Family Search for PF15763 (DUF4692)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15763 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

RHEX_HUMAN / Q6ZWK4 Regulator of hemoglobinization and erythroid cell expansion protein; Regulator of human erythroid cell expansion protein from Homo sapiens (Human) (see paper)
NP_001007545 regulator of hemoglobinization and erythroid cell expansion protein from Homo sapiens
Aligns to 7:172 / 172 (96.5%), covers 100.0% of PF15763, 277.9 bits

• function: Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874).
  subunit: Interacts with EPOR; this interaction occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874). Interacts with JAK2; this interaction occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874). Interacts (via tyrosine-phosphorylated form) with GRB2 (PubMed:25092874).
• A protein-protein interaction analysis tool for targeted cross-linking mass spectrometry.
  Park, Scientific reports 2023
  • “...various parameters, such as (1) the entry number of the desired target protein (e.g., P04439, Q6ZWK4), (2) the enzyme used for protein digestion, (3) the cross-linker employed in XL-MS 11 , 19 26 for identifying proteinprotein interactions, (4) the preferred peptide length range for MS/MS analysis,...”
• Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells.
  Franke, Cells 2023
  • GeneRIF: Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells.
• RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
  Verma, The Journal of experimental medicine 2014
  • GeneRIF: RHEX(C1orf186) comprises a new EPO/EPOR target and regulator of erythroid cell expansion that additionally acts to support late-stage erythroblast development

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