Family Search for PF15382 (DUF4609)

Running HMMer for PF15382

PF15382 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SPT33_MOUSE / Q8C624 Spermatogenesis-associated protein 33 from Mus musculus (Mouse) (see 3 papers)
Aligns to 63:130 / 132 (51.5%), covers 100.0% of PF15382, 132.9 bits

• function: Plays an important role in sperm motility and male fertility (PubMed:34446558). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (PubMed:34446558). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (PubMed:33087875). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (PubMed:33087875).
  subunit: Interacts (via PQIIIT motif) with PPP3R2 and PPP3CC (PubMed:34446558). Interacts with VDAC2 (PubMed:33087875, PubMed:34446558). Interacts with ATG16L1 (via WD repeats) (PubMed:33087875). Interacts with PPP3R1, PPP3CA and PPP3CB (By similarity).
  disruption phenotype: Mice exhibit reduced sperm motility because of an inflexible midpiece, leading to impaired male fertility (PubMed:34446558). Spata33 knockout in Sertoli cells and spermatogenic cells suppresses mitophagy (PubMed:33087875).

SPT33_HUMAN / Q96N06 Spermatogenesis-associated protein 33 from Homo sapiens (Human) (see paper)
NP_694570 spermatogenesis-associated protein 33 isoform b from Homo sapiens
Aligns to 70:137 / 139 (48.9%), covers 98.5% of PF15382, 132.9 bits

• function: Plays an important role in sperm motility and male fertility (By similarity). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (By similarity). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (By similarity). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (By similarity).
  subunit: Interacts (via PQIIIT motif) with PPP3R1, PPP3R2, PPP3CA, PPP3CB and PPP3CC (PubMed:34446558). Interacts with VDAC2 (By similarity). Interacts with ATG16L1 (via WD repeats) (By similarity).
• Gene alterations and expression spectrum of SPATA33 in nonobstructive azoospermic Iranian men.
  Monsef, Molecular reproduction and development 2018 (PubMed)
  • GeneRIF: the current study illustrated that alterations in SPATA33 gene, at least those found in this study, may not impair spermatogenesis in patients with nonobstructive azoospermia.

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