Family Search for PF15387 (DUF4611)

PF15387 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

GON7_HUMAN / Q9BXV9 EKC/KEOPS complex subunit GON7 from Homo sapiens (Human) (see 2 papers)
NP_115879 EKC/KEOPS complex subunit GON7 from Homo sapiens
Aligns to 3:98 / 100 (96.0%), covers 100.0% of PF15387, 148.5 bits

• function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:27903914, PubMed:31481669). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:27903914, PubMed:31481669). GON7 plays a supporting role to the catalytic subunit OSGEP in the complex (PubMed:27903914, PubMed:31481669).
  subunit: Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
• Commonality and diversity in tRNA substrate recognition in t6A biogenesis by eukaryotic KEOPSs.
  Wang, Nucleic acids research 2022
  • “...(UniProt No. Q96S44), TPRKB (UniProt No. Q9Y3C4), LAGE3 (UniProt No. Q14657) and GON7 (UniProt No. Q9BXV9) were amplified from cDNA obtained by reverse transcription of total RNA from human HEK293T cells. Ribosomal recognition sites (RBSs) were inserted between two adjacent coding genes into a pJ241 vector...”
• Proteomic Characterization of Proliferation Inhibition of Well-Differentiated Laryngeal Squamous Cell Carcinoma Cells Under Below-Background Radiation in a Deep Underground Environment
  Liu, Frontiers in public health 2020
  • “...ITIH2 0.3368894 0.393 Q6ZVX7 NCCRP1 1.517451 2.281 Q8WXA9 SREK1 0.5544262 1.554 Q96B23 C18orf25 0.6465517 0.837 Q9BXV9 GON7 0.6654836 0.607 Q9UPY3 DICER1 0.574236 1.017 Protein-Protein Interaction Network Construction and Module Analysis To further ascertain the functional interactions between the DAPs, the Cytoscape software was used to construct...”
• Brain Proteomic Profiling in Intractable Epilepsy Caused by TSC1 Truncating Mutations: A Small Sample Study.
  Liu, Frontiers in neurology 2020
  • “...25-hydroxycholesterol 7-alpha-hydroxylase (CYP7B1) 0.044656159 5.3 Endoplasmic reticulum Q9UL12 Sarcosine dehydrogenase, mitochondrial (SARDH) 0.002488866 5.73 Mitochondrion Q9BXV9 EKC/KEOPS complex subunit GON7 (GON7) 0.011582219 6.03 Nucleus Q7Z449 Cytochrome P450 2U1 (CYP2U1) 0.018037731 8.15 Endoplasmic reticulum Q92692 Nectin2 (NECTIN2) 0.013976793 8.63 Plasma membrane O15231 Zinc finger protein 185 (ZNF185)...”
• Porcine Reproductive and Respiratory Syndrome Virus strains with Higher Virulence Cause Marked Protein Profile Changes in MARC-145 Cells.
  Chen, Scientific reports 2018
  • “...up gi|297302073 MKI67 P46013 up gi|297305113 G6PD P11413 down gi|297716361 SP1 P08047 down gi|302565376 C14orf142 Q9BXV9 down gi|306482649 RPLP0 P05388 down gi|306875 HNRNPCL1 O60812 up gi|307133695 EEF1G P26641 down gi|310923118 TXN P10599 up gi|3126878 HNRNPM P52272 down gi|32189394 ATP5A1 P25705 down gi|33112236 CAPN1 P07384 down gi|3668141...”
  • “...up gi|297664392 VAV3 Q9UKW4 down gi|297671227 MANF P55145 up gi|297703839 DDX3X O00571 down gi|302565376 C14orf142 Q9BXV9 down gi|306482641 GAPDH P04406 up gi|310923118 TXN P10599 up gi|3126878 HNRNPM P52272 up gi|32189394 ATP5A1 P25705 up gi|4501891 FLNC Q14315 down gi|4502297 ATP5D P30049 down gi|4504281 HIST1H3A P68431 up gi|4506189...”
• Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.
  Arrondel, Nature communications 2019
  • GeneRIF: Mutations in GON7, encoding the fifth KEOPS subunit, lead to a milder form of Galloway-Mowat syndrome (GAMOS), an autosomal recessive disease characterized by early-onset steroid-resistant nephrotic syndrome and microcephaly. The structure and cellular characterization of GON7 suggest its involvement in the cellular stability and quaternary arrangement of the KEOPS complex.

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