GeneRIF: Data suggest that when MIG-38 is depleted, stimulation of a turning pathway is reduced, but MIG-15 could still couple with NCK-1 and promote distal tip cells (DTCs) motility.
UMAG_10422 uncharacterized protein from Ustilago maydis 521
Aligns to 164:252 / 946 (9.4%), covers 52.9% of PF15249, 32.4 bits
- Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components
Hernández-García, Communications biology 2022 - “...SMARCJ BCL7A, BCL7B, BCL7C - BDH1, BDH2 SMARCK GLTSCR1/1L AGABI1DRAFT_112712 ( A. bisporus , K5W2I3), UMAG_10422 ( U. maydis , A0A0D1DVN6), RhiirC2_747354 ( R. irregularis , PKK70026) BRIP1, BRIP2 SMARCL SS18, CREST, SS18L2 RiSS18/RirG_105530 ( R. irregularis , A0A015JMG5) GIF1, GIF2 SMARCM BCL11A, BCL11B - -...”
Or search for genetic data about PF15249 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory