Family Search for PF15252 (DUF4589)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15252 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

INSY1_MOUSE / Q8CD60 Inhibitory synaptic factor 1; InSyn1 from Mus musculus (Mouse) (see paper)
Aligns to 52:279 / 292 (78.1%), covers 100.0% of PF15252, 342.8 bits

• function: Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.
  subunit: Interacts with GPHN.

LARGN_HUMAN / Q569H4 Protein Largen; Mesenchymal stem cell protein DSC54; Proline-rich protein 16 from Homo sapiens (Human) (see paper)
Aligns to 53:304 / 304 (82.9%), covers 100.0% of PF15252, 260.5 bits

• function: Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration.
• Protein phosphatase 1α interacting proteins in the human brain.
  Esteves, Omics : a journal of integrative biology 2012

NP_057728 protein Largen isoform 2 from Homo sapiens
Aligns to 30:281 / 281 (89.7%), covers 99.6% of PF15252, 259.4 bits

• Largen: a molecular regulator of mammalian cell size control.
  Yamamoto, Molecular cell 2014 (PubMed)
  • GeneRIF: Largen, the product of a gene PRR16, increases cell size upon overexpression in human cells.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

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