Family Search for PF15425 (DUF4627)

PF15425 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BT4411 predicted hyaluronic acid binding protein (DUF4627) from Bacteroides thetaiotaomicron VPI-5482
BT4411, BT_4411 hypothetical protein from Bacteroides thetaiotaomicron VPI-5482
Aligns to 21:230 / 233 (90.1%), covers 100.0% of PF15425, 271.1 bits

• mutant phenotype: Specifically important in carbon source Hyaluronic acid sodium salt from Streptococcus equi. The adjacent polysaccharide lyase BT4410 has similar phenotypes. Both proteins are periplasmic and this protein belongs to DUF4627, which is related to a family of carbohydrate binding proteins (PF02018).
• Nutrient niche specificity for glycosaminoglycans is reflected in polysaccharide utilization locus architecture of gut Bacteroides species
  Overbeeke, Frontiers in microbiology 2022
  • “...thetaiotaomicron, the lyase BT_3328 in combination with surface binding proteins BT_3329 and BT_3330 and potentially BT_4411 are involved in HA breakdown. Furthermore, degradation of both compounds provides public goods for other Bacteroides, including non-degraders, suggesting that cooperative degradation as well as cross-feeding may be widespread in...”
  • “...B . uniformis . For the CS-HA degraders the two orthogroups contained the hypothetical protein BT_4411, and the hypothetical protein BT_3328. Next, a phylogenomic tree of 53 gut Bacteroides strains was created to determine if there was phylogenetic conservation of CS and HA degradation ability (...”
• Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments
  Liu, Cell reports 2021
  • “...vitro ( Ndeh et al., 2018 ). The first GAG utilization gene we identified was BT4411, which was important for growth on HA but not on CS ( Figure 3G ). BT4411 is predicted to be in the same operon as the CS lyase BT4410, which...”
  • “...proteins have putative signal peptides ( Yu et al., 2010 ), suggesting that BT4410 and BT4411 function together in HA catabolism. Finally, we found that BT3233 was important for growth on the following 3 GAGs: CS (mean fitness, 1.6), HA (mean fitness, 0.7), and heparin (mean...”

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