Family Search for PF15395 (DUF4617)

PF15395 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

XP_016875039 retroelement silencing factor 1 isoform X1 from Homo sapiens
Q9HCM1 Retroelement silencing factor 1 from Homo sapiens
Aligns to 669:1737 / 1747 (61.2%), covers 100.0% of PF15395, 1674.8 bits

• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
• The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer's Disease Reveals New Insights for AD Study
  Rochín-Hernández, International journal of molecular sciences 2023
  • “...FC ANOVA (p) Symptomatic carrier (P1) P68871 HBB Hemoglobin subunit beta 189.5 1.99 10 6 Q9HCM1 KIAA1551 Uncharacterized protein KIAA1551 52.0 1.05 10 5 P20591 MX1 Interferon-induced GTP-binding protein Mx1 37.1 4.19 10 6 A0A2R8Y7C0 HBA2 Hemoglobin subunit alpha (Fragment) 27.6 3.04 10 6 E7EMF1 ITGA2...”
• Synergistic Interactions of Cannabidiol with Chemotherapeutic Drugs in MCF7 Cells: Mode of Interaction and Proteomics Analysis of Mechanisms.
  Alsherbiny, International journal of molecular sciences 2021
  • “...subunit M2 1.13 Q8WVV9 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1.08 A0A2R8YET2 PRRC2C Protein PRRC2C 1.07 Q9HCM1 RESF1 Retroelement silencing factor 1 1.07 F8VWW7 SPRYD3 SPRY domain-containing protein 3 1.06 P54296 MYOM2 Myomesin-2 1.03 Q86XE3 MICU3 Calcium uptake protein 3_ mitochondrial 1.02 P49736 MCM2 DNA replication licensing...”
• Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate.
  Wang, MOJ proteomics & bioinformatics 2015
  • “...(IGFBP-3) 1.00 3 3.44 1.00 Q14624 inter-alpha-trypsin inhibitor heavy chain H4 0.99 4 2.17 0.99 Q9HCM1 KIAA1551 0.99 6 2.79 0.99 Q9C099 leucine-rich repeat and coiled-coil domain-containing l 0.98 5 2.19 0.98 Q9NZR2 low-density lipo receptor-related 1B 0.96 3 2.20 0.96 P26927 macrophage stimulating protein 1...”

RESF1_MOUSE / Q5DTW7 Retroelement silencing factor 1 from Mus musculus (Mouse) (see paper)
XP_006507146 retroelement silencing factor 1 isoform X1 from Mus musculus
Aligns to 451:1511 / 1521 (69.8%), covers 100.0% of PF15395, 1433.7 bits

• function: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
  subunit: Interacts with SETDB1.
• Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer.
  Majocha, PLoS genetics 2024
  • GeneRIF: Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer.
• Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry.
  Vojtek, Life science alliance 2021
  • GeneRIF: Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry.
• A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.
  Fukuda, Genome research 2018
  • GeneRIF: We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1

XP_416367 retroelement silencing factor 1 isoform X1 from Gallus gallus
Aligns to 733:1892 / 1897 (61.1%), covers 100.0% of PF15395, 1043.8 bits

• Conserved expression of a novel gene during gonadal development.
  Hudson, Developmental dynamics : an official publication of the American Association of Anatomists 2005 (PubMed)
  • GeneRIF: molecular cloning; expression of GET in the mullerian duct, wolffian duct, metanephric kidney, and external genitalia, suggests that GET may play a wider role in the development of the urogenital system

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