Family Search for PF15363 (BTBD8_C)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15363 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BTBD8_HUMAN / Q5XKL5 BTB/POZ domain-containing protein 8; AP2-interacting clathrin-endocytosis; APache from Homo sapiens (Human) (see 2 papers)
Aligns to 1749:1792 / 1792 (2.5%), covers 100.0% of PF15363, 85.4 bits

• function: Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
  subunit: Interacts (via N-terminus) with adapter protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1).

BTBD8_MOUSE / D3YUB6 BTB/POZ domain-containing protein 8; AP2-interacting clathrin-endocytosis protein; APache from Mus musculus (Mouse) (see paper)
NP_001365195 BTB/POZ domain-containing protein 8 isoform 1 from Mus musculus
Aligns to 1707:1751 / 1751 (2.6%), covers 100.0% of PF15363, 85.1 bits

• function: Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
  subunit: Interacts (via N-terminus) with adapter protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1).
• Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.
  Blasco, Molecular & cellular proteomics : MCP 2022
  • “...Q99KN9 protein binding 6 Months Lysophosphatidylserine lipase ABHD12 Q99LR1 hydrolase activity BTB/POZ domain-containing protein 8 D3YUB6 protein binding YES ATPase GET3 O54984 nucleotide binding Protein kinase c-binding protein NELL2 Q61220 calcium ion binding Protein PALS2 Q9JLB0 protein binding UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 Q3TW96 transferase activity Vacuolar...”
• APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.
  Piccini, Cell reports 2017 (PubMed)
  • GeneRIF: APache is a presynaptic AP2 interactor on clathrin-coated vesicles. APache silencing impairs clathrin-mediated endocytosis and synaptic function.

BTBD8_RAT / D4A0X3 BTB/POZ domain-containing protein 8; AP2-interacting clathrin-endocytosis protein; APache from Rattus norvegicus (Rat) (see paper)
Aligns to 1705:1749 / 1749 (2.6%), covers 100.0% of PF15363, 84.4 bits

• function: Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
  subunit: Interacts (via N-terminus) with adapter protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1).

Q9H6K5 Proline-rich protein 36 from Homo sapiens
Aligns to 1301:1346 / 1346 (3.4%), covers 93.5% of PF15363, 69.8 bits

• Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets.
  Qiu, Clinical proteomics 2023
  • “...Q9BVW5 TIPIN TIMELESS-interacting protein TIPIN_HUMAN 5.420841786 42.83867003 0.024706829 0.120254705 1097.918701 47,033.37696 1097.918701 53,906.45801 2.27E-13 51,368.51886 Q9H6K5 PRR36 Proline-rich protein 36 PRR36_HUMAN 5.277000873 38.77354861 0.010817348 0.075164197 1270.526734 49,262.83008 1482.28119 44,692.1954 473.497357 36,396.36268 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 SMRD1_HUMAN 5.204188829 36.86522939...”
• Proteomic differences in the hippocampus and cortex of epilepsy brain tissue.
  Pires, Brain communications 2021
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...protein ENSP00000382033 OS=Homo sapiens PE=2 SV=2 - [YQ018_HUMAN] 12.65 1 1 1 166 18.0 6.52 Q9H6K5 Putative uncharacterized protein FLJ22184 OS=Homo sapiens PE=1 SV=1 - [YS027_HUMAN] 1.95 1 1 1 616 60.0 4.91 Q6AHZ1 Zinc finger protein 518A OS=Homo sapiens GN=ZNF518A PE=1 SV=2 - [Z518A_HUMAN] 1.48...”

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