Family Search for PF15787 (DUF4704)

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PF15787 hits 25 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

NBEA_DROME / Q9W4E2 Neurobeachin; A-kinase anchor protein 550; AKAP 550; Protein rugose; dAKAP550 from Drosophila melanogaster (Fruit fly) (see 6 papers)
Aligns to 629:1123 / 3466 (14.3%), covers 99.8% of PF15787, 668.8 bits

• function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.
  subunit: Interacts with RII subunit of PKA and components of the EGFR- mediated and Notch-mediated signaling pathways.
  disruption phenotype: Mutants are viable and fertile but display a rough eye surface phenotype, impaired short-term memory, aberrant associative odor learning, aberrant neuromuscular junction morphology with increased numbers of synaptic boutons, and defective axonal morphology of the Kenyon cells, the neurons of the mushroom body.

NBEA_HUMAN / Q8NFP9 Neurobeachin; Lysosomal-trafficking regulator 2; Protein BCL8B from Homo sapiens (Human) (see 2 papers)
Aligns to 467:947 / 2946 (16.3%), covers 99.8% of PF15787, 608.7 bits

• function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).
  subunit: Interacts with RII subunit of PKA.

NBEA_MOUSE / Q9EPN1 Neurobeachin; Lysosomal-trafficking regulator 2 from Mus musculus (Mouse) (see paper)
Aligns to 457:937 / 2936 (16.4%), covers 99.8% of PF15787, 607.8 bits

• function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking.
  subunit: Interacts with RII subunit of PKA.

NBEA_CAEEL / Q19317 Putative neurobeachin homolog; Suppressor enhancer of lin-12 from Caenorhabditis elegans (see paper)
Aligns to 539:1024 / 2507 (19.4%), covers 99.8% of PF15787, 597.2 bits

• function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.
  subunit: Interacts with RII subunit of PKA.
  disruption phenotype: Worms lacking sel-2 exhibit a multivulva phenotype when combined with loss of lin-12.

LRBA_MOUSE / Q9ESE1 Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein from Mus musculus (Mouse) (see paper)
Aligns to 441:921 / 2856 (16.8%), covers 99.8% of PF15787, 580.6 bits

• function: Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (PubMed:11254716). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (By similarity).
  subunit: Interacts with TOM1 and TOLLIP.

LRBA_HUMAN / P50851 Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein; CDC4-like protein from Homo sapiens (Human) (see 4 papers)
Aligns to 441:921 / 2863 (16.8%), covers 99.8% of PF15787, 579.5 bits

• function: Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106).
  subunit: Interacts with TOM1 and TOLLIP.

BCHB_ARATH / F4I9T0 BEACH domain-containing protein B; BEACH-domain homolog B from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 693:1208 / 2604 (19.8%), covers 98.8% of PF15787, 556.2 bits

• function: May be involved in the suppression of BCHC1 activity.
  disruption phenotype: No visible phenotype.

BCHC1_ARATH / F4JD14 BEACH domain-containing protein C1; BEACH-domain homolog C1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
2 alignments in 318:863 / 1941 (25.5%), covering up to 54.5% of PF15787, 202.0 bits

• function: May act as a negative factor in protein storage vacuole (PSV) trafficking regulation and plant effector triggered immunity (ETI). Negatively regulated upon interaction with GSF12, and also probably by BCHB. Required for ETI, but not for cell death.
  subunit: Interacts (via BEACH-type PH domain) with GFS12 (via protein kinase 2 domain).
  disruption phenotype: No visible phenotype.

NBEL1_HUMAN / Q6ZS30 Neurobeachin-like protein 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein from Homo sapiens (Human) (see paper)
Aligns to 854:1291 / 2694 (16.3%), covers 62.3% of PF15787, 114.9 bits

NBEL2_DANRE / E7FAW3 Neurobeachin-like protein 2 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 910:1232 / 2801 (11.5%), covers 54.5% of PF15787, 113.4 bits

• function: Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.

NBEL2_HUMAN / Q6ZNJ1 Neurobeachin-like protein 2 from Homo sapiens (Human) (see 3 papers)
Aligns to 873:1172 / 2754 (10.9%), covers 57.4% of PF15787, 96.7 bits

• function: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.

BCL8_HUMAN / P0C6P0 Putative protein BCL8; Neurobeachin pseudogene 1 from Homo sapiens (Human) (see 2 papers)
Aligns to 2:93 / 100 (92.0%), covers 16.7% of PF15787, 73.0 bits

NBEA_CHICK / Q9DDD5 Neurobeachin from Gallus gallus (Chicken) (see paper)
Aligns to 1:44 / 793 (5.5%), covers 8.6% of PF15787, 48.0 bits

• function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).
  subunit: Interacts with RII subunit of PKA.

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