Family Search for PF15774 (DUF4702)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15774 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CC116_HUMAN / Q8IYX3 Coiled-coil domain-containing protein 116 from Homo sapiens (Human) (see paper)
Aligns to 18:404 / 613 (63.1%), covers 99.7% of PF15774, 713.1 bits

• Urinary Extracellular Vesicles and Salt-Losing Tubulopathies: A Proteomic Approach.
  Raimondo, Proteomes 2020
  • “...Q6P179 Endoplasmic reticulum aminopeptidase 2 prot mbr S-P medium P12955 Xaa-Pro dipeptidase prot cyt high Q8IYX3 Coiled-coil domain-containing protein 116 * na cyt NA Q8NCU4 Coiled-coil domain-containing protein 191 * na org medium Q8WW52 Protein FAM151A na mbr S-P high A8MUH7 PDZ domain-containing 1 pseudogene 1...”

XP_011528286 coiled-coil domain-containing protein 116 isoform X3 from Homo sapiens
Aligns to 1:369 / 578 (63.8%), covers 95.2% of PF15774, 686.2 bits

• A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers.
  Qin, Human genetics 2017 (PubMed)
  • GeneRIF: Our results suggest that a slight change in CCDC116 expression in normal tissues can confer risk to corresponding cancers.
• Expression of the coiled coil domain containing protein 116 in the pancreatic islets and endocrine pancreatic tumors.
  Tsolakis, Islets
  • GeneRIF: The CCDC116 protein is expressed in all islet cell types except the glucagon and ghrelin cells.

Q2TA26 Coiled-coil domain containing 116 from Bos taurus
Aligns to 18:364 / 364 (95.3%), covers 88.9% of PF15774, 591.3 bits

• TMT-Based Comparative Proteomic Analysis of the Spermatozoa of Buck (Capra hircus) and Ram (Ovis aries)
  Ren, Genes 2023
  • “...Accession Description Gene Name P02784 Seminal plasma protein PDC-109 15.48 1 5.2 1 0.002299 47.32 Q2TA26 Coiled-coil domain-containing 116 CCDC116 40.31 3 14.3 1 0.000542 27.11 F1MB31 PREDICTED: putative serine protease 46 PRSS46 33.36 2 7.3 1 0.001534 26.54 O77780 Disintegrin and metalloproteinase domain-containing protein 2...”

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