Family Search for PF15262 (DUF4592)

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PF15262 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

L8ICT8 DUF4592 domain-containing protein from Bos mutus
Aligns to 45:173 / 1228 (10.5%), covers 100.0% of PF15262, 154.2 bits

• Comparative Analysis of Erythrocyte Proteomes of Water Buffalo, Dairy Cattle, and Beef Cattle by Shotgun LC-MS/MS
  Guo, Frontiers in veterinary science 2019
  • “...L8J128 Phosphoinositide phospholipase C 1 1 130102.95 5.48 F1MY77 Uncharacterized protein 1 1 131421.8 6.31 L8ICT8 Uncharacterized protein 2 2 137720.45 6.22 Q8MI28 Limbin 1 1 137810.33 6.28 E1BLT5 Uncharacterized protein 1 1 140379.39 8.66 E1BM01 Uncharacterized protein 1 1 143087.6 6.91 G3X7C0 Structural maintenance of...”

F1MW73 Capping protein inhibiting regulator of actin dynamics from Bos taurus
Aligns to 45:173 / 1308 (9.9%), covers 100.0% of PF15262, 154.1 bits

• Comparison of nanotube-protein corona composition in cell culture media
  Shannahan, Small (Weinheim an der Bergstrasse, Germany) 2013
  • “...3 11,721,867 Q32PG0 WWP1 NEDD4-like E3 ubiquitin-protein ligase WWP1 12,260,233 MWCNT-Raw P01044 KNG1 Kininogen-1 1,012,523 F1MW73 MGC148692 KIAA1211 protein 1,568,099 F1MSG6 RAPGEF2 Rap guanine nucleotide exchange factor 2 1,952,045 Q2KHZ2 HBS1L HBS1-like protein 4,041,483 F1MAX6 KATNAL1 Katanin p60 ATPase-containing subunit A-like 1 4,289,983 F1N300 Bt.76801 Condensin...”

F7AQV3 Capping protein inhibiting regulator of actin dynamics from Equus caballus
Aligns to 45:173 / 1409 (9.2%), covers 100.0% of PF15262, 153.3 bits

• Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation
  Peffers, The Journal of biological chemistry 2014
  • “...Collagen -3(VI) chain 177 343,977 21 10 0.07 F6YR34 Thrombospondin-1 111 133,474 5 5 0.08 F7AQV3 Uncharacterized KIAA1211 protein 49 139,560 20 1 0.02 F6U4X2 -Fetoprotein 41 70,131 5 2 0.02 2 F6U3D3 Cartilage oligomeric matrix protein 539 84,675 59 32 0.77 F7E0P3 Thrombospondin-4 69 98,508...”

D4A5F4 Capping protein inhibiting regulator of actin dynamics from Rattus norvegicus
Aligns to 45:173 / 1330 (9.7%), covers 100.0% of PF15262, 148.2 bits

• The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity.
  Ji, PloS one 2022
  • “...isomerase F, mitochondrial 1.70 0.002718 B2RYT0_RAT B2RYT0 Mrps21 Mitochondrial ribosomal protein S21 1.70 0.010777 D4A5F4_RAT D4A5F4 RGD1311575 Hypothetical LOC289568 1.70 0.013594 ECH1_RAT Q62651 Ech1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 1.69 0.006191 ETFA_RAT P13803 Etfa Electron transfer flavoprotein subunit alpha, mitochondrial 1.69 0.002644 G3V9U2_RAT G3V9U2 Acaa2 3-ketoacyl-CoA thiolase, mitochondrial...”

CRACD_MOUSE / Q5PR69 Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics from Mus musculus (Mouse) (see paper)
Aligns to 45:173 / 1291 (10.0%), covers 100.0% of PF15262, 146.8 bits

• function: Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697). Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity).
  subunit: Directly interacts with actin-capping proteins CAPZA1, CAPZA2 and CAPZB; this interaction decreases the binding of capping proteins to actin.
  disruption phenotype: Knockout mice display adenoma development in the small intestine in an age-dependent manner. They also develop pulmonary lesions resembling early small cell lung cancer and solid- pseudopapillary neoplasm of the pancreas. Tumors from mutant animals show increased expression of Wnt/beta-catenin target genes without the alteration of other signaling pathways. Intestinal tumors exhibit disorganized and decreased levels of F-actin.
• Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
  Feng, Frontiers in neurology 2022
• Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.
  Li, Molecular biology of the cell 2021
  • “...Protein FAM107B 4.63 2 2.32 Q3TTY5 Keratin, type II cytoskeletal 2 epidermal 16.21 7 2.32 Q5PR69 Uncharacterized protein KIAA1211 24.31 10 2.43 P57746 V-type proton ATPase subunit D 8.1 3 2.70 P51880 Fatty acid-binding protein, brain 5.79 2 2.90 Q01405 Protein transport protein Sec23A 5.79 2...”

CRACD_HUMAN / Q6ZU35 Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics from Homo sapiens (Human) (see paper)
Aligns to 45:173 / 1233 (10.5%), covers 100.0% of PF15262, 145.6 bits

• function: Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.
  subunit: Directly interacts with actin-capping proteins CAPZA1, CAPZA2 and CAPZB; this interaction decreases the binding of capping proteins to actin.
• Using plasma proteomics to investigate viral infections of the central nervous system including patients with HIV-associated neurocognitive disorders.
  Ahmed, Journal of neurovirology 2022
  • “...1.43 0.62 C1S P09871 0.0378 0.44 1.42 0.67 IGKV1-8 A0A0C4DH67 0.0393 0.91 1.41 0.95 CRACD Q6ZU35 0.0419 2.77 1.38 1.67 TTN Q8WZ42 0.0421 0.81 1.38 0.9 LAMP2 P13473 0.0429 0.48 1.37 0.69 GP6 Q9HCN6 0.0447 0.98 1.35 0.99 ADGRF5 Q8IZF2 0.0455 3.33 1.34 1.82 LAMP1 P11279...”

XP_047271950 capping protein-inhibiting regulator of actin dynamics isoform X1 from Homo sapiens
Aligns to 130:258 / 1318 (9.8%), covers 100.0% of PF15262, 145.5 bits

• Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
  Chang, Cell reports 2022 (PubMed)
  • GeneRIF: Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
• Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.
  Cui, Bioscience reports 2020
  • GeneRIF: Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.
• Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer.
  Zhou, Respiratory research 2019
  • GeneRIF: The overall survival of small cell lung cancer patients carrying KIAA1211 mutation was significantly longer than those with wild-type KIAA1211.
• Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.
  Jung, Nature cell biology 2018
  • GeneRIF: Datam indicate that cancer-related regulator of actin dynamics (CRAD) as frequently mutated or transcriptionally downregulated and as a tumour suppressor in colorectal cancer (CRC).
  • GeneRIF: CRAD (Cancer-related Regulator of Actin Dynamics, previously KIAA1211) binds to and inhibits capping proteins, which leads to actin polymerization. CRAD is ubiquitously expressed in epithelial cells and is required for the maintenance of epithelial cell integrity. Genetic ablation of this gene deregulates Wnt signaling and induces the development of tumors in mouse models.

Q6NV74 CRACD-like protein from Homo sapiens
NP_997245 CRACD-like protein from Homo sapiens
Aligns to 130:240 / 962 (11.5%), covers 100.0% of PF15262, 105.0 bits

• Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes.
  Ferrer, Brain pathology (Zurich, Switzerland) 2018
• Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype
  Zanini, PloS one 2011
  • “...60 _ _ Q9H165 BC11A B-cell lymphoma/leukemia 11A 92565 6,15 8 11 56 _ _ Q6NV74 CB055 Uncharacterized protein C2orf55 102665 8,13 6 10 56 _ _ Q8IYJ1 CPNE9 Copine-9 62281 5,18 7 16 59 _ _ Q8N0V1 Cu121 Putative uncharacterized protein C21orf121 14961 9.08 3...”
• Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
  Alblooshi, BMC psychiatry 2020
  • GeneRIF: Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Q9ULL0 Acrosomal protein KIAA1210 from Homo sapiens
Aligns to 312:420 / 1709 (6.4%), covers 83.1% of PF15262, 52.7 bits

• Using plasma proteomics to investigate viral infections of the central nervous system including patients with HIV-associated neurocognitive disorders.
  Ahmed, Journal of neurovirology 2022
  • “...2.11 1.03 IGLV6-57 P01721 0.0087 1.35 2.06 1.16 PDCD1LG2 Q9BQ51 0.0112 0.63 1.95 0.79 KIAA1210 Q9ULL0 0.012 6.35 1.92 2.52 CSF1R P07333 0.0134 1.08 1.87 1.04 PLTP P55058 0.0175 0.2 1.76 0.44 HRNR Q86YZ3 0.0177 4.28 1.75 2.07 PRB4 P10163 0.0185 4.95 1.73 2.22 AZGP1 P25311...”

K1210_MOUSE / E9Q0C6 Acrosomal protein KIAA1210 from Mus musculus (Mouse) (see paper)
Aligns to 119:211 / 1637 (5.7%), covers 49.2% of PF15262, 41.7 bits

• subunit: Interacts with TOP2B.

XP_006541475 acrosomal protein KIAA1210 isoform X1 from Mus musculus
Aligns to 121:211 / 1720 (5.3%), covers 49.2% of PF15262, 41.5 bits

• Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes.
  Iwamori, Biology of reproduction 2017
  • GeneRIF: These findings suggest that KIAA1210 may be essential cell junction protein that interacts with TOP2B to regulate the dynamic change of chromatin structures during spermiogenesis.

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