Family Search for PF15806 (DUF4707)

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PF15806 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TPC14_DANRE / E7F240 Trafficking protein particle complex subunit 14; Microtubule-associated protein 11 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
Aligns to 162:594 / 595 (72.8%), covers 99.8% of PF15806, 840.3 bits

• function: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (By similarity). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is required for ciliogenesis (PubMed:30715179).
  subunit: Component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex. Interacts with alpha-tubulin during mitosis.
  disruption phenotype: Morpholino knockdown of the protein in early embryos results in curved bodies and small eyes. Morphants exhibit reduced ciliation in otic vesicles, neuromasts, and olfactory placodes (PubMed:31467083). In a knockout model mutant animals show head to body ratios lower than those of controls. They have decreased brain cell proliferation rate at 24 hpf (PubMed:30715179).

TPC14_HUMAN / Q8WVR3 Trafficking protein particle complex subunit 14; Microtubule-associated protein 11 from Homo sapiens (Human) (see 3 papers)
Aligns to 139:579 / 580 (76.0%), covers 100.0% of PF15806, 807.3 bits

• function: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:31467083, PubMed:30715179). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097).
  subunit: Component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex (PubMed:31467083). Interacts with alpha-tubulin during mitosis (PubMed:30715179). Interacts with RAB3IP (via the N-terminal region); this interaction mediates RAB3IP association with the TRAPP II complex (PubMed:31467083). Interacts with TRAPPC10 (PubMed:31467083). Interacts with FBF1 (PubMed:31467083).
• Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools.
  Gupta, Journal of biomolecular structure & dynamics 2021
  • “...as it is most closely related to a nonallergic sequence in its database (UniProt ID: Q8WVR3). This result indicates that the designed vaccine is nonallergic in nature and probably safe for human use. To characterize the immunogenicity and immune response profile of the designed vaccine, in...”

NP_001290399 trafficking protein particle complex subunit 14 isoform 2 from Homo sapiens
Aligns to 1:310 / 311 (99.7%), covers 69.7% of PF15806, 549.5 bits

• The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.
  Cuenca, The Journal of biological chemistry 2019
  • GeneRIF: C7orf43 directly binds to Rabin8 and that C7orf43 knockdown diminishes Rabin8 preciliary centrosome accumulation.

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