Family Search for PF15395 (DUF4617)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF15395 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
XP_016875039 retroelement silencing factor 1 isoform X1 from Homo sapiens
Q9HCM1 Retroelement silencing factor 1 from Homo sapiens
Aligns to 669:1737 / 1747 (61.2%), covers 100.0% of PF15395, 1674.8 bits
RESF1_MOUSE / Q5DTW7 Retroelement silencing factor 1 from Mus musculus (Mouse) (see paper)
XP_006507146 retroelement silencing factor 1 isoform X1 from Mus musculus
Aligns to 451:1511 / 1521 (69.8%), covers 100.0% of PF15395, 1433.7 bits
- function: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
subunit: Interacts with SETDB1. - Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry.
Vojtek, Life science alliance 2021 - GeneRIF: Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry.
- A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.
Fukuda, Genome research 2018 - GeneRIF: We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1
XP_416367 retroelement silencing factor 1 isoform X1 from Gallus gallus
Aligns to 733:1892 / 1897 (61.1%), covers 100.0% of PF15395, 1043.8 bits
Or search for genetic data about PF15395 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory