Family Search for PF15701 (DUF4668)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF15701 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
YL036_YEAST / Q07986 Uncharacterized protein YLR036C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YLR036C Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein from Saccharomyces cerevisiae
Aligns to 25:185 / 203 (79.3%), covers 99.4% of PF15701, 224.4 bits
YPR71_YEAST / Q12346 Uncharacterized membrane protein YPR071W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YPR071W Putative membrane protein; YPR071W is not an essential gene from Saccharomyces cerevisiae
Aligns to 29:196 / 211 (79.6%), covers 100.0% of PF15701, 203.1 bits
- Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
Hua, Cell systems 2018 - “...YLR130C, YNR039C, YJL099W, YKL146W, YPR003C, YHL017W, YOR245C, YER166W, YBR132C, YOR016C, YPR090W, YNL300W, YLR250W, YGR038W, YPL259C, YPR071W, YKL065C, YKL046C, YPL274W, YEL048C, YOR317W, YDR100W, YNL146W, YMR253C, YJR031C, YER011W, YJL078C, YIL016W, YML037C, YGR247W, YFL004W, YBR023C, YIL044C, YMR052W, YDL204W, YBR067C, YDR153C, YIL043C, YNL095C, YDR476C, YOR307C, YOR321W, YCR011C, YMR237W, YMR071C, YER004W,...”
- Remarkably ancient balanced polymorphisms in a multi-locus gene network
Hittinger, Nature 2010 - “...of 1,642 genes ( YBR159W , YGL100W , YJR006W , YJR013W , YKL077W , and YPR071W ) reject 44 the monophyly of both the Portuguese and non-IFO1803 Japanese populations ( c ). Figure 2 The divergence of the GAL loci sharply contrasts with the rest of...”
- Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome
Gordon, PLoS genetics 2009 - “...5 in Figure 5 ). The largest is a family of five genes related to YPR071W ( Figure 6 ). There is no obvious progenitor for this family in the ancestral genome, and there are no homologs in the NCBI databases outside the sensu stricto species....”
- “...most divergent pair ( Figure 6A ); they can be recognized as a family because YPR071W hits the four other members in a BLASTP search (E0.004). Interestingly, all five genes are located beside tRNA genes ( Figure 6B ). We also identified two other orphan families...”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YNL146w YPR064w YCL075w YER046w YHR212c YLR036c YNL150w YPR071w YCR001w YER048w-a YHR214w-a YLR046c YNL156c YPR094w YCR006c YER050c YHR217c YLR047c YNL174w...”
YIL089W Putative protein of unknown function from Saccharomyces cerevisiae
Aligns to 28:190 / 205 (79.5%), covers 98.8% of PF15701, 164.7 bits
- Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress
Lin, Oxidative medicine and cellular longevity 2019 - “...Protein with a putative role in response to acid stress YBR238C YBR238C Mitochondrial membrane protein YIL089W YIL089W Protein of unknown function found in the ER and vacuole lumen YCR101C YCR101C Putative protein of unknown function YNL034W YNL034W Putative protein of unknown function YDL172C YDL172C Dubious open...”
- One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
Yofe, Nature methods 2016 - “...new peroxisomal proteins have never been studied before and only have systematic names (Yel020c, Ygr168c, Yil089w, Ybl039w-b (that is also localized to another membrane)). One of the genes, Yel020c, has previously been suggested to be peroxisomal by computational predictions of PTS1 variants 41 and due to...”
- Diploid-specific [corrected] genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress
Alabrudzinska, PloS one 2011 - “...YBR197C, YBR300C, YBR124W, YDL062W, YDR193W, YDR209C, YDR290W, YDR370C, YER067C-A, YGR021W, YGR127W, YHL029C, YIL001W, YIL055C, YIL057C, YIL089W, YIL091C, YJL009W, YJL016W, YJR141W, YKL111C, YKR075C, YLR137W, YLR253W, YLR414C, YML079W, YML090W, YML131W, YMR111C, YMR185W, YMR194C-A, YMR206W, YMR279C, YNL046W, YNL086W, YNL140C, YNL143C, YNR065C, YOL079W, YOL087C, YOR139C, YOR304C-A, YPL238C genome integrity 42...”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YER172c-a YIL088c YLR151c YNL305c YPR203w YCR103c YER184c YIL089w YLR156w YNL320w YBL059w* YDL015c YER188c-a YIL090w YLR159w YNL324w YDL012c* YDL027c YFL015c...”
YIL029C Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) from Saccharomyces cerevisiae
Aligns to 1:140 / 142 (98.6%), covers 75.3% of PF15701, 127.3 bits
- Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5
Watcharawipas, Frontiers in microbiology 2018 - “...GTPase-activating protein that plays a role in the synthesis of -1,3-glucan by stimulating Rho1; and YIL029c , which encodes a protein with unknown function ( Mira et al., 2009 ). Yeast cells lacking RIM101 also exhibit impaired vacuole acidification, leading to acidic cytosolic pH under propionic...”
- A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence
Li, G3 (Bethesda, Md.) 2015 - “...function; identified by SAGE YBR013C YBR013C Unknown function, haploid mutant exhibits synthetic phenotype with alpha-synuclein YIL029C YIL029C 4,5 Deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) YIL092W YIL092W GFP-fusion protein localizes to the cytoplasm and to the nucleus Descriptions are derived from Saccharomyces Genome Database. Parentheses indicate...”
- Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells
Johnson, PloS one 2014 - “...UBP9 GTO1 RPI1 YHR022C EHT1 MPS2 UGA4 HBT1 RPN7 YIL001W ERG4 MRS3 UPS2 HES1 RRI2 YIL029C ESA1 MVD1 UPS3 Genes indicated in bold are upregulated; all other genes are downregulated. Underlining of adjacent gene names indicates cases where probes are incapable of discriminating between highly similar...”
- Hunger artists: yeast adapted to carbon limitation show trade-offs under carbon sufficiency
Wenger, PLoS genetics 2011 - “...CDS C 876 F RTT107 IX 301064 C T hom (Ref)->het CDS C 65 Y YIL029C XIII 46350 C A hom (Ref)->het intergenic CTK3/BUL2 XIV 155354 G T hom (Ref)->het CDS L 85 F ORC5 XV 76249 C A hom (Ref)->het CDS T 617 K ALR1...”
- Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view
Mira, Omics : a journal of integrative biology 2010 - “...in the stimulation of b1,3-glucan synthesis through Rho1p; YIL029c, encoding a protein of uncharacterized function (Mira et al., 2009). Consistent with its role...”
- The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids
Mira, FEMS yeast research 2009 (PubMed)- “...cell wall b-1,6-glucan synthesis and the uncharacterized ORF YIL029c, both required for maximal propionic acid resistance. Clustering of the genes that provide...”
- “...YGL188c-A, YGR050c, YGR150c, YHL026c, YPR175w-A, YIL028w, YIL029c, YIL064w, YIL077c, YIL092w, YIR016w, YJL120w, YJR018w, YJR079w, YKL096c-B, YKL118w, YLR414c,...”
- Expression and functional profiling reveal distinct gene classes involved in fatty acid metabolism
Smith, Molecular systems biology 2006 - “...2 a CDC10 1 1 PIP2 1 1 BUB3 3 2 POP2 3 2 a YIL029C 3 4 CKB2 2 1 PMP3 2 2 a CAP1 3 2 a PPR1 3 2 YIL165C 3 4 CLA4 2 2 POT1 1 2 CBC2 3 2 a PRE9...”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YER091c-a YIL025c YLR111w YNL203c YPR151c YCR062w YER097w YIL029c YLR112w YNL211c YPR153w YCR063w YER113c YIL040w YLR122c YNL255c YPR170c YCR085w YER135c...”
YP257_YEAST / Q08974 Uncharacterized membrane protein YPL257W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YPL257W Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene from Saccharomyces cerevisiae
Aligns to 26:183 / 193 (81.9%), covers 96.9% of PF15701, 53.4 bits
- function: May be required for cell cycle progression.
- Insights into cell robustness against lignocellulosic inhibitors and insoluble solids in bioethanol production processes
Moreno, Scientific reports 2022 - “...YMR029C, YMR032W, YMR078C, YMR117C, YMR199W, YNL196C, YNR009W, YOL069W, YOL132W, YOR026W, YOR301W, YOR315W, YOR372C, YOR373W, YPL256C, YPL257W, YPR119W GO:0,007,049 Cell wall organization or biogenesis 1.70E-06 YBR038W, YBR067C, YBR076W, YDL055C, YDL222C, YDR261C, YER011W, YHL028W, YHL043W, YHR143W, YIL123W, YJL158C, YKL096W, YKL096W-A, YKL164C, YKL187C, YML052W, YMR215W, YMR305C, YNL283C, YOL030W, YOL132W,...”
- The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer's Disease
Fruhmann, Frontiers in molecular neuroscience 2018 - “...(3), YMR160W (3), YMR178W (3), YMR244W (3), YMR316C-A (3), YMR317W (3), YNL146W (3), YOR263C (3), YPL257W (3), YGL109W (4), YJL007C (4), YMR114C (4), YNL338W (4), YNR071C (4), YGL072C (5), YLR149C (5), YML084W (5), YMR103C (5), YOR296W (5), YPL247C (5) Cell cycle END3 (2), RIM8 (2), CCR4...”
- Development of a GIN11/FRT-based multiple-gene integration technique affording inhibitor-tolerant, hemicellulolytic, xylose-utilizing abilities to industrial Saccharomyces cerevisiae strains for ethanol production from undetoxified lignocellulosic hemicelluloses
Hasunuma, Microbial cell factories 2014 - “...I10 regions are located between YFL021W and YFL020C, YGR249W and YGR250C, YKL219W and YKL218C, and YPL257W and YPL256C, respectively. The inter-ORF regions are situated downstream of both adjacent ORFs. Linker 1 consisting of P19 and P20 was introduced into the Xba I site of I2 region,...”
- Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology
Kottom, Yeast (Chichester, England) 2011 - “...substrates demonstrated significant phosphorylation by the kinase. For PcSte20, both potential substrates listed (Lrs4 and YPL257W) were successfully purified and phosphorylated by PcSte20. Attempts were made to further purify Glo3, but this yielded unusable quantities for kinase assay. Notably however, in these assays, both kinases effectively...”
- “...submitted to Western blotting with anti-V5 antibody recognizing the epitope tag. * Denotes expression of YPL257W and ** denotes expression of Lrs4. B. The epitope tagged purified yeast proteins were next submitted to phosphorylation reactions in the presence of [- 32 P]-ATP and in the presence...”
- Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19
Ren, PloS one 2011 - “...as Prp17 for both the S. pombe and S. cerevisiae orthologs), Urn1, Mih1, YOR314w, Uba3, YPL257w, and Ufd4. Cwc2 was expected to be a positive hit in the screen because we previously showed that it is a splicing factor that binds directly to the Prp19 WD40...”
- “.... Mih1 is a Cdc25 phosphatase family member involved in cell cycle control [49] . YPL257w is an uncharacterized ORF of unknown function and unknown localization and YOR314w is a dubious ORF. Ufd4 is an E3 ubiquitin ligase [50] and Uba3 is one of two subunits...”
- Microarray karyotyping of commercial wine yeast strains reveals shared, as well as unique, genomic signatures
Dunn, BMC genomics 2005 - “...found: the AYT1 gene (chromosome 12), the ENB1 gene (chromosome 15), and the un-characterized ORF YPL257W (chromosome 16). The circled regions on the relevant chromosomes in Fig. 3AD highlight these single-gene strain differences, while Fig. 5A shows the data in more detail for these three genes....”
- “...enterobactin transporter of the major facilitator superfamily involved in iron uptake [ 81 ], while YPL257W has no known function, although its predicted product has homology to membrane proteins. Intra-strain variation We observed relatively little genomic variation between independent isolates of each of the different strains....”
- A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p)
Millson, Eukaryotic cell 2005 - “...(1); YPL188w (POS5) (1); YPL199c (2); YPL246c (RBD2) (1); YPL257w (2); YPR089w (3); YPR115w (2); YPR127w (2); YPR148c (1). c ORF, open reading frame. d Mating...”
Or search for genetic data about PF15701 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory